John H. Eckfeldt, M.D., Ph.D.

Contact Information Phone: 612-626-3176 Fax: 612-626-2696 Email: eckfe001@umn.edu Address: MMC 609 Mayo 8609 420 Delaware Minneapolis, MN 55455

Professor

Dr. Eckfeldt is Professor of Laboratory Medicine in the Department of Laboratory Medicine and Pathology, as well as Medical Director of Clinical Pathology at University of Minnesota Medical Center, Fairview. In addition to his duties on the Residency Advisory Committee, Dr. Eckfeldt serves as the University of Minnesota Medical Center, Fairview, Site Director for the Residency Program and instructs residents during their chemistry rotation.

Educational Background

• University of Pennsylvania, Philadelphia, PA (1967), B.S. (Chemistry)
• Cornell University, Ithaca, NY (1969), M.S. (Physical Chemistry)
• University of Pennsylvania, Philadelphia, PA (1975), Ph.D. (Biophysics)
• University of Pennsylvania, Philadelphia, PA (1976), M.D.
• University of Minnesota, Minneapolis, MN (1978), Residency (Clinical and Chemical Pathology)

Board Certification

Clinical and Chemical Pathology, Clinical Chemistry

Professional Background

• Research Chemist, group leader in a surfactant application laboratory, Rohm and Haas Company, Spring House, PA, 1969 - 1971
• NSF Fellow and NIH Medical Scientist Training Program Fellow, University of Pennsylvania, Philadelphia, PA, M.D./Ph.D. training, 1971 - 1976
• Resident in clinical pathology, University of Minnesota, Minneapolis, MN, 1976 - 1978
• Assistant Professor, Department of Laboratory Medicine and Pathology, University of Minnesota Medical School, Minneapolis, MN, 1978 - 1985
• Chief of Clinical Chemistry and Toxicology, Veterans Affairs Medical Center, Minneapolis, MN, 1978 - 1985
• Associate Professor, Department of Laboratory Medicine and Pathology, University of Minnesota Medical School, Minneapolis, MN, 1985 - 1992
• Director of Clinical Chemistry, University of Minnesota Medical Center, Fairview, Minneapolis, MN, 1985 - 1992
• Professor, Department of Laboratory Medicine and Pathology, University of Minnesota Medical School, Minneapolis, MN, 1992 – 2005
• Ellis S. Benson endowed Professor, Department of Laboratory Medicine and Pathology, University of Minnesota Medical School, Minneapolis, MN, 2005 - present  
• Director, Clinical Chemistry, University of Minnesota Medical Center, Fairview, Minneapolis, MN, 1992 - 1996
• Director, Clinical Laboratories, University of Minnesota Medical Center, Fairview, Minneapolis, MN, 1996 - 1997
• Medical Director, Clinical Pathology, University of Medical Center, Fairview, Minneapolis, MN, 1996 - present
• Chief of Staff, University of Minnesota Medical Center, Fairview, Minneapolis, MN , 2003 - 2004
• Vice Chair for Clinical Affairs, Department of Laboratory Medicine and Pathology, University of Minnesota Medical School, Minneapolis MN, 2002 - present

Professional Memberships

• American Association for Clinical Chemistry, 1978 - present
• Academy of Clinical Laboratory Physicians and Scientists, 1979 - present
• Minnesota Society of Pathologists, 1979 - present
• Minnesota Department of Health Ad Hoc Technical Advisory Committee on Newborn Screening, Chair 1993 - 1996 and member 2004 - present
• Sigma Xi, 1980 - present
• College of American Pathologists, 1981 - present
• American Medical Association, 1985 - present
• Minnesota Medical Association, 1985 - present
• Hennepin County Medical Association, 1985 - present
• American Society for Human Genetics, 1995 - present

Publications

Dr. Eckfeldt has published extensively on topics including lipids, lipoprotein, and genetic markers as risk factors for cardiovascular disease, hypertension, and iron overload disorders.  

• Lynch AI, Boerwinkle E, Davis BR, Ford CE, Eckfeldt JH, Leiendecker-Foster C, Arnett DK. Antihypertensive pharmacogenetic effect of fibrinogen-beta variant -455G>A on cardiovascular disease, end-stage renal disease, and mortality: the GenHAT study. Pharmacogenet Genomics. 2009 Jun;19(6):415-21.
• Wang X, Leiendecker-Foster C, Acton RT, Barton JC, McLaren CE, McLaren GD, Gordeuk VR, Eckfeldt JH. Heme carrier protein 1 (HCP1) genetic variants in the Hemochromatosis and Iron Overload Screening (HEIRS) Study participants. Blood Cells Mol Dis. 2009 Mar-Apr;42(2):150-4.
• Pankow JS, Boerwinkle E, Adams PC, Guallar E, Leiendecker-Foster C, Rogowski J, Eckfeldt JH. HFE C282Y homozygotes have reduced low-density lipoprotein cholesterol: the Atherosclerosis Risk in Communities (ARIC) Study. Transl Res. 2008 Jul;152(1):3-10.
• Lynch AI, Boerwinkle E, Davis BR, Ford CE, Eckfeldt JH, Leiendecker-Foster C, Arnett DK. Pharmacogenetic association of the NPPA T2238C genetic variant with cardiovascular disease outcomes in patients with hypertension. JAMA. 2008 Jan 23;299(3):296-307.
• Bielinski SJ, Pankow JS, Foster CL, Miller MB, Hopkins PN, Eckfeldt JH, Hixson J, Liu Y, Register T, Myers RH, Arnett DK. Circulating soluble ICAM-1 levels shows linkage to ICAM gene cluster region on chromosome 19: the NHLBI Family Heart Study follow-up examination. Atherosclerosis. 2008 Jul;199(1):172-8.
• Bielinski SJ, Pankow JS, Miller MB, Hopkins PN, Eckfeldt JH, Hixson J, Liu Y, Register T, Myers RH, Arnett DK. Circulating MCP-1 levels shows linkage to chemokine receptor gene cluster on chromosome 3: the NHLBI family heart study follow-up examination. Genes Immun. 2007 Dec;8(8):684-90.
• Lynch AI, Arnett DK, Davis BR, Boerwinkle E, Ford CE, Eckfeldt JH, Leiendecker-Foster C. Sex-specific effects of AGT-6 and ACE I/D on pulse pressure after 6 months on antihypertensive treatment: the GenHAT study. Ann Hum Genet. 2007 Nov;71(Pt 6):735-45.
• Lynch AI, Arnett DK, Pankow JS, Miller MB, North KE, Eckfeldt JH, Hunt SC, Rao DC, Djoussé L. Sex-specific effects of ACE I/D and AGT-M235T on pulse pressure: the HyperGEN Study. Hum Genet. 2007 Aug;122(1):33-40.
• Leon JM, Freedman BI, Miller MB, North KE, Hunt SC, Eckfeldt JH, Lewis CE, Kraja AT, Djoussé L, Arnett DK. Genome scan of glomerular filtration rate and albuminuria: the HyperGEN study. Nephrol Dial Transplant. 2007 Mar;22(3):763-71.
• Tang W, Hong Y, Province MA, Rich SS, Hopkins PN, Arnett DK, Pankow JS, Miller MB, Eckfeldt JH. Familial clustering for features of the metabolic syndrome: the National Heart, Lung, and Blood Institute (NHLBI) Family Heart Study. Diabetes Care. 2006 Mar;29(3):631-6.
• Arnett DK, Davis BR, Ford CE, Boerwinkle E, Leiendecker-Foster C, Miller MB, Black H, Eckfeldt JH. Pharmacogenetic association of the angiotensin-converting enzyme insertion/deletion polymorphism on blood pressure and cardiovascular risk in relation to antihypertensive treatment: the Genetics of Hypertension-Associated Treatment (GenHAT) study. Circulation. 2005 Jun 28;111(25):3374-83.
   

For a complete listing of Dr. Eckfeldt's publications, please see the National Library of Medicine's PubMed Search (opens in a new window).