Chandy John, M.D., M.S.

Associate Professor
Mayo Mail Code 296
420 Delaware Street SE
Minneapolis, MN 55455
Phone: (612) 624-1966
Fax: (612) 624-8927
ccj@umn.edu

Chandy John, M.D., M.S., is an Associate Professor of Pediatrics in the Division of Pediatric Infectious Diseases and the Director of the Global Pediatrics Program at the University of Minnesota.

Dr. John received his M.D. degree at the University of Michigan, completed his internship and residency in Internal Medicine and Pediatrics at the University of Michigan, and his pediatric infectious disease fellowship at Rainbow Babies & Children's Hospital in Cleveland, Ohio. Dr. John also received a M.S. degree in Epidemiology at Case Western Reserve in Cleveland, Ohio. Prior to coming to the University of Minnesota, he was the Co-Director of the Center for International Child Health at Rainbow Babies & Children's Hospital. He was also a faculty member in the Division of Pediatric Diseases and Center for Global Health and Diseases at Case Western Reserve University. He is currently developing the pediatric global health track in the pediatric residency training at the University of Minnesota.

Dr. John's areas of interest include research in malaria immunology and epidemiology, and education in global health and infectious disease. He conducts malaria research in Kenya and Uganda. In Kenya his research focuses on highland areas at risk for epidemics, investigating how immune responses to P. falciparum antigens relate to risk of infection and disease. In Uganda, his project investigates how immune responses, particularly serum cytokine levels, relate to long-term cognitive outcomes in children with cerebral malaria.

Awards

2002 Glennan Teaching Fellow, Case Western Reserve University
2004 Young Investigator Award, Pediatric Infectious Diseases Society
2004 Best Contribution Award for Teaching Excellence, Case Western Reserve University
2005 Outstanding Contribution to Resident Education, Rainbow Babies & Children's Hospital

Recent Publications

1. Idro R, Aloyo J, Mayende L, Bitarakwate E, John CC and Kivumbi GW. Severe malaria in children in areas with low, moderate and high transmission intensity in Uganda. Trop Med Int Health (in press).
2. John CC, McHugh MM, Moormann AM, Sumba PO, Ofulla AV. Low prevalence of Plasmodium falciparum infection among asymptomatic individuals in a highland area of Kenya. Trans R Soc Trop Med Hyg (in press).
3. Ofulla AV, Moormann AM, Embury PE, Kazura JW, Sumba PO, John CC. Age-related differences in detection of P. falciparum infection by PCR and microscopy in a malaria holoendemic area of Kenya. Ann Trop Med Parasitol 2005;99:431-35.
4. John CC, Moormann AM, Pregibon DL, Sumba PO, McHugh MM, Narum DL, Lanar DE, Schluchter MD, Kazura JW. High-level antibodies to multiple pre-erythocytic antigens correlate with protection from infection. Am J Trop Med Hyg 2005 Jul;73(1):222-228.
5. Chelimo K, Ofulla AV, Narum DL, Kazura JW, Lanar DE, John CC. Antibodies to Plasmodium falciparum antigens vary by age and antigen in children in a malaria holoendemic area of Kenya. Ped Inf Dis J (in press).
6. Idro R, Bitarakwate E, Tumwesegire S, John CC. Clinical manifestations of severe malaria in the highlands of southwestern Uganda. Am J Trop Med Hyg 2005;72:561-67.
7. John CC, Moormann AM, Sumba PO, Ofulla AV, Pregibon DC, Kazura JW. IFN-g responses to P. falciparum liver-stage antigen-1 and thrombospondin-related adhesive protein and their relationship to age, transmission intensity and protection against malaria. Infect Immun 2004 ;72:5135-42.
8. John CC, Koech DK, Sumba PO, Ouma JH. Risk of P. falciparum infection during a malaria epidemic in highland Kenya, 1997. Acta Tropica 2004;92:55-61.
9. John CC, O'Donnell RA, Sumba PO, Moormann AM, deKoenig-Ward TF, King CL, Kazura JW, Crabb BS. Evidence that invasion-inhibitory antibodies specific for MSP-119 can play a protective role against blood-stage Plasmodium falciparum infection in individuals in a malaria endemic area of Africa. J Immunology 2004;173:666-672.