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Home > NHLBI Training Grant Program > Paul Grimsrud, PhD

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Paul Grimsrud, PhD


Dr. Paul Grimsrud Mentor:  Dr. David Bernlohr

Current Position:  Post-Doctoral Fellow, University of Wisconsin, Madison

Research Project:  "Proteomic analysis of 4-hydroxynonenal (HNE)-modified proteins"

Specific Aims:

  • Develop proteomic methodology for the investigation of HNE-modification of proteins
  • Determine targets and extent of HNE-modification in lung dysfunction
  • Determine the role of HNE-modification as a signaling molecule

Publications:

Pearson AR. De La Mora-Rey T. Graichen ME. Wang Y. Jones LH. Marimanikkupam S. Agger SA. Grimsrud PA. Davidson VL. Wilmot CM. Further insights into quinone cofactor biogenesis: probing the role of mauG in methylamine dehydrogenase tryptophan tryptophylquinone formation. Biochemistry   2004;  43(18):5494-502.

 Grimsrud PA, Picklo MJ, Griffin TJ, Bernlohr DA.  Carbonylation of adipose proteins in obesity and insulin resistance:  Identification of adipocyte fatty acid-binding protein as a cellular target of 4-hydroxynonenal. Mol Cell Proteomics 2007; 6:624-637.
(Article featured on cover of MCP issue and websites for MCP and ASBMB)

Grimsrud PA, Xie H, Griffin TJ, and Bernlohr DA. Oxidative stress and covalent modification of protein with bioactive aldehydes.  J Biol Chem, 2008 in press.

 Grimsrud PA, Xie X, Griffin  TJ, Bernlohr DA.  Oxidative stress and covalent modification of protein with bioactive aldehydes.  J Biol Chem, Revised MS submitted 2008.

Grimsrud PA, Hellberg K, Kruse A, Ohldendorf DO and Bernlohr DA. Crystal structure of AFABP with covalently-bound 4HNE.  MS in preparation, 2008.

Grimsrud PA, Wright WS, Curtis JM, Brestoff JR, Bernlohr DA.  Decreased GSTA4 expression in obesity links protein carbonylation to insulin resistance.  MS in preparation, 2008.

Conference Presentations

Identification of A-FABP as a Target of 4-HNE Modification Through Proteomic Analysis of Adipose Protein Carbonylation in Obesity.  Paul A. Grimsrud, Timothy J. Griffin, David A. Bernlohr.  Keystone Symposia on Cell Signaling and Proteomics, Steamboat Springs, Colorado (poster presented on March 23, 2007).

LC-MS/MS-Based Analysis of Proteins Modified with Reactive Lipids in Obesity. Paul A. Grimsrud, Timothy J. Griffin, David A. Bernlohr.  Gordon Conference on Thiol-Based Redox Regulation & Signaling, Biddeford, ME (poster presented on June 18, 2006).

Aldehyde Modification of Proteins in Obesity and Insulin Resistance.  Paul A. Grimsrud, Timothy J. Griffin, David A. Bernlohr.  Keystone Symposia on Diabetes Mellitus & Obesity, Keystone CO (poster presented on January 29, 2005).

Proteomic Analysis of HNE-Modified Proteins in Adipose Tissue.  Paul A. Grimsrud, Mikel R. Roe, Timothy J. Griffin, David A. Bernlohr.  American Chemical Society 36th Annual Great Lakes Regional Meeting, Peroria IL  (talk given on October 18, 2004).

Last revised 3/25/2008

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  Last modified on Wednesday Feb 06, 2008