Troy Lund, MD, PhD

Lab address:

Pediatric Hem/Onc/BMT
2-191 MoosT
515 Delaware St SE
Minneapolis, MN 55455

Campus Mail:

Department of Pediatrics
MMC 366
420 Delaware St S E
Minneapolis, MN 55455

Lab phone: 612-626-9890
E-mail: lundx072@umn.edu

Education:

B.S., 1991, University of Minnesota, Minneapolis, MN
Ph.D., 1996, Medical Sciences, University of South Florida, Tampa, FL
M.D., 2002, University of Minnesota, Minneapolis, MN
2003-2006, Residency: Pediatrics, University of Minnesota, Minneapolis, MN
2006-2009, Fellowship: Pediatric Hematology/Oncology, University of Minnesota, Minneapolis, MN 

Current Research:

Dr. Lund's research seeks to understand the role of the marrow microenvironment in the process of hematopoiesis as well as how the marrow microenvironment is able to recruit hematopoietic stem cells during the hematopoietic stem cell transplant. This understanding will allow the development of new compounds to make the process of stem cell homing and engraftment more efficient.

Publications:

Lund, T.C., et al., iTRAQ is a useful method to screen for membrane-bound protein differentially expressed in human natural killer cell types. J Proteome Res, 2007. 6(2): p. 644-53.

Lund, T.C., R.W. Grange, and D.A. Lowe, Telomere shortening in diaphragm andtibialis anterior muscles of aged mdx mice. Muscle Nerve, 2007. 36(3): p. 387-90.

Gupta, S., et al., Isolation and characterization of kidney-derived stem cells. J Am Soc Nephrol, 2006. 17(11): p. 3028-40.

Zeng, L., et al., Multipotent adult progenitor cells from Swine bone marrow. Stem Cells, 2006. 24(11): p. 2355-66.

Lamming, C.E., et al., Spontaneous circulation of myeloid-lymphoid-initiating cells and SCID-repopulating cells in sickle cell crisis. J Clin Invest, 2003. 111(6): p. 811-9.

Lewis, V.A., et al., Human nerve growth factor receptor and cytosine deaminase fusion genes. Hum Gene Ther, 2003. 14(10): p. 1009-16.

Collins, C.M., et al., The terminal repeats and latency-associated nuclear antigen of herpesvirus saimiri are essential for episomal persistence of the viral genome. J Gen Virol, 2002. 83(Pt 9): p. 2269-78.

Jiang, Y., et al., Pluripotency of mesenchymal stem cells derived from adult marrow. Nature, 2002. 418(6893): p. 41-9.

Kjellen, P., et al., The herpesvirus saimiri tip484 and tip488 proteins both stimulate lck tyrosine protein kinase activity in vivo and in vitro. Virology, 2002. 297(2): p. 281-8.

Lenvik, T., T.C. Lund, and C.M. Verfaillie, Blockerette-ligated capture t7-amplified rt-PCR, a new method for determining flanking sequences. Mol Ther, 2002. 6(1): p. 113-8.

Nakajima, H., et al., The BCR/ABL transgene causes abnormal NK cell differentiation and can be found in circulating NK cells of advanced phase chronic myelogenous leukemia patients. J Immunol, 2002. 168(2): p. 643-50.

Schwartz, R.E., et al., Multipotent adult progenitor cells from bone marrow differentiate into functional hepatocyte-like cells. J Clin Invest, 2002. 109(10): p. 1291-302.

Reyes, M., et al., Purification and ex vivo expansion of postnatal human marrow mesodermal progenitor cells. Blood, 2001. 98(9): p. 2615-25.

Toor, A.A., T.C. Lund, and J.S. Miller, T-cell factor-1 expression during human natural killer cell development and in circulating CD56(+) bright natural killer cells. Exp Hematol, 2001. 29(4): p. 499-506.

Hartley, D.A., et al., Activation of the Lck tyrosine protein kinase by the Herpesvirus saimiri tip protein involves two binding interactions. Virology, 2000. 276(2): p. 339-48.

Hartley, D.A., et al., Activation of the lck tyrosine-protein kinase by the binding of the tip protein of herpesvirus saimiri in the absence of regulatory tyrosine phosphorylation. J Biol Chem, 1999. 274(29): p. 20056-9.

Lund, T.C., et al., The Src-family kinase Lck can induce STAT3 phosphorylation and DNA binding activity. Cell Signal, 1999. 11(11): p. 789-96.

Lund, T.C., M.M. Medveczky, and P.G. Medveczky, Interferon-alpha induction of STATs1, -3 DNA binding and growth arrest is independent of Lck and active mitogen-activated kinase in T cells. Cell Immunol, 1999. 192(2): p. 133-9.

Lund, T.C., et al., The Lck binding domain of herpesvirus saimiri tip-484 constitutively activates Lck and STAT3 in T cells. J Virol, 1999. 73(2): p. 1689-94.

Lowe, D.A., T. Lund, and S.E. Alway, Hypertrophy-stimulated myogenic regulatory factor mRNA increases are attenuated in fast muscle of aged quails. Am J Physiol, 1998. 275(1 Pt 1): p. C155-62.

Lund, T.C., et al., Activation of STAT transcription factors by herpesvirus Saimiri Tip-484 requires p56lck. J Virol, 1997. 71(9): p. 6677-82.

Medveczky, M.M., et al., In vitro antiviral drug sensitivity of the Kaposi's sarcoma- associated herpesvirus. Aids, 1997. 11(11): p. 1327-32.

Lund, T., M.M. Medveczky, and P.G. Medveczky, Herpesvirus saimiri Tip-484 membrane protein markedly increases p56lck activity in T cells. J Virol, 1997. 71(1): p.378-82.

Lund, T., et al., A herpesvirus saimiri membrane protein required for interleukin-2 independence forms a stable complex with p56lck. J Virol, 1996. 70(1): p. 600-6.

Lund, T., et al., A herpesvirus saimiri protein required for interleukin-2 independence is associated with membranes of transformed T cells. J Virol, 1995. 69(7): p. 4495-9.

Whitaker, S., et al., A polycistronic transcript in transformed cells encodes the dihydrofolate reductase of herpesvirus saimiri. Virus Genes, 1995. 10(2): p. 163-72.