Angela Panoskaltsis-Mortari, PhD

Associate Professor of Pediatrics
Division of Hematology-Oncology and Blood and Marrow Transplantation
Director, Cytokine Reference Lab
Director, Graduate Studies for Clinical Laboratory Science
panos001@umn.edu

Dr. Panoskaltsis-Mortari received her PhD from the University of Western Ontario. She was a post-doctoral fellow in the Department of Pathology at the University of Alabama and a post-doctoral research associate in the Department of Pediatrics at the University of Minnesota. She joined the University of Minnesota faculty in 1995.

Panoskaltsis-Mortari has board certification from the American Board of Medical Laboratory Immunology. She is a member of numerous immunology, pulmonary and hematology professional societies, and the author of nearly 120 articles which have appeared in such publications as Journal of Experimental Medicine, Journal of Clinical Investigation, Blood, Biology of Blood and Marrow Transplantation, American Journal of Physiology (Lung, Cell. & Mol. Physiol.) and Journal of Immunology.


Research Interests

Dr. Panoskaltsis-Mortari's laboratory research focuses upon the study of bone marrow transplant-related lung injury (idiopathic pneumonia syndrome) and the biology of graft-versus-host disease, both of which are major complications causing morbidity and mortality post-BMT. She is also exploring novel methods of enhancing lung repair after transplant using growth factors and cellular therapies.


Selected Recent Publications

Jasperson LK, Bucher C, Panoskaltsis-Mortari A, Taylor PA, Mellor AL, Munn DH, Blazar BR. Indoleamine 2,3-dioxygenase is a critical regulator of acute graft-versus-host disease (GVHD) lethality. Blood 2007; 111:3257-3565.

Panoskaltsis-Mortari A, Tram K, Price A, Wendt C, Blazar BR.  A new murine model for obliterative bronchiolitis post-bone marrow transplant.  Amer J of Respir and Crit Care Med, Epub June 15, 2007; 176:713-723.

John CC, Panoskaltsis-Mortari A, Opoka RO, Park GS, Orchard PJ, Jurek A, Idro R, Byarugaba J, Boivin MJ. Elevated cerebrospinal fluid TNF-a levels correlate with neurologic and cognitive impairment in children with cerebral malaria. Amer. J. Tropical Med. Hygeine 2008; 78:198-205.

McCullar V, Oostendorp R, Panoskaltsis-Mortari A, Yung G, Lutz CT, Wagner J, Miller JS. Mouse fetal and embryonic liver cells differentiate human umbilical cord blood (UCB) progenitors into CD56 negative NK cell precursors in the absence of IL-15. Exp. Hematol., Epub Feb 22, 2008.

Panoskaltsis-Mortari A, Taylor PA, Riddle MJ, Shlomchik MA, Blazar BR. In situ identification of allospecific B cells using pentamers. Blood 2008; 111:3904-3905.

Anderson BE, Taylor PA, McNiff JM, Jain D, Demetris AJ, Panoskaltsis-Mortari A, Ager A, Blazar BR, Shlomchik WD, Shlomchik MJ. Effects of donor T cell trafficking and priming site on GVHD induction by naïve and memory phenotype CD4 T cells. Blood, Epub Feb 19, 2008.

Kelly RM, Panoskaltsis-Mortari A, Taylor PA, Contag CH, Boyd RL, Hollander GA, Blazar BR. Keratinocyte growth factor and androgen blockade work in concert to protect against conditioning-induced thymic epithelial damage and enhance T cell reconstitution following murine bone marrow transplantation. Blood, Epub March 11, 2008.

Highfill SL, Kelly RM, Zenovich AG, Panoskaltsis-Mortari A, Caron GJ, Kolb AG, Fremming R, Nelson WD, Taylor DA.  Sex-based differences in vascular repair with bone marrow cell therapy: Relevance of regulatory and Th2-type cytokines. Transplant Proc. 2008; 40:641-643.

O'Shaughnessy MJ, Zhou Q, Xia L, Panoskaltsis-Mortari A, Taylor PA, Tolar J, Blazar BR.  Multipotent adult progenitor cells (MAPC) can suppress graft-versus-host disease via prostaglandin E2 synthesis and only if localized to sites of allopriming. Blood. 2009 May 20. [Epub ahead of print]

Last Updated 6/4/2009