Warren Regelmann, M.D.

Interim Director of the Pediatric Cystic Fibrosis Center
Associate Professor
Mayo Mail Code 742
420 Delaware Street S.E.
Minneapolis, MN 55455
Phone:  612-626-2916
Fax:      612-624-0696

Warren E. Regelmann, M.D. is an Associate Professor of Pediatrics, in the Divisions of Pediatric Pulmonary and Critical Care Medicine and Pediatric Infectious Diseases.  Dr. Regelmann attends on the Pediatric Pulmonary and the Infectious Disease services.  His clinical specialty is childhood lung diseases, including asthma, cystic fibrosis, recurrent and persistent cough and recurrent pneumonias. 

After receiving his M.D. degree from the State University of New York, Downstate Medical Center, Dr. Regelmann completed his Pediatric Residency and Infectious Disease Fellowship at the University of Minnesota.  He joined the University of Minnesota Faculty in 1979. He is Board certified in Pediatric Pulmonology and Pediatric Infectious Diseases. He directs the CLIA approved Host Defense Laboratory for clinical evaluation of phagocyte function.

Dr. Regelmann’s clinical research is in the epidemiology of cystic fibrosis and its treatment, the genetic modifiers of the lung disease of cystic fibrosis, and the role of the enzymes of the neutrophil, a white blood cell, in the response to bacterial infection and the remodeling of lung tissue.  He is the Director of the Pediatric Pulmonary Fellowship Training Program.

Selected Recent Publications:

1. Regelmann, W.E., Siefferman, C.M., Herron, J.M., Elliott, G.R., Clawson, C.C., and Gray, B.H. 1995. Sputum peroxidase activity correlates with the severity of lung disease in cystic fibrosis. Pediatr Pulmonol 19:1-9.

2. Brottman, G.M., Regelmann, W.E., Slungaard, A., and Wangensteen, O.D. 1996. Effect of eosinophil peroxidase on airway epithelial permeability in the guinea pig. Pediatr Pulmonol 21:159-166.

3. Milla, C., Doherty, L., Raatz, S., Schwarzenberg, S.J., Regelmann, W., and Moran, A. 1996. Glycemic response to dietary supplements in cystic fibrosis is dependent on the carbohydrate content of the formula. JPEN J Parenter Enteral Nutr 20:182-186.

4. Milla, C.E., Wielinski, C.L., and Regelmann, W.E. 1996. Clinical significance of the recovery of Aspergillus species from the respiratory secretions of cystic fibrosis patients. Pediatr Pulmonol 21:6-10.

5. Wilmott, R.W., Amin, R.S., Colin, A.A., DeVault, A., Dozor, A.J., Eigen, H., Johnson, C., Lester, L.A., McCoy, K., McKean, L.P., et al. 1996. Aerosolized recombinant human DNase in hospitalized cystic fibrosis patients with acute pulmonary exacerbations. Am J Respir Crit Care Med 153:1914-1917.

6. Regelmann, W.E., Schneider, L.A., Fahrenkrug, S.C., Gray, B.H., Johnson, S., Herron, J.M., Clawson, C.C., Clawson, D.J., and Wangensteen, O.D. 1997. Proteinase-free myeloperoxidase increases airway epithelial permeability in a whole trachea model. Pediatr Pulmonol 24:29-34.

7. Shreve, M.R., Johnson, S.J., Milla, C.E., Wielinski, C.L., and Regelmann, W.E. 1997. PCR ribotyping and endonuclease subtyping in the epidemiology of Burkholderia cepacia infection. Am J Respir Crit Care Med 155:984-989.

8. Morgan, W.J., Butler, S.M., Johnson, C.A., Colin, A.A., FitzSimmons, S.C., Geller, D.E., Konstan, M.W., Light, M.J., Rabin, H.R., Regelmann, W.E., et al. 1999. Epidemiologic study of cystic fibrosis: design and implementation of a prospective, multicenter, observational study of patients with cystic fibrosis in the U.S. and Canada. Pediatr Pulmonol 28:231-241.

9. Shreve, M.R., Butler, S., Kaplowitz, H.J., Rabin, H.R., Stokes, D., Light, M., and Regelmann, W.E. 1999. Impact of microbiology practice on cumulative prevalence of respiratory tract bacteria in patients with cystic fibrosis. J Clin Microbiol 37:753-757.

10. McCarty, N.A., Standaert, T.A., Teresi, M., Tuthill, C., Launspach, J., Kelley, T.J., Milgram, L.J., Hilliard, K.A., Regelmann, W.E., Weatherly, M.R., et al. 2002. A phase I randomized, multicenter trial of CPX in adult subjects with mild cystic fibrosis. Pediatr Pulmonol 33:90-98.

11. Garner, H.P., Phillips, J.R., Herron, J.G., Severson, S.J., Milla, C.E., and Regelmann, W.E. 2004. Peroxidase activity within circulating neutrophils correlates with pulmonary phenotype in cystic fibrosis. J Lab Clin Med 144:127-133.

12. Rabin, H.R., Butler, S.M., Wohl, M.E., Geller, D.E., Colin, A.A., Schidlow, D.V., Johnson, C.A., Konstan, M.W., and Regelmann, W.E. 2004. Pulmonary exacerbations in cystic fibrosis. Pediatr Pulmonol 37:400-406.

13. Kharbanda, S., Panoskaltsis-Mortari, A., Haddad, I.Y., Blazar, B.R., Orchard, P.J., Cornfield, D.N., Grewal, S.S., Peters, C., Regelmann, W.E., Milla, C.E., and Baker, K.S. Inflamatory cytokines and the development of pulmonary complications after allogeneic heatopoietic cell transplantation in patients with inherited metabolic storage disorders. Biol Blood Marrow Transplant 2006; 12:430-7.

14. Phillips, J.R., Tripp, T.J., Regelmann, W.E., Schlievert, P.M., Wangensteen, O.D. Staphylococcal Alpha-toxin Causes Increased Tracheal Epithelial Permeability. Pediatr. Pumonol. 41:1146-52, 2006.

15. Beiraghi, S., Baker, S., and Regelmann, W.E. Oral Manifestation of a Possible New Periodic Fever Syndrome. Pediatric Dentistry. In press, 2007.

16. Konstan, M.W., Morgan, W.J., Butler, S.M., Pasta, D.J., Craib, M.L., Silva S.J., Stokes, D.C., Wohl, M.E.B., Wagener, J.S., Regelmann W.E., and Johnson, C.A. Risk Factors for Rate of Decline in FEV1 in Children and Adolescents with Cystic Fibrosis. J. Pedatr. In Press, 2007.