Deanna Diebold, MD

Mentor: Craig Henke, MD

Current Position:    Assistant Professor of Medicine, University of Minnesota

T32 Support: 2003 - 2005

Education:

1984 – 1988, University of Wisconsin, Madison
1988 – 1992, M.D., University of Minnesota
1992 – 1995, Residency, University of MN.
1995 – 1996, Chief Resident, VA Medical Center, Mpls, MN 
2002 – 2005, Pulmonary/Critical Care Fellow, Univ. of MN.

Project:          Dr. Diebold’s research focused on investigating translational control of fibroblast biology under the pro-apoptotic stress of the I collagen matrix contraction.  This involved work with multiple laboratory analyses, including cell culture, western blotting, sucrose-gradient polyribosome reaction, cDNA microarrays and real-time PCR.  Her research work resulted in publications listed below:

Grants Awarded:  American Lung Association Research Training Fellowship (national)

Publications:

Nho RS. Xia H. Kahm J. Kleidon J. Diebold D. Henke CA. Role of integrin-linked kinase in regulating phosphorylation of Akt and fibroblast survival in type I collagen matrices through a beta1 integrin viability signaling pathway.  Journal of Biological Chemistry 2005; 280(28):26630-9.

Diebold D, Peterson M, Kahm J, Fan F, Reilly C, Bitterman P, Henke C.  Translational control of collagen matrix contraction-triggered fibroblast apoptosis.  Proceedings of the American Thoracic Society 2005; 2:A210.

Nho RS. Xia H. Diebold D. Kahm J. Kleidon J. White E. Henke CA. PTEN regulates fibroblast elimination during collagen matrix contraction. Journal of Biological Chemistry 2006; 281(44):33291-301.

Larsson Ola, Diebold D, Fan D, Peterson M, Nho RS, Bitterman PB, Henke CA. Fibrotic fibroblasts manifest genome-wide derangements of translational control. 2007 PLoS Medicine, submitted.

Xia H, Diebold D*, Nho RS, Perman D, Kahm J, Kleidon J, Avdulor A, Peterson, M, Bitterman PB, Henke CA. Pathological integrin signaling enhances proliferation of primary lung fibroblasts from patients idiopathic pulmonary fibrosis. 2007, revision submitted to J. Clin. Invest – NOTE:  Drs Xia and Diebold are designated equal co-authors on this manuscript.