Pathogenesis of Cognitive/Neurologic Deficits in Central Nervous Malaria - MED - PEDS - Global Pediatrics, University of Minnesota
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Pathogenesis of Cognitive/Neurologic Deficits in Central Nervous Malaria

PEDSGLOB Research Uganda Team

 

COLLABORATING INSTITUTIONS: Makerere University; Kampala, Uganda
Michigan State University; East Lansing, MI
PI:Chandy John, M.D., M.S.
COLLABORATING PI:Dr. Robert Opoka (Makerere)
 
OTHER COLLABORATORS:Tracy Bergemann, Ph.D. (UMN)
Gretchen Birbeck, Ph.D. (MSU)
Michael Boivin, Ph.D. (MSU)
FUNDING SOURCE:NIH/NINDS
R01 NS055349
STUDY SUMMARY:To establish the areas, frequency and severity of cognitive and neurologic function affected by cerebral malaria in children of different ages (18 mo - 4 yo and 5 - 12 yo) and to identify the immunologic/inflammatory and genetic factors associated with cognivite and neurologic deficits in children with cerebral malaria.

PUBLICATIONS

Bangirana P, Giordani B, Page C, John CC, Opoka RO, Boivin MJ. Immediate neuropsychological and behavioral benefits of computerized cognitive rehabilitation in Ugandan pediatric cerebral malaria survivors. J Dev Behav Pediatr 2009, 30:310 –318.

Bangirana P, Musisi S, Allebeck P, Giordiani B, John CC, Opoka RO, Byarugaba J, Ehnvall A, Boivin MJ. Validity of the KABC-II in Assessing Cognition in Ugandan Cerebral Malaria Children. African Health Sciences 2009, accepted for publication.

Opoka RO, Bangirana P, Boivin MJ, John CC, Byarugaba J. Seizure activity and neurological sequelae in Ugandan children who have survived an episode of cerebral malaria. African Health Sciences, 2009, 9:75-81

Lovegrove FE, Tangpukdee N, Opoka RO, Lafferty EI, Rajwans N, Hawkes M, Krudsood S, Looareesuwan S, John CC, Liles WC, Kain KC. Serum angiopoietin-1 and -2 levels discriminate cerebral malaria from uncomplicated malaria and predict clinical outcome in African children. PLoS ONE 2009;4: e4912.

John CC, Bangirana P, Byarugaba J, Opoka RO, Idro R, Jurek AM, Wu B, Boivin MJ. Cerebral malaria in children is associated with long-term cognitive impairment. Pediatrics 2008; 122:e92-99.

John CC, Park GS, Sam-Agudu N, Opoka RO, Boivin MJ. Elevated serum levels of IL-1ra in children with P. falciparum malaria are associated with increased severity of disease. Cytokine 2008; 41: 204-208.

Opoka RO, Xia Z, Bangirana P, John CC. Inpatient mortality in children with clinically diagnosed malaria as compared to microscopically confirmed malaria. Ped Inf Dis J 2008; 27:319-324.

John CC, Panoskaltsis-Mortari A, Opoka RO, Park GS, Orchard PJ, Jurek AM, Idro R, Byarugaba J, Boivin MJ. Cerebrospinal fluid cytokine levels and cognitive impairment in cerebral malaria. Am J Trop Med Hyg 2008; 78(2):198-205.

John CC. Cerebral malaria pathogenesis: what can we learn from microarray analysis? Am J Pathology 2007; 171:1729-32.

Boivin MJ, Bangirana P, Opoka RO, Byarugaba J, Idro R, Jurek AM, John CC. Cognitive impairment following cerebral malaria in children: a prospective study. Pediatrics 2007; 119:e360-366. *Cited by the Faculty of Medicine 1000.

John CC, Opika-Opoka R, Byarugaba J, Idro R, Boivin M. Low RANTES levels are associated with mortality in children with cerebral malaria. J Infect Dis 2006; 194(6):837-45.

Bangirana P, Idro R, John CC, & Boivin MJ (2006). Rehabilitation for cognitive impairments following cerebral malaria in African children: strategies and limitations. Trop Med Int Health, 2006; 11:1341-49.

 

 

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