Caroline George, M.D.

Associate Professor
Mayo Mail Code 742
420 Delaware Street, S.E.
Minneapolis, MN  55445
Phone 612-626-2963
Fax 612-624-0696 

Dr. Caroline George is an Associate Professor in the Department of Pediatrics, Division of Critical Care Medicine.  She attends on the Pediatric Critical Care Unit and also in the Pediatric Sedation Unit.

Dr. George received her medical degree from the University of Minnesota College of Medicine in 1992, completed her Pediatric Residency program at the University of Iowa Carver College of Medicine in 1995, and completed the Pediatric Critical Care fellowship program at The Children’s Hospital in Denver Colorado in 1998.  She became a member of the Pediatric Critical Care division at the University of Iowa Hospital and Clinics in 1998 until 2007 when she joined the faculty at the University of Minnesota.  Dr. George is board certified in General Pediatrics and Pediatric Critical Care Medicine.

Dr. George’s research focus is on the collectins (surfactant associated protein-A and D) and their contribution to neonatal immunity.  This research is currently funded with a focus on both the maternal and neonatal contributions towards preventing infection in the newborn.  Other research interests include how the collectins may contribute to the prevention and therapy in the prevention of necrotizing enterocolotis the newborn. 

Dr. George’s areas of clinical interest in the Pediatric Critical Care unit include acute lung injury, care of post-operative cardiothoracic patients, and care of children that have experienced non-accidental trauma.

Honors and Awards

Recent Publications

1. George CLS, Hong J, Snyder JM, Wohlford-Lenane CL, O’Shaughnessy P, Kline JN, Thorne PS, O’Neill ME, Phipps JC, and Schwartz DA: Endotoxin responsiveness and subchronic grain dust induced airway disease.  Am J Physiol: Lung Cell Mol Physiol, 280:L203-L213, 2001.

2. Jain VV, Businga TR, Kitagaki K, Hussain I, O’Shaughnessy PT, George C, and Kline JN: CpG-oligodeoxynucleotides inhibit airway remodeling in a murine model of chronic asthma.  J Allergy Clin Immunol, 110:867-872, 2002.

3. George CLS, White M, O’Neill M, Thorne P, Schwartz D, Snyder J.: Altered surfactant protein-A gene expression and protein metabolism associated with repeat exposure to inhaled endotoxin. Am J Physiol: Lung Cell Mol Physiol.  285: L1337-L1344, 2003.

4. Jain VV, Businga TR, Kitagaki K, George C, O’Shaughnessy PT, and Kline JN: Mucosal immunotherapy with CpG oligonucleoxynucleotides reverses a murine model of chronic asthma induced by repeated antigen exposure.  Am J Physiol: Lung Cell Mol Physiol. 285: L1137-L1146, 2003.

5. Cho SJ, George CLS, Snyder JM, and Acarregui MJ: Retinoic acid and EPO maintain alveolar development in mice treated with an angiogenesis inhibitor.  Am J Respir Cell Mol Biol. 33(6):266-8, 2005.

6.George CLS, White M, Kulhankova K, Mahajan A, Thorne PS, Snyder JM, and Kline JN: Early exposure to organic dust alters pulmonary immunity and allergic responses.  Am J Physiol Lung Cell Mol Physiol 291(3):L512-22, 2006.

7. Foster, JJ, Goss KL, George CLS, Bangsund PJ, Snyder JM: Galectin-1 in   secondary alveolar septae of neonatal mouse lung.  Am J Physiol Lung Cell Mol Physiol. (August 4, 2006). 291(6):L1142-9, 2006.