H. Brent Clark M.D., Ph.D.

Contact Information Phone: 612-625-7636 Fax: 612-625-0440 Email: clark002@umn.edu Address: K-106 Diehl Hall 505 Essex St SE Minneapolis, MN 55455

Professor

Director, Neuropathology Services at UMMC Fairview

In addition to a full-time practice at University of Minnesota Medical Center, Fairview, Dr. Clark is a consultant at Hennepin County Medical Center and the Minneapolis Veterans Affairs Medical Center. He is active in the teaching of pathology residents on both the anatomic pathology and neuropathology specialty rotations. Residents from the Departments of Neurology and Neurosurgery rotate on his service and he teaches a lecture series for both programs. He also directs the neuropathology section of the second year medical student pathology course.

Research Interests

Dr. Clark’s research activities involve pathological studies of cerebellar ataxia both in human disease and experimental animal models. He is a co-investigator on a NIH R01 grant entitled "Molecular genetics of the SCA1 locus," and Director of the Neuropathology Core for the Bob Allison Ataxia Research Center at the University of Minnesota. 

Educational Background

• Washington University School of Medicine, St. Louis, MO (1978), M.D./Ph.D.
• Barnes Hospital / Washington University, St. Louis, MO (1982), Residency (Anatomic Pathology and Neuropathology)

Board Certification

Anatomic Pathology, Neuropathology

Publications

Dr. Clark has written on a number of subjects, including ataxia, middle cerebral artery dissection, tauopathies, treatment of brain tumors with stereotactic radiosurgery, and increased expression of nitric oxide synthase and cyclo-oxygenase-2 related to cerebral ischemic injury,.  He is a member of the Editorial Board of Brain Pathology and Human Pathology and an ad hoc reviewer for numerous other scientific journals including the Journal of Neuropathology and Experimental Neurology, The American Journal of Pathology, Journal of Neuroscience, and Neurobiology of Disease.

• Moore BM, Rothman SM, Clark HB, Vehe RK, Laguna TA. Epilepsy: An Anticipatory Presentation of Pediatric Wegener's Granulomatosis. Pediatr Neurol. 2010 Jul;43(1):49-52.
• Oz G, Hutter D, Tkác I, Clark HB, Gross MD, Jiang H, Eberly LE, Bushara KO, Gomez CM. Neurochemical alterations in spinocerebellar ataxia type 1 and their correlations with clinical status. Mov Disord. 2010 Jul 15;25(9):1253-61.
• Zu,T., Duvick, L.A., Kaytor, M.D., Berlinger, M., Zoghbi, H.Y., Clark, H.B. and Orr, H.T., Recovery from Polyglutamine-Induced Neurodegeneration in Conditional SCA1Transgenic Mice. J Neuroscience 24:8853-8861, 2004
• Emamian ES, Kaytor MD, Duvick LA, Zu T, Tousey SK, Zoghbi HY, Clark HB and Orr HT. Serine 776 of ataxin-1 is critical for polyglutamine-induced disease in SCA1 transgenic mice. Neuron 38:375-387, 2003.
• Skinner PJ, Vierra-Green CA, Clark HB, Zoghbi HY, and Orr HT: Altered trafficking of membrane proteins in Purkinje cells of SCA1 transgenic mice. Amer. J. Pathol. 159:905-913, 2001.
• Clark HB and Orr HT: Spinocerebellar ataxia type 1 -- Modeling the pathogenesis of a polyglutamine neurodegenerative disorder in transgenic mice. J. Neuropathol. Expt. Neurol : 59:265-270, 2000.