Mark Sprenkle, MD, MSc

Current Position:  Assistant Professor of Medicine, University of Minnesota

T32 Support: 2001 - 2003

Education:

1987 – 1991, B.A., University of Minnesota
1992 – 1996, M.D. Univ. of Minnesota
1996 – 1999, Internal Medicine Residency, Univ. of Washington, Seattle
1999 – 2000, Chief Resident, Univ. of Washington,  Seattle, WA
2000 – 2003, Pulmonary/Critical Care Fellowship, Univ.of Minnesota

Project:          Dr. Sprenkle enrolled in the master’s degree program in clinical research through the University of Minnesota School of Public Health.  Over the ensuing 2 years, he completed coursework in epidemiology, biostatistics, and clinical study design and management.  During this time, he initiated a thesis project necessary for completion of his master’s degree.  His principle thesis advisor, Dr. Kristin Nichol, provided access to an existing database regarding health-related quality of life in a population of veterans.  This project provided Dr. Sprenkle with important experience in measures of health status and implementation of multivariate models to determine whether health status is independently predictive of mortality and health care utilization in veterans with obstructive lung disease.  This master’s thesis project was successfully defended and his degree was conferred in 2003.  The results of his project were presented at the American Thoracic Society International Conference and have been submitted for publication.

As a secondary project, Dr. Sprenkle designed and conducted a systematic review.  This qualitative review involves OM-85 BV, an agent used in Europe for prevention of exacerbations in COPD.  This project was performed under the guidance of Dr. Timothy Wilt, an expert in systematic reviews and meta-analyses.

Publications:

Sprenkle MD. Niewoehner DE. Nelson DB. Nichol KL. The Veterans Short Form 36 questionnaire is predictive of mortality and health-care utilization in a population of veterans with a self-reported diagnosis of asthma or COPD. Chest 2004; 126(1):81-9.

Sprenkle MD. Niewoehner DE. MacDonald R. Rutks I. Wilt TJ. Clinical efficacy of OM-85 BV in COPD and chronic bronchitis: a systematic review.  COPD: Journal of Chronic Obstructive Pulmonary Disease 2005; 2(1):167-75.

Weinert CR. Sprenkle M. Post-ICU consequences of patient wakefulness and sedative exposure during mechanical ventilation. Intensive Care Med 2008; 34(1):82-90.

Last updated 3-27-2008