Kyriakie Sarafoglou, M.D.

Dr. Kyriakie Sarafoglou is a multi-specialist (Pediatric Endocrinology, Inborn Errors of Metabolism and Human Genetics) active in patient care, clinical research and education of medical students and pediatric residents. Dr. Sarafoglou has extensive clinical experience in adrenal and intersex disorders (congenital adrenal hyperplasia, gonadal dysgenesis, male and female pseudohermaphroditism, etc), inborn errors of metabolism, and disorders of growth and pubertal development (irregular menses, hirsutism, precocious or delayed puberty and short stature).  Her NIH and privately funded research focuses on pubertal development, growth and reproductive function in patients with congenital adrenal hyperplasia (CAH); other research focuses on whether intrauterine stress dysregulates the growth axis and immune system in patients born small for gestational age (SGA), and on partial growth insensitivity in patients born SGA or with idiopathic short stature.  Dr. Sarafoglou is also involved in Minnesota's State Newborn Screening of CAH.  In recognition of her clinical work and multi-specialty background, Dr. Sarafoglou has been contracted to write/edit a textbook for McGraw Hill Publications (Essential Pediatric Endocrinology and Inborn Errors of Metabolism) and was recently awarded a Pediatric Teaching Award by the Medical Students at Weill Medical College of Cornell University.  The McGraw Hill textbook, scheduled for a fall 2005 release in the U.S. and Europe, has over 40 of the leading doctors and scientists in the field of endocrinology and metabolism contributing chapters.

Education/Training:

• Pediatric Residency: University of Texas Health Science Center  San Antonio.
• Pediatric Endocrinology Fellowship: New York Presbyterian Hospital-Weill  Medical College of Cornell University.
• Human Genetics and Metabolism Fellowship: New York University School of Medicine

Academic/Clinical Appointments:

• New York Presbyterian Hospital-Weill Medical College of Cornell University
• Assistant Professor, Division of Pediatric Endocrinology and Metabolism
• Research Subject Advocate, Children's Clinical Research Center
• North Shore/Long Island Jewish Medical Center New York University School of Medicine
• Assistant Professor, Division of Metabolism

Clinical Research

1. Investigation of treatment modalities in children diagnosed with congenital adrenal hyperplasia who have accelerated growth and bone advancement (collaboration with Dr. Nelly Mauras, Chief of Pediatric Endocrinology, Nemours Medical Center).

2. Research protocol examining experimental treatment of males with congenital adrenal hyperplasia who have decreased spermatogenesis (collaboration with Dr. Peter Schlegel, Chairman of Urology, Weill Medical College of Cornell University).

3. A clinical and molecular investigation of partial growth hormone insensitivity among children with idiopathic short stature and/or born small-for-gestational age (collaboration with Dr. Bradley Miller, UMN).

4. Research protocol determining the normative values of adiponectin in newborns and young children (collaboration with Dr. Philip Scherer, Albert Einstein School of Medicine).

5. Longitudinal investigation of the effects of intrauterine stress on neuroendocrine function in small-for-gestational age (SGA) infants.

Selected Recent Bibliography

1. Last Minute Pediatrics. Editor Keith Meyer.  Associate Editor Kyriakie Sarafoglou.  McGraw Hill Companies, New York. 2004. Wrote chapters on Endocrinology, Metabolism and Genetics.

2. Sarafoglou K. Human Intersex Disorders.  Encyclopedia of the Human Genome. Macmillan-Nature Publishing Group: London, 2003.

3. Suchitra A, Sarafoglou K, LaQuaglia M, Sklar C. Thyroid neoplasms following therapeutic radiation for cancer during childhood or adolescence. Cancer 2003; 97:2397-403.

4. Ortenberg J, Oddoux C, Craver C, McElreavey K, Salas-Cortes L, Ostrer H, Sarafoglou K. SRY gene expression in the ovotestes of XX true hermaphrodites. Journal of Urology 2002; 167(4): 1828-31.

5. Sarafoglou K, Ostrer H. Familial Sex Reversal: A Review. Journal of Clinical Endocrinology and Metabolism 2000; 85 (2): 483-93.

6. Jansen V, Sarafoglou K, Rebarber A, Greco A, Genieser NB, Wallerstein R. Chondrodysplasia punctata, tibial_metacarpal type in a 16 week fetus. Journal of Ultrasound Medicine 2000; 19 (10): 719-22.

7. Oddoux C, Navarro EG, DiTivoli C, DiCave E, Clayton CM, Nelson H, Sarafoglou K, Axelrod F, Ostrer H. Mendelian Diseases Among Roman Jews: Implications for the Origins of Disease Alleles. Journal of Clinical Endocrinology and Metabolism 1999; 84 (12): 4405-9.

8. Sarafoglou K, Funai EF, Fefferman N, Zajac L, Wallerstein R. Short Rib Polydactyly Syndrome: More Evidence of a Continuous Spectrum. Clinical Genetics 1999;56 (2): 145-8.

9. Sarafoglou K, Boulad F, Gillio A, Sklar C. Gonadal Function After Bone Marrow Transplantation for Acute Leukemia: The Impact of Hyperfractionated Total Body Irradiation Before Puberty. Journal of Pediatrics 1996; 130 (2): 210-6.