Jeffrey Lande, PhD

Mentors: Marshall Hertz, MD and Richard King MD, PhD

Current Position:  BioInformatics Research Scientist at Medtronic

T32 Support: 2002 - 2005

Education:      1987 - 1991; B.S., University of Wisconsin,
                          Madison, WI
                        1992 – 1994; M.S.; University of Minnesota
                        1998 – 2000; General Coursework; University
                          of Minnesota
                         2000 – 2005; Ph.D.; University of Minnesota.

Project:  Jeffrey’s research was under the auspices of Dr. Marshall Hertz, and Dr. Richard King.  Immediately following his training on this grant, he held a postdoctoral research appointment at the University, followed by his current appointment to a research informatics position with Medtronics.

Over the course of his training under this fellowship, he received training in molecular, cellular, developmental biology, genetics and bioinformatics. His research was primarily directed towards gene expression microarray analysis in the area of human lung transplantation. Bronchoalveolar lavage fluid from lung transplant recipients was collected and a gene expression profile, marked by activation and proliferation markers of T-lymphocytes, was found that identified patients with and without concurrent histologic evidence of acute rejection from biopsy samples (published in 2003 in the Am J Respir Crit Care.)  Further work in this area has been submitted as a manuscript to the American Journal of Respiratory and Critical Care Medicine.  A second area of research was a microarray analysis of a mouse model of acute and chronic lung rejection published in 2005 in the American Journal of Transplantation. During his training he was awarded a Lillehei Predoctoral Fellowship and a University of Minnesota Institute of Human Genetics Fellowship which were used to fund the mouse microarray research.

Publications:

Freeman ML, Nelson DB, Sherman S, Haber GB, Herman ME, Dorsher PJ, Moore JP, Fennerty MB, Ryan ME, Shaw MJ, Lande JD, Pheley AM.  Complications of endoscopic biliary sphincterotomy. NEJM 1996; 335(13):909-18.

Hertz MI, Lande J, Gimino V, King R.  Gene expression patterns in lung rejection.  Transplantation Proceedings 2001; 33(7-8):3566-7.

Gimino VJ, Lande JD, Berryman TR, King RA, Hertz MI.  Gene expression profiling of bronchoalveolar lavage cells in acute lung rejection.  Am J Respir Crit Care Med. 2003; 168(10):1237-42.

Serra HG, Byam CE, Lande JD, Tousey SK, Joghbi HY, On HT.  Gene profiling links SCA1 pathophysiology to glutamate signaling in Purkinje cells of transgenic mice.  Hum Mol Genet. 2004; 13(20):2535-43.

Lande JD, Dalheimer SL, Mueller DL, Hertz MI, King RA. Gene expression profiling in murine obliterative airway disease.  Am J Transplant.  2005; 5(9):2170-84.

Lande JD, Patil J, Li N, Berryman TR, King RA, Hertz MI.  Novel insights into lung transplant rejection by microarray analysis.  Proc Am Thorac Soc. 2007; 4(1):44-51.

Patil J, Lande JD, Li N, Berryman TR, King RA, Hertz MI. Bronchoalveolar lavage cell gene expression in acute lung rejection: Development of a diagnostic classifier. Transplantation 2008: In press.

Last updated 3-26-2008