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  Home > Faculty and Staff > LaDora V. Thompson, PhD, BS PT
 

LaDora V. Thompson, PhD, BS PT

Dr. Ladora Thompson

LADORA V. THOMPSON, PhD, BS PT
Program in Physical Therapy, University of Minnesota
366 Children's Rehab Center
612-626-5271
thomp067@umn.edu

Position:
Director of the Program in Physical Therapy
Professor

Education:
University of Wisconsin, B.A. in Education, Marquette University, B.S. in Physical Therapy; Marquette University, Ph.D. in Biological Sciences (Muscle Physiology).

Teaching Responsibilities:
Theory of Therapeutic Exercise; Biology of Aging, Exercise Physiology of the Elderly.

Research Interests:
The Thompson laboratory is focused on elucidating cellular and molecular mechanisms responsible for age and inactivity-induced muscle dysfunction.  Current investigations are focused on skeletal muscle protein expression, post-translational chemical modifications of key muscle proteins, and the role of antioxidants.

Recent Publications with the last 3 years:

  1. Liu, H., Graber, T.G., Ferguson-Stegall, L., and L.V. Thompson, Clinically-relevant frailty index for mice. Journals of Gerontology: Biological Sciences, 2013 Dec 13. PMID: 24336799.

  2. Graber, T.G., Ferguson-Stegall, L., Kim, J.H., and L.V. Thompson. C57BL/6 Neuromuscular Healthspan Scoring System. Journals of Gerontology: Biological Sciences, 2013 Nov;68(11):1326-36. Doi: 10.1093/Gerona/glt032. PMID: 23585418

  3. Chen, C-N and L.V. Thompson. Interplay between aging and unloading on oxidative stress in fast-twitch muscles. J. Gerontol A Biol Sci Med Sci. 2013 Jul;68(7):793-802. Doi:10.1093/Gerona/gls240. PMID 23213028

  4. Romanick, M., Thompson, L.V., and H.M. Brown-Borg. Murine models of atrophy, cachexia, and sarcopenia in skeletal muscle. Biochim Biophys Acta. 2013 Mar 20. Doi:pii:S0925-4439(13)00085-0. 10.1016. PMID: 23523469

  5. Kim, J.H., Kwak, H.B., Thompson, L.V., and J.M. Lawler. Contribution of oxidative stress to pathology in diaphragm and limb muscles with Duchenne muscular dystrophy. J. Muscle Res Cell Motil. DOI 10.1007/s10974-012-9330-9. PMID: 23104273

  6. Kim, J.H., Torgerud, W.S., Mosser, K.H.H., Hirai, H., Watanabe, S., Asakura, A. and L.V. Thompson.  Myosin light chain 3f attenuates age-induced decline in contractile velocity in MHC type II single muscle fibers Aging Cell 11(2):203-12, 2012. DOI: 10.1111/j.1474-9726.2011.00774. PMID:22103752.

  7. Snow, L.M., Low, W.C., and L.V. Thompson. Skeletal muscle plasticity after hemorrhagic stroke: influence of spontaneous physical activity. Am J Phys Med Rehabil. 2012 Nov;91(11):965-76. Doi:10.1097/PHM.0b013e31825f18e1. PMID: 22760110

  8. Kim, J.H. and L.V. Thompson. Inactivity, age, and exercise: single fiber power generation. J Appl Physiol. 2013 Jan;114(1):90-8. doi: 10.1152/japplphysiol.00525.2012. Epub 2012 Oct 25. PMID: 23104693

  9. Templeton, D.L., Mosser, K.H.H., Chen CN, Stone, M.D., John, R., Dengel, D.R., and L.V. Thompson.  Effects of left ventricular assist devisce (LVAD) placement on myocardial oxidative stress markers.  Heart, Lung, and Circulation 2012 Sep;21(9):586-97. Epub 2012 May 29. PMID: 22647559

  10. Kim, J.H. and L.V. Thompson. Differential effects of mild therapeutic exercise during a period of inactivity on power generation in soleus type I single fibers with age. J Appl Physiol. 112(10):1752-61, 2012. PMID: 22422796

  11. Kostal, V., Leva, K., Swift, M., Skillrud, E., Chapman, M., Thompson, L.V., and E.A. Arriaga.  Semi-automated image analysis:  detecting carbonylation in subcellular regions of skeletal muscle.  Analytical and Bioanalytical Chemistry. 400(1):213-22, 2011.

  12. McLoon, L.K., Park, H., Kim, J.H., Pedrosa-Domellöf, F. and L.V. Thompson.  A continuum of myofibers in adult rabbit extraocular muscle:  force, shortening velocity, and patterns of myosin heavy chain co-localization. J Appl Physiol 111:1178-1189, 2011. PMCID: PMC3191789

  13. Thompson, L.V. Seeking the fountain of youth.  Exerc Sport Sci Rev. 2011 Jul;39(3):112. PMID: 21701280

  14. Chen, C-N, Brown-Borg, H., Rakoczy, S.G., Ferrington, D.A., and L.V. Thompson. Aging impairs the expression of glutamate cysteine ligase catalytic subunit in soleus muscle under stress.  J Gerontol A Biol Sci Med Sci., 65(2):129-37, 2010. PMID: 20018823

  15. Roe, M.R., McGowan, T., Thompson, L.V., and T.J. Griffin. Targeted 18O-labeling for improved proteomic analysis of carbonylated peptides by mass spectrometry.  Journal of the American Society for Mass Spectrometry, 21(7):1190-203, 2010. PMID: 20434358

  16. Xu, X, Chen, C-N, Arriaga, E.A. and L. V. Thompson. Asymmetric superoxide release inside and outside the mitochondria in skeletal muscle under conditions of aging and disuse.  J Appl Physiol. 109(4):1133-9, 2010. PMID: 20689097

  17. Xu, X., Thompson, L.V., Navratil, M., and E.A. Arriaga.  Analysis of superoxide production in single skeletal muscle fibers.  Analytical Chemistry, 1;82(11):4570-6, 2010. PMID: 20446672

 

Current Funded Research: 

NIH, R01: Structural and Calcium Regulatory Protein in Sarcopenia 2001-2013

NIH, T32: Training Grant: Functional Proteomics of Aging 2008-2013

NIH, R01 ARRA Supplement: Structural and Calcium Regulatory Protein in Sarcopenia 2009-2010

 

 

 

 

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