Amy Skubitz, Ph.D.

Associate Professor
612-625-5920
skubi002@umn.edu

Educational Background

• University of Maryland, Maryland (1980), B.S. (Biochemistry)
• John Hopkins University, Maryland (1984), Ph.D. (Pharm and Exp. Ther.)
• University of Minnesota, Minnesota (1988) Posdoctoral (Lab. Med and Pathol.)

Professional Background

• Postdoctoral Fellow, Dept. Lab Medicine & Pathology, Univ. of Minnesota, 1984 - 1987
• Research Associate, Dept. Lab Medicine & Pathology, Univ. of Minnesota, 1988 - 1990
• Assistant Professor, Dept. Lab Medicine & Pathology, Univ. of Minnesota, 1988 - 1996
• Assistant Professor of Biomedical Engineering, Univ. of Minnesota, 1991 - 1996
• Director, Cancer Center Tissue Procurement Facility, Univ. of Minnesota, 1995 - 2002
• Assoc. Professor, Dept. Lab Medicine & Pathology, Univ. of Minnesota, 1996 - present

Professional Honors

• Bowie Woman's Club Scholarship , University of Maryland, 1976 - 1977
• General Honors Program, University of Maryland, 1976 - 1980
• Dean's List Scholar, University of Maryland, 1976 - 1980
• Award for Distinguished Undergraduate Scholarship , University of Maryland, 1979
• Phi Kappa Phi National Honor Society, University of Maryland, 1979
• Phi Sigma Phi National Honor Society, University of Maryland, 1979
• Noxell Foundation Scholarship, University of Maryland, 1979 - 1980
• Award for excellence in the field of Pharmacology, Sandoz, 1985
• National Research Service Award, National Institutes of Health, 1986
• Postdoctoral Fellowship Award, American Cancer Society, 1986 - 1988

Professional Memberships

• Study Section Member: Grants-in-aid and fellowships, American Heart Association, MN Affiliate, 1991 - 1994
• Study Section Member: Special Review Committee, NIH/NCI, to review a Program Project, 1992
• & 1997, Study Section Member: External Referee, Study Section Member: Grants-in-aid of research for the Med. Research Council of Canada, 1992
• Study Section Member: External Reviewer; Research scholarships for The Fonds de la recherche en sante du Quebec, 1993
• Temporary Member; NIH, Oral Biology and Medicine Study Section, Subcommittee 2, 1998
• Member, Special Emphasis Panel, NIH/NCI to review applications in response to RFA U01CA02-001, "Tissue and Biological Fluids of HIV-related Malignancies" , 2001
• Scientific Reviewer for OCRP-1 Scientific Peer Review Panel, Department of Defense, U.S. Army Medical Research and Materiel Command, Congressionally Directed Medical Research Programs (CDMRP), Fiscal year 2004 Ovarian Cancer Research Program, 2004
• Memberships in Societies: International Society for Biological and Environmental Repositories, MNBIO, National Ovarian Cancer Coalition, University of Minnesota Cancer Center

Publications

• (selected from 76 peer-reviewed manuscripts, 34 book chapters, and 141 abstracts)
• Miles, A.J., Knutson, J.R., Skubitz, A.P.N., Furcht, L.T., McCarthy, J.B., and Fields, G.B. (1995) A peptide model of basement membrane collagen a1(IV)531-543 binds the alpha3 beta1 integrin. J. Biol. Chem. 270(49):29047-29050.
• Pattaramalai, S., Skubitz, K.M. and Skubitz, A.P.N. (1996) A novel recognition site on laminin for the alpha3 beta1 integrin. Exper. Cell Res. 222:281-290.
• Skubitz, A.P.N., Bast, R.C., Wayner, E.A., Letourneau, P.C., and Wilke, M.S. (1996) Expression of alpha6 and beta4 integrins in serous epithelial ovarian carcinoma correlates with expression of the basement membrane protein laminin. Amer. J. Pathol. 148:1445-1461.
• Skubitz, K.M., Campbell, K.D., and Skubitz, A.P.N. (1996) CD66a, CD66b, CD66c, and CD66d each independently stimulate neutrophils. J. Leukocyte Biol. 60:106-117.
• Skubitz, K.M., Campbell, K.D., Iida, J., and Skubitz, A.P.N. (1996) CD63 associates with tyrosine kinase activity and CD11/CD18, and transmits an activation signal in neutrophils. J. Immunol. 157:3617-3626.
• Schuger, L., Skubitz, A.P.N., Gilbride K., Mandel, R., and He, L. (1996) Laminin and heparan sulfate proteoglycan mediate epithelial cell polarization in organotypic cultures of embryonic lung cells: Evidence implicating involvement of the inner globular region of laminin b1 chain and the heparan sulfate groups of heparan sulfate proteoglycans. Developmental Biol. 179:264-273.
• Skubitz, K.M., Campbell, K.D., and Skubitz, A.P.N. (1997) CD50 monoclonal antibodies inhibit neutrophil activation. J. Immunol. 159: 820-828.
• Yanaka, K., Camarata, P.J., Spellman, S.R., Skubitz, A.P.N., Furcht, L.T., and Low, W.C. (1997) Laminin peptide ameliorates brain injury by inhibiting leukocyte accumulation in a rat model of transient focal cerebral ischemia. Journal of Cerebral Blood Flow and Metabolism 17:605-611.
• Schuger, L., Skubitz, A.P.N., Zhang, J., Sorokin, L., and He, L. (1997) Laminin a1 chain synthesis in the mouse developing lung: requirement for epithelial-mesenchymal contact and possible role in bronchial smooth muscle development. J. Cell Biol. 139:553-562.
• Skubitz, K.M. and Skubitz, A.P.N. (1998) Mechanism of transient dyspnea induced by pegylated-liposomal doxorubicin (Doxil TM). Anti-cancer Drugs 9:45-50.
• Skubitz, A.P.N., Campbell, K.D., Goueli, S., and Skubitz, K.M. (1998) Association of b1 integrin with protein kinase activity in large detergent resistant complexes. FEBS Letters 426:386-391.
• Skubitz, K.M., Butterfield, J., Ma, K., and Skubitz, A.P.N. (1998) Changes in neutrophil phenotype during hemodialysis. Inflammation 22:559-572.
• Skubitz, K.M., Campbell, K.D., and Skubitz, A.P.N. (1998) Tyrosine kinase activity is associated with CD44 in human neutrophils. FEBS Letters 439:97-100.
• Skubitz, K.M., Campbell, K.D., and Skubitz, A.P.N. (1998) CD43 is associated with tyrosine kinase activity in human neutrophils. J. of Leukocyte Biol. 64(6):800-802.
• Lessan, K., Aguiar, D.J., Oegema, T., Siebenson, L., and Skubitz, A.P.N. (1999) CD44 and the b1 integrin mediate ovarian carcinoma cell adhesion to peritoneal mesothelial cells. Amer. J. Pathol. 154:1525-1537.
• Silkensen, J.R., Skubitz, A.P.N., Skubitz, K.M., and Rosenberg, M.E. (1999) Identification of clusterin sequences mediating renal tubular cell interactions. J. of Peptide Res. 54(5):449-457.
• Skubitz, K.M., Campbell, K.D., and Skubitz, A.P.N. (2000) CD63 associates with CD11/CD18 in large detergent resistant complexes after translocation to the cell surface in human neutrophils. FEBS Letters 469:52-56.
• Skubitz, K.M., Campbell, K.D., and Skubitz, A.P.N. (2000) Synthetic peptides of CD66a stimulate neutrophil adhesion to endothelial cells. Journal of Immunology 164:4257-4264.
• Casey, R.C. and Skubitz, A.P.N. (2000) CD44 and beta1 integrins mediate ovarian carcinoma cell migration toward extracellular matrix proteins. Clin. & Exper. Metast. 18:67-75.
• Casey, R.C., Burleson, K.M., Skubitz, K.M., Pambuccian S.E., Oegema, T.R. Jr., Ruff, L.E., and Skubitz, A.P.N. (2001) b1-integrins regulate the formation and adhesion of ovarian carcinoma multicellular spheroids. Amer. J. Pathol. 159:2071-2080.
• Skubitz, A.P.N. (2001) Adhesion Molecules. In Ovarian Cancer volumne (ed. M.S. Stack and D.A. Fishman) of Cancer Treatment and Research (S.T. Rosen, series editor) Kluwer Academic Publishers, Boston, pp. 305-329.
• Skubitz, K.M., Campbell, K.D., Skubitz, A.P.N. (2001) Synthetic peptides from the N-domains of CEACAMs activate neutrophils. J. Peptide Res. 58: 515-526.
• Skubitz, K.M. and Skubitz, A.P.N. (2002) Differential gene expression in renal cell cancer. J. Lab. Clin. Med. 140:52-64.
• Casey, R.C., Oegema Jr., T.R., Skubitz, K.M., Pambuccian, S.E., Grindle, S.M., and Skubitz, A.P.N. (2003) Cell membrane glycosylation mediates the adhesion, migration, and invasion of ovarian carcinoma cells. Clin. & Exper. Metast. 20:143-152.
• Casey, R.C., Koch, K.A., Oegema, T.R., Jr., Skubitz , K.M., Pambuccian, S.E., Grindle, S.M., and Skubitz, A.P.N. (2003) Establishment of an in vitro assay to measure the invasion of ovarian carcinoma cells through mesothelial cell monolayers. Clin. & Exper. Metast. 20:343-356.
• Skubitz, K.M. and Skubitz, A.P.N. (2003) Differential gene expression in uterine leiomyoma. J. Lab. Clin. Med. 141:297-308.
• Skubitz, K.M. and Skubitz, A.P.N. (2003) Differential gene expression in leiomyosarcoma. Cancer 98:1029-1038.
• Iida, G., Skubitz, A.P.N., McCarthy, J.B., and Skubitz, K.M. (2003) Protein kinase activity is associated with CD63 in melanoma cells. Current Opinion in Clinical and Experimental Research (in press).
• Hibbs, K., Skubitz, K.M., Pambuccian, S.E., Casey, R.C., Burleson, K.M, Oegema, T.R., Thiele, J.J., Grindle, S.M., Bliss, R.L., and Skubitz, A.P.N. "b8 integrin, claudin-4 and S100A1 are candidate biomarkers of ovarian carcinoma" (Submitted).
• Skubitz, K.M. and Skubitz, A.P.N. (2004) Gene expression in aggressive fibromatosis. J. Lab. Clin. Med. 143:89-98.
• Burleson, K.M., Casey, R.C., Skubitz, K.M., Pambuccian, S.E., Oegema, T.R., and Skubitz, A.P.N. (2004) Ovarian carcinoma ascites spheroids adhere to extracellular matrix components and mesothelial cell monolayers. Gynecologic Oncology 93:170-181.
• Skubitz, K.M., and Skubitz, A.P.N. (2004) Characterization of sarcomas by means of gene expression. J. Lab. Clin. Med. 144:78-91.
• Skubitz, K.M., Cheng, E.Y., Clohisy, D.R., Thompson, R.C., and Skubitz, A.P.N. (2004) Gene expression in giant tumor cells. Journal of Laboratory and Clinical Medicine (in press).
• Hibbs, K., Skubitz, K.M, Pambuccian, S.E., Casey, R.C., Burleson, K.M, Oegema, T.R., Thiele, J.J., Grindle, S.M., Bliss, R.L., and Skubitz, A.P.N. (2004) Differential gene expression in ovarian carcinoma: Identification of potential biomarkers. Amer. J. Pathol. 165(2):397-414.
• Skubitz, K.M. and Skubitz, A.P.N. (2004) Role of gene expression arrays in sarcomas. Current Oncology Reports 6:309-314.
• Skubitz, K.M., Cheng, E.Y., Clohisy, D.R., Thompson, R.C., and Skubitz, A.P.N. (2004) Gene expression in giant-cell tumors. J. Lab. Clin. Med. 144:193-200.
• Burleson, K.M., Hansen, L.K., Skubitz, A.P.N. (2004) Ovarian carcinoma spheroids disaggregate on type I collagen and invade live human mesothelial cell monolayers. Clin. & Exper. Metast. 21:685-697.
• Skubitz, K.M., Cheng, E.Y., Clohisy, D.R., Thompson, R.C., and Skubitz, A. (2005) Differential gene expression in liposarcoma, lipoma, and adipose tissue. Cancer Invest. 23:105-118.