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Our department’s research strength lies with the strong collaborations between our clinical researchers and basic science researchers. Because of this, we have moved notable discoveries from the laboratory into the clinic in areas such as macular degeneration, cornea transplantation, and oculo-plastics.

Basic Research

Ferrington Lab

Gregerson Lab

McLoon Lab

Yuan Lab

Clinical Studies

Pediatric Ophthalmology and Strabismus

Intermittent Exotropia Study 2: A Randomized Clinical Trial of Observation versus Occlusion Therapy for Intermittent Exotropia-
The objective of this study is to determine the safety and effectiveness of occlusion for the treatment of intermittent exotropia in children ages 1 to <11 years.

Investigators: Drs. Anderson (Principal Investigator), Bothun, De Becker, and Summers
Coordinator: Ann Holleschau 612.625.4120

Amblyopia Treatment Study 15: Increasing Patching for Amblyopia-
This study is designed to evaluate the effectiveness of increasing prescribed patching treatment from 2 to 6 hours daily after visual acuity has stabilized with initial treatment but amblyopia is still present in children ages 3 to <8 years. The study consists of two phases: a run-in phase in which all children are treated with 2 hours of daily patching until vision has stabilized, and a randomized trial in which daily occlusion either remains at 2 hours or is increased to 6 hours.

Investigators: Drs. Anderson (Principal Investigator), Bothun, De Becker, and Summers
Coordinator: Ann Holleschau 612.625.4120

Amblyopia Treatment Study 16: Augmenting Atropine Treatment for Amblyopia-
The purpose of this study is to evaluate the effectiveness if adding a plano lens to weekend atropine after visual acuity has stabilized with weekend atropine but amblyopia is still present in children ages 3 to <8 years. The study consists of two phases: a run-in phase of weekend atropine until vision has stabilized, and a randomized trial of continuing with weekend atropine or adding a plano lens to the weekend atropine regimen.

Investigators: Drs. Anderson (Principal Investigator), Bothun, De Becker, and Summers
Coordinator: Ann Holleschau 612.625.4120

Infant Aphakia Treatment Study-
This study is a randomized involving infants less than 7 months old who were born with a unilateral cataract. Infants are randomized 1:1 to receive either a contact lens or an intraocular lens at the time of cataract removal and followed for 5 years to assess visual outcome, as well as parrental stress and re-operations.

Investigator: Dr. Bothun
Coordinator: Ann Holleschau 612.625.4120

Intermittent Exotropia Study 1: A Randomized Trial of Bilateral Rectus Recession versus Unilateral Rectus Recession with Medial Retus Resection for Intermittent Exotropia-
The purpose of this study is to evaluate the effectiveness of bilateral lateral rectus muscle recession versus unilateral lateral rectus recession with medial rectus resection procedures for the treatment of basic and pseudo divergence excess type intermittent exotropia in children 3 to <11 years.

Investigators: Drs. Bothun (Principal Investigator), Anderson, De Becker, and Summers
Coordinator: Ann Holleschau 612.625.4120

Correction of Refractive Error in Amblyopia-
The purpose of this study is to provide glasses for correction of refractive error for amblyopia prior to enrollment into another recruiting amblyopia treatment study in the series.

Investigators: Dr. Summers (Principal Investigator), Anderson, Bothun, and De Becker
Coordinator: Ann Holleschau 612.625.4120

Clinical Trial to Evaluate Levodopa as Treatment to Improve Vision in Individuals with Albinism-
This randomized, double-masked trial is designed to evaluate the effect of two doses of levodopa versus a placebo on the visual acuity of individuals (ages 3 to 60) with albinism.

Investigators: Drs. Summers (Principal Investigator) and De Becker
Coordinator: Ann Holleschau 612.625.4120

Albinism: Visual Function Studies-
The purpose of this comprehensive study is to increase our knowledge of albinism, the specific eye problems associated with each type of albinism and the changes over time by following individuals for many years. Many separate sub-studies of albinism exist under this main study.

Investigators: Drs. Summers (Principal Investigator) and De Becker
Coordinator: Ann Holleschau 612.625.4120

Amblyopia Treatment Study: Occlusion versus Pharmacologic Therapy for Moderate Amblyopia-
This study compares the effectiveness of patching versus daily atropine for the treatment of amblyopia in children 3 to <7 years old. It follows children to age 15 years.

Investigator: Dr. Summers
Coordinator: Ann Holleschau 612.625.4120

Amblyopia Treatment Study 17: A Randomized Trail of Levodopa as Treatment for Residual Amblyopia-
The primary objective of this study is to compare the safety and efficacy of oral levodopa and occlusion versus oral placebo and occlusion after 4 months of treatment for amblyopia in children 7 to <13 years of age. Maximum improvement in visual acuity will be evaluated as well as the frequency of recurrence of amblyopia following 3 months of no therapy.

Investigators: Drs. Bothun (Principal Investigators), Summers, Anderson, and De Becker
Coordinator: Ann Holleschau 612.625.4120

A Phase 3B, Multicenter, Randomized, Double-Masked, Parallel-Group, Active-Controlled Study of the Safety and Efficacy of Difluprednate Ophthalmic Emulsion, 0.05% (Durezol) 4 Times Daily (QID) and Prednisolone Acetate Ophthalmic Suspension, 1.0% (Pred Forte) QID for the Treatment of Inflammation Following Cataract Surgery in Children 0 to 3 Years of Age-
This study enrolls children from birth to age 3 who are undergoing cataract surgery in one eye. Children will be randomized to either Pred Forte (the standard steroid used after pediatric cataract surgery) or Durezol QID. Dosing schedule continues for 4 weeks after surgery with visits until 3 months after surgery. The primary objective of this study is to assess the safety and efficacy of Durezol as compared to Pred Forte.

Investigators: Drs. Bothun (Principal Investigator) and Anderson
Coordinator: Ann Holleschau 612.625.4120

Topical Betaxolol for the Prevention of Retinopathy of Prematurity-
The specific aim of this study is to compare the safety and effectiveness of a topical beta adrenergic receptor blocker in halting or slowing the progression of retinopathy of prematurity. It will enroll premature infants born weighing less than 1000 grams to receive either betaxolol or placebo topically for 3 weeks. Eyes will be examined weekly.

Investigators: Drs. De Becker (Principal Investigator), Bothun and Anderson
Coordinator: Ann Holleschau 612.625.4120

Telemedicine Approaches to Evaluating Acute-phase Retinopathy of Prematurity-
This multicenter clinical study will evaluate the validity, reliabilty, feasibility, safety and relative cost-effectiveness of a retinopathy of prematurity evaluation system to detect eyes of at-risk babies. Routine diagnostic eye exams for retinopathy of prematurity will be performed and results compared to digital retinal images on babies weighing less than 1251 grams at birth. These images will be collectied and graded at a central reading center.

Investigators: Drs. Bothun (Principal Investigator), Anderson and De Becker
Coordinator: Ann Holleschau 612.625.4120

Research Study of the Anatomy of the Eye Muscles-
Many aspects of the structure and function of the human eye muscle are not well known. This study examines the structure of extraocular muscles and how they differ from other skeletal muscles. It is hoped that this anatomical study may provide opportunities for treatment in a number of serious muscle disorders.

Investigators: Drs. Bothun (Principal Investigator), Anderson, Harrison, De Becker, and McLoon
Coordinator: Ann Holleschau 612.625.4120

Neuro-ophthalmology

A Multicenter, Double-Blind, Randomized, Placebo-Controlled Study of Weight-Reduction and/or Low Sodium Diet Plus Acetozolamide vs. Diet Plus Placebo in Subjects with Idiopathic Intracranial Hypertension with Mild Visual Loss-
This study compares treatment of IIH with a supervised dietary program and acetazolomide to a supervised dietary program and placebo.

Investigators: Drs. Lee (Principal Investigator) and Harrison
Coordinator: Jamie Walski 612.625.4130

A Phase I Open Label, Dose Escalation Trial for QPI-1007 Delivered by a Single Intravitreal Injection to Patients with Optic Nerve Atrophy (Stratum I) and Acute Non-Arteritic Anterior Ischemic Optic Neuropathy (NAION) (Stratum II)-
The purpose of this study is to determine the safety of QPI-1007.

Investigators: Drs. Lee (Principal Investigator), Harrison, Koozekanani and Montezuma
Coordinator: Jamie Walski 612.625.4130

A Phase IV, Prospective, Observational Trial Evaluating Xeomin (Incobotulinumtoxin A) for Cervical Dystonia or Blepharospasm in the United States-
This study aims to collect, evaluate and report obsevational data about the clinical use of Xeomin in a  "real world" setting to determine which muscles are injected, the dose used, and how doctors administer the injection.

Investigators: Drs. Harrison (Principal Investigator) and Lee
Coordinators: Jamie Walski 612.625.4130

Case-Crossover Study of PDE5 Inhibitor Exposure as a Potential "Trigger Factor" for Acute NAION-
The purpose of this study is to collect information to see whether a certain class of medications taken on an "as needed" basis can trigger the onset of acute NAION within a few days after taking the medication.

Investigators: Drs. Lee (Principal Investigator) and Harrison
Coordinator: Jamie Walski 612.625.4130

Prospective Study to Determine the Proportion of Patients with Isolated Thrid, Fourth and Sixth Nerve Palsies of Microvascular versus Non-Microvascular Etiology-
This study's objective is to identify causes, risk-factors, and outcomes for patients with isolated third, fourth or sixth nerve palsy.

Investigator: Dr. Lee
Coordinator: Jamie Walski 612.625.4130

Proteomics and Genomics of Giant Cell Arteritis-
The objective of this study is to better understand the genetic, immunologic and environmental factors involved in the pathophysiology of giant cell arteritis.

Investigator: Dr. Lee
Coordinator:  Jamie Walski 612.625.4130

A Comparison of the Course of Disease and Response to Treatment for Male and Female Patients with Benign Essential Blepharospasm- 
This study explores the difference between male and female patients with blepharospasm in terms of the time interval between treatments and the perceived handicap caused by the disease.

Investigators: Drs. Lee (Principal Investigator) Harrison, and Johnson
Coordinator: Jamie Walski 612.625.4130

The Effects of Fundus Photography on the Multifocal Electroretinogram-
The purpose of this study is to determine the effect of flash photography on the mfERG.

Investigators: Drs. Lee (Principal Investigator) and Tienor
Coordinator: Jamie Walski 612.625.4130

The Effect of Accommodation on Autorefraction-
The purpose of this study is to look at how much an individual can intentionally cause an autorefactor to overestimate myopia by accommodating during an exam.

Investigators: Drs. Lee (Principal Investigator) and Harrison
Coordinator: Jamie Walski 612.625.4130

 

Cornea

Cornea Donor Study-
When a patient needs a corneal transplant, an eye bank provides the donor cornea. Some eye banks consider the age of the donor when selecting a cornea suitable for transplant while other do not. Several small studies have shown that donor age is not important. In the Corneal Donor Study, corneas from donors whose ages are not known by the doctor or the patient are used for transplant. This study is currently in the ten year follow-up phase.

Investigator: Dr. Doughman
Coordinator: Ann Holleschau 612.625.4120

Astigmatic Stability Following Suture Removal in Penetrating Keratoplasty-
The objective of this study is to determine whether any change in astigmatism in the month after removing one or two sutures affects the decision of which suture(s) to remove next following a corneal transplantation.

Investigator: Dr. Kaufman
Coordinator: Jamie Walski 612.625.4130

Pilot Study to Determine if Isopto Carbachol Eye Drops or Isopto Carbachol Plus Brimonidine Eye Drops Improve Reading and Reduce the Need for Reading Glasses-
The objective of this study is to determine whether the use of isopto carbachol eye drops or isopto carbachol plus brimonodine eye drops will allow patients to read without reading glasses on a temporary basis, to determine which concentrations of eye drops are efficient, and how long the effects of the eye drops will allow patients to read without reading glasses.

Investigator: Dr. Kaufman
Coordinator: Jamie Walski 612.625.4130

Glaucoma

Lidocaine Concentration in Aqueous Humor in Controls and Patients with Glaucoma Shunts-
This study compares the spread of lidocaine in patients with and without glaucoma shunts and looks to provide recommendations for the utility of lidocaine anesthesia in patients with glaucoma shunts.

Investigators: Drs. Grajewski (Principal Investigator) and Wright
Coordinator: Jamie Walski 612.625.4130

 Thyroid Eye Disease

Measurement of Axial Globe Position, a Prospective Evaluation-
The objective of this study is to identify a clinically reasonable, reproducible method of measurement for axial globe position (proptosis) that allows valid comparison between patient visits, different observers and multiple centers.

Investigators: Drs. Harrison (Principal Investigator), Lee and Bothun
Coordinator: Jamie Walski 612.625.4130

Passive Smoking Effects on Thyroid Eye Disease-
The purpose of this study is to better understand thyroid eye disease and the role that smoke exposure has in the course of the disease.

Investigators: Drs. Lee (Principal Investigator), Harrison and Bothun
Coordinator: Jamie Walski 612.625.4130

 

 

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