J. Carlos Manivel, M.D.

Professor, Head of Anatomic Pathology
(612) 273-5848
maniv001@umn.edu

Dr. Manivel is responsible for signing surgical pathology cases working with pathology residents, medical students, and fellows. He also shares responsibility for cytology and organizes weekly conferences for surgical pathology. In addition, Dr. Manivel is director of the laboratory for electron microscopy.

Educational Background

Board Certification

Research Interests

Dr. Manivel’s research focus is on diagnostic pathology and clinical science. One area is the characterization of pseudotumors, lesions that can simulate benign or malignant neoplasms clinically, grossly, and microscopically. Most pseudotumors are reactive and inflammatory developmental masses, such as cysts. Dr. Manivel is concentrating on pseudotumors of the male genitourinary tract.

Dr. Manivel also is conducting or collaborating in clinical investigations of a number of unusual pathologies. These include: transitional cell carcinoma post-chemotherapy (clinicopathological correlation, in situ hybridization (ISH) for prognostic factors, molecular diagnosis); Epstein-Barr involvement in dedifferentiated lymphomas, gastric carcinomas, benign lymphoepithelial lesions, and Sjogren disease (ISH for prognostic factors, immunohistochemistry [IHC] for virus receptor); epithelial atypia of the endocervix and endometrium in newborns (morphologic analysis, IHC analysis for estrogen and progesterone receptor); mesonephric papillomas (IHC); polykaryocytes in vulvar skin (morphologic, IHC); testicular stromal tumors in children (clinicopathologic correlation, morphologic, IHC); tissue factor activation in endothelial injury in patients with sickle cell disease (morphologic, IHC); renal cell carcinoma (morphologic, clinicopathologic correlation, IHC); and a large number of retinoblastomas provided by a colleague in Argentina (clinicopathologic correlation, morphologic, IHC for oncogene products, flow cytometry, molecular diagnosis).

Publications (list publications during the year)

Peer reviewed publications           

• Moriya R, Manivel JC, Mauer M: Juxtaglomerular apparatus T-cell infiltration affects glomerular structure in Type 1 diabetic patients. Diabetologia 47:82-88, 2004
• Gulbahce EH, Pambuccian SE, Jessurun J, Woodward JP, Steiner ME, Manivel JC, Hite S, Ramsay NKC, Baker KS: Pulmonary nodular lesions in post-bone marrow transplant patients: Impact of histologic diagnosis on patient management and prognosis. Am J Clin Pathol 121:205-210, 2004.
• Manivel JC: Trophoblastic Neoplasms of the Testis Other than Choriocarcinoma. In: Germ cell tumors.  221-249. In: Pathology and Genetics. Tumours of the Urinary System and Male Genital Organs.  World Health Organization Classification of Tumors. Lyon, 2004.
• Pettinato G, Manivel JC, Panico L, Sparano L, Petrella G: Invasive micropapillary carcinoma of the breast. Clinicopathologic study of 62 cases of a poorly recognized variant with highly aggressive behavior.  Am J Clin Pathol 121:857-866, 2004.
• Avdulov S, Li S, Michalek V, Berrichter D, Peterson M, Perlman D, Manivel JC, Sonenberg N, Yee D, Bitterman PB, Polunovsky VA: Activation of translation complex elF4F is essential for the genesis and maintenance of the malignant phenotype in human mammary epithelial cells. Cancer Cell 5:553-563, 2004.
•  DL Aslan, HE Gulbahce, SE Pambuccian, JC Manivel, J Jessurun. Preservation of Immunoreactivy for MIB-1 Aids in the Differential Diagnosis of Pulmonary Small Cell Carcinoma and Carcinoid Tumor in Specimens with Extensive Crush Artifacts. Am J Clin Pathol (In Press)
• Canales BK, Weiland D, Hoffman N, Slaton J, Tran M, Manivel JC, Monga M: A review of angiomyofibroblastoma-like tumors.  International Journal of Urology (In Press)
• Hom DB, Unger G, Pernell KJ, Manivel JC: Improving Surgical wound healing with basic fibroblast growth factor after radiation.  The Laryngoscope (In Press).
• Peters A, Manivel JC, Dolan M, Gulbahce HE, Baker KS, Verneris MR: Pulmonary Cytolytic Thrombi After Hematopoietic Cell Transplantation: A Further Histological Description. Biology of Blood and Marrow Transplantation (In Press).
• Koutlas I, Manivel JC: Perivascular epithelioid cell tumor of the oral mucosa. Archives of Pathology and Laboratory Medicine (In Press).
• Canales B, Manivel JC: Radiation-induced intratesticular leiomyosarcoma. Urology (In Press).
• Aslan D, Pambuccian SE, Gulbahce HE, Tran ML, Manivel JC: Prostatic glands and urothelial epithelium in a seminal vesicle cyst: Report of a case and review of pathologic features and prostatic ectopy. Archives of Pathology and Laboratory medicine (In Press)

Peer reviewed publications submitted but not published during the year

• Koushik R, Garvey C, Manivel JC,  Matas AJ,.Kasiske BL, :Persistent asymptomatic hematuria in prospective kidney donors. (Submitted to: Transplantation)
• Roychoudhury M, Pambuccian SE, Aslan DL, Jessurun J, Rose AG, Manivel JC, Gulbahce HE: Pulmonary complications after bone marrow transplantation: an autopsy study from a large transplant center. Archives of Pathology and Laboratory Medicine (Submitted)