Short Stature (Growth Hormone Imbalance)

Children with primary insulin-like growth factor-1 (IGF-1) deficiency are short in stature and have an imbalance in the levels of growth hormone and IGF-1 that their body produces. Their growth hormone levels are normal or even high, but IGF-1 levels do not increase in response to the production of growth hormone and, as a result, they have a type of growth hormone insensitivity and inability to grow normally.

You are eligible for these studies:

IF YOUR CHILD	AND DOES NOT HAVE	YOUR CHILD IS ELIGIBLE FOR
Has a chronological age of greater than or equal to 3 years or bone age of less than or equal to 11 in girls and less than or equal to 12 in boys, is prepubertal, height SD less than -2, IGF-1 SD less than -2, Stim test greater than or equal to 7 (can have test as part of the study), and has adequate nutrition	Prior GF treatment, growth failure due to organic caus, chronic illness or ADHD medications	Recombinant human insulin- like growth factor-1 (rhIGF-1) treatment of prepubertal children with growth failure associated with primary IGF-1 deficiency.

IF YOUR CHILD IS	AND HAS	YOUR CHILD IS ELIGIBLE FOR
1.5 years to 14 years of age with ISS and/or SGA	Has height below 2 SD, growth velocity below the 25th percentileansence of known endocrine disease or skeletal dysplasia, and no evidence of malnutrition or GI malabsorption	Partial growth hormone insensitivity in idiopathic short stature/small-for- gestational-age patients.

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