Angela Panoskaltsis-Mortari, Ph.D.

Associate Professor
Mayo Mail Code 366
420 Delaware St. SE
Minneapolis, MN 55455
Phone: (612) 626-2961
Fax: (612) 626-4074
panos001@umn.edu
Preferred method of contact:  Email

Angela Panoskaltsis-Mortari, Ph.D. is an Associate Professor of Pediatrics in the Division of Blood and Marrow Transplantation and the Division of Pulmonary Medicine. Dr. Panoskaltsis-Mortari is the Director of the Cytokine Reference Laboratory.

Dr. Panoskaltsis-Mortari received her PhD from the University of Western Ontario. She was a post-doctoral fellow in the Department of Pathology at the University of Alabama and a post-doctoral research associate in the Department of Pediatrics at the University of Minnesota. She joined the University of Minnesota faculty in 1995.

Panoskaltsis-Mortari has board certification from the American Board of Medical Laboratory Immunology. She is a member of numerous pulmonary, immunology and hematology professional societies, and the author of nearly 180 articles which have appeared in such publications as Journal of Clinical Investigation, Journal of Experimental Medicine, Blood, Biology of Blood and Marrow Transplantation, American Journal of Respiratory & Critical Care Medicine, American Journal of Physiology (Lung, Cell. & Mol. Physiol.) and Tissue Engineering.

Research Interests

Dr. Panoskaltsis-Mortari’s laboratory research focuses upon bioengineering the lung using adult stem cells and decellularized whole lung scaffolds with the goal of creating autologous lungs for transplant. The Mortari lab also studies bone-marrow transplant-related lung injuries such as idiopathic pneumonia syndrome and obliterative bronchiolitis which are major complications causing morbidity and mortality post-BMT. She is also exploring methods of enhancing proper lung repair in several lung injury models using mesenchymal stromal cells, anti-fibrotic interventions and novel antioxidants.

Selected Recent Publications:

Panoskaltsis-Mortari A chair, Griese M, Madtes DK, Belperio JA, Haddad IY, Folz RJ, Cooke KR. An official ATS Research Statement: Non-infectious lung injury after hematopoietic stem cell transplantation: Idiopathic Pneumonia Syndrome. American Journal of Respiratory and Critical Care Medicine, 183:1262-1279, 2011.

England KA, Price AP, Tram KV, Shapiro SD, Blazar BR, Panoskaltsis-Mortari A. Evidence for early fibrosis and increased airway resistance in bone marrow transplant recipient mice deficient in MMP12. Amer. J. Physiol: Lung, Cell. Mol. Physiol. 301:L519-526, 2011.

Srinivasan M, Flynn R, Price A, Ranger A, Browning JL, Taylor PA, Ritz J, Antin JH, Murphy WJ, Luznik L, Shlomchik MJ, Panoskaltsis-Mortari A*, Blazar BR* (co-senior authors). Donor B-cell alloantibody deposition and germinal center formation are required for the development of murine chronic GVHD and bronchiolitis obliterans. Blood, Epub, Nov 9, 2011.

Price AP, England K, Matson A, Blazar BR, Panoskaltsis-Mortari A. Development of a decellularized lung bioreactor system for bioengineering the lung: The matrix reloaded. Tissue Engineering,16:2581-2591, 2010.

Panoskaltsis-Mortari A, Tram K, Price A, Wendt C, Blazar BR. A new murine model for obliterative bronchiolitis post-bone marrow transplant. Amer. J. of Respir. and Crit. Care Med 176:713-723, 2007.