| Mentors: Robert Kratzke, MD and Peter Bitterman, MD
Education:
1995 – 1997 The Colorado College, Colorado Springs, CO
1997 – 1998 The University of Manchester, Manchester, England
1998 – 1999 B.A., The Colorado College, Colorado Springs, CO
1999 – 2001 Pulmonary Research, University of Chicago (Dr. Julian Solway) 2001 – 2005 M.D., University of Wisconsin-Madison Medical School
2005 – 2007 Internal Medicine Residency, University of Minnesota
2007 – Present Pulmonary/Critical Care Fellow, University of Minnesota
Honors:
2005 Promoted to Captain in the Wisconsin Army National Guard
2002 Shapiro Foundation Excellence in Student Research Award
1998 Howard Hughes Summer Research Fellowship
Project Summary:
Lung cancer continues to be the leading cause of cancer-related deaths in the US. Despite aggressive therapies currently available the survival rates remain abysmal with only 15% 5-year survival in non-small-cell lung cancer (NSCLC). The underlying biology of lung cancer tumorigenesis is not fully understood. There is mounting evidence that enhanced mRNA translation plays a large role in other malignancies and may offer specific points amenable to novel therapeutics. I hope to develop an in vitro model of NSCLC by enhancing translation in concert with specific mutations known to be present in lung cancer. This model would then allow for a more detailed assessment of pathways leading to NSCLC tumorigenesis with the goal of developing improved therapeutic agents.
Publications:
Liu HW, Halayko AJ, Fernandes DJ, Harmon GS, McCauley JA, Kocieniewski P, McConville J, Fu Y, Forsythe SM, Kogut P, Bellam S, Dowell M, Churchill J, Lesso H, Kassiri K, Mitchell RW, Hershenson MB, Camoretti-Mercado B, Solway J. The RhoA/Rho kinase pathway regulates nuclear localization of serum response factor. Am J Respir Cell Mol Biol. 2003 Jul; 29(1): 39-47.
Forsythe SM, Kogut PC, McConville JF, Fu Y, McCauley JA, Halayko AJ, Liu HW, Kao A, Fernandes DJ, Bellam S, Fuchs E, Sinha S, Bell GI, Camoretti-Mercado B, Solway J. Structure and transcription of the human m3 muscarinic receptor gene. Am J Respir Cell Mol Biol. 2002 Mar; 26(3): 298-305.
Solway J, Bellam S, Dowell M, Camoretti-Mercado B, Dulin N, FErnandes D, Halayko A, Kocieniewski P, Kogut P, Lasker O, Liu HW, McCauley J, McConville J, Mitchell R. Actin dynamics: a potential integrator of smooth muscle (Dys-)function and contractile apparatus gene expression in asthma. Chest 2003 Mar; 123(3 suppl): 392S-8S. Review.
Last updated 7-29-2008
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