Linda K. McLoon, Ph.D. - MED - Ophthalmology and Visual Neurosciences, University of Minnesota
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Linda K. McLoon, Ph.D.


Professor
Departments of Ophthalmology & Visual Neurosciences, Neuroscience
Linda K. McLoon, Ph.D.

Contact Information



Phone:
Office: (612) 626-0777
Lab: (612) 626-0778
Fax: (612) 626-0781

Email: mcloo001@umn.edu

Address:
Department of Ophthalmology & Visual Neurosciences
374 Lions Research Building
2001 6th Street S.E.
Minneapolis, Minnesota 55455

Research

  • Development of pharmacologic treatments for strabismus and infantile nystagmus syndrome
  • Extraocular muscles and their stem cells
  • Sparing of the extraocular muscles in muscular dystrophies
  • Molecular control of extraocular muscle properties and how these are affected in strabismus and nystagmus

Education and Training

Graduate School: University of Illinois at the Medical Center
Post-doc: University of Washington; Medical University of South Carolina

Honors and Awards

American Society of Ophthalmic Plastic and Reconstructive Surgery Research Award for the most outstanding research published in the journal in 2002.
Lew Wasserman Mid-Career Merit Award, Research to Prevent Blindness, 2005-06
Gold Fellow, Association for Research in Vision and Ophthalmology, 2009-present
Elected to Board of Trustees, Association for Research in Vision and Ophthalmology, 2011-present
Honorary Member (one of 6 so honored), American Association for Pediatric Ophthalmology and Strabismus, 2012-present
Scientific Review Committee, Fight for Sight, 2011-present

Published Works

Peer-Reviewed Publications

Kallestad KM, Hebert SL, McDonald AA, Daniel ML, Cu SR, McLoon LK. Sparing of extraocular muscle in aging and dystrophic skeletal muscle: A myogenic precursor cell hypothesis. Exp. Cell Res. 317:873-885, 2011.

Anderson BC, Daniel ML, Kendall J, Christiansen SP, McLoon LK. Sustained release of bone morphogenetic protein-4 in adult rabbit extraocular muscle results in decreased force and muscle size: potential for strabismus treatment. Invest. Ophthalmol. Vis. Sci. 52: 4021-4029, 2011.

McLoon LK. What experimental embryology can tell us about extraocular muscle development in anophthalmia: At the interface of basic and clinical science. Invited editorial. Arch. Ophthalmol. 129: 1077-1079, 2011.

McLoon LK, Park H, Kim JH, Pedrosa-Domellöf F, Thompson LV. A continuum of myofibers in adult rabbit extraocular muscle: force, shortening velocity, and patterns of myosin heavy chain co-localization. J. Appl. Physiol. 111: 1178-1189, 2011.

Willoughby CL, Christiansen SP, Mustari MJ, McLoon LK. Effects of the sustained release of IGF-1 on extraocular muscle of the infant non-human primate: Adaptations at the effector organ level. Invest. Ophthalmol. Vis Sci. 53: 68-75, 2012.

Willoughby CL, Christiansen SP, Mustari MJ, McLoon LK. Effects of the sustained release of IGF-1 on extraocular muscle of the infant non-human primate: Adaptations at the effector organ level. Invest. Ophthalmol. Vis Sci. 53: 68-75, 2012.

Berg KT, Hunter DG, Bothun ED, Antunes-Foschini R, McLoon LK. Extraocular muscles in subjects with infantile nystagmus: Adaptations at the effector level. Arch. Ophthalmol. 130:1-8, 2012.

Willoughby CL, Ralles S, Christiansen SP, McLoon LK. Effects of sequential injections of hepatocyte growth factor and insulin-like growth factor-I on adult rabbit extraocular muscle. J AAPOS 16:354-360, 2012.

Hebert SL, Daniel ML, McLoon LK. The role of Pitx2 in maintaining the phenotype of myogenic precursor cells in the extraocular muscles. PLoS One 8(3):e58405, 2013.

Stager DR, McLoon LK, Felius J. Postulating a role for connective tissue elements in inferior oblique overaction. Trans. Am. Ophthalmol. Soc. 111:70-81, 2013.

McDonald AA, Kunz MD, McLoon LK. Dystrophic changes in extraocular muscles after gamma irradiation in mdx:utrophin+/- mice. PLoS One: in press.

Books and Recent Book Chapters:

Craniofacial Muscle Control: A New Framework for Understanding the Effector Side. Eds: LK McLoon, F Andrade. Springer, 2012. 338 pages.

McLoon LK. The Extraocular Muscles, Chapter 7, In: Adler’s Physiology of the Eye, 11th edition, Eds: Kaufman P, Alm A, Levin LA, Nilsson S, Ver Hoeve J, Wu SM. Elsevier. New York. pp. 182-207, 2011.