J. Carlos Manivel, M.D.

Contact Information Phone: (612) 273-5848 Fax: (612) 273-1142 Email: maniv001@umn.edu Address: C446 Mayo 420 Delaware St SE Minneapolis, MN 55455

Professor, Head of Anatomic Pathology

Dr. Manivel is responsible for signing surgical pathology cases working with pathology residents, medical students, and fellows. He also shares responsibility for cytology and organizes weekly conferences for surgical pathology. In addition, Dr. Manivel is director of the laboratory for electron microscopy.

Research Interests

Dr. Manivel’s research focus is on diagnostic pathology and clinical science. One area is the characterization of pseudotumors, lesions that can simulate benign or malignant neoplasms clinically, grossly, and microscopically. Most pseudotumors are reactive and inflammatory developmental masses, such as cysts. Dr. Manivel is concentrating on pseudotumors of the male genitourinary tract.

Dr. Manivel also is conducting or collaborating in clinical investigations of a number of unusual pathologies. These include: transitional cell carcinoma post-chemotherapy (clinicopathological correlation, in situ hybridization (ISH) for prognostic factors, molecular diagnosis); Epstein-Barr involvement in dedifferentiated lymphomas, gastric carcinomas, benign lymphoepithelial lesions, and Sjogren disease (ISH for prognostic factors, immunohistochemistry [IHC] for virus receptor); epithelial atypia of the endocervix and endometrium in newborns (morphologic analysis, IHC analysis for estrogen and progesterone receptor); mesonephric papillomas (IHC); polykaryocytes in vulvar skin (morphologic, IHC); testicular stromal tumors in children (clinicopathologic correlation, morphologic, IHC); tissue factor activation in endothelial injury in patients with sickle cell disease (morphologic, IHC); renal cell carcinoma (morphologic, clinicopathologic correlation, IHC); and a large number of retinoblastomas provided by a colleague in Argentina (clinicopathologic correlation, morphologic, IHC for oncogene products, flow cytometry, molecular diagnosis).

Educational Background

• National Autonomous University of Mexico (1977), M.D.
• General Hospital Mexico City, National Autonomous University of Mexico (1982), Residency (Anatomic Pathology)
• University of Minnesota (1983), Residency (Surgical Pathology)

Publications

Member of the Editorial Board:

• American Journal of Clinical Pathology 1991-present
• International Journal of Surgical Pathology
• Human Pathology 1989-present
• International Board, Revista Medica del Hospital General, S.S. (Mexico).
• Editorial Board member: Patologia. Revista Latinoamericana. 2007- present

Peer-Reviewed Articles

• Singh C, Manivel JC, Pambuccian SE. Histiocytic Corona Around a Glomeruloid Intrafollicular Polyp of the Thyroid. Int J Surg Pathol. 2009 Aug 10.
• Arerangaiah R., Chalasani N., Udager A., Manivel J., Griffin R., Song C., Gupta K.: Opioids Induce Renal Alterations in Tumor Bearing Mice. Nephron Exp Nephrol 2007;105:80-89
• Lynda Polgreen , Marie Steiner , J.Carlos Manivel , Anna Petryk: Thymic hyperplasia in a child treated with growth hormone. Growth Hormone and IGF Research 17:41-46, 2007.
• Speltz MC, Manivel JC, Tobias AH, Hayden DW: Primary cardiac fibrosarcoma in a Labrador Retriever. Veterinary Pathology 44:403-407. 2007.
• Skubitz KM, Manivel JC: Giant cell tumor of the uterus: case report and response to chemotherapy. BMC Cancer 2007, 7:46.
• Chauhan A, Dhurairaj T, Manivel­ JC, Yonke B, Froelich JW: Recurrent Aggressive Fibromatosis Imaged By PET/CT: A Case Report. (Submitted to Annals of the Rheumatic Diseases)
• Zwolak P, Manivel JC, Jasinski P, Fisher J, Kirstein MN, Dudek AZ, Cheng EY: The cytotoxic effect of zoledronic acid loaded bone cement on multiple myeloma, giant cell tumor and renal cell carcinoma cell lines. (Submitted to Journal of Bone and Joint Surgery)
• Bella G, Manivel JC, Cheng E.: Intramuscular hemangiomas: Recurrence -free survival after surgery. Clinical Orthopaedics and Related Research 459:186-191, 2007.
• Aslan D, Pambuccian SE, Gulbahce HE, Tran ML, Manivel JC: Prostatic glands and urothelial epithelium in a seminal vesicle cyst: Report of a case and review of pathologic features and prostatic ectopy. Archives of Pathology and Laboratory medicine 130:194-197, 2006
• Canales BK, Weiland D, Hoffman N, Slaton J, Tran M, Manivel JC, Monga M: Angiomyofibroblastoma-like tumors (cellular angiofibroma). International Journal of Urology, 2006, Feb;13(2):177-9.
• Koushik R,. Garvey C, Manivel JC, Matas AJ,.Kasiske BL: Persistent asymptomatic hematuria in prospective kidney donors. Transplantation 80:1425-1429, 2005.
• Cheng EY, Zwolak P, Le CT, Manivel JC, Dusenbery KE, Clohisy DR, Skubitz KM, Thomspon RC: Positive margins after attempted wide excision of a soft tissue sarcoma: Is further excision necessary? (Submitted to Cancer).
• Goblirsch M, Lynch C, Mathews W, Manivel JC, Mantyh PW, Clohisy DR:L Radiation treatment decreases bone cancer pain though direct effect on tumor cells. Radiation Research164:400-408, 2005
• Zwolak, P, Manivel JC, Clohisy D: Forearm mass in an adolescent: Intraosseous neurilemmoma of the ulna. Clinical Orthopaedics and related research (In press).
• Rheault MN, Manivel JC, Levine SC, Sinaiko AR: Sarcoidosis presenting with hearing loss and granulomatous interstitial nephritis in an adolescent. Pediatr Nephrol. 2006 Sep;21(9):1323-6. Epub 2006 Jun 30
• Argani P, Lae M, Ballard ET, Rodriguez M, Amin M, Manivel C, Hutchinson B, Reuter VE, Ladanyi M: Translocation carcinomas of the kidney after chemotherapy in childhood. Journal of Clinical Oncology 24(10):1529-1534, 2006.
• DL Aslan, HE Gulbahce, SE Pambuccian, JC Manivel, J Jessurun. Ki67 Immunoreactivy in the Differential Diagnosis of Pulmonary Neuroendocrine Neoplasms in Specimens with Extensive Crush Artifacts. Am J Clin Pathol 123(6):874-878, 2005.
• Roychoudhury M, Pambuccian SE, Aslan DL, Jessurun J, Rose AG, Manivel JC, Gulbahce HE: Pulmonary complications after bone marrow transplantation: an autopsy study from a large transplant center. Archives of Pathology and Laboratory Medicine 2005 Mar;129(3):366-71.
• Hom DB, Unger G, Pernell KJ, Manivel JC: Improving Surgical wound healing with basic fibroblast growth factor after radiation. The Laryngoscope 115:412-422, 2005.
• Peters A, Manivel JC, Dolan M, Gulbahce HE, Baker KS, Verneris MR: Pulmonary Cytolytic Thrombi After Hematopoietic Cell Transplantation: A Further Histological Description. Biology of Blood and Marrow Transplantation Jun;11(6):484-5, 2005
• Koutlas I, Manivel JC: Perivascular epithelioid cell tumor of the oral mucosa. Archives of Pathology and Laboratory Medicine 129:690-693, 2005

Invited Lectures

• General Hospital of Mexico City, Department of Pathology: Surgical Pathology Seminar: Recently described Tumors of the Soft Tissues. December, Friday 21st, 2007.
• Latin American Society of Pediatric Pathologists. XIII Biannual meeting. Pulmonary Tumors in Pediatric Patients. Punta del Este, Uruguay. September 24-25, 2007.
• Association of Pathologists of the Northwest (Mexico) Surgical Pathology: Soft Tissue Tumors Seminar. Tijuana, Baja California Norte Aug 17, 2007.
• Second Atlantic Conference on Molecular Pathology. Testicular Germ Cell tumors: Pathology and Molecular Biology. Fuerteventura, Canary Islands, Spain. June 8-11, 2006.
• Second Atlantic Conference on Molecular Pathology. Lung tumors: Pathology and Molecular Biology. Fuerteventura, Canary Islands, Spain. June 8-11, 2006.
• Conference: Pathology and Pathobiology of Gastrointestinal Stromal Tumors. Department of Pathology. University of Naples, Naples, Italy. September 12, 2005.
• Surgical pathology of difficult and unusual neoplasms, Seminar Coordinator.. Modanella, Italy. Sept 6 to 8, 2005.
• 48th Annual Congress, Mexican Association of Pathologists. Recent advances in renal tumor pathology. May 6th, 2005. Puerto Vallarta, Jalisco, Mexico.
• 48th Annual Congress, Mexican Association of Pathologists. Gastrointestinal stromal tumors (GISTS) Pathology and Pathobiology. May 6th, 2005. Puerto Vallarta, Jalisco, Mexico.
• 48th Annual Congress, Mexican Association of Pathologists. Recent advances in tumors of the urinary bladder. May 7th, 2005. Puerto Vallarta, Jalisco, Mexico.
• Guest Speaker, General Hospital “Manuel Gea Gonzalez”: Conference on “Pathology at the Dawn of the Third Millennium”. May 3rd, 2005. Mexico City, Mexico.
• 29th E.T. Bell symposium. Department of Laboratory Medicine and Pathology. Testicular germ cell tumors in adults: Pathology and pathobiology. Minneapolis, MN. Continuing Medical Education, University of Minnesota. November 5, 2004.
• 29th E.T. Bell symposium. Department of Laboratory Medicine and Pathology. Renal tumors in adults: Pathology and pathobiology. Minneapolis, MN. Continuing Medical Education, University of Minnesota. November 5, 2004.
• 67th Annual Meeting, Mexican Association of Pathologists and 4th National Congress of the Mexican Federation of Anatomic Pathology. Update in tumors of the testis. Cancun, Quintana Roo, Mexico. May 1 to May 4, 2004.
• 67th Annual Meeting, Mexican Association of Pathologists and 4th National Congress of the Mexican Federation of Anatomic Pathology. Update and Controversies in Neoplastic Pathology of the Kidney. Cancun, Quintana Roo, Mexico. May 1 to May 4, 2004.
• 67th Annual Meeting, Mexican Association of Pathologists and 4th National Congress of the Mexican Federation of Anatomic Pathology. Surgical Pathology Seminar Cancun, Quintana Roo, Mexico. May 1 to May 4, 2004
• Pathology Course to celebrate 50th Anniversary of Department of Pathology. General Hospital, National University, Mexico City. Lecture on: Recent Advances on the pathology of Testicular Germ Cell Tumors. April 10, 2003.
• 28th E.T. Bell symposium. Department of Laboratory Medicine and Pathology. Hepatic tumors. Minneapolis, MN. Continuing Medical Education, University of Minnesota. November 7, 2003.
• Association of Pathologists of the Northwest (Mexico), Annual Meeting. Surgical Pathology Seminar. November 19-21, 2003. La Paz, Baja California Sur, Mexico.