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  Home > Research > Malaria Transmission and Immunity in Highland Kenya
 

Malaria Transmission and Immunity in Highland Kenya

PEDSGLOB Research Kenya Team

 

PI:Chandy John, M.D., M.S.
COLLABORATING INSTITUTIONS: Kenya Medical Research Institute (KEMRI); Kisumu, Kenya
COLLABORATING PI:John Vulule, Ph.D.
OTHER COLLABORATORSJames Hodges, PhD
Gregory Noland, PhD
Gregory Park, PhD
FUNDING SOURCE:

NIH/NIAID
U01 AI056270

STUDY SUMMARY:This study assesses how malaria transmission affects development of clinical and biological immunity in two highland areas of Kenya, and how parasite genotype changes relate to changes in malaria incidence in these areas.

PUBLICATIONS

 

Ernst KC, Lindblade KA, Koech D, Kowuor DO, John CC, Wilson ML. Environmental, socio-demographic and behavioral determinants of malaria risk in the western Kenyan highlands: a case-control study. Trop Med Int Health 2009, accepted for publication.

Moormann AM, Sumba PO, Tisch D, Embury P, King CH, Kazura JW, John CC. Stability of interferon-gamma and interleukin-10 responses to Plasmodium falciparum liver-stage antigen-1 and thrombospondin-related adhesive protein immunodominant epitope peptides in a highland population from western Kenya. Am J Trop Med Hyg 2009, accepted for publication.

John CC, Riedesel MA, Magak NG, Lindblade KA, Menge DM, Hodges JM, Vulule JM, Akhwale W. Possible interruption of malaria transmission in two highland areas of Kenya. Emerg Inf Dis 2009, accepted for publication.

Noland GS, Hendel-Paterson B, Min XM, Moormann AM, Vulule JM, Narum DL, Lanar DE, Kazura JW, John CC. Low prevalence of antibodies to pre-erythrocytic but not blood-stage Plasmodium falciparum antigens in an area of unstable as compared to prevalence in an area of stable malaria transmission. Infect Immun: 2008; 76(12):5721-8.

Menge DM, Ernst KC, Vulule JM, Zimmerman PA, Guo H, John CC. Microscopy underestimates the frequency of symptomatic Plasmodium falciparum infection in symptomatic individuals in a low transmission highland area. Am J Trop Med Hyg 2008; 79:173-177.

Cohen JM, Ernst KC, Lindblade KA, Vulule JM, John CC, Wilson ML. Topography-derived wetness indices are associated with household-level malaria risk in two communities in the western Kenyan highlands. Malaria Journal, 2008; 7: 40. PMCID: PMC2276221.

 

 

 

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