Michael Linden, M.D., Ph.D.

Contact Information Phone: 612-273-5629 Fax: 612-624-6662 Email: linde013@umn.edu Address: MMC 609 Mayo 420 Delaware St SE Minneapolis, MN 55455

Assistant Professor

Dr. Linden is an Assistant Professor in the Division of Hematopathology within the Department of Laboratory Medicine and Pathology. In addition, he is the Assistant Director of the Special Hematology Laboratory. As a graduate student, Dr. Linden’s thesis work helped develop a new mouse model of multiple myeloma. Dr. Linden completed residency and fellowship training in Hematopathology at the University of Washington. He now attends on the University of Minnesota Medical Center’s Hematopathology and Flow Cytometry services. Dr. Linden continues to have a strong interest in plasma cell and other hematopoietic neoplasms and enjoys research that applies his clinical skills to improving clinical laboratory diagnoses and predicting clinical outcomes. More specifically, he is investigating optimum diagnostic methods for monitoring residual disease in myeloma patients and developing diagnostic tests to predict chemotherapeutic sensitivity of the neoplastic plasma cells. In addition, he greatly values resident/fellow education and mentorship.

Educational Background

• Saint Mary’s University, Winona, MN (1998), B.A. (Biology)
• University of Minnesota, Minneapolis, MN (2006), M.D., Ph.D. (Medical Scientist Training Program)
• University of Washington Medical Center, Seattle, WA (2006-2010), Residency (Anatomical and Clinical Pathology)
• University of Washington Medical Center, Seattle, WA (2010-2011), Fellowship (Hematopathology)

Professional Background

Board Certification (American Board of Pathology)

• Anatomic and Clinical Pathology, 2010
• Hematology, 2011

Professional Organizations

• Academy of Clinical Laboratory Physicians and Scientists (ACLPS)
• American Society for Clinical Pathology (ASCP)
• American Society of Hematology (ASH)
• United States and Canadian Academy of Pathology (USCAP)
• Society for Hematopathology
   

Awards/Honors

• Resident Distinguished Teaching Award in Clinical Pathology, 2012
• Institute of Human Genetics Seed Grant Recipient (Co-Investigator), 2012
• Certificate of Excellence (top 5% of all reviewers for Laboratory Investigation), 2011
• J. Jacob Kaplan Research Award, 2006
• J. Thomas Livermore Research Award, 2004
• University of Minnesota Medical School Advanced Admissions Program Acceptance, 1996
• CRC Press Freshman Chemistry Award, 1995
   

Publications

Editorial Responsibilities

• Assistant editor (Hematology Section), Lab Medicine 2012-Present
• Editorial board of the Open Journal of Blood Diseases 2012-Present
• Intern, Laboratory Investigation editorial internship program, 2009 to present
   

Ad hoc reviewer for:

• British Journal of Hematology
• Experimental Hematology
   

Book Chapters

Linden MA, Ward J, and Cherian S. The Hematopoietic System. In: Comparative Anatomy and
Histology for the Translational Pathologist: A Mouse and Human Atlas, Dintzis S and Treuting
P., ed. Elsevier Press, Maryland Heights, MO, 2011.

Peer Reviewed (or Refereed Journals)

• Singh, C, Yohe S, Baughn L, and Linden MA. Utility of flow cytometry to classify abnormal plasma cell populations in marrow samples collected from patients with putative plasma cell neoplasms. Submitted to Open Journal of Blood Diseases.

• Conway A, Kaufman SC, Rudrapatna V, and Linden MA. Crystalizing immunoglobulin presenting as polychromatic crystalline keratopathy; an unusual clinical presentation of monoclonal gammopathy of undetermined significance (MGUS). Submitted to Archives of Pathology and Laboratory Medicine (in revision).

• Lunde L, Chuang C, Linden MA, Williams, SA, Sachs Z, Young JH, and Ustun C. Lethal Bowel Complication During Acute Promyelocytic Leukemia Induction. American Journal of Hematology (in press).

• Linden MA, Bachanova V, Sachs Z, Young JH, Singleton TP, and Ustun C. Transformed large B cell lymphoma in a rituximab-allergic chronic lymphocytic leukemia patient after allogeneic stem cell transplantation: successful treatment with ofatumumab. Leukemia and Lymphoma (in press)

• Linden MA, Gopal A, and Edlefsen KL. Acute appendicitis in a man undergoing therapy for mantle cell lymphoma. Case Reports in Hematology (in press)

• Yan D, Wang P, Linden M, Knudsen B, and Randolph T. Automated quantification of immunohistochemical staining for improved tissue microarray image scoring by Tissue Array Co-Occurrence Matrix Analysis (TACOMA). Annals of Applied Statistics (in press)

• Linden MA, Kirchhof N, Carlson CS, Van Ness BG. Targeted overexpression of an activated N-ras gene results in B- and plasma cell lymphoproliferation and cooperates with c-myc to induce fatal B-cell neoplasia. Experimental Hematology. 2012 Mar; 40(3):216-27. PMCID: PMC3279594.

• Linden MA and Apple FS. Use of B-type natriuretic peptide testing in a community teaching hospital 4 years after implementation and agreement of results with discharge diagnoses. Clinical Chemistry. 2006 Apr; 52(4):767-8.

• Dunn T, Linden MA, Vercellotti GM, and Gruessner RWG. Factor V Leiden and hepatic artery thrombosis after liver transplantation. Clinical Transplantation. 2006 Jan; 20(1):132-5.
   
• Linden MA, Kirchhof N, Kvitrud M, and Van Ness BG. ABL-MYC retroviral infection elicits bone marrow plasma cell tumors in bcl-XL transgenic mice. Leukemia Research. 2005 Apr; 29(4):435-444.
   
• Cheung WC, Kim JS, Linden MA, Van Ness BG, Polakiewicz R, Janz S. Novel targeted deregulation of c-myc and bcl-XL causes plasma cell neoplasms in mice. J Clinical Investigation. 2004 Jun; 13(12):1763-73.
   
• Linden MA, Kirchhof N, Carlson CS, Van Ness BG. Targeted overexpression of bcl-XL in B-lymphoid cells results in lymphoproliferative disease and plasma cell malignancies. Blood. 2004 Apr 1; 03(7):2779-86.
   
• Croonquist PA, Linden MA, Zhao F, Van Ness BG. Gene profiling of a myeloma cell line reveals similarities and unique signatures among IL-6 response, N-ras-activating mutations, and co-culture with bone marrow stromal cells. Blood. 2003 Oct 1; 102(7): 2581-92.
   
• Liu X, Linden M, Van Ness B. Induced kappa receptor editing shows no allelic preference in a mouse pre-B cell line. J Immunol. 2000 Dec 15; 165(12): 7058-63.