 Mentor: Peter Bitterman, MD
Current Position: Assistant Professor of Medicine, University of Minnesota
T32 Support: 2000 - 2002
Education: B.A., Carlton College, 1992
M.D., University of Minnesota, 1996
Residency, Hennepin County Medical Center,
Mpls. MN 1996 - 1999
Pulmonary/Critical Care Fellowship, Univ. of
Minnesota, 1999 - 2002
Project: David has received training in a wide variety of lab techniques such as cell culture, DNA and RNA preparations (Poly-A and Polysomal RNA), gene transfer and molecular cloning. His research focused on mechanisms of translational control of apoptosis by manipulating CAP-dependent and IRES-mediated translation, and by using microarray analysis to identify mRNA messages subject to translation control.
Grants Awarded: American Lung Association Research Fellowship T32
NIH K08
Publications:
Perlman, DM. Enhancing Medical Care at the End of Life. Fellow Reporter. Vol. 7, No. 5, July 2002.
DM Perlman, O. Larsson, E. Ljungstrom, K. Mashayekhi, V. Polunovsky, N. Sonenberg et al. Translational control of apoptosis: combining polyribosome analysis with gene expression microarray to identify transcripts encoding rescue proteins. Translational Control Meeting, Cold Spring Harbor N.Y., Sept 2002; pg. 279.
DM Perlman, O Larson, V.A. Polunovsky, M. Peterson, P. Bitterman. Identifying molecular targets for anti-fibrotic drug discovery. Respiratory and Critical Care Medicine 2003; (7):A340.
Li S, Takasu T, Perlman DM, Peterson MS, Burrichter D, Avdulov S, Bitterman PB, Polunovsky VA. Translation factor eIF4E rescues cells from Myc-dependent apoptosis by inhibiting cytochrome c release. J Biol Chem 2003; 278:3015-22.
Li S, Perlman DM, Peterson MS, Burrichter D, Avdulov S, Polunovsky VA, Bitterman PB. Translation initiation factor 4E blocks endoplasmic reticulum-mediated apoptosis. J Biol Chem 2004; 279:21312-7.
Avdulov S, Li S, Michalek V, Burrichter D, Peterson M, Perlman DM, Manivel JC, Sonenberg N, Yee D, Bitterman PB, Polunovsky VA. Activation of translation complex eIF4F is essential for the genesis and maintenance of the malignant phenotype in human mammary epithelial cells. Cancer Cell 2004; 5:553-563.
Larsson O, Perlman DM, Fan D, Reilly CS, Peterson M, Dahlgren C, Liang Z, Li S, Polunovsky VA, Wahlestedt C, Bitterman PB. Apoptosis resistance downstream of eIF4E: posttranscriptional activation of an anti-apoptotic transcript carrying a consensus hairpin structure. Nucleic Acids Res 2006; 34(16):4375-86.
Xia H, Diebold D, Nho RS, Perlman D, Kahm J, Kleidon J, Avdulor A, Peterson M, Bitterman P, Henke CA. IPF fibroblasts display a durable pathological phenotype characterized by altered alpha-2-beta-1 integrin signaling resulting in aberrant proliferation on polymerized type 1 collagen. 2008, J Clin Invest, revision submitted.
Updated 2-14-2008
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