Angela Panoskaltsis-Mortari, PhD

Associate Professor of Pediatrics
Division of Hematology-Oncology and Blood and Marrow Transplantation
Director, Cytokine Reference Lab
Director, Graduate Studies for Clinical Laboratory Science
Contact Information

Dr. Panoskaltsis-Mortari received her PhD from the University of Western Ontario. She was a post-doctoral fellow in the Department of Pathology at the University of Alabama and a post-doctoral research associate in the Department of Pediatrics at the University of Minnesota. She joined the University of Minnesota faculty in 1995.

Panoskaltsis-Mortari has board certification from the American Board of Medical Laboratory Immunology. She is a member of numerous immunology, pulmonary and hematology professional societies, and the author of nearly 120 articles which have appeared in such publications as Journal of Experimental Medicine, Journal of Clinical Investigation, Blood, Biology of Blood and Marrow Transplantation, American Journal of Physiology (Lung, Cell. & Mol. Physiol.) and Journal of Immunology.


Research Interests

Dr. Panoskaltsis-Mortari's laboratory research focuses upon the study of bone marrow transplant-related lung injury (idiopathic pneumonia syndrome) and the biology of graft-versus-host disease, both of which are major complications causing morbidity and mortality post-BMT. She is also exploring novel methods of enhancing lung repair after transplant using growth factors and cellular therapies.

Selected Recent Publications

(For a comprehensive listing of Dr. Panoskaltsis-Mortari's recent publications refer to PubMed, a service of the National Library of Medicine)

Highfill SL, Kelly RM, Zenovich AG, Panoskaltsis-Mortari A, Caron GJ, Kolb AG, Fremming R, Nelson WD, Taylor DA.  Sex-based differences in vascular repair with bone marrow cell therapy: Relevance of regulatory and Th2-type cytokines. Transplant Proc. 2008; 40:641-643. 

Gram K, Yang S, Steiner M, Somani A, Hawgood S, Blazar BR, Panoskaltsis-Mortari A, Haddad IY. Simultaneous absence of surfactant proteins A and D increases lung inflammation and injury after allogenic HCST in mice. Am J Physiol Lung Cell Mol Physiol. 2009;296(2):L167-75. 

Luikart SD, Panoskaltsis-Mortari A, Hinkel T, Perri RT, Gupta K, Oegema TR, Gupta P. Mactinin, a fragment of cytoskeletal alpha-actinin, is a novel inducer of heat shock protein (Hsp)-90 mediated monocyte activation. BMC Cell Biol. 2009;10:60.

Highfill SL, Kelly RM, O'Shaughnessy MJ, Zhou Q, Xia L, Panoskaltsis-Mortari A, Taylor PA, Tolar J, Blazar BR.  Multipotent adult progenitor cells (MAPC) can suppress graft-versus-host disease via prostaglandin E2 synthesis and only if localized to sites of allopriming. Blood 2009;114(3):693-701.

Bauer JW, Petri M, Batliwalla FM, Koeuth T, Wilson J, Slattery C, Panoskaltsis-Mortari A, Gregersen PK, Behrens TW, Baechler EC.  Interferon-regulated chemokines as biomarkers of systemic lulpus erythematosus disease activity: a validation study. Arthritis Rheum. 2009;60(10):3098-107. 

Jasperson LK, Bucher C, Panoskaltsis-Mortari A, Mellor AL, Munn DH, Blazar BR. Inducing the tryptophan catabolic pathway, indoleamine 2,3-dioxygenase (IDO), for suppression of graft-versus-host disease (GVHD) lethality. Blood 2009;114(24):5062-70.

Bucher C, Koch L, Vogtenhuber C, Goren E, Munger M, Panoskaltsis-Mortari A, Sivakumar P, Blazar BR.  IL-21 blockade reduces graft-versus-host disease mortality by supporting inducible T regulatory cell generation.  Blood 2009;114(26):5375-84. 

Radojcic V, Pletneva MA, Yen HR, Ivcevic S, Panoskaltsis-Mortari A, Gilliam AC, Drake CG, Blazar BR, Luznik L.  STAT3 signaling in CD4+ T cells is critical for the pathogenesis of chronic sclerodermatous gravt-versy-host disease in a murine model.  J Immunol 2009; Dec. 7.  [Epub ahead of print=PMID: 19995899]