Timothy Rich, MD

Mentors: David Ingbar, MD and Grant Anderson, PhD

T32 Support: 2005 - 2007

Education:    

1983 – 1984, Nursing Assistant Certificate, St. John University, Collegeville, MN
1984 – 1985, Undergraduate Coursework, U.S. Air Force Academy, Colorado
1983 – 1988, B.S. (Biology B.A. (Psychology), University of Minnesota, Duluth,
1996 – 2001, M.D., University of Minnesota Medical School
2001 – 2004, Residency, Dept. of Internal Medicine, University of Minnesota
2004 – 2007, Pulmonary/Critical Care Fellow, University of Minnesota

Current Position:  Assistant Professor of Medicine, University of Minnesota (Duluth campus)

Project:  Dr. Rich’s research examined whether thyroid hormone transporters were present in rat lung and whether their expression was altered during development or by hypo- or hyper-thyroidism.  His results were:  (1) Characterization of six thyroid hormone transporters in rat lung that were not previously described.  (2.)  Determination that specific transporters are regulated by developmental state while other transporters are regulated by thyroidal status. His research used PCR, western blotting immunocytochemistry and in situ hybridization to quantitate these transporters and to determine the specific cell types that express them.  He currently is studying lung deiodinases and discovered that they are markedly upregulated with human ARDS, possibly creating a local hypothyroid state.  This research is continuing with Drs. Ingbar, Anderson and Mariash (Director of the Endocrinology Division) along with collaborators in the Beth Israel (Harvard) Endocrine Division.

Publications:

Rich TP, Bastian TW, Mariash CN, Anderson GW, Ingbar DH.  “Thyroid Hormone Transporter Expression Is Regulated by Development and Thyroidal Status in Rat Lung”.  Am J Respir Crit Care Med (Abstract) 2007, 175:118A.

Rich TP, Huang SA, Schmechel SC, Anderson GW, Mariash CN, Ingbar DH.  Expression of iodothyronine deiodinase type III (D3) in acute lung injury human tissue.  To be presented at American Thoracic Society Intl Conference, Toronto, 2008.

Rich TP, Bastian TW, Westholm DE, Mariash CN, Anderson GW, Ingbar DH.  Ontogeny of Thyroid Hormone Transporter Expression in Rat Lung.  (manuscript in preparation for Am J Resp Cell Molec Biol)

Last updated 2-19-2008