LaDora V. Thompson, PhD, BS PT
LADORA V. THOMPSON, PhD, BS PT
Program in Physical Therapy, University of Minnesota
366 Children's Rehab Center
Director of the Program in Physical Therapy
University of Wisconsin, B.A. in Education, Marquette University, B.S. in Physical Therapy; Marquette University, Ph.D. in Biological Sciences (Muscle Physiology).
Theory of Therapeutic Exercise; Biology of Aging, Exercise Physiology of the Elderly.
The Thompson laboratory is focused on elucidating cellular and molecular mechanisms responsible for age and inactivity-induced muscle dysfunction. Current investigations are focused on skeletal muscle protein expression, post-translational chemical modifications of key muscle proteins, and the role of antioxidants.
Recent Publications with the last 3 years:
Xu, X, Chen, C-N, Arriaga, E.A. and L. V. Thompson. Asymmetric superoxide release inside and outside the mitochondria in skeletal muscle under conditions of aging and disuse. J Appl Physiol. 2010 Aug 5. [Epub ahead of print]
Xu, X, Thompson, L.V., Navratil, M., and E.A. Arriaga. Analysis of superoxide production in single skeletal muscle fibers. Analytical Chemistry, 1;82(11):4570-6, 2010.
Roe, M.R., McGowan, T., Thompson, L.V., and T.J. Griffin. Targeted 18O-labeling for improved proteomic analysis of carbonylated peptides by mass spectrometry. Journal of the American Society for Mass Spectrometry, 21(7):1190-203, 2010.
Chen, C-N, Brown-Borg, H., Rakoczy, S.G., Ferrington, D.A., and L.V. Thompson. Aging impairs the expression of glutamate cysteine ligase catalytic subunit in soleus muscle under stress. J Gerontol A Biol Sci Med Sci. 65(2):129-37, 2010.
Sanchez, O., Walseth, T., Snow, L.M., Serfass, R., and L.V. Thompson. Skeletal muscle sorbitol levels in diabetic rats with and without insulin therapy and endurance exercise training. Exp Diabetes Res. 2009;2009:737686. Epub 2009 Nov 23.
Lehman SL, L. V. Thompson. Skeletal muscle fatigue: the tortoise's advantage. Exerc Sport Sci Rev. 37(1):2, 2009.
Snow, L.M.and L.V. Thompson. Influence of insulin and muscle fiber type in N-carboxymethyl)lysine accumulation in soleus muscle of rats with streptozotocin-induced diabetes mellitus. Pathobiology,76:227-234, 2009.
Feng, J., Xie, H., Meany, D.L., Thompson, L.V., Arriaga, E.A., and T.J. Griffin. Quantitative proteomic profiling of muscle type and age-dependent protein carbonylation in rat skeletal muscle mitochondria. J Gerontol A Biol Sci Med Sci. 63(11):1137-52, 2009.
Thompson, L.V. Age-related muscle dysfunction. Experimental Gerontology, 44(1-2):106-11, 2009.
Chen, C-N, Brown-Borg, H.M., Rakoczy, S.G. and L.V. Thompson. Muscle disuse: adaptation of antioxidant systems is age-dependent. Journals of Gerontology 63(5):461-466, 2008.
Arora, P., Husom, A.D., Ferrington, D.A., and L.V. Thompson. Age-dependent effects of treadmill exercise during a period of inactivity. Experimental Gerontology, Jul;43(7):668-73. Epub 2008 Mar 20, PMID: 18445515, 2008.
Feng, J., Navratil, M., Thompson, L.V., and E.A. Arriaga. Estimating relative carbonyl levels in muscle microstructures by fluorescence imaging. Analytical and Bioanalytical Chemistry,Aug;391(7):2591-8. Epub 2008 Jun 12, PMID: 18548236, 2008.
Feng, J., Navratil, M., Thompson, L.V., and E.A. Arriaga. Principal component analysis reveals age- and muscle-type related differences in protein carbonyl profiles of muscle mitochondria. J Gerontol A Biol Sci Med Sci. 63(12):1277-88, 2008.
Chen, C-N, Ferrington, D.A., and L.V. Thompson. Carbonic Anhydrase III and Four-and-a-Half LIM Protein 1 are preferentially oxidized with muscle hindlimb unloading. Journal of Applied Physiology, 105(5):1554-61, 2008.
Prochniewicz, E, Lowe, D.A., Spakowicz,D., Higgins, L., O'Conor, K., Thompson, L.V., Ferrington, D.A., and D.D. Thomas. Functional, structural and chemical effects of hydrogen peroxide oxidation of muscle fibers: an in vitro model of muscle aging. American Journal of Physiology, Cell, 294: C613-C626, 2008.
Prochniewicz, E, Thompson, L.V. and D.D. Thomas Age-related decline in actomyosin structure and function, Experimental Gerontology 42(10):931-8, 2007.
Harrison, A., Anderson, B., Thompson, L.V., L.K. McLoon. Three-dimensional localization of neuromuscular junctions in normal and botulinum toxin treated adult extraocular muscles. Invest Ophthalmol Vis Sci. 48:3594–3601, 2007.
Snow, L.M., Fugere, N.A., and L.V. Thompson. N-carboxymethyl)lysine (CML) accumulation and associated protein modification in skeletal muscle with aging. Journals of Gerontology, 62 (11):1204-1210, 2007.
Zhong, S. and L.V. Thompson. The roles of myosin ATPase activity and myosin light chain content in the slowing of type II fibers with hindlimb unweighting. Am. J. Physiol. - Cell. 293: C723-C728, 2007.
Meany, D., Xie, H., Thompson, L.V., Arriaga, E.A., and Griffin, T.J. Identification of carbonylated proteins from enriched rat skeletal muscle mitochondria using affinity chromatography-stable isotope labeling and tandem mass spectrometry. Proteomics 7:1150-1163, 2007.
Meany, D., Thompson, L.V., and Arriaga, E.A. Simultaneously monitoring the superoxide in the mitochondrial matrix and extramitochondrial space by micellar electrokinetic chromatography with laser-induced fluorescence. Analytical Chemistry 79(12) pp 4588-4594, 2007.
Prochniewicz, E, Thompson, L.V. and D.D. Thomas. Age-related decline in actomyosin structure and function, Experimental Gerontology 42(10):931-8, 2007.
Current Funded Research:
NIH, R01: Structural and Calcium Regulatory Protein in Sarcopenia 2001-2013
NIH, T32: Training Grant: Functional Proteomics of Aging 2008-2013
NIH, R01 ARRA Supplement: Structural and Calcium Regulatory Protein in Sarcopenia 2009-2010