Research
We believe that advances in understanding and treating kidney disease in children requires highly motivated clinicians and scientists with specifc training in Pediatric Nephrology. Our physicians are uniquely trained to provide the best medical care and to share their passion for research and discovery. PUBLICATIONS, ABSTRACTS, and PRESENTATIONS2011 PUBLICATIONS
Chavers BM, Rheault MN, Foley RN. Kidney function reference values in US adolescents: National Health and Nutrition Examination Survey 1999-2008. Clin J Am Soc Nephrol, 6(8):1956-1962, 2011. Chavers BM, Solid CA, Sinaiko A, Daniels FX, Chen S-C, Collins AJ, Frankenfield DL, Herzog CA. Diagnosis of cardiac disease in pediatric end-stage renal disease. Nephrol Dial Transplant 26:1640-1645, 2011. Collins AJ, Foley R, Herzog C, Chavers B, Gilbertson D, Ishani A, Kasiske B, Liu J, Mau LW, McBean M, Murray A, St. Peter W, Guo H, Gustafson S, Li Q, Li S, Li S, Peng Y, Qiu Y, Roberts T, Skeans M, Snyder J, Solid C, Wang C, Weinhandl E, Zaun D, Arko C, Chen SC, Dalleska F, Daniels F, Dunning S, Ebben J, Frazier E, Hanzlik C, Johnson R, Sheets D, Wang X, Forrest B, Constantini E, Everson S, Eggers P, Agodoa L. United States Renal Data System 2010 Annual Data Report. Am J Kidney Dis 57(Suppl 1) A8, e1-526, 2011. de Boer IH, Rue TC, Cleary PA, Lachin JM, Molitch ME, Steffes MW, Sun W, Zinman B, Brunzell JD; Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Study Research Group, White NH, Danis RP, Davis MD, Hainsworth D,Hubbard LD, Nathan DM. Long-term renal outcomes of patients with type 1 diabetes mellitus and microalbuminuria: An analysis of the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications cohort. Arch Intern Med 14:171(5);412-420, 2011. PMCID: PMC3085024
Kashtan C, Segal Y. Genetic disorders of glomerular basement membranes. Nephron Clin Pract 118:c9-c18, 2011. Kashtan CE, Segal Y. Glomerular basement membrane disorders in experimental models for renal diseases: Impact on understanding pathogenesis and improving diagnosis. Contrib Nephrol 169:175-182, 2011. Rheault MN, Bechtel H, Neglia JP, Kashtan CE. Reversible Fanconi syndrome in a pediatric patient on deferasirox. Pediatr Blood Cancer 56(4):674-676, 2011. Park HW, Kim Y, Kim KH, Mauer M. Angiotensin II receptor blocker pretreatment of rats undergoing sudden renal ablation. Nephrol Dial Transplant in press. E-pub ahead of press June 1, 2011. Verghese P, Kim Y. Unilateral localized cystic kidney: Answer. Pediatr Nephrol 26(5):715-716, 2011. Verghese P, Kim Y. Unilateral localized cystic kidney: Question. Pediatr Nephrol 26(5):713-714, 2011. Fioretto P, Mauer M. Effects of pancreas transplantation on the prevention and reversal of diabetic nephropathy. Contributions to Nephrology 170:237-246, 2011. Fioretto P, Najafian B, Sutherland DER, Mauer M. Tacrolimus and cyclosporine nephrotoxicity in native kidneys of pancreas transplant recipients. Clin J Am Soc Nephrol 6:101-106, 2011. Harindhanavudh T, Mauer M, Klein R, Zinman B, Sinaiko A, Caramori ML for the Renin Angiotensin System Study (RASS) Group. Benefits of renin angiotensin blockade on retinopathy in type 1 diabetes vary with glycemic control. Diabetes Care, 34(8):1838-1842, 2011
Lind-Ayres M, Thomas W, Holme B, Mauer M, Caramori ML, Moran A . Microalbuminuria in patients with cystic fibrosis. Diabetes Care 34(7):1526-1528, 2011. Najafian B, Masood A, Malloy P, Campos A, Hansen BA, Mauer M, Caramori ML. Glomerulopathy in spontaneously obese rhesus monkeys with type 2 diabetes: A stereological study. Diabetes Metab Res Rev 27(4):341-347, 2011. Najafian B, Mauer M. Quantitating glomerular endothelial fenestration: An unbiased stereological approach. Am J Nephrol 33:34-39, 2011. Najafian B, Svarstad E, Bostad L, Gubler M-C, Tøndel C, Whitley C, Mauer M. Progressive podocyte injury and globotriaosylceramide (GL-3) accumulation in young patients with Fabry disease. Kidney Int 79(6):663-670, 2011. Verghese PS, Garvey CA, Mauer MS, Matas AJ. Media appeals by pediatric patients for living donors and the impact on a transplant center. Transplantation 91(6):593-596, 2011. Warnock DG, Ortiz A, Mauer M, Linthorst GE, Oliveira JP, Serra AL, Maródi L, Mignani R, Vujkovac B, Beitner-Johnson D, Lemay R, Cole A, Svarstad E, Waldek S, Germain DP, Wanner C, on behalf of the Fabry Registry. Renal outcomes of agalsidase beta treatment for Fabry disease: Role of proteinuria and timing of treatment initiation. Nephrol Dialy Transpl, in press 2011. Rheault MN. Women and Alport syndrome. Pediatr Nephrol in press. Epub ahead of print March 5, 2011. Dengel DR, Jacobs DR, Steinberger J, Moran A, Sinaiko AR. Gender differences in vascular function and insulin sensitivity in young adults. Clin Sci (Lond) 120(4):153-160, 2011. Frohnert BI, Sinaiko AR, Serrot FJ, Foncea RE, Moran A, Ikramuddin S, Choudry U, Bernlohr DA. Increased adipose protein carbonylation in human obesity. Obesity. 19(9):1735-1741, 2011.
Hearst MO, Laska MN, Himes JH, Butterbrodt M, Sinaiko A, Iron Cloud R, Tobacco M, Story M. The co-occurrence of obesity, elevated blood pressure, and acanthosis nigricans among American Indian school children: Identifying individual heritage and environment-level correlates. Am J Hum Biol 23:346-352, 2011. Kelly AS, Steinberger J, Jacobs DR, Hong CP, Moran A, Sinaiko AR. Predicting cardiovascular risk in young adulthood from the metabolic syndrome, its component risk factors, and a cluster score in childhood. Int J Pediatr Obes 6(2-2):e283-289, 2011. 2010 PUBLICATIONS
Collins AJ, Foley R, Herzog C, Chavers B, Gilbertson D, Ishani A, Kasiske B, Liu J, Mau LW, McBean M, Murray A, St. Peter W, Xue J, Fan O, Guo H, Li O, Li S, Li S, Li S, Peng Y, Qiu Y, Roberts T, Skeans M, Snyder J, Solid C, Wang C, Weinhandl E, Zaun D, Zhang R, Arko C, Chen SC, Dalleska F, Daniels F, Dunning S, Ebben J, Frazier E, Hanzlik C, Johnson R, Sheets D, Wang X, Forrest B, Constantini E, Everson S, Eggers P, Agodoa L. Excerpts from the United States Renal Data System 2009 Annual Data Report. Am J Kidney Dis 55(Suppl 1) S1 S420, A6-7, 2010. PMCID: PMC2829836. Kashtan C. Collagen IV-related nephropathies (Alport syndrome and thin basement membrane nephropathy) in: GeneReviews at GeneTests: Medical Genetics Information Resource [database online]. Copyright, University of Washington, Seattle. 1997-2010. Available at http://www.genetests.org Kashtan CE, Segal Y, Flinter F, Makanjuola D, Gan J, Watnick T. Aortic abnormalities in males with Alport syndrome. Nephrology Dialysis Transplant 25:3554-3560, 2010. Luo W, Wang XP, Kashtan CE, Borza D. Alport alloantibodies but not Goodpasture autoantibodies induce murine glomerulonephritis: Protection by quinary crosslinks locking cryptic alpha3(IV) collagen autoepitopes in vivo. J Immunol 185:3520-3528, 2010. Pedchenko V, Bondar O, Fogo AB, Vanacore R, Voziyan P, Kitching R, Wieslander J, Kashtan C, Borza D, Neilson E, Wilson CB, Hudson BG. Molecular architecture of the Goodpasture autoantigen in anti-GBM nephritis. N Engl J Med, 363:343-354, 2010. Rheault MN, Kren SM, Hartich LA, Wall M, Thomas W, Mesa HA, Avner P, Lees G, Kashtan CE, Segal Y. X inactivation modifies disease severity in female carriers of murine X-linked Alport syndrome. Nephrol Dial Transpl 25:764-769, 2010. Smith KM, Windsperger A, Alanee S, Humar A, Kashtan C, Shukla AR. Risk factors and treatment success for ureteral obstruction after pediatric renal transplantation. J Urol 183:317-322, 2010. Vinge L, Lees GE, Nielsen R, Kashtan CE, Bahr A, Christenson E. The effect of progressive glomerular disease on megalin-mediated endocytosis in kidney. Nephrology Dialysis Transplant 25:2458-2467, 2010. Genovese G, Tonna S, Knob AU, Appel GB, Katz A, Bernhardy AJ, Needham AW, Lazarus R, Pollak MR. A risk allele for focal segmental glomerulosclerosis in African Americans is located within a region containing APOL1 and MYH9. Kidney Int 78(7):698-704, 2010. Alvarez-Muñoz P, Mauer M, Kim Y, Rich SS, Miller ME, Russell GB, Lopez-Novoa JM, Caramori ML. Cellular basis of diabetic nephropathy: V. Endoglin expression levels and diabetic nephropathy risk in patients with type 1 diabetes. J Diabetes Complications 24(4):242-249, 2010. Fioretto P, Mauer M. Diabetic nephropathy--challenges in pathologic classification. Nat Rev Nephrol 6(9):508-10, 2010. Klein R, Knudtson MD, Klein BEK, Zinman B, Gardiner R, Suissa S, Sinaiko AR, Donnelly SM, Goodyer P, Strand T, Mauer M. The relationship of retinal vessel diameter to changes in diabetic nephropathy structural variables in patients with type 1 diabetes. Diabetologia 53(8):1638-1646, 2010. PMCID: PMC2892559 Klein R, Myers CE, Klein BEK, Zinman B, Gardiner R, Suissa S, Sinaiko AR, Donnelly SM, Goodyer P, Strand T, Mauer M. Relationship of blood pressure to retinal vessel diameter in type 1 diabetes mellitus. Arch Ophthalmol 128(2):198-205, 2010. PMCID: PMC2945902 Kukla A, El-Shahawi Y, Leister E, Kasiske B, Mauer M, Matas A, Ibrahim HN. GFR-estimating models in kidney transplant recipients on a steroid-free regimen. Nephrol Dial Transplant 25(5):1653-1661, 2010. PMCID: PMC2910331 Ramaswami U, Najafian B, Schieppati A, Mauer M, Bichet DG. Assessment of renal pathology and dysfunction in children with Fabry disease. Clin J Am Soc Nephrol 5(2):365-370, 2010. Stevens LA, Schmid CH, Greene T, Zhang Y, Beck GJ, Froissart M, Hamm LL, Lewis JB, Mauer M, Navis GJ, Steffes MW, Eggers PW, Coresh J, Levey AS. Comparative performance of the CKD Epidemiology Collaboration (CKD-EPI) and the Modification of Diet in Renal Disease (MDRD) Study equations for estimating GFR levels above 60mL/min/1.73m2. Am J Kidney Dis 56(3):486-495, 2010. PMCID: PMC2926290 Wanner C, Oliveira JP, Ortiz A, Mauer M, Germain DP, Linthorst GE, Serra AL, Maródi L, Mignani R, Cianciaruso B, Vujkovac B, Lemay R, Beitner-Johnson D, Waldek S, Warnock DG. Prognostic indicators of renal disease progression in adults with Fabry disease: Natural history data from the Fabry registry. Clin J Am Soc Nephrol 5(12):2220-2228, 2010. Vezina HE, Brundage RC, Nevins TE, Balfour HH Jr. The pharmacokinetics of valganciclovir prophylaxis in pediatric solid organ transplant patients at risk for Ebstein-Barr virus disease. Clinical Pharmacology: Advances and Applications 2:1-7, 2010. Kelly AS, Hebbel RP, Solovey AN, Schwarzenberg SJ, Metzig AM, Moran A, Sinaiko AR, Jacobs DR, Steinberger J. Circulating activated endothelial cells in pediatric obesity. J Pediatrics 157:547-551, 2010. Kelly AS, Jacobs DR Jr, Sinaiko AR, Moran A, Steffen LM, Steinberger J. Relation of circulating oxidized LDL to obesity and insulin resistance in children. Pediatric Diabetes 11:552-555, 2010. Levy-Marchal C, Arslanian S, Cutfield W, Sinaiko A, Druet C, Marcovecchio ML, Chiarelli F; ESPE-LWPES-ISPAD-APPES-APEG-SLEP-JSPE; Insulin Resistance in Children Consensus Conference Group. Insulin resistance in children: Consensus, perspective, and future directions. J Clin Endocrinol Metab 95(12):5189-5198, 2010. Verghese P, Smith J, Nelson K, Warner P, McDonald R. Impaired graft survival in pediatric renal transplant recipients with donor-specific antibodies detected by solid-phase assays. Pediatr Transplant 14(6):730-4, 2010. 2009 PUBLICATIONS
Chavers BM, Chang YK, Gillingham KJ, Matas A. Pediatric kidney transplantation using a novel protocol of rapid (6-day) discontinuation of prednisone: 2 year results. Transplantation 88(2):237-241, 2009. Chavers BM, Snyder JJ, Skeans MA, Weinhandl ED, Kasiske BL. Racial disparity trends for graft failure in the US pediatric kidney transplant population, 1980-2004. Am J Transplant 9:543-549, 2009. Chavers BM, Solid CA, Daniels FX, Chen S-C, Collins AJ, Frankenfield DL, Herzog CA. Hypertension in pediatric long-term hemodialysis patients in the United States. Clin J Am Soc Nephr 4(8):1363-1369, 2009. Collins AJ, Foley R, Herzog C, Chavers B, Gilbertson D, Ishani A, Kasiske B, Liu J, Mau LW, McBean M, Murray A, St. Peter W, Xue J, Fan O, Guo H, Li O, Li S, Li S, Li S, Peng Y, Qiu Y, Roberts T, Skeans M, Snyder J, Solid C, Wang C, Weinhandl E, Zaun D, Zhang R, Arko C, Chen SC, Dalleska F, Daniels F, Dunning S, Ebben J, Frazier E, Hanzlik C, Johnson R, Sheets D, Wang X, Forrest B, Constantini E, Everson S, Eggers P, Agodoa L. United States Renal Data System 2008 Annual Data Report Abstract. Am J Kidney Dis 53(Suppl 1):vi-vii, S8 S374, 2009. Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) Research Group, Nathan DM, Zinman B, Cleary PA, Backlund JY, Genuth S, Miller R, Orchard TJ. Modern-day clinical course of type 1 diabetes mellitus after 30 years' duration. The Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications and Pittsburgh Epidemiology of Diabetes Complications experience (1983-2005). Arch Intern Med 169(14):1307-1316, 2009. Rheault MN, Rajpal J, Chavers B, Nevins TE. Outcomes of infants <28 days old treated with peritoneal dialysis for end-stage renal disease. Pediatr Nephrol 24(10):2035-2039, 2009. Gross O, Borza D, Anders H, Licht C, Weber M, Segerer S, Torra R, Gubler M, Heidet L, Harvey S, Cosgrove D, Lees G, Kashtan C, Gregory M, Savige J, Ding J, Thorner P, Abrahamson D, Antignac C, Tryggvason K, Hudson B, Miner J. Stem cell therapy for Alport syndrome: the hope beyond the hype. Nephrol Dial Transpl, 24:731-734, 2009. Gross O, Kashtan C. Treatment of Alport syndrome: beyond animal models. Kidney Int 76:599-603, 2009. Kashtan C. Familial hematurias (teaching article). Pediatr Nephrol 24:1951-1958, 2009.
Kashtan C. Women with Alport syndrome: risks and rewards of kidney donation (invited editorial). Nephrol Dial Transpl 24:1369-1370, 2009. Kashtan CE. Familial hematurias: Alport syndrome and thin basement membrane nephropathy. In, Lerma EV, Nissenson AR, Berns JS (Eds), Current Diagnosis and Treatment in Nephrology and Hypertension, McGraw Hill Medical, New York, pp. 422-425, 2009. Caramori ML, Mauer M. Pathogenesis and pathophysiology of diabetic nephropathy. In, Primer on Kidney Diseases, 5th ed. Greenberg A, Cheung AK, Coffman TM, Falk RJ, Jennette JC (Eds), Elsevier, Saunders 2009, pp. 214-223. Luscri N, Mauer M, Sarafoglou K, Moran A, Tolar J. Lactic acidosis and hypoglycemia with ALL relapse following engrafted bone marrow transplant: A case report and brief review of literature. Pediatr Blood Cancer 53:223-225, 2009. Mauer M, Zinman B, Gardiner R, Suissa S, Sinaiko A, Strand T, Drummond K, Donnelly S, Goodyer P, Gubler MC, Klein R. Renal and retinal effects of Enalapril and Losartan in type 1 diabetes. N Engl J Med 361:40-51, 2009. NIHMSID #247249. Authors reply to letter to editor. N Engl J Med 361:1411, 2009. Najafian B, Mauer M. Progression of diabetic nephropathy in type 1 diabetic patients. Diab Res Clin Pract 83:1-8, 2009. Fine RN, Becker Y, De Geest S, Eisen H, Ettenger R, Evans R, LaPointe Rudow D, Mckay D, Neu A, Nevins T, Reyes J, Wray J, Dobbels F. Non-Adherence Consensus Conference Summary Report. Am J Transplant 9:35-41, 2009. Nevins TE, Thomas W. Quantitative patterns of azathioprine adherence after renal transplantation. Transplantation 87:711-718, 2009. Holt E, Steffen LM, Moran A, Basu S, Steinberger J, Ross JA, Hong CP, Sinaiko A. Fruit and vegetable consumption and its relation to markers of inflammation and oxidative stress in adolescents. J Am Diabetes Assoc 109:414-421, 2009. Rademacher ER, Jacobs DR Jr, Moran A, Steinberger J, Prineas RJ, Sinaiko AR. Relation of blood pressure and body mass index during childhood to cardiovascular risk factor levels in young adults. J Hypertension 27:1766-1774, 2009. Rademacher ER, Sinaiko AR. Albuminuria in children. Current Opinion in Nephrology and Hypertension 18:246-251, 2009. Hobbs D, Barletta G, Rajpal J, Rajpal M, Weismantel D, Birmingham J, Bunchman T. Severe paediatric systemic lupus erythematosus nephritis – a single-center experience. Nephrol Dial Transplant. 2010 Feb;25(2):457-63. Epub 2009 Sep 15. Rasmussen-Torvik LJ, Pankow JS, Jacobs DR Jr, Sinaiko AR. No association between TCF7L2 rs7903146 and euglycemic-clamp derived insulin sensitivity in a mixed-age cohort. Metabolism 58:1369-1371, 2009. Rasmussen-Torvik LJ, Pankow JS, Jacobs DR Jr, Steinberger J, Moran A, Sinaiko AR. The association of SNPs in ADIPOQ, ADIPOR1, and ADIPOR2 with insulin sensitivity in a cohort of adolescents and their parents. Human Genetics 125:21-28, 2009. Rasmussen-Torvik LJ, Pankow JS, Jacobs Jr. DR, Steinberger J, Moran A, Sinaiko AR. Influence of waist on adiponectin and insulin sensitivity in adolescence. Obesity 17:156-161, 2009. Verghese PS, Finn LS, Englund JA, Sanders JE, Hingorani SR. BK nephropathy in pediatric hematopoeitic stem cell transplant. Pediatr Transplant 13(7):913-918, 2009. 2008 PUBLICATIONS
Collins AJ, Foley R, Herzog C, Chavers B, Gilbertson D, Ishani A, Kasiske B, Liu J, Mau LW, McBean M, Murray A, St. Peter W, Xue J, Fan O, Guo H, Li O, Li S, Li S, Li S, Peng Y, Qiu Y, Roberts T, Skeans M, Snyder J, Solid C, Wang C, Weinhandl E, Zaun D, Zhang R, Arko C, Chen SC, Dalleska F, Daniels F, Dunning S, Ebben J, Frazier E, Hanzlik C, Johnson R, Sheets D, Wang X, Forrest B, Constantini E, Everson S, Eggers P, Agodoa L. Excerpts from the United States Renal Data System 2007 Annual Data Report. Am J Kidney Dis 51(Suppl 1):S1 S320, 2008. Donnelly SM, Gardiner R, Goodyer P, Gubler MC, Klein R, Kramer M, Mauer M, Moss SE, Sinaiko AR, Strand T, Suissa S, Zinman B, Basgen J, Palmer A, Groppoli T, Rozen S, Herbert P, Bucksa J, Nowicki M, Sawyer K, Chavers B, Kupcho S, Lohr B, Luke D, Johnson K, Stanitis P, Cohen M, Stein J, Pederson J, Laforte D, Carro-Ciampi G, Marcon L, Maruca B, Roy A, Barnie A, Bowyer K, Roode A, Vivero E, Tuason L, Gaudreau D, Hebert C, Lucas V, Senecal M, Delaney C. Comparing the automated versus manual method of needle biopsy for renal histology artefacts. Nephrol Dial Transplant 23(6):2098-2100, 2008. Rademacher E, Mauer M, Jacobs Jr DR, Chavers B, Steinke J, Sinaiko A. Albumin excretion rate in normal adolescents: Relation to insulin resistance and cardiovascular risk factors and comparisons to type 1 diabetes mellitus patients. Clin J Am Soc Nephrol 3:998-1105, 2008. Kashtan CE. Alport syndrome and thin basement membrane nephropathy. In, Geary D, Schaefer F (Eds), Comprehensive Pediatric Nephrology, 1st ed., Mosby Elsevier, Philadelphia, pp. 229-238, 2008. Tonna SJ, Needham A, Polu K, Uscinski A, Appel GA, Falk R, Katz A, Al-Waheeb S, Jerums G, Kaplan BS, Jerums G, Savige J, Harmon J, Zhang K, Curhan GC, Pollak MR. NPHS2 variation in focal and segmental glomerulosclerosis. BMC Nephrology 9:13, 2008. Bendel-Stenzel MR, Steinke J, Dohil R, Kim Y. Intravenous delivery of cysteamine for the treatment of cystinosis: Association with hepatotoxicity. Pediatr Nephrol 23:311-315, 2008. Donnelly S, Goodyer P, Mauer M, Gardiner R, Gubler MC, Klein R, Kramer M, Moss SE, Sinaiko AR, Suissa S, Zinman B. Comparing the automated versus manual method of needle biopsy for renal histology artifacts. Nephrol Dial Transplant 23:2098-2100, 2008. Fioretto P, Caramori ML, Mauer M. The kidney in diabetes: Dynamic pathways of injury and repair. The Camillo Golgi Lecture 2007. Diabetologia 51:1347-1355, 2008. Steinke JM, Mauer M, for the International Diabetic Nephropathy Study Group. Lessons learned from studies of the natural history of diabetic nephropathy in young type 1 diabetic patients. Ped Endocrinol Rev 5 (Suppl 4):958-963, 2008. Schram BR, Tze LE, Ramsey LB, Liu J, Najera L, Vegoe AL, Hardy RR, Hippen KL, Farrar MA, Behrens TW. B cell receptor basal signaling regulates antigen-induced Ig light chain rearrangements. J Immunology 180:4728-4741, 2008. Pescovitz MD, Knechtle S, Alexander SR, Colombani P, Nevins T, NieforthK, Bouw MR. Safety and pharmacokinetics of daclizumab in pediatric renal transplant recipients. Pediatr Transplantation 12:447-455, 2008. Moran A, Jacobs DR, Steinberger J, Steffen LM, Pankow JS, Hong CP, Sinaiko AR. Changes in insulin resistance and cardiovascular risk during adolescence. Establishment of differential risk in males and females. Circulation 117:2361-2368, 2008. Nelsestuen GL, Harvey SB, Zhang Y, Kasthuri RS, Sinaiko AR, Ely EW, Bernard GR, Homoncik M, Jilma B. Top-down proteomic analysis by MALDI-TOF profiling: concentration-independent biomarkers. Proteomics Clin Appl 2:158-166, 2008. Schwartz B, Jacobs DR, Moran A, Steinberger J, Hong CP, Sinaiko AR. Measurement of insulin sensitivity in children: comparison between the euglycemic-hyperinsulinemic clamp and surrogate measures. Diabetes Care 31:783-788, 2008. Sinaiko AR. Antihypertensive therapy in children: Implications for future studies. Hypertension 52:201-202, 2008. Steffen LM, Vessby B, Jacobs DR, Steinberger J, Moran A, Hong CP, Sinaiko AR. Serum phospholipid and cholesterol ester fatty acids and estimated desaturase activities are related to overweight and cardiovascular risk factors in adolescents. Int J Obes 32:1297-1304, 2008 2007 PUBLICATIONS
Chavers B, Najarian JS, Humar A. Kidney transplantation in infants and small children. Pediatr Transplantation 11:702-708, 2007. Chavers BM, Ellis D. Pediatric kidney transplantation. Current Opinion in Organ Transplantation 12:357-361, 2007. Chavers BM, Solid CA, Gilbertson DT, Collins AJ. Infection-related hospitalization rates in pediatric vs. adult patients with end-stage renal disease in the United States. J Am Soc Nephrol 18:952-959, 2007. Collins AJ, Kasiske B, Herzog C, Chavers B, Foley R, Gilbertson D, Grimm R, Liu J, Louis T, Manning W, McBean M, Murray A, St. Peter W, Zue J, Fan O, Guo H, Li O, Li S, Oiu Y, Li S, Roberts T, Skeans M, Snyder J, Solid C, Wang C, Weinhandl E, Zhang R, Arko C, Chen SC, Dalleska F, Daniels F, Dunning S, Ebben J, Frazier E, Hanzlik C, Johnson R, Sheets D, Wang X, Forrest B, Berrini D, Constantini E, Everson S, Eggers P, Agodoa L. Excerpts from the United States Renal Data System 2006 Annual Data Report. Am J Kidney Dis 49(1 Suppl 1):A6-A7, S1 S296, 2007. Khositseth S, Askiti V, Nevins T, Matas A, Ingulli E, Najarian JS, Gillingham KJ, Chavers BM. Increased urological complications in children after kidney transplants for obstructive and reflux uropathy. Am J Transplant 7(9):2152-2157, 2007. Rheault MN, van Burik J-A, Mauer M, Ingulli E, Ferrieri P, Jessurun J, Chavers BM. Cat-scratch disease in a kidney transplant recipient. Pediatr Transplant 11(1):105-109, 2007.
Davidson A, Bell R, Lees G, Kashtan C, Davidson G, Murphy K. Genetic cause of autosomal recessive hereditary nephropathy in English cocker spaniels. J Vet Int Med 21:391-401, 2007. Kang JS, Kashtan CE, Turner AN, Heidet L, Hudson BG, Borza DB. The alloantigenic sites of the alpha3 alpha4 alpha5 collagen IV network: pathogenic alloantibodies from X-linked Alport patients with post-transplant nephritis target two accessible conformational epitopes in the alpha5 NC1 domain. J Biol Chem, 282:106670-10677, 2007. Kashtan C. Alport syndrome and the X chromosome: implications of a diagnosis of Alport syndrome in females. Nephrology Dialysis Transplant 22:1499-1505, 2007. Kashtan C. The wages of thin (Invited editorial). J Amer Soc Nephrol 18:2800-2802, 2007. Nabity M, Boggess M, Kashtan C, Lees G. Day-to-day variation of the urine protein:creatinine ratio in female dogs with stable glomerular proteinuria caused by X-linked hereditary nephropathy. J Vet Intern Med 21:425-430, 2007. Askenazi D, Katz A, Tenney F, Benfield M, Barnhart D. An unusual case of peritoneal dialysis malfunction. Kidney Int 72:524, 2007. Park HW, Kim Y, Kim KH, Jeong HJ, Shin M-H, Rozen S, Mauer M. Angiotensin II receptor blockade blocker pre-treatment largely prevents injury from gradual renal ablation in rats. JRASS 8(3):110-117, 2007. Toyoda M, Najafian B, Kim Y, Caramori ML, Mauer M. Podocyte detachment and reduced glomerular capillary endothelial fenestration in human type 1 diabetic nephropathy. Diabetes 56(8):2155-2160, 2007. Tsuchiya K, Toyama K, Tsuprun V, Hamajima Y, Kim Y, Ondrey FG, Lin J. Pneumococcal peptidoglycan-polysaccharides induce the expression of interleukin-8 in airway epithelial cells by way of nuclear factor-KappaB, nuclear factor interleukin-6, or activation protein-1 dependent mechanisms. The Laryngoscope 117(1):86-91, 2007. Caramori ML, Fioretto P, Mauer M. The need for early predictors of diabetic nephropathy risk: Is albumin excretion rate sufficient? In, Commentaries on Perspectives in Diabetes Vol. 3 (1998-2002). Robertson RP (Ed), American Diabetes Association, Alexandria VA, 2007, pp. 230-241. Fioretto P, Mauer M. Histopathology of diabetic nephropathy. Semin Nephrol 27(2):195-207, 2007. Clewing JM, Antalfy BC, Lucke T, Najafian B, Marwedel KM, Hori A, Powel RM, Safo Do AF, Najera L, SantaCruz K, Hicks MJ, Armstrong DL, Boerkoel CF. Schimke immuno-osseous dysplasia: A clinicopathological correlation. J Med Genet 44(2):122-130, 2007. Fox MA, Sanes JR, Borza D-B, Eswarakumar PV, Fassler R, Hudson B, John SWM, Ninomiya Y, Pedchenko V, Rheault MN, Sado Y, Segal Y, Werle MJ, Umemori H. Distinct target-derived signals organize formation, maturation, and maintenance of motor nerve terminals. [Provided animals and tissue processing] Cell 129:179-193, 2007. Rasmussen-Torvik LJ, Pankow J, Jacobs Jr. D, Steffen L, Moran A, Steinberger J, Sinaiko A. Heritability and genetic correlations of insulin sensitivity measured by the euglycemic clamp. Diabetic Medicine 24:1286-1289, 2007. Sinaiko, AR. Obesity, insulin resistance and the metabolic syndrome. J Pediatr (Rio J) 83:3-4, 2007. Verghese P, Luckritz K, Eddy A. Interstitial Nephritis. In, Clinical Pediatric Nephrology. Geary DF and Schaefer F (Eds). Elsevier, Philadelphia, PA, 2007. 2006 PUBLICATIONS
Greer KA, Higgins MA, Cox ML, Ryan TP, Berridge BR, Kashtan CE, Lees GE, Murphy KE. Gene expression analysis in a canine model of X-linked Alport syndrome. Mammal Genome 17:976-990, 2006. Kashtan CE. Avancées récentes dans le syndrome d'Alport. In, Lesavre P, Drüeke T, Legendre C, Niaudet P (Eds), Actualités Néphrologiques Jean Hamburger, Médecine-Sciences Flammarion, Paris, pp. 35-48, 2006. Kashtan CE. Renal transplantation in patients with Alport syndrome. Pediatric Transpl 10:651-657, 2006. Caramori ML, Kim Y, Fioretto P, Huang C, Rich SS, Miller ME, Russell GB, Mauer M. Cellular basis of diabetic nephropathy: IV. Antioxidant enzyme mRNA expression levels in skin fibroblasts of type 1 diabetic sibling pairs. Nephrol Dial Transplant 21:3122-3126, 2006. Huang C, Kim Y, Caramori ML, Moore JH, Rich SS, Mychaleckyj JC, Walker PC, Mauer M. Diabetic nephropathy is associated with gene expression levels of oxidative phosphorylation and related pathways. Diabetes 55:1826-1831, 2006. Najafian B, Crosson JT, Kim Y, Mauer M. Glomerulotubular junction abnormalities are associated with proteinuria in type 1 diabetes. J Am Soc Nephrol 17:S53-S60, 2006.
Basgen JM, Nicholas SB, Mauer M, Rozen S, Nyengaard JR. Comparison of methods for counting cells in the mouse glomerulus. Nephron Exp Nephrol 103:e139-e148, 2006.
Caramori ML, Fioretto P, Mauer M. Enhancing the predictive value of urinary albumin for diabetic nephropathy. J Am Soc Nephrol 17(2):339-352, 2006. Fioretto P, Sutherland DER, Najafian B, Mauer M. Remodeling of renal interstitial and tubular lesions in pancreas transplant recipients. Kidney Int 69(5):907-912, 2006. Klein R, Moss SE, Sinaiko AR, Zinman B, Gardiner R, Suissa S, Donnelly SM, Kramer MS, Goodyer P, Strand T, Mauer, M. The relation of ambulatory blood pressure and pulse rate to retinopathy in type 1 diabetes mellitus: The Renin-Angiotensin System Study (RASS). Ophthalmology 113(12):2231-2236, 2006. Mauer M, Najafian B. The structure of human diabetic nephropathy. In, The Diabetic Kidney (Contemporary Diabetes Series). Cortes P, Mogensen CE (Eds), Humana Press 2006, pp. 361-374. Spetie DN, Nadasdy T, Nadasdy G, Agarwal G, Mauer M, Agarwal AK, Khabiri H, Nagaraja HN, Nahman Jr. NS, Hartman JA, Hebert LA. Proposed pathogenesis of idiopathic loin pain--hematuria syndrome. Am J Kidney Dis 47:419-427, 2006. Summer AP, Stauffer W, Maroushek SR, Nevins TE. Hematuria in children due to schistosomiasis in a non-endemic setting. Clinical Pediatrics. 45(2):177-81, 2006. Rheault MN, Manivel JC, Levine SC, Sinaiko AR. Sarcoidosis presenting with hearing loss and granulomatous interstitial nephritis in an adolescent. Pediatr Nephrol 21(9):1323-1326, 2006.
Messinger Y, Sheaffer JW, Mrozek J, Smith CM, Sinaiko AR. Renal outcome of neonatal renal venous thrombosis: Review of 28 patients and effectiveness of fibrinolytics and heparin in 10 patients. Pediatrics 118:1478-1484, 2006. Schwarzenberg SJ, Sinaiko AR. Obesity and inflammation in children. Paediatr Respir Rev 7:239-246, 2006. Sinaiko AR, Steinberger J, Moran A, Hong CP, Prineas RJ, Jacobs DR. Influence of insulin resistance and BMI at age 13 on systolic blood pressure, triglycerides and HDL-C at age 19. Hypertension 48:730-736, 2006. Sivanandam S, Sinaiko AR, Jacobs DR, Steffen L, Moran A, Steinberger J. Relation of increase in adiposity to increase in left ventricular mass from childhood to young adulthood. Am J Cardiol 98:411-415, 2006. 2011 ABSTRACTS
Chavers BM, Gillingham K, Matas A. Graft loss due to recurrent disease is not increased in pediatric steroid avoidance kidney transplant recipients. Am Transpl Congress, Phiadelphia, PA, 2011. Rizzari MC, Suszynski TM, Matas A, Gillingham K, Chavers BM. Impact of hypertension at 5 years posttransplant on long-term outcomes in pediatric kidney transplant recipients. Am Transpl Congress, Philadelphia, PA, 2011. Verghese P, Dunn T, Kim Y, Najafian B, Matas A. Microvascular inflammation – An ignored predictor of renal allograft survival. American Transplant Congress, Philadelphia, PA, 2011 (poster). Rajpal JS, Vogel RI, Kashtan CE, Smith AR. Incidence and outcomes of dialysis after pediatric bone marrow transplantation: A comparison of two decades. Pediatric Academic Societies Annual Meeting, Denver, CO. April 30-May 3, 2011. Baker KS, Chow E, Koves I, Goodman P, Leisenring W, Hoffmeister P, Steffen LM, Dietz AC, Petryk A, Dengel D, Sinaiko AR, Mulrooney DA, Steinberger J. Adverse impact of hematopoietic cell transplantation on body composition and insulin resistance is associated with increased cardiovascular risk. American Society of Bone Marrow Transplantation, February 2011. Frohnert B, Jacobs DR, Steinberger J, Moran AM, Steffen LM, Sinaiko AR. The relation of serum free fatty acids to obesity and insulin resistance from adolescence to adulthood. Pediatric Academic Societies Meeting, 2011. Polgreen LE, Thomas W, Nathan B, Moran A, Sinaiko AR. Association of osteocalcin with insulin resistance, obesity, and other cardiovascular risk factors in young adults age 17-22. Pediatric Academic Societies Meeting, 2011. Steinberger J, Sinaiko AR, Jacobs DR, Moran A, Dengel D, Zhou X, Steffen LM. Influence of parental cardiovascular risk profile on offspring risk factors. Joint conference - Nutrition, Physical Activity and Metabolism and Cardiovascular Disease Epidemiology and Prevention, March 2011. 2010 ABSTRACTS
Olaru F, Luo W, Hudson B, Kashtan C, Wang X, Borza D. Culprit and victim: distinct roles of αlpha3 αlpha4 αlpha5(IV) and αlpha5 αlpha5 αlpha 6(IV) collagen networks in the pathogenesis of X-linked Alport post-transplant nephritis. American Society of Nephrology Annual Meeting, Denver, November 17-21, 2010. Verghese P, Dunn T, Kim Y, Gillingham K, Matas A. C4d now and then. The Transplantation Society Meeting, 2010, Vancouver (oral presentation). Verghese P, Garvey C, Mauer M, Matas A. Media appeals for living donors and the impact on a transplant center. American Transplant Congress, San Diego 2010 (poster). Koessler R, Rheault MN. Drebrin is a novel regulator of podocyte process formation. American Society of Nephrology Annual Meeting (poster), Denver, CO. November 2010. Baker KS, Steffen LM, Zhou X, Kelly AS, Lee J, Petryk A, Sinaiko AR, Dengel DR, Mulrooney D, Steinberger J. Characteristics of insulin resistance and cardiovascular risk after hematopoietic cell transplant for childhood hematologic malignancies. 11th International Conference on Long-Term Complications of Treatment of Children and Adolescents for Cancer, June 2010.
Dreyfus J, Steffen L, Rasmussen-Torvik LR, Steinberger, Moran A, Jacobs D, Hong CP, Sinaiko A. The association of the PPARgamma Pro12Ala polymorphism with cardiovascular disease risk factors among adolescents. Society of Perinatal and Epidemiologic Research, 2010. Frohnert BI, Sinaiko A, Serrot FJ, Foncea R, Moran A, Ikramuddin S, Choudry U, Bernlohr DA. Relation of insulin sensitivity to protein carbonylation and antioxidant activity in human adipose tissue. Obesity Society Meeting, 2010. Mulrooney DA, Dietz AC, Kelly AS, Baker KS, Steffen LM, Lunsford-Lee, J, Petryk A, Sinaiko AR, Dengel DR, Perkins, J, Messinger Y, Zhou X, Steinberger J. Insulin resistance and vascular stiffness in survivors of childhood hematologic malignancies. 11th International Conference on Long-Term Complications of Treatment of Children and Adolescents for Cancer, June 2010. Polgreen L, Petryk A, Dietz AC, Leisenring W, Goodman P, Norris A, Hoffman M, Mulrooney D, Perkins J, Steffen L, Kelly A, Sinaiko S, Moran A, Dengel DR, Baker KS, and Steinberger J. Bone mineral density in childhood cancer survivors, June 2010. Polgreen L, Petryk A, Dietz AC, Leisenring W, Goodman P, Steffen L, Dengel DR, Baker KS, Sinaiko A, Steinberger J. Bone mineral content deficits in childhood cancer survivors compared to healthy siblings. ASBMR Annual Meeting, 2010. Rademacher E, Jacobs DR Jr, Steffen LM, Moran A, Sinaiko AR. Relation of parental blood pressure and body mass index to their development in offspring. Annual Conference on Cardiovascular Disease Epidemiology and Prevention in association with the Council on Nutrition, Physical Activity and Metabolism, 2010. Verghese P, Dunn T, Gillingham K, Matas A. C4d before we knew about C4d. American Transplant Congress, San Diego 2010 (poster). 2009 ABSTRACTS
Chavers BM, Solid CA, Frazier ET, United States Renal Data System, Minneapolis Medical Research Foundation, University of Minnesota Twin Cities. Trends in epidemiology of ESRD incidence among pediatric patients 1980-2007. Am Soc Nephrol, San Diego, CA, 2009. Rezcallah A, Humar A, Najarian J, Mauer M, Chavers B, Hill M, Jie T, Aerts J, Gillingham K, Matas A. What happens to children with renal allograft survival greater than ten years? Am J Transpl 9(2):713, 2009. Kashtan CE, Cassidy T, Kwon G, Gregory M. Natural history of microalbuminuria and proteinuria in untreated boys with Alport syndrome: a report of the Alport Syndrome Treatments and Outcomes Registry. American Society of Nephrology Annual Meeting, San Diego, October 29-November 1, 2009. Caramori ML, Hansen BC, Mauer M, Levi M, Tigno X, Aslam S, Najafian B. Dyslipidemia is associated with diabetic nephropathy in spontaneously obese nonhuman primates. Diabetes 58(1):A7-A8, 2009. Rheault MN, Mundel P. Drebrin is a novel regulator of podocyte process formation. Pediatric Academic Societies/American Society of Pediatric Nephrology Annual Meeting, (free communication), Baltimore, MD, May 2009. Baker KS, Kelly AS, Petryk A, Sinaiko AR, Steffen LM, Moran A, Dengel DR, Gujral K, Zhou X, Steinberger J. Cardiometabolic risk in survivors of childhood cancer who received hematopoietic cell transplant. American Society of Clinical Oncology, 2009. Baker KS, Steffen LM, Zhou X, Kelly AS, Petryk A, Sinaiko AR, Dengel DR, Mulrooney D, Steinberger S. Total body irradiation increases cardio-metabolic risk and induces carotid vascular stiffness in survivors after hematopoietic cell transplant for childhood hematologic malignancies. American Society of Hematology, 2009. Bishop LA, Steffen LM, Tsai A, Hanson N, Baker KS, Dengel DR, Kelly A, Sinaiko AR, Petryk A, Frohnert B, Foncea RE, Ikramuddin S, Sinaiko A, Bernlohr DA. Protein carbonylation and GSTA4 expression in adipose tissue of obese and lean subjects. Pediatric Research, Education and Scholarship Symposium (PRESS), 2009. Frohnert BI, Foncea R, Ikramuddin, S, Sinaiko, A, Bernlohr, DA. Protein carbonylation and GSTA4 expression in adipose tissue of obese and lean subjects. Lawson Wilkins Pediatric Endocrine Society/ European Society for Pediatric Endocrinology. New York, NY, September 2009. Gujral K, Petryk A, Steffen L, Baker KS, Perkins J, Kelly AS, Zhou X, Sinaiko A, Moran A, Steinberger J. Growth hormone deficiency and cardiovascular risk factors in childhood cancer survivors. American Society of Clinical Oncology, 2009. Kelly AS, Baker KS, Petryk A, Sinaiko AR, Steffen LM, Moran A, Dengel DR, Gujral K, Perkins J, Zhou X, Steinberger J. Cardiometabolic risk in pediatric survivors of childhood cancer. American Diabetes Association Scientific Sessions, 2009. Kelly AS, Hebbel RP, Solovey AN, Schwarzenberg SJ, Metzig AM, Moran A, Sinaiko AR, Jacobs DR Jr, Steinberger J. Circulating activated endothelial cells in severely obese children. American Heart Association, 2009. Mulrooney DA, Kelly AS, Baker KS, Steffen LM, Lunsford-Lee J, Petryk A, Sinaiko AR, Dengel DR, Perkins J, Messinger Y, Zhou X, Steinberger J. Cardiometabolic risks among survivors of childhood hematologic malignancies. American Society of Hematology, 2009. 2008 ABSTRACTS
Kashtan CE, Cassidy T, Gregory MC, Denison J. Strategies for recruiting subjects with a rare genetic renal disease for clinical studies. American Society of Nephrology Annual Meeting, Philadelphia, November 6-9, 2008. Luo W, Wang X, Kashtan CE, Borza D. FcgammaRIIB-/- mice develop severe anti-GBM glomerulonephritis after transfer of patient Alport alloantibodies but are resistant to Goodpasture autoantibodies due to structural sequestration of collagen IV autoepitopes. American Society of Nephrology Annual Meeting, Philadelphia, November 6-9, 2008. Caramori L, Kim Y, Rich SS, Miller ME, Russell GB, Mauer M. Gene expression levels in cultured skin fibroblast of identical twins discordant for type 1 diabetes and normal controls. Diabetes 57 (suppl 1):A317, 2008. Najafian B, Kim KH, Lee HS, Kim Y, Crary G, Mauer M. Podocyte detachment does not precede idiopathic focal segmental glomerulosclerosis in children. J Am Soc Nephrol 19:664A, 2008. Mauer M, Zinman B, Gardiner R, Suissa S, Sinaiko A, Strand T, Drummond K, Donnelly S, Goodyer, Klein R. The Renin Angiotensin System Study (RASS): Effects of enalapril and losartan on diabetic nephropathy and diabetic retinopathy in normotensive, normoalbuminuric patients with type 1 diabetes mellitus. European Diabetic Nephropathy Study Group, Hannover, Germany, May 16-17, 2008. Najafian B, Gubler M-C, Basgen J, Mauer M. Podocyte injury is an early event in Fabry disease. J Am Soc Nephrol 19:595A, 2008. Nevins TE, Robiner WN, Thomas W. Patterns of immunosuppressive medication nonadherence following renal transplant. J Am Soc Nephrol 19:227A, 2008. Rheault MN, Faul C, Mundel P. Tropomyosin regulates actin dynamics by blocking the proteasomal degradation of RhoA. J Am Soc Nephrol 19:215A, 2008. Baker KS, Mitby P, Steffen L, Gurney J, Mulrooney D, Parekh D, Dengel DR, Sinaiko A, Moran A, Steinberger J, Petryk A. Growth hormone deficiency is associated with metabolic syndrome in survivors of childhood cancer who received hematopoietic cell transplant. 10th International Conference on Long-Term Complications of Treatment of Children and Adolescents for Cancer. Niagara on the Lake, Ontario, Canada, 2008. Mitby P, Petryk A, Steffen L, Baker KS, Parekh D, Perkins J, Dengel DR, Sinaiko A, Moran A, Steinberger J. Growth hormone deficiency is associated with insulin resistance and adiposity in childhood cancer survivors. 10th International Conference on Long-Term Complications of Treatment of Children and Adolescents for Cancer. Niagara on the Lake, Ontario, Canada, 2008. Rademacher E, Jacobs DR, Moran A, Steffen L, Sinaiko A. The individual and interactive influence of BMI and SBP at age 13 on cardiovascular risk and insulin resistance at age 22-27. Am Soc Ped Nephrol, 2008. Verghese P, Finn L, Englund J, Sanders J, Hingorani S. BK nephropathy in pediatric hematopoietic stem cell transplant. American Transplant Congress, Toronto, Canada 2008 (poster). Verghese P, Warner P, Smith J, Nelson K, McDonald R. Donor-specific HLA antibodies detected with sensitive solid-phase assays are associated with impaired allograft survival in pediatric renal transplant recipients. (poster) Am J Transplant 8(2):419, 2008. 2007 ABSTRACTS
Chavers B, Snyder JJ, Peng Y, Kasiske BL. Post-transplant fractures in the pediatric kidney transplant recipients in the US, 1995-2004. J Am Soc Nephrol 18:881A, 2007. Chavers B, Snyder JJ, Skeans MA, Weinhandl ED, Kasiske BL. Trends in racial disparities in graft failure rates in the US pediatric kidney transplant population, 1980-2004. J Am Soc Nephrol 18:673A, 2007. Rademacher E, Mauer M, Jacobs DR, Chavers B, Sinaiko, A. Albumin excretion rate in normal adolescents compared to type 1 diabetes mellitus adolescents. Pediatric Academic Societies' Meeting, 2007. Caramori ML, Kim Y, Moore JH, Rich SS, Mychaleckyj JC, Walker PC, Mauer M. Microarray gene expression abnormalities in mitochondria related pathways in cultured skin fibroblasts of type 1 diabetic patients. Diabetes 56 (suppl 1):A286, 2007. Munoz PA, Caramori ML, Kim Y, Lopez-Novoa JM, Mauer M. Endoglin expression and diabetic nephropathy risk in patients with type 1 diabetes. Diabetes 56 (suppl 1):A196, 2007. Toyoda M, Najafian B, Kim Y, Mauer M. Glomerular endothelial fenestration is reduced in type 1 diabetic patients. Diabetes 56 (suppl 1):A203, 2007. Caramori ML, Hansen BC, Levi M, Najafian B, Aslan S, Wang X, Jiang T, Mauer M. Renal cortical lipid content and renal lesions in non-human primate with type 2 diabetes. Diabetes 56 (suppl 1):A198, 2007. Caramori ML, Hansen BC, Mauer M, Levi M, Tigno X, Aslam S, Najafian B. Renal structural-functional relationships in spontaneously obese Rhesus monkeys. J Am Soc Nephrol 18:175A, 2007. Steinke J, Mauer M. Predictors of glomerular basement membrane width progression in young subjects with type 1 diabetes mellitus. Diabetes 56 (suppl 1):A485, 2007. Howard LN, Steffen LM, Steinberger J, Moran A, Jacobs DR, Hong CP, Sinaiko AR. Physical activity is related to insulin sensitivity and the metabolic syndrome in adolescents. 47th Annual Conference on Cardiovascular Disease Epidemiology and Prevention in association with the Council on Nutrition, Physical Activity and Metabolism, 2007. Parekh DR, Raatz S, Hong CP, Jacobs DR, Steinberger J, Sinaiko, A. CT versus other estimates of visceral fat in adolescents and young adults. Pediatric Academic Societies' Meeting, 2007. Rasmussen-Torvik LJ, Pankow JS, Jacobs DR, Steffen LM, Moran A, Steinberger J. Sinaiko AR. Waist is associated longitudinally with adiponectin but not with clamp-derived insulin sensitivity in a cohort of adolescents. 47th Annual Conference on Cardiovascular Disease Epidemiology and Prevention in association with the Council on Nutrition, Physical Activity and Metabolism, 2007. Steffen LM, Vessby V, Jacobs DR, Pankow JS, Steinberger J, Moran A, Hong CP, Sinaiko AR. Fatty acid desaturase activity is related to metabolic syndrome risk factors. 47th Annual Conference on Cardiovascular Disease Epidemiology and Prevention in association with the Council on Nutrition, Physical Activity and Metabolism, 2007. 2006 ABSTRACTS
Chavers BM, Chang C, Gillingham KJ, Matas AJ. Successful pediatric kidney transplantation using a novel protocol of rapid discontinuation of prednisone. J Am Soc Nephrol 17:672A, 2006. Chavers BM, Frazier E, Gilbertson D, Collins AJ. Trends in mean hemoglobin levels and erythropoietin usage at dialysis initiation in pediatric chronic dialysis patients. J Am Soc Nephrol 17:186A, 2006. Chavers BM, Frazier ET, Gilbertson DT, Collins AJ. Achievement of K/DOQI target hemoglobin levels at chronic dialysis initiation in pediatric patients by race, gender, and year. J Am Soc Nephrol 17:580A, 2006. Chavers BM, Solid CA, Collins AJ, Herzog CA. Cardiovascular disease in pediatric kidney transplant patients. J Am Soc Nephrol 17:671A, 2006. Donaher E, Mauer M, Jacobs DR Jr, Chavers B, Sinaiko A. Albumin excretion rate in normal adolescents: Relation to insulin resistance and cardiovascular risk factors and comparisons to type 1 diabetes mellitus patients. J Am Soc Nephrol 17:678A, 2006. Kang JS, Kashtan CE, Hudson BG, Borza DB. Alloantibodies mediating anti-GBM nephritis in the renal allograft of X-linked Alport patients target two conformational alloepitopes in the NC1 domain of alpha5(IV) collagen. American Society of Nephrology Annual Meeting, San Diego, November 14-19, 2006. Kashtan C, Mangini J, Kren S, Segal Y, Watnick T. Aortic disease in patients with Alport syndrome. American Society of Nephrology Annual Meeting, San Diego, November 14-19, 2006. Rheault MN, Kren S, Pan Z, Kashtan CE, Segal Y. X-inactivation determines disease severity in female carriers of murine X-linked Alport syndrome. J Am Soc Nephrol 17:520A, 2006. Caramori ML, Najafian B, Levi M, Mauer M, Fioretto P, Hansen B. Renal cortical lipid content and renal lesions in a non-human primate model of type 2 diabetes. European Diabetic Nephropathy Study Group, Helsingør, Denmark, May 19-20, 2006. Ibrahim HN, Rogers TB, Matas AJ, Mauer SM, Kasiske B. The serial profile of the renin-aldosterone axis in stable renal transplant recipients. J Am Soc Nephrol 17:849A, 2006. Nadasdy T, Nadasdy G, Agarwal G, Satoskar A, Mauer M, Agarwal A, Spetie D, Rovin BH, Hebert LA. Idiopathic thick glomerular basement membrane nephropathy: A newly recognized cause of glomerular hematuria. J Am Soc Nephrol 17:258A, 2006. Steinke J, Mauer M. for the International Diabetic Nephropathy Study Group (IDNSG). Baseline predictors of the rates of renal structural change over 5 years in young, type 1 diabetic patients. European Diabetic Nephropathy Study Group, Helsingør, Denmark, May 19-20, 2006. Steinke J, Mauer M. Baseline predictors of the rates of renal structural change over 5 years in young patients with type 1 diabetes mellitus. J Am Soc Nephrol 17:160A, 2006. Steinke J, Najafian B, Mauer M. A novel approach to age correction of the glomerular basement membrane width change over time in subjects with type I diabetes mellitus. J Am Soc Nephrol 17:392A, 2006. Rheault MN, Nevins TE. The outcome of neonatal end-stage kidney failure. Pediatric Academic Societies’ Annual Meeting, San Francisco, CA, April 29, 2006. Rheault MN, Mundel P. Functional similarities between synaptopodin and tropomyosin in stress fiber formation. J Am Soc Nephrol 17:291A, 2006. Moran A, Jacobs D, Steinberger J, Steffen L, Pankow J, Hong C-P, Sinaiko. Natural history of the metabolic syndrome in youth. American Diabetes Association, Scientific Sessions, Washington DC, 2006. Rasmussen-Torvik LJ, Pankow JS, Jacobs DR, Steffen LM, Moran A, Steinberger J, Leiendecker-Foster C, Sinaiko AR. Heritability, genetic correlations, and genetic associations of fasting insulin and insulin resistance measured by the euglycemic hyperinsulinemic clamp. 46th Annual Conference on Cardiovascular Disease Epidemiology and Prevention in association with the Council on Nutrition, Physical Activity and Metabolism, 2006
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Schwartz B, Jacobs D, Moran A, Steffen L, Steinberger J, Pankow JS, Hong C-P, Sinaiko A. Euglycemic clamp versus surrogate estimates of insulin sensitivity in youth. American Diabetes Association, 2006. 2011 PRESENTATIONS
Mauer M. Studies of renal injury in diabetes. Slovenia Diabetes Society. Ljubljana, Slovenia, May 19, 2011. Mauer M. Lessons learned from renal biopsies in Fabry disease. Lysosomal Disease Club. Vancouver, Canada, June 3, 2011. Rheault MN. The role of Drebrin in the podocyte. Center for Clinical and Translational Research, The Research Institute at Nationwide Children’s Hospital. Columbus, OH, April 25, 2011. Sinaiko AR. Pediatric Academic Societies Annual Meeting. Denver, CO, April 30, 2011. 2010 PRESENTATIONS
Kashtan CE. Visiting Professor. Children’s Hospital, National Medical Center, Washington, DC. April 15, 2010. Kashtan CE. Moderator and Speaker. Alport syndrome, a symposium for physicians, researchers and families. 15th Congress of the International Pediatric Nephrology Association. New York NY, August 28, 2010. Kashtan CE. Distinguished faculty, in-depth nephrology course: Hereditary nephritis and thin basement membrane nephropathy. American Society of Nephrology Annual Meeting. Denver, CO, November 16, 2010. Mauer M. Natural history and structural functional relationships in Fabry renal disease. Lysosomal Disease Network WORLD Symposium. Miami, FL, February 12, 2010. Mauer M. Diabetic nephropathy in children. Pediatric Nephrology Seminar. Miami Beach, FL, March 14, 2010. Mauer M. RAS inhibition and primary prevention of diabetic nephropathy (Keynote Speaker). 5th Annual Meeting of the Japan Diabetes Society. Okayama, Japan, May 28, 2010.
Jurat S. Rajpal, Rachel I. Vogel, Clifford E. Kashtan, Angela R. Smith. Incidence and Outcomes of Dialysis after Pediatric Hematopoietic Stem Cell Transplantation: A comparison of two decades. Pediatric Academic Society Meeting. Poster Presentation. May 2, 2011. Denver CO, USA. Rheault MN. Women and Alport syndrome. IPNA/Alport Syndrome Symposium. New York, NY, August 28, 2010. Sinaiko AR. World Congress on Insulin Resistance. Los Angeles, CA, November 4, 2010. 2009 PRESENTATIONS
Kashtan CE. Alport syndrome: Diagnostic advances. 36th Pediatric Nephrology Seminar. University of Miami. Miami, FL, February 29, 2009. Kashtan CE. Familial hematuric syndromes. World Congress of Nephrology. Milan, Italy, May 22-26, 2009. Kashtan CE. Pediatric Grand Rounds. Alport syndrome: The evolving story of a basement membrane disorder. Case Western Reserve University. Cleveland, Ohio, June 10, 2009. Kashtan CE. Renal Grand Rounds, Division of Nephrology. Alport syndrome: The challenges of clinical trials. Case Western Reserve University. Cleveland, Ohio, June 10, 2009. Kashtan CE. Distinguished faculty, in-depth nephrology course: Hereditary nephritis and thin basement membrane nephropathy. American Society of Nephrology Annual Meeting. San Diego, CA, October 27, 2009. Sinaiko AR. World Congress on Insulin Resistance. San Francisco, CA. Sinaiko AR. Protein carbonylation and GSTA4 expression in adipose tissue of obese and lean subjects. Lawson-Wilkins Pediatric Endocrine Society/European Society for Pediatric Endocrinology joint meeting. New York, NY. September 2009. Sinaiko AR. Consensus Conference on Insulin Resistance. Paris, France. Sinaiko AR. State of California Biennial Obesity Conference. Los Angeles, CA. 2008 PRESENTATIONS
Kashtan CE. Scientific Co-chair and Speaker. 5th International workshop on Alport syndrome: Changing the natural history of Alport kidney disease. National Institute of Transplantation. University of Southern California, Santa Monica, CA, January 31-February 2, 2008. Kashtan CE. ISN-COMGAN CME 2008: Challenges in prevention of chronic kidney disease for a developing country. St. John's Medical College, Bangalore, India, March 9, 2008. Kashtan CE. Alport syndrome. David Cornfeld Lecture in Pediatric Nephrology. Children's Hospital of Philadelphia, Philadelphia, PA, April 2, 2008. Kashtan CE. Collagen nephropathies symposium: Thin basement membrane nephropathy and Alport syndrome. American Society of Nephrology Annual Meeting. Philadelphia, PA, November 8, 2008. Kashtan CE. Clinical trials in Alport syndrome. Canadian Association of Pediatric Nephrology Meeting. Philadelphia, PA, November 8, 2008. Kashtan CE. Alport syndrome. Grand Rounds, Division of Nephrology, Department of Medicine, Johns Hopkins University School of Medicine, December 19, 2008. Mauer M. Factors associated with the progression and remission of diabetic nephropathy. Shiga International Symposium on Diabetic Nephropathy. Shiga, Japan, March 20, 2008. Mauer M. Proteinuria as a surrogate outcome in chronic kidney disease. National Kidney Foundation-FDA Conference. Silver Spring, MD, May 1, 2008. Mauer M. European Diabetic Nephropathy Study Group (EDNSG). Osterby Lecture. Hanover, Germany, May 16, 2008. Mauer M. Structural and functional considerations of interstitial and tubular injury in type 1 diabetes. International Society of Nephrology Nexus Symposia. Dublin, Ireland, June 27, 2008. Mauer M. Diabetic nephropathy—Pathophysiology. 4th Menarini International Meeting. Lido di Camaiore, Lucca, Italy, November 28, 2008. Rheault MN. Women with Alport syndrome. International Workshop on Alport Syndrome, National Institute of Transplantation. Los Angeles, CA, February 1, 2008. Sinaiko AR. Expert Panel on Metabolic Syndrome in Children. Washington, DC. Sinaiko AR. Pediatric Academic Societies. Honolulu, HI Sinaiko AR. Department of Physiology. University of Wisconsin. Milwaukee, WI. Sinaiko AR. World Congress of Insulin Resistance. Los Angeles, CA. 2007 PRESENTATIONS
Mauer M. Towards early treatment of Fabry disease. European Roundtable on Fabry Disease. Rome, Italy, October 12, 2007. Mauer M. Structural and functional relations in diabetic nephropathy: Implications for children. Prevention of Renal Complication of Diabetes Type 1 and Type 2 in Children Symposium. SUNY Downstate Medical Center. Brooklyn, NY, October 17, 2007. Mauer M. Cellular basis of diabetic nephropathy using the skin fibroblast as a model. European Renal Association-EDTA Symposium. Madrid, Spain, November 29, 2007. Rheault MN. Mechanisms of glucocorticoid and cyclosporine action in podocytes. ASPN Annual Meeting. Toronto, Canada, May 8, 2007. Rheault MN. Tropomyosin regulates actin organization by blocking smurf1-mediated degradation of RhoA. CHRCDA A Annual Conference. Newport, RI, November 3, 2007. Sinaiko AR. University of Pittsburgh, Department of Pediatrics. Sinaiko AR. World Congress of Insulin Resistance. 2006 PRESENTATIONS
Kashtan CE. Adult kidney disease due to genetic errors in renal morphogenesis. Experimental Biology 2006, American Association of Anatomists Annual Meeting. San Francisco, CA, April 1-5, 2006. Kashtan CE. Recent aspects of Alport syndrome. Necker Seminars in Nephrology. Hopital Necker, Paris, France, April 24-26, 2006. Mauer M. Renal cortical lipid content and renal lesions in a non-human primate model of type 2 diabetes. European Diabetic Nephropathy Study Group (EDNSG). Helsinki, Finland, May 19, 2006. Sinaiko AR. Insulin resistance and the insulin resistance syndrome in childhood. Denver Children’s Hospital, CO. April 14, 2006.
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