Catherine M. Bendel, M.D.

MMC 39, D-136 Mayo
420 Delaware St. SE
Minneapolis, MN 55455
612-626-3250 Tel
612-624-8176 Fax
bende001@umn.edu

Catherine M. Bendel, M.D. is an associate professor in the Division of Neonatology. She earned her M.D., served her internship and residency and completed her Neonatal-Perinatal Medicine Fellowship at the University of Minnesota. In addition to attending on the Neonatal Intensive Care Unit, Dr. Bendel serves as the Director of the Neonatal-Perinatal Medicine Fellowship Program. Her research interests include Candida albicans, Saccharomyces cerevisiae and neonatal infectious diseases, and she received two U.S. patents for Candida albicans integrin-like proteins. She has been published in Pediatric Research, Critical Care Medicine and Pediatric Infectious Disease (to name a few), in addition to abstracts and contributions to book chapters. Dr. Bendel has twice been named a “Top Doctor in Neonatology” by Minneapolis/St. Paul Magazine.

CURRICULUM VITAE FOR CATHERINE M. BENDEL, M.D.(last revised 10/11/04)

EDUCATION
1977-81  B.A. The College of Saint Catherine; St. Paul, Minnesota
1981-85  M.D. University of Minnesota Medical School; Minneapolis, Minnesota

POSTDOCTORAL TRAINING
1985-88 Pediatric Resident, University of Minnesota Hospital and Clinic
1988-89 Clinical Fellow in Neonatal-Perinatal Medicine; University of Minnesota Hospital and Clinic
1989-91 Research Fellow in Neonatal-Perinatal Medicine; University of Minnesota Hospital and Clinic

ACADEMIC APPOINTMENTS
1991-94 Instructor, Department of Pediatrics, Division of Neonatology University of Minnesota Medical School
1994-2004 Assistant Professor, Department of Pediatrics, Division of Neonatology, University of Minnesota Medical School
2004- Associate Professor, Department of Pediatrics, Division of Neonatology, University of Minnesota Medical School

ACADEMIC ADMINISTRATIVE APPOINTMENTS
1994- Director of Education, Division of Neonatology
1998- Director, Neonatal-Perinatal Medicine Fellowship Program

CLINICAL/HOSPITAL APPOINTMENTS
1991-96 Staff Physician, University of Minnesota Hospital and Clinics
1994-96 Interim Co-Director, Neonatal intensive Care Unit, University of Minnesota Hospital and Clinics/Fairview-University Medical Center
1997- Staff Physician, Fairview-University Medical Center

AWARDS AND HONORS
Undergraduate Phi Beta Kappa (1980 — Junior year)
Academic rank of third in class (1981)
Dean’s List, all eight semesters
Iota Sigma Pi (Chemistry — 1980)
Medical School Alpha Omega Alpha (1984 — Junior year)
Janet M. Glasgow Memorial Achievement Citation (1985)
Postdoctoral Second Place, University of Minnesota, Department of Pediatrics Fellows’ Research Symposium for presentation of “Functional Correlates of Integrin-Like Proteins in Pathogenic and Non-Pathogenic Yeasts” (1990)
The Society for Pediatric Research Fellow’s Basic Research Award for presentation of “Correlation of Adhesion and Pathogenic Potential in Yeast” (1991)
Department of Pediatrics, University Children’s Foundation Scholar Award (1995)
University of Minnesota Child Health Research Center Pediatric Scholar Award (1995)
University of Minnesota Child Health Research Center Pediatric Scientist Award (1997)
Pediatric AIDS Foundation Scholar Award (2002)
Mpls.St.Paul Magazine Top Doctor Award (2001, 2002, 2003)
Best Doctors in America (2002, 2003)

BOARD CERTIFICATION
Diplomate, National Board of Medical Examiners (1986)
Diplomate in Pediatrics, The American Board of Pediatrics (June 2, 1989)
Recertification in Pediatrics (September 21, 2001, for the period 2001 – 2007)
Diplomate in Neonatal-Perinatal Medicine, The American Board of Pediatrics (September 1, 1993, for the period 1993 - 2000)
Recertification in Neonatal-Perinatal Medicine (April 29, 1999, for the period 2001 – 2007)
NRP Certification (September 19, 2003, for the period 9/19/2003 – 9/18/2005)

LICENSURE
1987 Minnesota

MEMBERSHIP AND OFFICES IN PROFESSIONAL AND SCIENTIFIC SOCIETIES
1984 Alpha Omega Alpha
1991 Minnesota Medical Association / Hennepin County Medical Society
1991 Minnesota Women Physicians
1992 American Academy of Pediatrics, Fellow
1998 American Society for Microbiology
1999 American Academy of Pediatrics, Perinatal Section Member
2000 Society for Pediatric Research
2000 Perinatal Research Society
2004 Midwest Society for Pediatric Research, Council Member 2004-

PATENTS
Candida albicans integrin-like protein US patent # 5,886,151
DNA encoding Candida albicans integrin-like protein US patent # 6,346,411

SCIENTIFIC ACTIVITIES — JOURNAL AND GRANT REVIEWS
1996-present Member, Minnesota Medical Foundation Research Grants Committee
1997-present Ad hoc grant reviewer for the University of Minnesota GCRC
1995-present Ad hoc reviewer for Pediatrics
1996-present Member, Planning Board for the North Central Neonatal Issues Conference
1998-present Member, National Neonatal Candidiasis Study Group
2003-present Ad hoc reviewer for Journal of Infectious Diseases
2003-present Ad hoc grant reviewer for the Thrasher Foundation

CONSULTING POSITIONS
2002-present Member, MedImmune Midwest Neonatal Advisory Board

COMMITTEE AND ADMINISTRATIVE SERVICE
National
1998-present Member, American Academy of Pediatrics Organization of Neonatal Training Program Directors

Medical School
1998-present Member, Graduate Medical Education Committee (as Program Director for Neonatal-Perinatal Medicine Fellowship)
2000-01 Member, Search Committee for Head of Obstetrics, Gynecology and Women’s Health
2003-present Member, Graduate Education Task Force, National Center of Excellence in Women’s Health

Department
1993-94 Strategies and Initiatives for the Future; MCMC Relationship Committee
1993-95 Neonatology Affiliation Committees—Education, Research and Financial
1995-96 Faculty Goal Setting and Assessment
1995-96 Department of Pediatrics Academic Mission Committee
1997-98 Communication/Information/Faculty Interaction Committee
2000-01 Task force on the Integration of the Department of Pediatrics with the Children’s Hospitals
2001-02 Department of Pediatrics, CSU Board member
2000-present Medical Fellow Committee, Department of Pediatrics

Hospital/Clinical
1993-95 Neonatal Medical Staff Liaison Committee—Fairview Riverside/UMHC
1994-96 Fairview-Riverside Medical Center Resident Integration Task Force
1995-97 Fairview-University Women’s, Infants’, Children’s Services Case Review Committee
1995-98 NICU Committees on Operations and Management, Education and CQI
1996-97 UKids Quality Committee
1998-2000 University of Minnesota Physicians, Planning and Marketing Committee
1994-present Fairview-University NICU Collaborative Practice Council (Chair 1994-96)
1994-present ECMO Case Review Committee
1994-present Fairview-University NICU Clinical Standards Committee (Chair 1994-96)

Community Service
1988-95 Member, The Association for the Children’s Theatre, Minneapolis Children’s Theatre Company (Board member 1994-95)
1991-present Board Member, The College of Saint Catherine Alumnae Association (1991-93); Leadership Conference Planning Committee (1995); currently active volunteer member
1992- present Mentor for The College of St. Catherine “Shadow” Program
1996-2000 St. Paul seminary, archdiocesan teaching parish committee member, St. John the Evangelist parish; seminary student sponsored: Scott Carl
1996-present Member of The College of St. Catherine Health Care Advisory Board
1997-present Instructor, “Young Scientist Roundtable,” Hopkins/Minnetonka School District
2002 Presentation of Commencement Address at The College of St. Catherine, May 18, 2002

FUNDED RESEARCH GRANTS
Primary Investigator
1983-84 Minnesota Medical Foundation Student Research Grant, “Hypopigmentation in Prader-Willi Syndrome,” $3,000.

1990-92 University of Minnesota, Department of Pediatrics Viking Children’s Fund Grant, “Functional Correlates of Integrin-Like Proteins in Pathogenic and Non-Pathogenic Yeasts,” $6,500.

1992-94 Pediatric AIDS Foundation Scholar Award from The American Foundation for AIDS Research, #770193-11-PF, “Epithelial Adhesion in C. albicans/C. tropicalis,” $72,600.

1995-97 University of Minnesota, Department of Pediatrics Viking Children’s Fund Grant, “Epithelial Adhesion in Candida albicans and Candida tropicalis,” $8,000.

1995-97 University of Minnesota Child Health Research Center Pediatric Scholar Award, “Cloning and Characterization of a Beta1 Integrin Homolog in Candida tropicalis,” $105,000.

1995-98 University Children’s Foundation Scholar Award, “Epithelial Adhesion in Candida albicans and Candida tropicalis,” $50,000.

1997-98 University of Minnesota Child Health Research Center Pediatric Scientist Award, “Integrin-like adhesins in Candida albicans: Characterization of the role of INT1 in candidal adhesion,” $60,000.

1999-00 University of Minnesota Graduate School Grant-in-Aid of Research, Artistry and Scholarship, “Integrin-like adhesins in Candida albicans: Characterization of the role of INT1 in candidal adhesion,” Proposal # 17924, $15,934.

1999-00 The Hubbard Foundation, “Prevention of life-threatening yeast infections in premature infants,” $5,000.

1999-02 University of Minnesota, Department of Pediatrics Viking Children’s Fund Grant, “Integrin-like adhesins in Candida albicans: Characterization of the role of INT1 in candidal adhesion,” $9,195.

1999-02 March of Dimes Birth Defects Foundation Research Grant, #1-FY99-481, “Integrin-like adhesins in Candida albicans: Characterization of the role of INT1 in candidal adhesion,” $182,562.

2002-04 University of Minnesota, Department of Pediatrics Viking Children’s Fund Grant, “Candida pathogenesis in neonates: The role of gastrointestinal colonization,” $25,000.

2004-07 March of Dimes Birth Defects Foundation Research Grant, #6-FY04-53, “Candida pathogenesis in neonates: The role of gastrointestinal colonization,” $249,215.

Co-investigator/Participant
1996-99 NEI-funded National Multicenter Study of “Supplemental Therapeutic Oxygen for Prethreshold Retinopathy of Prematurity, STOP-ROP” (Principal investigator: Dale Phelps, M.D., Strong Research Center, Rochester, NY). Role: Minnesota Consortium, Certified STOP-ROP Neonatologist #6308.

1996-00 University of Minnesota, Department of Pediatrics, Nitric Oxide Study Group (Principal investigator: David Cornfield, M.D., University of Minnesota). Role: Certified neonatologist with participation in three ongoing protocols for evaluating the use of inhaled nitric oxide in newborns.

1996-  SPR Multicentered Clinical Studies Grant “Neonatal Candidiasis Study Group” (Principal investigator: Judith L. Rowen, M.D., University of Texas, Galveston). Role: Coinvestigator and Director of the University of Minnesota Center.

1997-99 University of Minnesota Children’s Cancer Research Fund/Molecular Epidemiology Center, Protocol 97-01, “The Molecular Epidemiology of Down Syndrome Leukemia and Congenital Anomalies” (Principal investigator: John Perentesis, M.D., University of Minnesota). Role: Participant and University of Minnesota Neonatal Coordinator.

1999-03 NIH RO1 GM59221-01 “Candida pathogenesis in surgery and trauma.” (Principal investigator: Carol L. Wells, Ph.D., University of Minnesota). Annual direct costs of $166,693. Role: Co-PI at 3% effort.

2000-03 EI Grant U10-EY12471-01, National Multicenter Study of “Early Treatment for Retinopathy of Prematurity, ETROP” (Principal investigators: Robert Hardy, Ph.D., and William Good, M.D., School of Public Health, University of Texas, Houston, TX). Role: Minnesota Consortium, Certified ETROP Neonatologist.

2003-08 NIH RO1 GM59221-01 “Candida pathogenesis in surgery and trauma.” (Principal investigator: Carol L. Wells, Ph.D., University of Minnesota). Annual direct costs of $250, 000. Role: Co-PI at 5% effort.

PUBLICATIONS
Peer-reviewed Articles
1. Creel DJ, Bendel CM, Wiesner GL, Wirtschafter JD, Arthur DC, King RA. Abnormalities of the visual pathways in Prader-Willi syndrome associated with hypopigmentation. N Engl J Med 314:1606-1609, 1986.

2. Wiesner GL, Bendel CM, Olds DP, White JG, Arthur DC, Ball DW, King RA. Hypopigmentation in the Prader-Willi syndrome. Am J Hum Genet 40:431-442, 1987.

3. Gustafson KS, Vercellotti GM, Bendel CM, Hostetter MK. Molecular mimicry in Candida albicans. Role of an integrin analogue in adhesion of the yeast to human endothelium. J Clin Invest 87:1896-1902, 1991.

4. Bendel CM, Hostetter MK. Distinct mechanisms of epithelial adhesion for Candida albicans and Candida tropicalis: Identification of the participating ligands and development of inhibitory peptides. J Clin Invest 92:1840-1849, 1993.

5. Bendel CM, St. Sauver J, Carlson S, Hostetter MK. Epithelial adhesion in yeast species: Correlation with surface expression of the integrin analog. J Inf Dis 171:1660-1663, 1995.

6. Gale CA, Bendel CM, McClellan MA, Hauser M, Becker JM, Berman JA, Hostetter MK. Linkage of adhesion, filamentous growth and virulence in Candida albicans to a single gene, INT1. Science 279:1355-1358, 1998.

7. Rowen JL, Tate JM for the Neonatal Candidiasis Study Group. Management of neonatal candidiasis. Pediatr Infect Dis 17:1007-1011, 1998.

8. Bendel CM, Kinneberg KM, Jechorek RP, Gale CA, Erlandsen SL, Hostetter MK, Wells CL. Systemic infection following intravenous inoculation of mice with Candida albicans int1 mutant strains. Molec Genet Metab 67:343-351, 1999.

9. Rowen JL, Tate JM, Nordoff N, Passarell L, McGinnis MR and the Neonatal Candidiasis Study Group. Candida isolates from neonates: frequency of misidentification and reduced fluconazole susceptibility. J Clin Micobiol 37:3735-3737, 1999.

10. Kinneberg KM, Bendel CM, Jechorek RP, Cebelinski, EA, Gale, CA, Berman JG, Erlandsen SL, Hostetter MK, Wells CL. Effect of INT1 gene on Candida albicans murine intestinal colonization. J Surg Res 87:245-251, 1999.

11. The STOP-ROP Multicenter Study Group. Supplemental therapeutic oxygen for prethreshold retinopathy of prematurity (STOP-ROP), a randomized, controlled trial. I: Primary outcomes. Pediatrics 105:295-310, 2000.

12. Bendel CM, Kinneberg KM, Jechorek RP, Erlandsen SL, Sahar DE, Wells CL. The Candida albicans INT1 gene facilitates cecal colonization in endotoxin-treated mice. Shock 13:453-458, 2000.

13. Wiesner SM, Jechorek RP, Garni RM, Bendel CM, Wells CL. Gastrointestinal colonization of Candida albicans mutant strains in antibiotic-treated mice. Clin Diag Lab Immunol 8:192-195, 2001.

14. Wiesner SM, Bendel CM, Moore EA, Erlandsen SL, Wells CL. Adherence of yeast and filamentous forms of Candida albicans to cultured enterocytes. Crit Care Med 30:677-683, 2002.

15. Bendel CM, Wiesner SM, Garni RM, Cebelinski E, Wells CL. Cecal colonization and systemic spread of Candida albicans in mice treated with antibiotics and dexamethasone. Pediatr Res 51:290-295, 2002.

16. Bendel CM, Hess DM, Garni RM, Henry-Stanley M, Wells CL. Comparative virulence of Candida albicans yeast and filamentous forms in orally and intravenously inoculated mice. Crit Care Med 31:501-507, 2003.

17. Kim AS, Garni RM, Henry-Stanley MJ, Bendel CM, Erlandsen SL, Wells CL. Hypoxia and extraintestinal dissemination of Candida albicans yeast forms. Shock 19:257-262, 2003.

Review Articles/Editorials
1. Bendel CM, Hostetter MK. Systemic candidiasis and other fungal infections in the newborn. Semin Pediatr Infect Dis 5:35-41, 1994.

2. Gale CA, Bendel CM, Hostetter MK, Berman JG. The INT1 of Candida albicans: comment and response. Trends Microbiol 6:300-303, 1998.

3. Bendel CM. Colonization and epithelial adhesion in the pathogenesis of neonatal candidiasis. Semin Perinatol 27:357-364, 2003.

4. Candidiasis. In: The Report of the Committee on Infectious Diseases. American Academy of Pediatrics, Elk Grove, IL. In preparation for publication in 2006 (CM Bendel section reviewer/editor).

Book Chapters
1. Hostetter MK, Michael EJ, Bendel CM. Complement receptors in Candida albicans and other yeasts: Structure, function and role in pathogenesis. In: Dimorphic Fungi in Biology and Medicine, edited by H. Vanden Bossche, et al. New York: Plenum Press, 281-289, 1993.

2. Shah M, Bendel CM. Neonatal infectious diseases. In: Just the Facts in Pediatrics, edited by Thomas P. Green, et al. McGraw-Hill, in press, 2004.

3. Bendel CM. Candidiasis. In: Infectious Diseases of the Fetus and Newborn Infant, 6th Ed, edited by JS Remington, et al. Philadelphia: Elsevier Science. In press, 2004.

4. Bendel CM, Maldonao YA. Pneumocystis and other less common fungal infections. In: Infectious Diseases of the Fetus and Newborn Infant, 6th Ed, edited by JS Remington, et al. Philadelphia: Elsevier Science. In press, 2004

Abstracts
1. Wiesner GL, Bendel CM, King RA. Hypopigmentation in Prader-Willi syndrome. Am J Hum Genet 36(4):815, 1984. Poster presentation at the 1984 annual meeting of the American Society for Human Genetics.

2. Bendel CM, Herman DJ, Hostetter MK. Expression of the iC3b receptor in pathogenic and non-pathogenic yeast. Poster presentation at the Second Conference on Candida and Candidiasis, Philadelphia, PA, April 1–4, 1990.

3. Bendel CM, Hostetter MK. Correlation of adhesion and pathogenic potential in yeast. Pediatr Res 29:167A, 1991. Platform presentation at the annual meeting of the Society for Pediatric Research, New Orleans, LA, April 29 – May 2, 1991. Winner of the 1991 Society for Pediatric Research Fellows’ Basic Science Research Award.

4. Herman DJ, Kendrick KE, Bendel CM, Tao N, Hostetter MK. Integrin analogs in yeast: Implications for pathogenesis. Clin Res 39:244A, 1991. Platform presentation at the annual meeting of the Society for Pediatric Research, New Orleans, LA, April 29 – May 2, 1991.

5. Hostetter MK, Bendel CM, McClellan M, Michael EJ. Integrin analogs in Candida albicans, other Candida species and Saccharomyces cerevisiae. J Cell Biochem [Suppl] 16F:149, 1992. Poster presentation at the 1992 Keystone conference on Integrins, Keystone, CO.

6. Bendel CM, Hostetter MK. Inhibitory peptides and target proteins for epithelial adhesion in pathogenic Candida species. Pediatr Res 30:157A, 1992. Platform presentation at the annual meeting of the Society for Pediatric Research, Baltimore, MD, May 4–7, 1992.

7. Hostetter MK, Bendel CM, Michael EJ. Integrin analogs in adhesion of Candida species to epithelium and endothelium. Poster presentation at the 32nd Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC), May 1992.

8. Bendel CM, Tao N, Hostetter MK. Distinct epithelial adhesins for C. albicans and C. tropicalis. Clin Res 41:280A, 1993. Platform presentation at the joint meeting of the Society for Pediatric Research and the American Federation for Clinical Research, Washington, D.C., April 30 - May 3, 1993.

9. Carlson S, Hostetter MK, Finkel D, Bendel CM. Genotypic and functional analysis of Candida albicans strains from mother-infant pairs. Pediatr Res 35:295A, 1994. Poster presentation at the annual meeting of the Society for Pediatric Research, Seattle, WA, May 2–5, 1994.

10. Meinke M, Tao N, Bendel CM, St. Sauver J, Hostetter MK. Cloning of C. albicans DNA encoding an integrin analog. Pediatr Res 35:187A, 1994. Platform presentation at the annual meeting of the Society for Pediatric Research, Seattle, WA, May 2–5, 1994.

11. Berman JA, Gale CA, Bendel CM, Hostetter MK. Expression of C. albicans INT1 in S. cerevisiae induces germ tubes, hyphal growth and yeast adhesion to human epithelial cells. Platform presentation at the Cold Spring Harbor Conference on Yeast Genetics and Human Disease, August 1996.

12. Bendel CM, Finkel DA, Olson JS, Gale CA, Hostetter MK. Mapping the adhesive domains of the C. albicans gene INT1. Pediatr Res 41:117A, 1997. Platform presentation at the annual meeting of the Pediatric Academic Societies, Washington, D.C., May 2–6, 1997.

13. Gale CA, Bendel CM, Hostetter MK. Induction of epithelial adhesion and morphologic switching by a single gene from Candida albicans. Pediatr Res 41:119A, 1997. Platform presentation at the annual meeting of the Pediatric Academic Societies, Washington, D.C., May 2–6, 1997.

14. Bendel CM, Kinneberg K, Jechorek R, Gale CA, Berman JG, Wells CL, Hostetter MK. Effects of deleting the C. albicans gene INT1 on mortality and yeast tissue survival in a mouse model of fungemia. Pediatr Res 43:141A, 1998. Platform presentation at the annual meeting of the Pediatric Academic Societies, New Orleans, LA, May 1–5, 1998.

15. Rowen JL, Tate JM for the Neonatal Candidiasis Study Group. Consensus and concerns in the care of neonatal candidiasis: a questionnaire. Pediatr Res 43:251A, 1998. Poster presentation at the annual meeting of the Pediatric Academic Societies, New Orleans, LA, May 1–5, 1998.

16. Kinneberg K, Bendel CM, Jechorek R, Gale CA, Hostetter MK, Wells CL. INT1 gene deletion is associated with decreased intestinal colonization of Candida albicans in mice. Poster presentation at the 98th American Society of Microbiology Meeting, Miami, FL, May 1998.

17. Kinneberg K, Bendel CM, Jechorek R, Gale CA, Hostetter MK, Wells CL. LPS-induced intestinal overgrowth of Candida albicans is modulated by the INT1 gene. Platform presentation at the Twenty-First Annual Conference on Shock, June 1998.

18. Bendel CM, Kinneberg K, Jechorek R, Gale CA, Berman JG, Hostetter MK, Cebelinski E, Wells CL. Effect of INT1 gene disruption on cecal colonization of Candida albicans in orally inoculated mice. Poster presentation at the 5th American Society of Microbiology Conference on Candida and Candidiasis, Charleston, SC, March 1–4, 1999.

19. Bendel CM, Kinneberg J, Hoag JA, Jechorek R, Hostetter MK, Erlandsen S, Wells CL. Effect of INT1 on Candida albicans adherence to cultured Caco-2 enterocytes. Poster presentation at the 5th American Society of Microbiology Conference on Candida and Candidiasis, Charleston, SC, March 1–4, 1999.

20. Bendel CM, Kinneberg K, Jechorek R, Gale CA, Berman JG, Hostetter MK, Cebelinski E, Wells CL. Effects of alteration of the Candida albicans gene INT1 on cecal colonization in orally inoculated mice. Pediatr Res 45:156A, 1999. Poster presentation at the annual meeting of the Pediatric Academic Societies, San Francisco, CA, April 30 – May 3, 1999.

21. Bendel CM, Kinneberg K, Jechorek R, Hostetter MK, Erlandsen S, Wells CL. The role of Candida albicans germ tube formation in adherence to cultured enterocytes. Pediatr Res 45:156A, 1999. Platform presentation at the annual meeting of the Pediatric Academic Societies, San Francisco, CA, April 30 – May 3, 1999.

22. Rowen JL, Tate JM, Pasarell L, McGinnis MR for the Neonatal Candidiasis Study Group. Candida isolates from neonates: Frequency of misidentification and reduced susceptibility to fluconazole. Pediatr Res 45:273A, 1999. Poster presentation at the annual meeting of the Pediatric Academic Societies, San Francisco, CA, April 30 – May 3, 1999.

23. Wells C, Bendel CM, Erlandsen S. Candida albicans endotoxin and the intestinal epithelial barrier. Platform presentation at the 7th Vienna Shock Forum. Vienna, Austria, November 13-16, 1999.

24. Sahar D, Bendel CM, Jechorek R, Garni R, Feltis B, Cebelinski E, Weisner S, Erlandsen S, Wells CL. Hyphal formation may not facilitate invasion of intestinal Candida albicans. Platform presentation at the 20th annual meeting of the Surgical Infection Society, Providence, RI, April 27–29, 2000.

25. Sahar D, Jechorek R, Cebelinski E, Erlandsen S, Wells CL, Bendel CM. Reduced hyphal formation in Candida albicans INT1 mutants may not affect intestinal invasion/translocation. Pediatr Res 47:346A, 2000. Poster presentation at the annual meeting of the Pediatric Academic Societies, Boston, MA, May 12–16, 2000.

26. Weisner S, Jechorek R, Erlandsen S, Wells CL, Bendel CM. Filamentation facilitates Candida albicans adherence to cultured enterocytes. Pediatr Res 47:349A, 2000. Platform presentation at the annual meeting of the Pediatric Academic Societies, Boston, MA, May 12–16, 2000 and the 100th general meeting of the American Society for Microbiology, Los Angeles, CA, May 21–25, 2000.

27. Bendel CM, Weisner S, Hess D, Wells CL. Adherence of Candida albicans INT1/INT1 and int1/int1 to cultured human enterocytes. Pediatr Res 49:309A, 2001. Poster presentation at the annual meeting of the Pediatric Academic Societies, Baltimore, MD, April 27 - May 1, 2001.

28. Bendel CM, Hess DM, Garni RM, Henry-Stanley M, Wells CL. Comparative virulence of Candida albicans mutant strains in orally and intravenously inoculated mice. Poster presentation at the 6th American Society of Microbiology Conference on Candida and Candidiasis, Tampa, FL, January 13–17, 2002.

29. Karlowicz MG, Rowen JL, Barnes-Eley ML, Burke BL, Lawson ML, Bendel CM, Shattuck KE, Horgan M, Albritton WL. The role of birth weight and gestational age in distinguishing extremely low birth weight infants at high risk of developing candidemia from infants at low risk: a multicenter study. Pediatr Res 51:301A, 2002. Poster presentation at the annual meeting of the Pediatric Academic Societies, Baltimore, MD, May 4-7, 2002.

30. Kim A, Garni RM, Bendel CM, Wells CL. Hypoxia and extraintestinal dissemination of Candida albicans yeast forms. Platform presentation at the 25th Annual Conference on Shock, Big Sky Montana, June 8-11, 2002.

31. Keane MB, Bendel CM. Alterations in the adherence of Candida albicans to cultured human enterocytes following treatment with dexamethasone. Pediatr Res 53:314A, 2003. Poster presentation at the annual meeting of the Pediatric Academic Societies, Seattle, WA, May 3-6, 2003.

32. Keane MB, Swanson EC, Wells CL, Bendel CM. Alterations in the adherence of Candida albicans to cultured human enterocytes following steroid treatment. Poster presentation at the 7th American Society of Microbiology Conference on Candida and Candidiasis, Austin, TX, March 18-22, 2004.

33. Keane MB, Wells CL, Bendel CM. Preferential adhesion of Candida species to cultured human enterocytes. Pediatr Res 55: 394A, 2004. Poster presentation at the annual meeting of the Pediatric Academic Societies, San Francisco, CA, May 1-4, 2004.

INTRAMURAL INVITED PRESENTATIONS
1. “Correlation of Adhesion and Pathogenic Potential in Yeast.” University of Minnesota, Department of Pediatrics Grand Rounds, September 2, 1992.

2. “Neonatal Candidiasis.” University of Minnesota, Department of Pediatrics Grand Rounds, August 6, 1997.

3. “The Candida albicans gene INT1 and its role in morphogenesis and adhesion.” University of Minnesota, Developmental Biology Center Research Meeting, January 7, 1998.

4. “Why is Candida albicans the most frequent fungal isolate in the clinical laboratory?” Catherine M. Bendel and Carol L. Wells. University of Minnesota, Department of Laboratory Medicine and Pathology Grand Rounds, December 8, 1999.

5. “Epithelial Adhesion in the Pathogenesis of Neonatal Candida Infections.” University of Minnesota, Department of Pediatrics Grand Rounds, October 15, 2003.

EXTRAMURAL INVITED PRESENTATIONS
1. “Intrauterine Parvovirus Infection.” Great Plains Organization for Perinatal Health Care, 21st Annual Meeting, May 20, 1991, Minneapolis, Minnesota.

2. “Perinatal Care Then and Now: 25 Years of the GPO” and “Parvovirus and Chlamydia During Pregnancy and the Perinatal Period.” Great Plains Organization for Perinatal Health Care, 25th Annual Meeting, May 21-23, 1995, Minneapolis, Minnesota.

3. “The role of filamentation in Candida albicans mucosal adhesion, colonization and systemic disease.” Neonatal and CHRC Research Seminar, Yale University School of Medicine, New Haven, CT, May 17, 2000.

4. “Cecal colonization and systemic spread of Candida albicans in mice treated with antibiotics and dexamethasone.” Pediatric Evidence-Based Journal Club via TeleTeach at Allegheny General Hospital and MCP Hahnemann School of Medicine, Pittsburgh, PA, April 12, 2002.

5. The College of St. Catherine, Minneapolis Campus, Commencement Address. The College of St. Catherine, St. Paul, MN, May 18, 2002.

6. “Neonatal Candidiasis.” Neonatal Grand Rounds, Children’s Memorial Hospital and Northwestern University, Chicago, IL, June 5, 2002.

7. “Neonatal Candidiasis: Clinical and Research Perspectives.” North Central Neonatal Issues Conference, Lake Geneva, WI, June 13-15, 2003.

8. “Neonatal Sepsis.” Grand Rounds, Fairview Ridges Hospital, Burnsville, MN, October 8, 2004.

TRAINING RECORD / MENTORSHIPS
Medical Students
1993-95 Sarah Carlson —1993 CBS Life Sciences Summer Undergraduate Research Program project. 1993-95 Medical Student Research Project. Both on surface expression of int1p in C. albicans and related Candida species. This work was presented as a poster at the 1994 SPR meeting in Seattle, WA (see abstract listing above).

1994, Jennifer Olson — 1994 Department of Microbiology Directed Research course

1996–97 project for two quarters. 1996-97 medical student research project. Both evaluating the adhesion of various yeasts transformed with mutant INT1 genes to elucidate the mechanisms mediated by this gene.

Undergraduates
1999 Kristin Hokanson — 1999 CBS Life Sciences Summer Undergraduate Research Program project to evaluate the time course of surface expression of int1p in transformed S. cerevisiae using GFP-tagged constructs and fluorescent microscopy. She presented her preliminary findings at a poster session for the CBS.

Graduate Students
2002-03 Mary Keane — Undergraduate research project evaluating mediators of the adhesion of Candida to cultured enterocytes, including dexamethasone and hypoxia. This work was presented as poster at the 2003 PAS meeting in Seattle, WA and the 2004 ASM Candida and Candidiasis conference (see abstract listings above).

Neonatal-Perinatal Medicine Fellows
2004 - Mary-Alice Johnson — Fellowship research project on the pathogenesis of Candida parapsilosis infections in the neonate.

ADVISEES
Medical Students
Sarah Carlson (1995-97)
Joanna Perkins (1995-97)
Jennifer Olson (1996-97)
Kimberly Condon (1996-98)
Kristina Loken (1996-98)
Sandra Wiita (1996-98)
April Sherren (1997-98)
Kimberly Smith (1998-01)
Amy Hentges (1999-01)
Melena Bellin (2001-03)
Kong Xiong (2002-03)

Fellows
Marissa De Ungria (1996-99)
Joel Manaligod (1996-99)
Danna Premer (1996-2000)
Jennifer Merchant (1997-2000)
Asha Jyothi M. Siddappa (1998-2001; 2003-04)
Karen Hospodar Scott (1999- 2002)
Jill Therien (1999-2002)
Ramesh Krishnan (2000-03)
Linda Black (2000-03)
Nina Perdue (2001-04)
Raz Tirosh (2001-04)
Joan Nold (2002-present)
Mary-Alice Johnson (2003-present)
Kay Ward (2003-present)
Andrea Lampland (2004- present)
Andrew Nordine (2004-present)

Pediatric Residents
Jennifer Lessin (1992-95)
Marissa De Ungria (1993-96)
Nicolette Myers (Med/Peds 1995-99)
Karen Hospodar (1996-99)
Andrea Lampland (2002-04
Christina Falgier (2003-present)

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