|
Home > NHLBI Training Grant Program > Yong Kim
Yong Kim
 Mentor: Peter Bitterman, MD
Research Project: "Translational Control of Tumor Genesis in
Lung Epithelial Cells"
Specific Aims:
- The tobacco combustion product NNK is a well-established lung carcinogen. Members of the 4E-BP family of translational inhibitors are hypothesized to function as tumor suppressors. We propose to examine this hypothesis in 4E-BP null mice treated with NNK, by examining the time to tumor formation, the number of tumors formed and tumor size using serial high resolution CT scans to detect lung tumors.
- Systematically produce lung cancer-relevant oncogenic alterations in lung epithelial cells in vitro and examine the ability of each individually and in combination to confer cell autonomous functions characteristic of a malignant phenotype (proliferation, clonogenicity and apoptosis resistance in vitro; and tumorigenicity).
Publications
Kim YY, von Weymarn L, Murphy s, Hecht SS, Bitterman PB. Members of the 4E-BP family of translational repressoirs function in tumor defense. 2008, submitted.
Last updated 4-21-2008
|
Feedback | Notice of Privacy Practices
|
|
|
Return to: Department of Medicine : Medical School : Academic Health Center : myU : U of M Home
