Faculty Research
The faculty of the Endocrine Division of the University of Minnesota Pediatric Department are actively involved in many research projects. Currently funded projects and recent publications include: Antoinette Moran, M.D.
Research Grants
Osiris Therapeutics, Inc. A Phase II Study of PROCHYMAL (ex vivo cultured adult human mesenchymal stem cells) for Treatment of Recently Diagnosed T1D.
PI: Antoinette Moran
Objective is to determine if human mesenchymal stem cells, derived from adult bone marrow, can prevent progression of newly diagnosed type 1 diabetes.
N01-15415 Immune Tolerance Network (NIH)
Effect of Antithymocyte Globulin on Preserving Beta-Cell Function in New Onset T1D.
PI: Antoinette Moran
The objective of this project is to determine the drug thymoglobulin can prevent progression of newly diagnosed type 1 diabetes.
NIH U01-DK61036
Type 1 Diabetes - A Proposal for Prevention (TrialNet)
PI: Antoinette Moran
The aim of this multi-center study is to identify and test agents which may cure or prevent progression of type 1 diabetes. Benaroya Research Institute at Virgina Mason
Type 1 Diabetes Genetics Consortium
PI: Antoinette Moran
The goal of this project is to identify genes which predispose to type 1 diabetes. NIH R01 HL52851
Influence of Insulin on BP Change in Adolescence
PI: Alan Sinaiko
Co-investigator: Antoinette Moran
A cohort of approximately 350 young adults have been studied since the age of about 11 in order to understand the development of the metabolic syndrome from its earliest origins in youth. Siblings and parents are also being studied. NIH R01 DK56963
Tolerance to Islet Allografts in Type 2 Diabetes
PI: Bernhard Hering
Coinvestigator: Antoinette Moran
This project seeks to improve the success of islet transplantation for type 1 diabetes. Juvenile Diabetes Foundation
USCF – U of M Center Grant, Islet Transplantation
PI: Bernhard Hering
Core D (Metabolism) Core Leader: Antoinette Moran
Project seeks to improve the success of islet transplantation for type 1 diabetes. Juvenile Diabetes Research Foundation
The Islet Sanctuary
PI: Bernhard Hering
Coinvestigator: Antoinette Moran
Project seeks to improve the success of islet transplantation for type 1 diabetes. NCI/NIDDK, 1RO1CA113930
Metabolic syndrome in childhood cancer survivors
PI: Julie Steinberger
Coinvestigator: Antoinette Moran
Project explores the development of insulin resistance and metabolic syndrome in childhood cancer survivors. NIDDK T32 DK065519
Pre-Faculty Research Training in Pediatric Endocrinology
PI: Antoinette Moran
This grant supports the training of pediatricians to become pediatric endocrinologists. Recent Publications
Mahon J. Sosenko, JM, Ratkin-Mervis LE, Strause-Steinrauf H, Lachin JM, Thompson C, Bingley PJ, Bonifacio E, Palmer JP, Eisenbarth GS, Wolfsdorf J, Skyler JS, for the TrialNet Natural History Committee and Type 1 Diabetes TrialNet Study Group. The TrialNet natural history study of the development of type 1 diabetes: objectives, design, and initial results. Pediatric Diabetes 10:97-104, 2009. Holt EM, Steffen LM, Moran A, Basu S, Steinberger J, Ross JA, Hong C-P, Sinaiko, AR. Fruit and vegetable consumption and its relation to markers of inflammation and oxidative stress in adolescents. J Am Diet Assoc 109:414-21, 2009. Rasmussen-Torvik LJ,Pankow JS,Jacobs DR,Steinberger J, Moran A, Sinaiko AR. Influence of waist on adiponectin and insulin sensitivity in adolescence.Obesity 17:156-61, 2009 Rasmussen-Torvik LJ, Pankow JS, Jacobs DR, Steinberger J, Moran A, Sinaiko AR. The association of SNPs in ADIPOQ, ADIPOR1 and ADIPOR2 with insulin sensitivity in a cohort of adolescents and their parents. Hum Genet 125:22, 2009 Polgreen LE, Thomas W, MacMillan ML, Wagner JE, Moran A, Petryk A. First phase insulin release and glucose tolerance in patients with Fanconi anemia after hematopoietic cell transplantation. Pediatric Blood and Cancer, 53:191-6, 2009. Chase HP, Lescheck E, Rafkin-Mervis L, Krause-Steinrauf H, Chritton S, Asare SM, Adams S, Skyler JS, Clare-Salzler M and the Type 1 Diabetes TrialNet NIP Study Group. Nutritional Intervention to Prevent (NIP) Type 1 Diabetes, A Pilot Trial. Infant, Child and Adolescent Nutrition 1:98-107, 2009. Barrett JC, Clayton, DG, Concannon P, Akolkar B, Cooer JD, Erlich HA, Julier C, Morahan G, Nerup J, Neirras C, Plagnol V, Pocito F, Schuilenburg H, Smyth DJ, Stevens H, Todd JA, Walker NM, Rich SS, and the type 1 Diabetes Genetics Consortium. Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes. Nature Genetics, 41:703-7, 2009 Luscri N, Mauer M, Sarafoglou K, Moran A, Tolar J. Lactic acidosis and hypoglycemia with ALL relapse following engrafted BMT. Pediatr Blood Cancer 53:223-225, 2009. Moran A, Dunitz J, Nathan B, Saeed A, Holme B, Thomas W. CFRD: Current Trends in Prevalence, Incidence and Mortality. Diabetes Care 32:1626-31, 2009. Moran A, Pekow P, Grover T, Zorn M, Slovis B, Pilewski J, Tullis E, Liou TG, Allen H. Insulin Therapy to Improve BMI in Cystic Fibrosis Related Diabetes Without Fasting Hyperglycemia: Results of the CFRDT Trial. Diabetes Care 32:1783-8, 2009. Herold KC, Brooks-Worrell B, Palmer J, Dosch HM, Peakman M, Gottlieb P, Reijonen H, Arif S, Spain LM, Thompson C, Lachin JM, and the Type 1 Diabetes TrialNet Research Group. Validity and reproducibility of measurement of islet autoreactivity by T-cell assays in subjects with early type 1 diabetes. Diabetes, 58:2588-95, 2009. Pescovitz M, Greenbaum CJ, Krause-Steinrauf H, Gitelman WE, Roland R, Gottlieb P, Marks JB, McGee P, Moran A, Raskin P, Rodriquez H, Schatz DA, Wherrett D, Wilson D, Lachin JM, Skyler JS. Preservation of beta-cell function by B-lymphocyte depletion with rituximab in patients with new onset autoimmune diabetes. N Engl J Med 361:2143-52, 2009 Kobayashi T, Manivel JC, Bellin M, Carlson A, Moran A, Hering B, Sutherland DER. Correlation of histopathology of excised pancreas and islet yield in children with chronic pancreatitis. Pancreas, 39:57-63, 2010. Gottlieb, PA, Quinlan S, Krause-Steinrauf H, Greenbaum C, Wilson D, Rodriquez, H, Schatz D, Moran A, Lachin J, Skyler J. Failure to preserve beta-cell function with mycophenolate mofetil and daclizumab combined therapy in patients with new onset type 1 diabetes. Diabetes Care, 33:826-32, 2010.
Bellin DM, Blondet JJ, Beilman G, Thomas, W, Suthland DER, Moran A. Predicting islet yield in pediatric patients undergoing pancreatectomy and autoislet transplantation for chronic pancreatitis. Pediatric Diabetes, 11: 227-34, 2010.
Kelly A, Hebbel RP, Solovey AN, Schwarzenberg SJ, Metzig AM, Moran A, Sinaiko AR, Jacobs DR, Steinberger J. Circulating activated endothelial cells in pediatric obesity, J Pediatr: 157:547-51, 2010.
Bellin DM, Blondet JJ, Beilman G, Thomas, W, Suthland DER, Moran A. Predicting islet yield in pediatric patients undergoing pancreatectomy and autoislet transplantation for chronic pancreatitis. Pediatric Diabetes, in press 2010. Ode KL, Frohnert B, Laguna T, Phillips J, Holmes B, Regelmann W, Thomas W, Moran A. Oral Glucose Tolerance Testing in Children with Cystic Fibrosis. Pediatric Diabetes, in press 2010. Kelly AS, Jacobs DR, Sinaiko AR, Moran A, Steffen LM, Steinberger J. Relation of circulating oxidized LDL with obesity and insulin resistance in children. Pediatric Diabetes, in press 2010. Gottlieb, PA, Quinlan S, Krause-Steinrauf H, Greenbaum C, Wilson D, Rodriquez, H, Schatz D, Moran A, Lachin J, Skyler J. Failure to preserve beta-cell function with mycophenolate mofetil and daclizumab combined therapy in patients with new onset type 1 diabetes. Diabetes Care, in press 2010.
Kobayashi T, Manivel JC, Bellin M, Carlson A, Moran A, Hering B, Sutherland DER. Correlation of histopathology, islet yield, and islet graft function after islet autotransplantation in chronic pancreatitis. In Press, Pancreas.
Moran A, Becker D, Casella S, Gottlieb PA, Kirkman MS, Marshall BC, Slovis B. Epidemiology, pathophysiology and prognostic implications of CFRD: a technical review. Diabetes Care, in press, 2010.
Moran A, Brunzell C, Cohen RC, Katz M, Marshall BC, Onaday G, Robinson KA, Sabadosa KA, Stecenko A, Slovis B. Clinical Care Guidelines for Cystic Fibrosis Related Diabetes: Recommendations from the Cystic Fibrosis Foundation, the American Diabetes Association, and the Pediatric Endocrine Society. Diabetes Care, In press.
Melena Bellin, M.D.
Peer-Reviewed Publications
Bellin MD, McCarthy S., Drevlow L, and Pierach C. Medical Students' Exposure to Pharmaceutical Marketing: A Survey at One U.S. Medical School. Academic Medicine 2004; 79(11):1041-5.
Bellin MD, Carlson A, Kobayashi T, Gruessner A, Hering B, Sutherland D, Moran A. Outcomes after pancreatectomy and islet autotransplantation in a pediatric population. Journal of Pediatric Gastroenterology and Nutrition 2008; 47(1): 37-44.
Bellin MD, Kandaswamy R, Parkey J, Zhang H, Liu B, Ihm S, Ansite J, Witson J, Bansal-Pakala P, Balamurugan AN, Papas K, Moran A, Sutherland DER, Hering B. Prolonged insulin-independence after islet allotransplants in recipients with type 1 diabetes mellitus. American Journal of Transplantation 2008; 8(11):2463-70. NIHMS68461
Sutherland D, Gruessner A, Carlson A, Blondet J, Balamurugan A.N., Reigstad K, Beilman G, Bellin MD, Hering B. Islet autotransplant outcomes after total pancreatectomy: A contrast to islet allograft outcomes. Transplantation 2008; 86: 1799-1803.
Anazawa T, Balamurugan AN, Bellin MD, Zhang HJ, Matsumoto S, Yonekawa Y, Tanaka T, Loganathan G, Papas KK, Beilman GJ, Hering BJ, Sutherland DE. Human islet isolation for autologous transplantation: comparison of yield and function using SERVA/Nordmark versus Roche enzymes. American Journal of Transplantation 2009 Oct;9(10):2383-91.
Kobayashi T, Manivel C, Bellin MD, Carlson A, Moran A, Hering B, Sutherland D. Correlation of pancreas histopathology and islet yield in children with chronic pancreatitis. Pancreas, 2010 Jan;39(1):57-63.
Bellin MD, Blondet J, Beilman G, Dunn T, Balamurugan AN, Thomas W, Sutherland D, Moran A. Predicting islet yield in pediatric patients undergoing pancreatectomy and autoislet transplantation for chronic pancreatitis. Pediatric Diabetes, 2010; 11:227-34.
Posselt AM, Bellin MD, Tavakol M, Szot GL, Frassetto LA, Masharani U, Kerlan RK, Fong L, Vincenti FG, Hering BJ, Bluestone JA, Stock PG. Islet transplantation in type 1 diabetics using an immunosuppression protocol based on the anti-LFA1 antibody efalizumab. American Journal of Transplantation, 2010; 10(8):1870-80.
Kobayashi T, Manivel C, Carlson A, Bellin MD, Moran A, Hering B, Sutherland D. Correlation of histopathology, islet yield, and islet graft function after islet autotransplantation in chronic pancreatitis. Pancreas. In press 2010.
Bellin MD, Hong-McAtee I, Sutherland D, Balamarugan AN, Hering B, Moran A. Ssimilar islet function in alloislet and autoislet transplant recipients, despite the lower mass of islet autotransplants. Transplantation. In press 2010
Invited Book Chapters
Bellin MD, Nathan B, Sarafoglou K. “Precocious Puberty”, chapter in Essential Pediatric Endocrinology and Inborn Errors of Metabolism, editor Dr. Kyriakie Sarafoglou, McGraw-Hill Professional; 1st edition. 2008. Invited Review Articles
Blondet JJ, Carlson AM, Kobayashi T, Jie T, Bellin MD, Hering BJ, Freeman ML, Beilman GJ, Sutherland DER. The Role of Total Pancreatectomy and Islet Autotransplantation for Chronic Pancreatitis. Surgical Clinics of North America 2007; 87: 1477-1501. Bellin MD & Sutherland DER. Pediatric islet autotransplantation: Indication, technique, and outcomes. Current Diabetes Reports 2010;10(5):326-31. Selected Abstracts
Bellin MD, Carlson A, Gruessner A, Sutherland D, Moran A. Outcomes after pancreatectomy and autologous islet cell transplantation in a pediatric population. Oral Abstract. Presented at Lawson Wilkins Pediatric Endocrine Society and Pediatric Academic Societies, Toronto, CA. May 2007;
Bellin MD, Carlson A, Gruessner A, Moran A, Sutherland DER. Outcomes after pancreatectomy and autologous islet cell transplantation in a pediatric population. Oral Abstract. International Pancreas and Islet Transplant Association/Transplantation Society Joint Conference, Minneapolis, MN September 2007. Xenotransplantation 2007; 14(5): 431.
Bellin MD, Blondet JJ., Beilman GJ, Moran A, Hering BJ, Sutherland DER. Islet function and glycemic control after total pancreatectomy and islet autotransplant. Oral Abstract (presented by Dr. David Sutherland). The Cell Transplant Society and The Japan Society for Organ Preservation and Medical Biology, Japan, 2009. Organ Biology 16[1], 122. 4-20-2009.
Bellin MD, Blondet J, Thomas W, Beilmann G, Sutherland D, Moran A. Relationship of preopeartive hemoglobin A1c and mixed meal tolerance test results with islet yield in total pancreatectomy and islet autotransplant in pediatric patients. Poster. Lawson Wilkins Pedaitric Endocrine Society/ Pediatric Academic Societies, Baltimore, MD, May 2009.
Bellin MD, Hong-McAtee I, Sutherland D, Butler P, Hering B, Moran A. Islet function is similar in alloislet and autoislet transplant recipients despite the lower mass of islet autotransplants. Oral abstract. American Diabetes Association, New Orleans, LA, June 2009.
Bellin MD, Blondet J, Beilman G, Sutherland D, Moran A. Islet function and glycemic control after total pancreatectomy and islet autotransplant. Poster. American Diabetes Association, New Orleans, LA, June 2009.
Bellin MD, Blondet M, Beilman G, Sutherland D, Moran A. Successful islet autotransplant permits normal glucose regulation without severe hypoglycemia in pediatric patients undergoing total pancreatectomy for chronic pancreatitis. Oral Abstract. Lawson Wilkins Pediatric Endocrine Society/ European Society for Pediatric Endocrinology, New York, NY, September 2009.
Bellin MD, Barton F, Hering B, and the investigators of the Collaborative Islet Transplant Registry. Sustained insulin independence is superior in T1D alloislet transplant recipients given T-cell depleting therapies for induction immunosuppression. Oral Abstract. International Pancreas and Islet Transplant Association, Venice, Italy, 2009. Xenotransplantation 2009.
Bellin MD, Sutherland D, Butler P, Hong-McAtee I Moran A, Hering B. Islet function is similar in alloislet and autoislet transplant recipients despite the lower mass of islet autotransplants. Poster Abstract. International Pancreas and Islet Transplant Association, Venice, Italy, 2009. Xenotransplantation 2009; 16: 329.
Bellin MD, Sutherland DER, Dunn T, Blondet JJ, Beilman GJ, Moran A. Predicting islet yield before surgery in patients undergoing total pancreatectomy and islet autotransplant for chronic pancreatitis. Poster Abstract. American Diabetes Association, Orlando, FL, June 2010.
Bellin MD, Sutherland DER, Dunn T, Blondet JJ, Beilman GJ, Moran A. Islet function and insulin use 1 year after pancreatectomy and islet autotransplant. Poster Abstract. American Diabetes Association, Orlando, FL, June 2010.
Bellin MD, Freeman ML, Schwarzenberg SJ, Dunn, TB, Beilman, GJ, Vickers SM, Chinnakotla S, Balamurugan AN, Hering BJ, Radosevich DM, Moran A, Sutherland DER. Quality of life after total pancreatectomy and islet autotransplant for management of chronic pancreatitis in pediatric patients. Oral Abstract. American Pancreatic Association, Chicago, IL, November 2010.
Bradley S. Miller, M.D. Research Grants
Minnesota Medical Foundation (PI: Bradley Miller)
Inhibition of Brain Tumor Growth by Disrupting IGF Signaling by Specific IGF-1R Antibody, ScFvFc 7/07-6/09
Clinical Science:
Abbott Labs, Inc. (PI: Bradley Miller)
Phase 3 Multi-center Clinical Trial of Leuprolide Acetate 11.25 and 30 mg Formulations in Central Precocious Puberty 2/08-12/11
Tercica, Inc. (PI: Bradley Miller)
Phase 3 Multi-center Clinical Trial of rhGH and rhIGF-1 for Treatment of Short Stature 2/08-5/13 Recent Peer-Reviewed Publications
Miller, B.S., Bronk, J.T., Nishiyama, T., Yamagiwa, H., Srivastava, A., Bolander, M.E. and C.A. Conover. Pregnancy Associated Plasma Protein-A is Necessary for Expeditious Fracture Healing in Mice. Journal of Endocrinology, 192:505-513, 2007. Polgreen, L.E., Plog, M., Tolar, J., Himes, J.E., Orchard, P., Miller, B.S., and A. Petryk. Growth and endocrine function in patients with Hurler syndrome after hematopoietic stem cell transplantation. Bone Marrow Transplantation 41, 1005–1011, 2008. Barthell, J.E., Schwartz, B.L., Miller, B.S., and I. Agarwal. Neonatal Diabetes Mellitus in a Full-Term Male Infant. Journal of Neonatal-Perinatal Medicine 1(2): 127-30, 2008. Fuglestad, A.J., Lehmann, A.E., Kroupina, M.G., Petryk, A., Miller, B.S., Iverson, S.L., Johnson, D.E., and M. K. Georgieff. Iron deficiency in International Adoptees from Eastern Europe. Journal of Pediatrics 153(2):272-7, 2008. Khan K.M., Miller B.S., Hoggard E., Somani A., Sarafoglou K.. Application of Ultrasound for Bone Age Estimation in Clinical Practice. Journal of Pediatrics 154:243-7, 2009. Miller, B.S., Kroupina, M.G., Iverson, S.L., Mason, P., Himes, J.H., Johnson, D.E., and A. Petryk. Auxological evaluation and determinants of growth failure at the time of adoption in Eastern European adoptees. Journal of Pediatric Endocrinology and Metabolism 22:31-9, 2009. Miller, B.S., Khosravi, M.J., Patterson, M.C. and C.A. Conover. The Insulin-like Growth Factor System in Children with Congenital Disorders of Glycosylation. Clinical Endocrinology 70:892-7, 2009. Polgreen, L.E., Plog, M., Schwender, J.D., Tolar, J., Thomas, W., Orchard, P.J., Miller, B.S., and A. Petryk. Short-term growth hormone treatment in children with Hurler syndrome after hematopoietic stem cell transplantation. Bone Marrow Transplantation 44:279-85, 2009. Invited Book Chapters
Frohnert, B. and B.S. Miller. Developmental Disorders of the Anterior Pituitary. In: Essential Pediatric Endocrinology and Inborn Errors of Metabolism, Kyriakie Sarafoglou, Ed., McGraw Hill, 2009. Hong-McAtee, I. and B.S. Miller. Endocrine Assays. In: Essential Pediatric Endocrinology and Inborn Errors of Metabolism, Kyriakie Sarafoglou, Ed., McGraw Hill, 2009. Stratakis, C.A., Sarafoglou, K. and B.S. Miller. Turner Syndrome. In: Essential Pediatric Endocrinology and Inborn Errors of Metabolism, Kyriakie Sarafoglou, Ed., McGraw Hill, 2009
Brandon Nathan, M.D.
Past Research Grants
NIH U01-DK61036
Type 1 Diabetes – A Proposal for Prevention (TrialNet)
Co-Investigator: Brandon Nathan
Principal Investigator, NIP study (Nutritional Intervention to Prevent Type 1 Diabetes Mellitus) Minnesota Medical Foundation
Hormonal Profiles of Overweight Boys with Delayed Puberty Endocrine Fellows Foundation
Genetic Regulation of Pubertal Timing Recent Peer-Reviewed Publications
Nathan BM, Sedlmeyer IS, Palmert MR. Impact of body mass index on growth of boys with delayed puberty. Journal of Pediatric Endocrinology and Metabolism, 2006; 19(8): 971-9.
Nathan BM, Hodges CA, Supelak PJ, Burrage LC, Nadeau JH, Palmert MR. A quantitative trait locus on chromosome 6 regulates the onset of puberty in mice. Endocrinology, 2006; 147(11): 5132-8.
Skyler JS, Greenbaum CJ, Lachin JM, Leschek E, Rafkin-Mervis L, Savage P, Spain, L, and the Type 1 Diabetes TrialNet Study Group. Type 1 Diabetes Trialnet – An International Collaborative Clinical Trials Network. Annals of the New York Academy of Sciences, 2008; 1150: 14-24.
Skyler JS and the Type 1 Diabetes TrialNet Study Group. Update on Worldwide Efforts to Prevent Type 1 Diabetes. Annals of the New York Academy of Sciences, 2008; 1150: 190-6.
Mahon J, Sosenko JM, Rafkin-Mervis LE, Krause-Steinrauf H, Lachin JM, Thompson C, Bingley PJ, Bonifacio E, Palmer JP, Eisenbarth GS, Wolfsdorf J, Skyler JS, for the TrialNet Natural History Committee and Type 1 Diabetes TrialNet Study Group. The TrialNet Natural Histroy Study of the Development of Type 1 Diabetes: objectives, design, and initial results. Pediatric Diabetes, 2009; 10:97-104
The Type 1 Diabetes TrialNet NIP Study. Nutritional intervention to prevent (NIP) Type 1 Diabetes, a pilot trial. Infant, Child, and Adolescent Nutrition, 2009; 1:98-107
Moran A, Dunitz J, Nathan BM, Saeed A, Holme B, Thomas W. Cystic Fibrosis Related Diabetes: Current Trends in Prevalence, Incidence and Mortality. Diabetes Care, 2009; 32(9):1626-31
Barrett JC, Clayton, DG, Concannon P, Akolkar B, Cooer JD, Erlich HA, Julier C, Morahan G, Nerup J, Neirras C, Plagnol V, Pocito F, Schuilenburg H, Smyth DJ, Stevens H, Todd JA, Walker NM, Rich SS, and the type 1 Diabetes Genetics Consortium. Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes. Nature
Genetics, 41:703-7, 2009
Herold KC, Brooks-Worrell B, Palmer J, Dosch HM, Peakman M, Gottlieb P, Reijonen H, Arif S, Spain LM, Thompson C, Lachin JM, and the Type 1 Diabetes TrialNet Research Group. Validity and reproducibility of measurement of islet autoreactivity by T-cell assays in subjects with early type 1 diabetes. Diabetes, 58:2588-95, 2009.
Pescovitz M, Greenbaum CJ, Krause-Steinrauf H, Gitelman WE, Roland R, Gottlieb P, Marks JB, McGee P, Moran A, Raskin P, Rodriquez H, Schatz DA, Wherrett D, Wilson D, Lachin JM, Skyler JS and the Type 1 Diabetes TrialNet Research Group. Preservation of beta-cell function by B-lymphocyte depletion with rituximab in patients with new onset autoimmune diabetes. N Engl J Med 361:2143-52, 2009
Gottlieb, PA, Quinlan S, Krause-Steinrauf H, Greenbaum C, Wilson D, Rodriquez, H, Schatz D, Moran A, Lachin J, Skyler J, and the Type 1 Diabetes TrialNet Research Group . Failure to preserve beta-cell function with mycophenolate mofetil and daclizumab combined therapy in patients with new onset type 1 diabetes. Diabetes Care, in press 2010.
Ode KL, Frohnert B, Moran A, Nathan BM, Regelmann W, Dunitz J, Holmes B, Thomas W. Prevalence of Glucose Tolerance Abnormalities by Age in Cystic Fibrosis. Pediatric Diabetes in press 2010. Invited Reviews
Nathan BM, Hirschhorn JN, Palmert MR. Strategies for studying complex genetic traits. The Endocrinologist, 2004; 14(6): 346-52.
Nathan BM, Palmert MR. Regulation and disorders of pubertal timing. Endocrinology and Metabolism Clinics of North America, 2005; 34(3): 617-41.
Nathan BM, Hodges CA, Palmert MR. The use of mouse chromosome substitution strains to investigate the genetic regulation of pubertal timing. Molecular Cellular Endocrinology, 2006; 254-255: 103-8.
Nathan BM, Moran A. Metabolic complications of obesity in childhood and adolescence: more than just diabetes. Current Opinion in Endocrinology, Diabetes & Obesity, 2008; 15: 21-9.
Nathan BM, Sockalosky J, Nelson L, Lai S, Sergi C, Petryk P. The use of hormonal therapy in pediatric heart disease. Frontiers in Bioscience, 2009; 1:358-375.
Ode KL, Frohnert BI, Nathan BM. Identifying and treating metabolic complications associated with pediatric obesity. Reviews in Endocrine and Metabolic Disorders, 2009; 10(3): 167-88
Nathan BM. The current state of pediatric obesity treatment. Reviews in Endocrine and Metabolic Disorders, 2009; 10(3): 163-5.
Textbook Chapters
Nathan BM, Allen DB. Growth Hormone Treatment. In Lifshitz F, ed. Pediatric Endocrinology, 5th edition. New York: Informa, 2007; vol. 2: 113-143.
Bellin M, Sarafoglou K, Nathan BM. Precocious Puberty. In: Sarafoglou K, ed. Pediatric Endocrinology and Inborn Errors of Metabolism, 1st edition. New York: McGraw-Hill: 2009; 495-512
Berry S, Nathan BM, Hoffman GF, Sarafaglou K. Endocrine and Metabolic Emergencies. In: Sarafoglou K, ed. Pediatric Endocrinology and Inborn Errors of Metabolism, 1st edition. New York: McGraw-Hill: 2009; 3-16
Anna Petryk, M.D. Research Grant Support NIH R01 DE016601
Twisted gastrulation and mandibular arch morphogenesis
PI: Anna Petryk
NIH R01 AR056642
Role of Twisted gastrulation in osteoclastogenesis
PI: Raj Gopalakrishnan
Co-investigator: Anna Petryk
NIH R01 CA112530
Metabolic syndrome following transplant for leukemia
PI: Scott Baker
Co-investigator: Anna Petryk
NIH R01 CA113930
Metabolic syndrome in childhood cancer survivors
PI: Julia Steinberger
Co-investigator: Anna Petryk
Recent Peer-Reviewed Publications Petryk A, Bergemann TL, Polga KM, Ulrich KJ, Raatz SK, Brown DM, Robison LL, Baker KS. Prospective study of changes in bone mineral density and turnover in children after hematopoietic cell transplantation. JCEM 2006; 91: 899-905. Polgreen L, Steiner M, Dietz CA, Manivel JC, Petryk A. Thymic hyperplasia in a child treated with growth hormone. Growth Horm IGF Res 2007; 17: 41-46. Perkins JL, Kunin-Batson AS, Youngren NM, Ness KK, Hansen MJ, Ulrich KJ, Petryk A, Steinberger J, Anderson FS, Baker KS. Long-term follow-up of children who underwent hematopoietic cell transplant (HCT) for AML or ALL at less than three years of age: the University of Minnesota experience. Pediatr Blood Cancer, 2007; 49: 958-963. Misra M, Pacaud D, Petryk A, Collett-Solberg P, Kappy M. Vitamin D deficiency in children and its management: Review of current knowledge and recommendations. Pediatrics 2008; 122: 398-417. Polgreen LE, Tolar J, Plog M, Himes JH, Orchard PJ, Whitley CB, Miller B, Petryk A. Growth and endocrine function in patients with Hurler syndrome after hematopoietic stem cell transplantation. BMT 2008; 41: 1005-1011. Fuglestad AJ, Lehmann AE, Kroupina MG, Petryk A, Miller B, Iverson SL, Johnson DE, Georgieff MK. Iron deficiency in international adoptees from Eastern Europe. J Pediatr, 2008; 153: 272-277. Tolar J, Petryk A, Khan K, Bjoraker KJ, Jessurun J, Dolan M, Kivisto T, Charnas L, Shapiro EG, Orchard PJ. Long-term metabolic, endocrine, and neuropsychological outcome of hematopoietic cell transplantation for Wolman disease. BMT, 2009; 43: 21-27. Miller BS, Kroupina M, Iverson SL, Mason P, Narad C, Himes JH, Johnson DE, Petryk A. Auxological evaluation and determinants of growth failure at the time of adoption in Eastern European adoptees. J Pediatr Endocinol Metab, 2009; 22: 31-39. Polgreen LE, Plog M, Schwender JD, Tolar J, Orchard PJ, Miller B, Petryk A. Short-term growth hormone treatment in children with Hurler syndrome after hematopoietic cell transplantation. BMT, 2009; 44: 279-285. Mar 2. NIHMS89628 Nathan B, Sockalosky J, Nelson L, Lai S, Sergi C, Petryk A. The use of hormonal therapy in pediatric heart disease. Front Biosci 2009; 1: 358-375. Polgreen LE, Thomas W, MacMillan ML, Wagner JE, Moran A, Petryk A. First phase insulin release and glucose tolerance in children with Fanconi anemia after hematopoietic cell transplantation. Pediatr Blood Cancer 2009; 53: 191-196. [PMC2737087] Ward LM, Petryk A, Gordon CM. Use of bisphosphonates in the treatment of pediatric osteoporosis. Int J Clin Rheumatol 2009; 4: 657-672. Martinez C, Polgreen LE, Defor TE, Kivisto T, Petryk A, Tolar J, Orchard PJ. Characterization and management of hypercalcemia following transplantation for osteopetrosis. BMT 2010; 45: 939-944. Chapters in Books Petryk A, O'Connor MB (2003) Introduction to TGFß-related signaling. In "Inborn Errors of Development: The Molecular Basis of Clinical Disorders of Morphogenesis" C. J. Epstein, R.P. Erickson, and A. Wynshaw-Boris eds. Oxford University Press, Inc. Wajnrajch MP, Rose SR, Petryk A (2003) Endocrine Disorders in FA. In “Fanconi Anemia – Standards for Clinical Care.” Fanconi Anemia Research Fund, Inc. Rose SR, Petryk A, Stratakis C (2008) Endocrine disorders in Fanconi anemia. In “Fanconi Anemia – Guidelines for Diagnosis and Management.” Fanconi Anemia Research Fund, Inc. Polgreen L, Sarafoglou K, Petryk A (2009)Adrenal Insufficiency. In “Pediatric Endocrinology and Inborn Errors of Metabolism.” K. Sarafoglou, G.F. Hoffmann, K.S. Roth eds. McGraw Hill Companies. Miller BS, Johnson DE, Eckerle-Kang J, Petryk A. Growth Failure in International Adoptees. In” The Handbook of Growth and Growth Monitoring in Health and Disease.” Springer. Accepted for publication, 2010.
Lynda Polgreen, M.D. Research Grants
NIH NIAMS 1 K23 AR057789-01A1 (PI: Lynda Polgreen)
“Natural history of bone disease and the impact of growth hormone treatment in MPS.” NIH NINDS U54NS065768-01 (PI: Chester Whitley)
“Lysosomal Disease Network.”
Role: Sub-Project PI University Pediatrics Foundation Scholar Award (PI: Lynda Polgreen)
“Study of Bone Metabolism in Pediatrics: post-HCT and MPS.” Irvine McQuarrie Clinical Research Scholar Award (PI: Lynda Polgreen)
“A Cross-Sectional Study of Bone Regulation of Energy Metabolism in Children with Insulin Resistance.”
University Pediatrics Foundation Scholar Award
A clinical trial of Nutropin AQ in children with MPS I, II, and VI
PI: Lynda Polgreen
The aim of this study is to determine the safety and efficacy of human growth hormone in the treatment of short stature in children with MPS I, II, and VI, and the impact on bone and neuropsychological functioning.
Peer-Reviewed Publications
L. Polgreen, M. Steiner, C.A. Dietz, J.C. Manivel, A. Petryk. Thymic hyperplasia in a child treated with growth hormone. Growth Hormone & IGF Research 2007;17(1):p41-6.
L. Polgreen, M. Plog, J. Tolar, J.H. Himes, P.J. Orchard, C.B. Whitley, B. Miller, A. Petryk. Growth and endocrine function in children with Hurler syndrome after hematopoietic stem cell transplantation. Bone Marrow Transplantation 2008 Jun;41(12):1005-11.
L.E. Polgreen, M. Plog, J.D. Schwender, J. Tolar, W. Thomas, P.J. Orchard, B. Miller, A. Petryk. Short-term growth hormone treatment in children with Hurler syndrome after hematopoietic cell transplantation. Bone Marrow Transplantation. 2009 Sep;44(5):279-85.
L.E. Polgreen, W. Thomas, M.L. MacMillan, J.E. Wagner, A. Moran, A. Petryk. First phase insulin release and glucose tolerance in patients with Fanconi anemia after hematopoietic cell transplantation. Pediatric Blood & Cancer. 2009 Aug:53(2):191-6.
C. Martinez*, L.E. Polgreen*, T.E. Defor, T.Kivisto, A. Petryk, J.Tolar, P.J. Orchard. Characterization and management of hypercalcemia following transplantation for osteopetrosis. Bone Marrow Transplantation. 2010 May;45(5):939-44. *co-first authors.
Invited Editorials & Reviews
L.E. Polgreen. Keeping a broad approach to managing pediatric bone disease. Journal of Pediatric Gastroenterology & Nutrition. Invited editorial on an article by Schmidt et al. titled “Familial Resemblance of Bone Mineral Density in Children with Inflammatory Bowel Disease”. (in press, 2010)
L.E. Polgreen, B.S. Miller. Growth and growth hormone in the mucopolysaccharidoses. Journal of Pediatric Rehabilitation Medicine. (in press 2010)
Selected Abstracts
L.E. Polgreen, D. Stevenson, K. Bjoraker, B. Miller, M. Deyo, H. Hanson, L. Charnas, M. Petit, D. Viskochil, A. Petryk. Longitudinal study of bone disease and the impact of growth hormone treatment in MPS I, II, and VI. Lysosomal Disease Network WORLD Symposium, San Diego, CA, February 18-20, 2009. Abstract published in Molecular Genetics and Metabolism 2009; 96(2):S35. (poster presentation)
L.E. Polgreen, A. Minnenko, A. Petryk. High prevalence of low bone mineral density in children with hurler syndrome after hematopoietic stem cell transplantation. Lysosomal Disease Network WORLD Symposium, San Diego, CA, February 18-20, 2009. Abstract published in Molecular Genetics and Metabolism 2009; 96(2):S35. (poster presentation).
L.E. Polgreen, M. Deyo, K.S. Baker, M. Petit, A. Petryk. Increased bone resorption within the first 6 months after pediatric hematopoietic cell transplantation. Pediatric Academic Societies annual meeting. Vancouver, B.C., May 1-4, 2010. (oral presentation)
Kyriakie Sarafoglou, M.D.
Current Research Factors associated with obesity in patients with CAH. PI: Kyriakie Sarafoglou. The project is a collaboration with the Mayo Clinic and Children’s Hospital-Minneapolis. Comparison of 17-OHP and adrenal androgens levels measured on filter paper by liquid chromatography tandem mass spectrometry (LC/MS/MS) with standard blood serum measurements to develop a new method of monitoring. PI: Kyriakie Sarafoglou. (Piero Rinaldo, M.D., Chairman of Biochemical Genetics co-investigator). Previously Undetected Heterozygous Primary Maternal Carnitine Deficiency Identified by Expanded Newborn Screening. A project I mentor pediatric resident Angelia Tridgell. Galactosemia and Bone Disease. Mentored research with UMN medical student Sara Moassesfar which is a combined project of creating a monitoring protocol for galactosemia and bone disease for prospective research and a retrospective study of UMN galactosemia patients. Maternal B12 in Newborn Screening. A project I mentor pediatric resident John Rodgers. Application of Ultrasound for Bone Age Estimation in Clinical Practice. Collaborative project with GI and Radiology. Creation of CAH/DSD registry and long term follow-up (medical, urological and psychological) for the CAH/DSD work group of the Region 4 Genetics Collaborative. Previous Research CReFF grant for Aromatase Inhibitors in CAH Males with Decreased Spermatogenesis (2002).
The evaluation of hypothalamic-pituitary adrenal (HPA) axis in patients with congenital heart disease before and after surgery including the role of hydrocortisone therapy and the effects of the cytokines and endothelin. Mentored research project with Dr. Shari Crow (Pediatric ICU fellow) which received a K12 award (Child Health Research Career Development Award) (2007).
Inhibiting the aromatization of elevated adrenal adrogens to estrogens in males with congenital adrenal hyperplasia and decreased spermatogenesis. Sub-Study: Inhibiting the aromatization of elevated adrenal adrogens to estrogens in congenital adrenal hyperplasia pre-pubertal patients with advanced bone age and accelerated growth. PI: Kyriakie Sarafoglou (R03 HD046531-01 Funding period 2005-07).
Partial growth hormone insensitivity in patients with idiopathic short stature and/or born small for gestational age due to receptor and post-signaling receptor defects. PI: Kyriakie Sarafoglou. (Investigator Initiated; Funded by Eli Lilly Pharmaceuticals; Funding period 2005-2008).
The Genetics and Neuroendocrinology of Short Stature International Study. PI: Kyriakie Sarafoglou (Funded by Eli Lilly & Co.; Funding period 2005-2008)
Recent Peer-Reviewed Publications Cardiac conduction improvement in two heterozygotes for primary carnitine deficiency on l-carnitine supplementation. Sarafoglou K, Tridgell AH, Bentler K, Redlinger-Grosse K, Berry SA, Schimmenti LA. Clin Genet. 2010 Jan 4. [Epub ahead of print] PMID: 20095986 High incidence of profound biotinidase deficiency detected in newborn screening blood spots in the Somalian population in Minnesota. Sarafoglou K, Bentler K, Gaviglio A, Redlinger-Grosse K, Anderson C, McCann M, Bloom B, Babovic-Vuksanovic D, Gavrilov D, Berry SA. J Inherit Metab Dis. 2009 Sep 7. [Epub ahead of print] PMID: 19757147 Lactic acidosis and hypoglycemia with ALL relapse following engrafted bone marrow transplant. Luscri N, Mauer M, Sarafoglou K, Moran A, Tolar J. Pediatr Blood Cancer. 2009 Aug;53(2):223-5. PMID: 19405138 Application of ultrasound for bone age estimation in clinical practice. Khan KM, Miller BS, Hoggard E, Somani A, Sarafoglou K. J Pediatr. 2009 Feb;154(2):243-7. Epub 2008 Sep 27. PMID: 18823906 Expanded newborn screening identifies maternal primary carnitine deficiency. Schimmenti LA, Crombez EA, Schwahn BC, Heese BA, Wood TC, Schroer RJ, Bentler K, Cederbaum S, Sarafoglou K, McCann M, Rinaldo P, Matern D, di San Filippo CA, Pasquali M, Berry SA, Longo N. Mol Genet Metab. 2007 Apr;90(4):441-5. Epub 2006 Nov 28. PMID: 17126586 Thyroid neoplasms after therapeutic radiation for malignancies during childhood or adolescence. Acharya S, Sarafoglou K, LaQuaglia M, Lindsley S, Gerald W, Wollner N, Tan C, Sklar C. Cancer. 2003 May 15;97(10):2397-403. PMID: 12733137 SRY gene expression in the ovotestes of XX true hermaphrodites. Ortenberg J, Oddoux C, Craver R, McElreavey K, Salas-Cortes L, Guillen-Navarro E, Ostrer H, Sarafoglou K, Clarke V, Yee H. J Urol. 2002 Apr;167(4):1828-31. Erratum in: J Urol 2002 Oct;168(4 Pt 1):1510. PMID: 11912443 Chondrodysplasia punctata, tibial-metacarpal type in a 16 week fetus. Jansen V, Sarafoglou K, Rebarber A, Greco A, Genieser NB, Wallerstein R. J Ultrasound Med. 2000 Oct;19(10):719-22. No abstract available. PMID: 11026586 Clinical review 111: familial sex reversal: a review. Sarafoglou K, Ostrer H. J Clin Endocrinol Metab. 2000 Feb;85(2):483-93. Review. PMID: 10690846 Chapters in Books
Pediatric Endocrinology and Inborn Errors of Metabolism. Eds: Kyriakie Sarafoglou. Georg F. Hoffmann, Karl S. Roth. McGraw Hill Companies, New York, 2009 (ISBN# 0-07-143915-3). Hardbound, 1,000 page, full color medical textbook with 50 chapters and 93 contributors covering approximately 500 endocrine and metabolic disorders.
Berry SA, Nathan B, Hoffmann GF, Sarafoglou K. “Emergency Assessment and Managementof Suspected Inborn Errors of Metabolism and Endocrine Disorders.” In: Pediatric Endocrinology and Inborn Errors of Metabolism. Eds: Kyriakie Sarafoglou. Georg F. Hoffmann, Karl S. Roth. McGraw Hill Companies, New York, 2009.
Sarafoglou K, Harrington KD, Bockting WO. “Congenital Adrenal Hyperplasia.” In: Pediatric Endocrinology and Inborn Errors of Metabolism. Eds: Kyriakie Sarafoglou. Georg F. Hoffmann, Karl S. Roth. McGraw Hill Companies, New York, 2009.
Magiakou MA, Sarafoglou K, Stratakis CA, Chrousos GP. “Cushing Syndrome in Children and Adolescents.” In: Pediatric Endocrinology and Inborn Errors of Metabolism. Eds: Kyriakie Sarafoglou. Georg F. Hoffmann, Karl S. Roth. McGraw Hill Companies, New York, 2009.
Polgreen L, Sarafoglou K, Petryk A. “Adrenal Insufficiency.” In: Pediatric Endocrinology and Inborn Errors of Metabolism. Eds: Kyriakie Sarafoglou. Georg F. Hoffmann, Karl S. Roth. McGraw Hill Companies, New York, 2009.
Stratakis CA, Sarafoglou K, Miller BS. “Turner Syndrome.” In: Pediatric Endocrinology and Inborn Errors of Metabolism. Eds: Kyriakie Sarafoglou. Georg F. Hoffmann, Karl S. Roth. McGraw Hill Companies, New York, 2009.
Bellin M, Sarafoglou K, Nathan B. “Precocious Puberty.” In: Pediatric Endocrinology and Inborn Errors of Metabolism. Eds: Kyriakie Sarafoglou. Georg F. Hoffmann, Karl S. Roth. McGraw Hill Companies, New York, 2009.
Roth KSM, Ward RJ, Chan JCM, Sarafoglou K. “Disorders of Calcium, Phosphate and Bone Metabolism.” In: Pediatric Endocrinology and Inborn Errors of Metabolism. Eds: Kyriakie Sarafoglou. Georg F. Hoffmann, Karl S. Roth. McGraw Hill Companies, New York, 2009.
Rosenberg B, Sarafoglou K, Houk CP, Lee PA. “Variants of Pubertal Progression.” In: Pediatric Endocrinology and Inborn Errors of Metabolism. Eds: Kyriakie Sarafoglou. Georg F. Hoffmann, Karl S. Roth. McGraw Hill Companies, New York, 2009.
Vilain E, Sarafoglou K, Yehya N. “Disorders of Sex Development.” In: Pediatric Endocrinology and Inborn Errors of Metabolism. Eds: Kyriakie Sarafoglou. Georg F. Hoffmann, Karl S. Roth. McGraw Hill Companies, New York, 2009.
Last Minute Pediatrics. Editor, Keith Meyer. Associate Editor, Kyriakie Sarafoglou. McGraw Hill Companies, New York (2004). Besides editing duties, also wrote the following chapters: Endocrinology, Metabolism and Genetics.
Sarafoglou K. Human Intersex Disorders. Encyclopedia of the Human Genome. Nature Publishing Group, London (2003).
Misc. Publications Congenital Adrenal Hyperplasia due to 21-Hydroxylase Deficiency. CME Article for Pedslink, University of Minnesota Children’s Hospital, Fairview Press, Dec. 2008. Congenital Adrenal Hyperplasia in the Newborn. Kyriakie Sarafoglou. Fairview Press. 2007 (Free handbook available through UMN, MDH-NBS, Region 4 Genetics Collaborative). Living with Congenital Adrenal Hyperplasia Kyriakie Sarafoglou. Fairview Press. 2007 (Free handbook available through UMN, MDH-NBS, Region 4 Genetics Collaborative).
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