LaDora V. Thompson, PhD, BS PT

LADORA V. THOMPSON, PhD, BS PT
Program in Physical Therapy, University of Minnesota
366 Children's Rehab Center
612-626-5271
thomp067@umn.edu

Position:
Professor

Education:
University of Wisconsin, B.A. in Education, Marquette University, B.S. in Physical Therapy; Marquette University, Ph.D. in Biological Sciences (Muscle Physiology).

Teaching Responsibilities:
Theory of Therapeutic Exercise; Biology of Aging, Exercise Physiology of the Elderly.

Research Interests:
The Thompson laboratory is focused on elucidating cellular and molecular mechanisms responsible for age and inactivity-induced muscle dysfunction.  Current investigations are focused on skeletal muscle protein expression, post-translational chemical modifications of key muscle proteins, and the role of antioxidants.

Recent Publications with the last 3 years:

Xu, X, Chen, C-N, Arriaga, E.A. and L. V. Thompson.  Asymmetric superoxide release inside and outside the mitochondria in skeletal muscle under conditions of aging and disuse.  J Appl Physiol. 2010 Aug 5. [Epub ahead of print]

Xu, X, Thompson, L.V., Navratil, M., and E.A. Arriaga.  Analysis of superoxide production in single skeletal muscle fibers.  Analytical Chemistry, 1;82(11):4570-6, 2010.

Roe, M.R., McGowan, T., Thompson, L.V., and T.J. Griffin.  Targeted ¹⁸O-labeling for improved proteomic analysis of carbonylated peptides by mass spectrometry.  Journal of the American Society for Mass Spectrometry, 21(7):1190-203, 2010.

Chen, C-N, Brown-Borg, H., Rakoczy, S.G., Ferrington, D.A., and L.V. Thompson. Aging impairs the expression of glutamate cysteine ligase catalytic subunit in soleus muscle under stress. J Gerontol A Biol Sci Med Sci. 65(2):129-37, 2010.

Sanchez, O., Walseth, T., Snow, L.M., Serfass, R., and L.V. Thompson.  Skeletal muscle sorbitol levels in diabetic rats with and without insulin therapy and endurance exercise training.  Exp Diabetes Res. 2009;2009:737686. Epub 2009 Nov 23.

Lehman SL, L. V. Thompson. Skeletal muscle fatigue: the tortoise's advantage. Exerc Sport Sci Rev. 37(1):2, 2009.

Snow, L.M.and L.V. Thompson. Influence of insulin and muscle fiber type in N-carboxymethyl)lysine accumulation in soleus muscle of rats with streptozotocin-induced diabetes mellitus.  Pathobiology,76:227-234, 2009.

Feng, J., Xie, H., Meany, D.L., Thompson, L.V., Arriaga, E.A., and T.J. Griffin. Quantitative proteomic profiling of muscle type and age-dependent protein carbonylation in rat skeletal muscle mitochondria. J Gerontol A Biol Sci Med Sci. 63(11):1137-52, 2009.

Thompson, L.V. Age-related muscle dysfunction. Experimental Gerontology, 44(1-2):106-11, 2009.

Chen, C-N, Brown-Borg, H.M., Rakoczy, S.G. and L.V. Thompson. Muscle disuse: adaptation of antioxidant systems is age-dependent. Journals of Gerontology 63(5):461-466, 2008.

Arora, P., Husom, A.D., Ferrington, D.A., and L.V. Thompson. Age-dependent effects of treadmill exercise during a period of inactivity. Experimental Gerontology, Jul;43(7):668-73. Epub 2008 Mar 20, PMID: 18445515, 2008.

Feng, J., Navratil, M., Thompson, L.V., and E.A. Arriaga.  Estimating relative carbonyl levels in muscle microstructures by fluorescence imaging.  Analytical and Bioanalytical Chemistry,Aug;391(7):2591-8. Epub 2008 Jun 12, PMID: 18548236, 2008.

Feng, J., Navratil, M., Thompson, L.V., and E.A. Arriaga. Principal component analysis reveals age- and muscle-type related differences in protein carbonyl profiles of muscle mitochondria. J Gerontol A Biol Sci Med Sci. 63(12):1277-88, 2008.

Chen, C-N, Ferrington, D.A., and L.V. Thompson. Carbonic Anhydrase III and Four-and-a-Half LIM Protein 1 are preferentially oxidized with muscle hindlimb unloading.  Journal of Applied Physiology, 105(5):1554-61, 2008.

Prochniewicz, E, Lowe, D.A., Spakowicz,D., Higgins, L., O'Conor, K., Thompson, L.V., Ferrington, D.A., and D.D. Thomas. Functional, structural and chemical effects of hydrogen peroxide oxidation of muscle fibers: an in vitro model of muscle aging. American Journal of Physiology, Cell, 294: C613-C626, 2008.

Prochniewicz, E, Thompson, L.V. and D.D. Thomas Age-related decline in actomyosin structure and function, Experimental Gerontology 42(10):931-8, 2007.

Harrison, A., Anderson, B., Thompson, L.V., L.K. McLoon. Three-dimensional localization of neuromuscular junctions in normal and botulinum toxin treated adult extraocular muscles. Invest Ophthalmol Vis Sci. 48:3594–3601, 2007.

Snow, L.M., Fugere, N.A., and L.V. Thompson. N-carboxymethyl)lysine (CML) accumulation and associated protein modification in skeletal muscle with aging. Journals of Gerontology, 62 (11):1204-1210, 2007.

Zhong, S. and L.V. Thompson.  The roles of myosin ATPase activity and myosin light chain content in the slowing of type II fibers with hindlimb unweighting. Am. J. Physiol. - Cell. 293: C723-C728, 2007.

Meany, D., Xie, H., Thompson, L.V., Arriaga, E.A., and Griffin, T.J.  Identification of carbonylated proteins from enriched rat skeletal muscle mitochondria using affinity chromatography-stable isotope labeling and tandem mass spectrometry.  Proteomics 7:1150-1163, 2007.

Meany, D., Thompson, L.V., and Arriaga, E.A.  Simultaneously monitoring the superoxide in the mitochondrial matrix and extramitochondrial space by micellar electrokinetic chromatography with laser-induced fluorescence.  Analytical Chemistry 79(12) pp 4588-4594, 2007.

Prochniewicz, E, Thompson, L.V. and D.D. Thomas.  Age-related decline in actomyosin structure and function, Experimental Gerontology 42(10):931-8, 2007.

Current Funded Research:

NIH, R01: Structural and Calcium Regulatory Protein in Sarcopenia 2001-2013

NIH, T32: Training Grant: Functional Proteomics of Aging 2008-2013

NIH, R01 ARRA Supplement: Structural and Calcium Regulatory Protein in Sarcopenia 2009-2010