Maneesh Bhargava, MD

Assistant Professor
Contact Information 

Dr. Bhargava attended medical school at King George's Medical College in Lucknow, India. He had his residency in Internal Medicine here at the University of Minnesota. His fellowship in Critical Care was completed at the Hennepin County Medical Center and his fellowship in Pulmonary & Critical Care was completed at the University of Minnesota. Dr. Bhargava currently works at the Pulmonary Clinic in the Transplant Center at the University of Minnesota Medical Center, Fairview and with inpatient services at both the University of Minnesota and Fairview Southdale Medical Centers. 

Clinical Interests 

• General pulmonary medicine
• Diffuse lung diseases
• Pulmonary infection by non tuberculous mycobacteria
• Medical critical care

Research Interests 

• Ion transport across alveolar epithelium
• Treatment of pulmonary edema with focus on agents to stimulate absorption of extravascular lung water
• Biomarker discovery for diagnosing and prognosticating lung injury

Selected Recent Publications 

Bhargava M, Runyon MR, Wangensteen OD, Swenson ER, Ingbar DH.  Acetazolamide stimulates alveolar fluid clearance in ventilated adult rat lungs.  ATS Proceedings, 2:A479, 2005.

Bhargava M, Runyon M, Wangensteen OD, Ingbar DH. Intra-alveolar 3,3’,5 triiodo-L-thyronine (T3) stimulates alveolar fluid clearance in normal rat lungs and hyperoxia-induced lung injury in rats.  ATS Proceedings, 3:A205, 2006.

Bhargara M, Lei J, Mariash C, Ingbar DH.  Thyroid hormone rapidly stimulates alveolar NA, K-ATPase by activation of phyophatidylinositol 3-kinase.  IN Current Opinions in Diabetes and Endocrinology  14(5) 416-420, 2007.

Lei J, Mariash C, Bhargava M, Wattenberg E,  Ingbar D .  T3 increases NA, K-ATPase activity via a MAPK ERK1/2-dependent pathway in rat adult alveolar epithelial cells. Am J Physiol Lung Cell Mol Physiol 2008; 294(4):L749-754. 

Bhargava M, Runyon M, Smirnov D, Lei J, Groppoli T, Mariash C, Podobinski J, Wangensteen OD, Ingbar DH. Triiodo-l-thyronine rapidly stimulates alveolar fluid clearance in normal and hyperoxia-injured rat lungs.  Am J Resp Crit Care Med, 2008;178(5):506-12.

Lei J, Bhargava M, Ingbar DH.  Cell-specific signal transduction pathways for regulating NA+-K+-ATPase: Focus on "short term effects" of thyroid hormones on the Na+-K+-ATPase activity of chick embryo hepatocytes during development.  Am J Physiol Cell Physiol. 2009; 296(1):C1-3.

Bhargava M, Lei J, Ingbar DH.  Nongenomic actions of L-thyroxine and 3,5,3'-triiodo-L-thyronine. Focus on "L-Thyroxine vs. 3,5,3'-triiodo-L-thyronine and cell proliferation: activation of mitogen-activated protein kinase and phosphatidylinositol 3-kinase".  Am J Physiol Cell Physiol. 2009; 296(5):C977-9.

Ingbar DH, Bhargava M, O'Grady SM.  Mechanisms of alveolar epithelial chloride absorption. Am J Physiol Lung Cell Mol Physiol. 2009;297(5):L813-5.

Current Research Support

University of Minnesota Grant-in-Aid 2009-2010. Alveolar epithelial cell proteomics in hyperoxic lung injury.

Minnesota Medical Foundation Biomedical Research Grant 2008-2010:  Proteomic biomarkers in acute respiratory distress syndrome.

Recent Research Support

AHC SEED Award 2007-2008. Stimulation of alveolar fluid clearance by carbonic anhydrase inhibition.

Minnesota Medical Foundation Biomedical Research Grant 2007-08:  Protein biomarkers in acute respiratory distress syndrome.