Ongoing Clinical Research Studies

Protocol 08-104: A Multi-Center, Double-Blind, Randomized, Placebo-Controlled, 28-Day Study of Denufosol Tetrasodium (INS37217) Inhalation Solution in Patients with Cystic Fibrosis Lung Disease
The purpose of this study is to investigate the safety and effectiveness of two dose strengths of INS37217 compared to placebo. INS37217 might improve the body's ability to clear mucus out of the lung and it is being developed for use in CF.

Evaluation of Cystic Fibrosis Patient Perception of Symptom Improvement Following Inhaled Antibiotic Treatment
This study is being done to see if questions asked in surveys of quality of life measure well how CF patients are doing in daily life while taking an inhaled antibiotic called TOBI®.

A Phase 3, Double-Blind, Multicenter, Randomized, Placebo-Controlled Trial with Aztreonam Lysinate for Inhalation in Cystic Fibrosis Patients with Pulmonary P. aeruginosa Requiring Frequent Antibiotics (AIR-CF2)
The purpose of this research study is to test an experimental drug called aztreonam lysinate for inhalation (AI) to find out if AI is safe and effective in CF patients with lung infections.

Assessment of Induced Sputum as a Tool to Evaluate Anti-inflammatory Agents in Patients with Cystic Fibrosis
The purpose of this study is to see if sputum induction can be used to evaluate CF patients who are being treated with the anti inflammatory medication ibuprofen and those who are receiving no treatment. Sputum will be collected and tested for markers of inflammation.

Epidemiologic Study of Cystic Fibrosis: A Multicenter, Longitudinal Follow-up Study of Patients with Cystic Fibrosis for Monitoring Pulmonary Function, Pulmonary Exacerbations, and the Safety of Long-Term Treatment with Pulmozyme

Women's Health in Cystic Fibrosis
The purpose of this study is to determine what effect hormonal changes have on pulmonary function and sputum production in women with CF.

Diabetes Therapy to Improve BMI and Lung Function in CF
The purpose of this research is to determine whether treatment with either insulin or an oral diabetes agent that increases endogenous insulin secretion will improve body mass index (BMI) and pulmonary function in cystic fibrosis patients who have diabetes without fasting hyperglycemia.

Insulin Therapy in the Hospitalized CF Patient
The purpose of this research is to determine whether 7 days of insulin treatment on an insulin pump will show an improvement in pulmonary function, weight, protein catabolism and inflammation in hospitalized hyperglycemic CF patients.

A New Chloride Sweat Test for Cystic Fibrosis Screening
The purpose of this study is to test a new quantitative "gold standard" Gibson Cooke sweat test that will eliminate almost all causes of error in the current versions of the Gibson Cooke test and reduce the test time required by 75% and the sweat required by 90%.

Genetic Modifiers in Cystic Fibrosis Lung Disease
The purpose of this multi-center study is to analyze DNA from blood samples to determine if non-CF genes (modifiers) may contribute to the severity or mildness of CF lung disease.

Genetic Modifiers of Cystic Fibrosis: Twin and Sibling Study
The purpose of this study is to understand the factors that may be responsible for the variation in severity of illness among patients with CF.

If you would like to receive more information about any of these studies or are interested in participating in research please contact Brooke Noren, RN, at 612-625-7995 or by email at boer0039@umn.edu.