Haojie Huang, Ph.D.

Assistant Professor
612-624-3306
huang253@umn.edu

Education/Training

• 1986 - 1990     B.S., Biology, Nanjing Normal University, Nanjing, China
• 1990 - 1995     Ph.D., Genetics, Nanjing Normal University, Nanjing
• 1995 - 1997     Postdoctoral Researcher, The State Key Laboratory of Genetic Engineering, Institute of Genetics, Fudan University, Shanghai
• 1997 - 1999     Research Fellow, Department of Laboratory Medicine and Pathology, Mayo Clinic/Foundation, Rochester, MN
• 1999 - 2002     Senior Research Fellow, Departments of Urology and Biochemistry/Molecular Biology, Mayo Clinic/Foundation, Rochester, MN

Academic Appointments/Employment

• 2002 – 2004    Senior Research Associate, Department of Urology, Mayo Clinic/Foundation, Rochester, MN
• July 2004         Professional Associate in Research, Department of Urology, Mayo Clinic College of Medicine, Rochester, MN
• 2004-present    Assistant Professor, Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine, Rochester, MN

Honors and Awards:

• Zhu Jin Wen Superb Award, Nanjing Normal University
• Chen Yifeng Award, Nanjing Normal University
• 1995    Fellowship, National Postdoctoral Foundation in China
• Travel Award, Society for Basic Urologic Research (SBUR) - Fall Symposium, Fort Myers, Florida
• American Association for Cancer Research (AACR)-AFLAC Scholar-in-Cancer Research Award, the 93th Annual Meeting of the AACR, San Francisco, California
• Travel Award, Society for Basic Urologic Research (SBUR) - Fall Symposium, Tucson, Arizona
• Travel Award, 4^th International Symposium on Hormonal Carcinogenesis, Valencia, SPAIN
• 2003    American Association for Cancer Research (AACR)-Aventis Oncology Scholar-in-Training Award, the 94th Annual Meeting of the AACR, Washington, DC
• 2005    Travel Award, Prostate Cancer: Road Map to the Future Conference, Niagara Falls, New York

Committee

• 2004-present    Member of the Teaching/Examining Committee, Tumor Biology Program, Mayo Clinic College of Medicine, Rochester, MN

News and Views

ASBMB (American Society for Biochemistry & Molecular Biology) Today “Key Cellular Process in Prostate, Other Cancers May Lead to Better Treatment” pp10-11, May 2005

KAAL TV “Breakthrough Medicine” news: “New potential therapeutic target for prostate cancer.” March 23, 2005, Austin, Minnesota

Mayo Clinic News: “Mayo Clinic identifies key cellular process in prostate and other cancers – new targets for better treatments.” February 14, 2005, Rochester, Minnesota

RESEARCH INFORMATION

Research Support

Completed

Title:     Molecular mechanism of upregulation of Bcl-2 in prostate cancer

Source: National Cancer Institute-CA96956-DR1

Role:     PI: Haojie Huang, Ph.D.

             50% effort

Period:  July 2001 – June 2003

Total Award:   $100,000 (direct costs)

The major goals of this project are (1) to explore the molecular basis for transcriptional repression of the Bcl-2 gene by androgens; (2) to evaluate the effect of loss of PTEN on regulation of Bcl-2 gene expression; (3) to examine whether there is a correlation between loss of PTEN, nuclear localization of the AR and overexpression of Bcl-2 mRNA in human PCa tumors.

Ongoing

Title:               Androgenic inactivation of FKHR (FOXO1) in prostate cancer

Source: NIDDK/NIH – R01DK65236

Role:                Co-PI: Haojie Huang, Ph.D. (PI: DJ Tindall, Ph.D.)

                        25% effort

Period:             August 2003 – July 2007

Total Award:   $1,011,500 (including indirect costs)

The major goals of this project are (1) to determine the proteolytic cleavage site in the FKHR protein; (2) to identify androgen-regulated protease(s) that cleaves FKHR protein; (3) to determine whether blockage of the effect of androgens on FKHR favors the death of prostate cancer cells.

Title:               Elucidation of the molecular mechanisms underlying lymph node metastasis in prostate cancer

Source: DOD – W81XWH-04-1-0901

Role:                Co-Investigator: Haojie Huang, Ph.D. (PI: K Datta, Ph.D.)

                        10% effort

Period:             August 2004 – July 2007

Total Award:   $325,125 (including indirect costs)

The major goals of this project are (1) to determine the role of lymphagiogenesis in prostate cancer for lymph node metastasis: Importance of VEGF-C, -D in this process; (2) to elucidate the molecular pathway that regulates the expression of VEGF-C in prostate cancer.

Pending

(This grant has been recommended as an alternate for funding

Title:                CBP and p27^KIP1 in prostate carcinogenesis

Source: DOD – PC050913

Role:                PI: Haojie Huang, Ph.D.

                        25% effort

Period:             August 2005 – July 2008

Total Award:  $553,125 (including indirect costs)

The major goals of this project are (1) to establish CBP knockout mice with or without concomitant deletion of one allele of p27^KIP1; (2) to determine whether tumors in CBP/p27^KIP1 double knockout mice progress at an accelerated rate compared to those in CBP single knockout mice; (3) to determine whether inhibitors of histone deacetylase and proteasomes are able to attenuate tumor progression in CBP/p27^KIP1 knockout mice

National Scientific Participation

Academic Societies

• Full Member, American Association for Cancer Research
• Member, Society for Basic Urologic Research
• Member, American Society of Human Genetics (past)

Reviewer for Scientific Journals

Ad Hoc Reviewer

• Cancer Research

Review Participant

• Cancer Cell
• Cancer Research
• Endocrinology
• Molecular Cancer Therapeutics
• Nature Medicine
• Oncogene
• The Journal of Urology
• The Proceedings of the National Academy of Sciences USA
• The Prostate

Mentoring/Teaching

Mayo Graduate School Teaching (Together with Dr. Donald Tindall)

Time: October 24-28, 2005

Class: TBio (Tumor Biology) I - Introduction to Cancer Biology:

Molecular, Cellular, and Genetic Basis of Cancer

                        Section: Cell Cycle Control

Since 1997 I have served as a professional mentor for research projects of junior colleagues, graduate students, and medical students at the Mayo Clinic

2004-pressent  Diping Wang, Ph.D. candidate in Dr. DJ Tindall’s Lab

Project: “Regulation and function of FOXO3a (FKHRL1) in prostate cancer”

2002    Richard Bennett, Ph.D. candidate rotated in Dr. DJ Tindall’s Lab

Project: “Destruction of the FOXO1 (FKHR) protein in prostate cancer”

2001    Douglas Benson, Tumor Biology Summer Student in Dr. DJ Tindall’s Lab

Project: “Molecular characterization of androgenic regulation of E2F1 expression”

2001    Jose Debes, M.D., Research Trainee in Dr. DJ Tindall’s Lab

Project: “Role of co-activators CBP and p300 in activation of the androgen receptor by interleukin-6 (IL-6)”

2001    Steven Johnsen, Ph.D. candidate rotated in Dr. DJ Tindall’s Lab

Project: “Effects of tea polyphenols on the PI3K/Akt pathway in prostate cancer”

1999-2000       Horacio Murillo, M.D./Ph.D. candidate in Dr. DJ Tindall’s Lab

Project: “Role of the PI3K/Akt pathway in survival of prostate cancer cells under androgen depletion conditions”

1999                Gwen Lomberk, Ph.D. candidate in Dr. DI Smith’s Lab

Project: “Genetic alterations within fragile site regions in ovarian cancer”

1998                Eric Thorland, Ph.D. candidate in Dr. DI Smith’s Lab

Project: “HPV-16 integration in fragile sites in cervical cancer”

1998                Kurt Krummel, Ph.D. candidate in Dr. DI Smith’s Lab

Project: “Genes mutated within the FRA16D fragile site region in prostate cancer”

Qiping, Ph.D. candidate in Dr. Long Yu’s Lab at Fudan University, Shanghai, China

Project: “Chromosome mapping of novel genes by using the fluorescence in situ hybridization (FISH) technique”

Yufang Shao, undergraduate in Dr. Long Yu’s Lab at Fudan University, Shanghai

Project: “cDNA identification and cloning in the chromosome region 17q11-12”

1994    Shujuan Pan, M.S. candidate in Professor Yifeng Chen’s Lab at Nanjing Normal University, Nanjing

Project: “Chromosome homology analysis in human and rhesus monkey”

1991    Teaching Assistant for the course of “Genetics Laboratory” in the Department of Biology at Nanjing Normal University, Nanjing

Invited Speaker

December 12   Prostate and Urological Cancer Program, Cancer Center and Department of Urology, University of Pittsburgh Medical Center. “FOXO1-mediated death of cancer cells in response to DNA damage”

November 29   Eppley Cancer Institute, University of Nebraska Medical Center, Omaha, Nebraska. “Role of CBP in prostate carcinogenesis”

November 28   Eppley Cancer Institute, University of NebraskaMedical Center, Omaha, Nebraska. “FOXO1-mediated death of cancer cells in response to DNA damage”

November 14   University Hospital Cancer Center, UMDNJ New Jersey Medical School, Newark, New Jersey. “FOXO1-mediated regulation of apoptosis in response to DNA damage”

October 2005  T.J. Martell Foundation Annual Meeting, West Greenwich, Rhode Island. “A FOXO1-dependent regulatory mechanism links DNA damage to cell death”

July 2005         Prostate Cancer: Road Map to the Future Conference, Niagara Falls, New York. “Skp2-mediated degradation of the tumor suppressor protein FOXO1: A new therapeutic target of prostate cancer”

March 2005     Mayo Clinic Cancer Center GU Multidisciplinary Cancer Conference, March 2005, Rochester, Minnesota. “Skp2-mediated degradation of FOXO1: a potential therapeutic target for prostate cancer”

January 2005    National Cancer Institute InterProstate SPORE Meeting, Houston, Texas. “Skp2 inhibits FOXO1 in tumor suppression through ubiquitin-mediated degradation”

October 2004  T.J. Martell Foundation Annual Meeting, West Greenwich, Rhode Island. “Skp2 inhibits FOXO1 in tumor suppression through ubiquitin-mediated degradation”

October 2003  T.J. Martell Foundation Annual Meeting, West Greenwich, Rhode Island. “Conditional knockout of the CBP and p300 genes in the mouse prostate”

October 2002  Mayo Prostate Cancer SPORE Annual Retreat, Rochester, Minnesota. “Molecular characterization of androgenic regulation of Bcl-2 in prostate cancer”

April 2002        93th AACR Annual Meeting, San Francisco, California. “Androgens block FKHR-induced apoptosis in prostate cancer through a proteolytic mechanism”

May 2000        Mayo Clinic Cancer Center Prostate Seminar Series, Rochester, Minnesota. “The PI3K/Akt signaling in the survival and progression of prostate cancer”

April 1999        90th AACR Annual Meeting, Philadelphia, Pennsylvania. “A novel carboxypeptidase A3 (CPA3) is highly inducible by histone deacetylase inhibitors in the differentiation of prostate epithelial cells”

October 1997  NCI-Funded Consortium Meeting on “Fragile Sites and Cancer,” University of Chicago, Chicago, Illinois. “Molecular cloning of the FRA7G common fragile site”

PUBLICATIONS

Peer-reviewed Articles

Huang, H., Regan, K.M., Lou, Z, Chen, J., and D.J. Tindall. A FOXO1-dependent regulatory mechanism links DNA damage to apoptotic cell death ( Under revision for Nature ).

Huang, H., Regan, K.M., Wang, F., Wang, D., Smith, D.I, van Deursen, and D.J. Tindall. Skp2 inhibits FOXO1 in tumor suppression through ubiquitin-mediated degradation. Proc Natl Acad Sci U S A . 102(5):1649-54, 2005.

Comments on this finding can be found in Cancer Cell 2005 Mar; 7(3): 209-10.

Huang, H., Muddiman, D.C., and Tindall, D.J. Androgens negatively regulate forkhead transcription factor FKHR (FOXO1) through a proteolytic mechanism in prostate cancer cells. J Biol. Chem. 279: 13866-13877, 2004.

Huang, H., Zegarra-Morro, O.L., Benson, D., and Tindall, D.J. Androgens repress Bcl-2 expression via activation of the retinoblastoma (RB) protein in prostate cancer cells. Oncogene 23(12): 2161-76, 2004.

Debes, J.D., Schmidt, L.J., Huang, H., and Tindall, D.J. p300 mediates interleukin-6-dependent transactivation of the androgen receptor. Cancer Res. 62: 5632-5636, 2002

Zegarra-Moro, O.L., Schmidt, L.J., Huang, H., and Tindall, D.J. Disruption of androgen receptor function inhibits proliferation of androgen-refractory prostate cancer cells. Cancer Res. 62: 1008-1013, 2002

Murillo, H.*, Huang, H.* (* these authors contribute equally), Schmidt, L.J., Smith, D.I., and Tindall, D.J. Role of PI3K signaling in survival and progression of LNCaP prostate cancer cells to the androgen-refractory state. Endocrinology 142: 4795-4805, 2001

Huang, H., Cheville, J.C., Pan, Y., Roche, P.C., Schmidt, L.J., and Tindall, D.J. PTEN induces chemosensitivity in PTEN-mutated prostate cancer cells by suppression of Bcl-2 expression. J Biol. Chem. 276: 38830-38836, 2001.

Shridhar, V., Bible, K.C., Staub, J., Avula, R., Lee, Y.K., Kalli, K., Huang, H., Hartmann, L.C., Kaufmann, S.H., and Smith DI. Loss of expression of a new member of the DNAJ protein family confers resistance to chemotherapeutic agents used in the treatment of ovarian cancer. Cancer Res. 61: 4258-4265, 2001.

Zhang, J.S., Wang, L., Huang, H., Nelson, M., and Smith, D.I. Keratin 23 (K23), a novel acidic keratin, is highly induced by histone deacetylase inhibitors during differentiation of pancreatic cancer cells. Genes Chromosomes Cancer 30: 123-135, 2001.

Huang, H., Reed, C.P., Zhang, J.S., Shridhar, V., Wang, L., and Smith, D.I. Carboxypeptidase A3 (CPA3): a novel gene highly induced by histone deacetylase inhibitors during differentiation of prostate epithelial cancer cells. Cancer Res. 59: 2981-2988, 1999.

Wang, L., Darling, J., Zhang, J.S., Huang, H., Liu, W., and Smith, D.I. Allele-specific late replication and fragility of the most active common fragile site, FRA3B. Hum. Mol. Genet. 8: 431-437, 1999.

Huang, H., Reed, C.P., Mordi, A., Lomberk, G., Wang, L., Jenkins, R.B., and Smith, D.I. Frequent deletion within FRA7G in invasive epithelial ovarian cancer. Genes Chromosomes Cancer 24: 48-55, 1999.

Mai, M., Huang, H., Reed, C.P., Qian, C., Smith, J.S., Alderete, B., Jenkins, R.B., Smith, D.I., and Liu, W. Genomic Organization of p73 and mutation analysis of this gene in oligodendrogliomas with chromosome 1p deletions. Genomics 51: 359-63, 1998.

Huang, H., Qian, J., Profitt, J., Wilber, K., Jenkins, R.B., and Smith, D.I. FRA7G extends over a broad region: coincidence of human endogenous retroviral sequences (HERV-H) and small polydispersed circular DNAs (spcDNA) and fragile sites. Oncogene 16: 2311-2319, 1998.

Huang, H., Qian, C., Jenkins, R.B., and Smith, D.I. FISH mapping of YAC clones at human chromosomal band 7q31.2: Identification of YACs spanning FRA7G within the common region of LOH in breast and prostate cancer. Genes Chromosomes Cancer 21: 152-159, 1998.

Jenkins, R.B., Qian, J., Lee, H.K., Huang, H., Hirasawa, K., Bostwick, D.G., Proffitt, J., Wilber, K., Lieber, M.M., Liu, W., and Smith, D.I. A molecular cytogenetic analysis of 7q31 in prostate cancer. Cancer Res. 58: 759-766, 1998.

Papers published in Chinese Scientific Journals

Shi.,Q., Zhang, J., Pan, S., Zhang, X., Chen, Y., San, X., Huang, H., Yu, L., Zhao, S., Zhang, Q., and Adler, I.D. Studies of meiotic origin of the extra chromosome 21 in Down syndromes detected by using (GT)n polymorphic DNA markers. Acta Genetica Sinica 25: 478-484, 1998.

Qinghua Shi , Xiannian Shan , Jian Zhang, Xiran Zhang, Yifeng Chen, Haojie Huang, Long Yu , Shouyuan Zhao, Qiping Zheng, and ID Adler. A DNA probe suitable for the detection of chromosome 21 copy number in human interphase nuclei by fluorescence in situ hybridization. Chinese Journal of Medical genetics 16: 36-40, 1999.

Haojie Huang, Xiran Zhang, and Yifeng Chen. Chromosomal homologies between Homo sapiens and Macaca mulatta and implications for human chromosome evolution. Acta Zoologica Sinica  50: 187-196, 1998.

Xiran Zhang, Haojie Huang, and Yifeng Chen. Construction of hybrid cells by fusion of murine myeloma cells and lymphocytes of Taihu pig. Journal of Nanjing Normal University (Natural Science) 21: 35-42, 1998.

Yong Pan, Yongquan Xue, Haojie Huang, Yifeng Chen, Xueming Xia, Yu Guo, Xin Xie, and Changgeng Ran. The application of chromosome painting technique to study hematological malignancies. Chinese Journal of Medical Genetics 14 (4): 203-206, 1997.

Shujuan Pan, Xiran Zhang, Haojie Huang, Yifeng Chen, and Gongqing Huang. Study of human, Macaca mulatta, Macaca fasicularis chromosome using fluorescence in situ hybridization (FISH). Hereditas (Beijing) 19 (3): 9-12, 1997.

Guangdan Zhu, Long Yu, Xin Huang, Haojie Huang, Qiping Zheng, and Shouyuan Zhao. Screening for coding sequences in a 330 kb region on the human chromosome 17q12. Journal of Fudan University (Natural Science) 36 (2): 234-238, 1997.

Shunsheng Han, Long Yu, Haojie Huang, Lu Xu, Xueyi Li, and Shouyuan Zhao. A new method of isolating YAC DNA used as probe for FISH. High Technology Letters 6 (12): 38-41, 1996.

Xiran Zhang, Haojie Huang, Yifeng Chen, Yong Pan, Yongquan Xue, Yu Guo, Xin Xie, and Changgeng Ran. Detection of rare ph translocation in chronic myelogenous leukemia by chromosome painting. Chinese Journal of Medical Genetics 13 (6): 337-340, 1996.

Yingxia Cui, Jianxiang Geng, Lizhu Wei, Xiran Zhang, Haojie Huang, and Yifeng Chen. Detection of a patient with t (2;18) by FISH. Chinese Journal of Medical Genetics, 13 (1): 4, 1996.

Haojie Huang, Xiran Zhang, Yifeng Chen, and YingXia Cui. A study on complicated chromosome translocation by fluorescence in situ hybridization (FISH) of G-banded chromosomes. Acta Genetica Sinica 23 (5): 338-342, 1996.

Xiran Zhang, Haojie Huang, and Yifeng Cheng. Homology of chromosomes of Homo sapiens and Macaca mulatta and implications for their chromosome evolution. In “Primates Reservation and Research” (Ed by Wuping Xia and Rongzhu Zhang), Foresty Press (Beijing), pp34-42, 1995.

Haojie Huang, Xiran Zhang, Meilang Xue, Yifeng Chen, Zhengfeng Xu, and Xunmei Wang. A de novo chromosome aberration in uterine leiomyomas detected by fluorescence in situ hybridization. Chinese Journal of Medical Genetics 12 (4): 237-238, 1995.

Haojie Huang, Xiran Zhang, and Yifeng Chen. Studies of the homology of chromosomes between human being and rhesus monkey with chromosomal in situ suppression hybridization. Acta Genetica Sinica  20 (3): 193-200, 1993.

Haojie Huang, and Yifeng Chen. Nonradioactive chromosomal in situ hybridization and its applications. Foreign Medicine (Genetics) 16 (2): 70-75, 1993.

Invited Review Articles

Huang, H. and Tindall, D.J. FOXO proteins: About life and death. Future Oncology , 2005 (in press).

Santos, A.F., Huang, H., and Tindall, D.J. The androgen receptor and its clinical relevance in prostate cancer. Steroid 69(2): 79-85, 2004.

Deocampo, N.D., Huang, H., and Tindall, D.J. The role of PTEN in the progression and survival of prostate cancer. Minerva Endocrinol . 28(2): 145-53, 2003.

Huang, H., and Tindall, D.J. The role of the androgen receptor in prostate cancer cells. Crit Rev Eukaryot Gene Expr. 12(3): 193-207, 2002

Grossmann, M.E., Huang, H., and Tindall, D.J. Androgen receptor signaling in androgen refractory prostate cancer. J Natl. Cancer Inst. 93: 1687-1697, 2001

Smith, D.I., Huang, H., and Wang, L. Common fragile sites and Cancer. Int. J Oncol. 12: 187-196, 1998.

 Book Chapters

Huang, H. and Tindall, D.J. PI3-kinase signaling pathway and PTEN in growth promotion of prostate cancer. In “Prostate Cancer: Signaling Networks, Genetics, and New Treatment Strategies” Ed by R.G. Pestell and M. Nevalainen. The Humana Press, Inc., 2006 (in preparation).

Huang, H. and Tindall, D.J. Role of the androgen receptor and PI3K/Akt in the survival of androgen-refractory prostate cancer cells. In “Hormonal Carcinogenesis IV” Ed by J. J. Li, S.A. Li, and A. Llombart-Bosch. Springer Science+Business Media, Inc., pp233-244, 2005.

Haojie Huang, and Long Yu. The technique of fluorescence in situ hybridization and its applications. In “Advances in cellular and molecular biology” (Ed by Xiran Zhang, Xiangnan Shan, Guoxin Shi and Sheng Yuan), Nanjing Normal University Press, pp17-27, 1996.

Published Abstracts

Huang, H., Regan, K.M., Wang, F., Wang, D., Smith, D.I, van Deursen, and D.J. Tindall. Skp2-mediated degradation of the tumor suppressor protein FOXO1: A new therapeutic target of prostate cancer. Prostate Cancer: Road Map to the Future Conference. Niagara Falls, NY, July 28-30, 2005.

Huang, H., Regan, K.M., and D.J. Tindall. Regulation of Expression of the Skp2 Gene by Androgens in Prostate Cancer Cells. Hormone Action on Development & Cancer. Gordon Research Conference, Mount Holyoke College, South Hadley, MA, July 10-15, 2005.

Huang, H., Regan, K.M., Wang, F., Wang, D., Smith, D.I, van Deursen, and D.J. Tindall. Skp2 inhibits FOXO1 in tumor suppression through ubiquitin-dependent degradation. Proceedings Supplement – Latest discoveries in Etiology, Diagnosis, Treatment, and Prevention. 96th Annual Meeting of the American Association for Cancer Research, Anaheim, Orange County, California, April 16-20, 2003, LB-13, pp7.

Huang, H., Regan, K.M., Wang, F., Wang, D., Smith, D.I, van Deursen, and D.J. Tindall. Skp2 inhibits FOXO1 in tumor suppression through ubiquitin-mediated degradation. National Cancer Institute (NCI) InterProstate SPORE Meeting, January 30-February 1, 2005, Houston, Texas, pp45.

Huang, H., Regan, K.M., and D.J. Tindall. Biphasic regulation of Skp2 expression by androgens in LNCaP prostate cancer cells. AACR Special Conference in Cancer Research: Basic, Translational, and Clinical Advances in Prostate Cancer. November 17-21, 2004, Bonita Springs, Florida, Abstract A11.

Huang, H., Cheville, J.C., Zegarra-Moro, O.L., and Tindall, D.J. Androgenic activation of RB protein inhibits transcription of Bcl-2 gene in prostate cancer cells. Proceedings of 94th Annual Meeting of the American Association for Cancer Research, Washington, D.C., July 11-14, 2003, A3579.

Huang, H., Zegarra-Moro, O.L., Benson, D., and Tindall, D.J. Androgens inhibit Bcl-2 expression via activation of the retinoblastoma protein (RB) in prostate cancer cells. 11^th SPORE Investigators’ Workshop, Baltimore, Maryland, July 8-10, 2003, A076

Huang, H., Zegarra-Moro, O.L., Benson, D., and Tindall, D.J. Androgens inhibit Bcl-2 expression via activation of the retinoblastoma protein (RB) in prostate cancer cells. 4^th International Symposium on Hormonal Carcinogenesis, Valencia, SPAIN, June 21-25, 2003, A58.

Zegarra-Moro, O.L., Huang, H., and Tindall, D.J. Role of p300 in androgen-refractory prostate cancer. Proceedings of 94th Annual Meeting of the American Association for Cancer Research, Washington, D.C., July 11-14, 2003, A4335.

Huang, H. and Tindall, D.J. Androgens block FKHR-induced apoptosis in prostate cancer cells via the proteasome degradation pathway. Proceedings of 93th Annual Meeting of the American Association for Cancer Research, San Francisco, CA, April 6-10, 2002: A4952, pp999.

Huang, H., Cheville, J.C., and Tindall, D.J. Androgenic activation of RB protein inhibits transcription of Bcl-2 gene in prostate cancer cells. Functional genomics in the urogenital system. 10^th Annual Society for Basic Urologic Research (SBUR) Fall Symposium. Tucson, Arizona, December 5-8, 2002: pp57.

Debes, J.D., Schmidt, L.J., Huang, H., and Tindall, D.J. p300 mediates interleukin-6-dependent activation of the androgen-receptor. Proceedings of 93th Annual Meeting of the American Association for Cancer Research, San Francisco, CA, April 6-10, 2002: A804, pp161.

Zegarra-Moro, O. L., Huang, H., and Tindall, D.J. Role of CREB-binding protein in androgen refractory prostate cancer cells. Proceedings of 93th Annual Meeting of the American Association for Cancer Research, San Francisco, CA, April 6-10, 2002: A3590, pp724.

Huang, H., Pan, Y., Cheville, J.C., Roche, P.C., and Tindall, D.J. Loss of PTEN/MMAC1 enhances chemoresistance in prostate cancer cells by facilitating Bcl-2 expression. Proceedings of 92th Annual Meeting of the American Association for Cancer Research, New Orleans, March 24-28, 2001: A3357, pp625.

Zegarra-Moro, O.L., Schmidt, L.J., Huang, H., and Tindall, D.J. Antibody microinjection reveals a role for the androgen receptor in refractory prostate cancer cells. Proceedings of 92th Annual Meeting of the American Association for Cancer Research, New Orleans, March 24-28, 2001: A942, pp175.

Debes, J.D., Huang, H., and Tindall, D.J. Modulation of growth factor-dependent androgen receptor activity by CBP/p300. Proceedings of 92th Annual Meeting of the American Association for Cancer Research, New Orleans, March 24-28, 2001: A4809, pp896.

Murillo, H., Huang, H., and Tindall, D.J. Tyrphostin AG825 triggers p38 MAP kinase-dependent cell death in androgen-independent prostate cancer cells. Proceedings of 92th Annual Meeting of the American Association for Cancer Research, New Orleans, March 24-28, 2001: A5132, pp954.

Huang, H., Murillo, H., Smith, D.I, and Tindall, D.J. Neuroendocrine-like survival of LNCaP prostate cancer cells under in vitro androgen ablation conditions is dependent on PI3K-Akt. Proceedings of 91th Annual Meeting of the American Association for Cancer Research, San Francisco, CA, April 1-5, 2000: A2574, pp405.

Murillo, H., Huang, H., and Tindall, D.J. PI3K-Akt signaling contributes to cell killing resistance in androgen refractory prostate cancer cell lines C4 and C4-2. Proceedings of 91th Annual Meeting of the American Association for Cancer Research, San Francisco, CA, April 1-5, 2000: A310, pp49.

Huang, H., Cheville, J.C., Roche, P.C., and Tindall, D.J. Loss of PTEN facilitates the expression of Bcl-2 in prostate cancer. Tissue Interactions in Prostate Cancer. 8^th Annual Society for Basic Urologic Research Fall Symposium. Ft. Myers, Florida, November 9-12, 2000: I-30.

Huang, H., Reed, C.P., Zhang, J.S., Shridhar, V., and Smith, D.I. A novel carboxypeptidase A3 (CPA3) is highly inducible by histone deacetylase inhibitors in the  differentiation of prostate epithelial cells. Proceedings of 90th Annual Meeting of the American Association for Cancer Research, Philadelphia, PA, April 10-14, 1999: A4855, pp735.

Zhang, J.S., Wang, L., Huang, H., Nelson, M., and Smith, D.I.. Identification and characterization of HAIK1, a novel type I keratin, and a potential differentiation marker for pancreatic cancer. Proceedings of 90th Annual Meeting of the American Association for Cancer Research, Philadelphia, PA, April 10-14, 1999: A4846, pp734.

Mai, M., Huang, H., Reed, C.P., Qian, Q., Smith, J.S., Alderete, B., Jenkins, R.B., Smith, D.I, and Liu, W. Genomic Organization of p73 and mutation analysis of this gene in oligodendrogliomas with chromosome 1p deletions. The American Journal of Human genetics 63 (4): A76 ppA415, 1998.

Huang, H., Reed, C.P., Qian, J., Profitt, J., Wilber, K., Liu, W., Jenkins, R.B., and Smith, D.I. Colocalization of the common fragile site, FRA7G, and the common region of deletion in prostate, breast, and ovarian cancer. The American Journal of Human genetics 63 (4): A74 (A395), 1998.

Qian, J., Lee, H.K., Huang, H., Hirasawa, K., Bostwick, D.G., Proffitt, J., Wilber, K., Lieber, M.M., Liu, W., Smith, D.I, and Jenkins, R.B. A molecular cytogenetic analysis of 7q31 in prostate cancer. Proceedings of 89th Annual Meeting of the American Association for Cancer Research, New Orleans, LA, March 28-April 1, 1998: A875, pp128.

Huang, H., Qian, Q., Jenkins, R.B., and Smith, D.I. Identification of YAC clones spanning FRA7G within the common region of LOH in breast, prostate, and ovarian cancer. The American Journal of Human genetics 61 (4): A69, ppA373, 1997.