Immunological (Rejection) Loss by Category and Duct Management, International Pancreas Transplant Registry at the University of Minnesota

FOR 2000-2004 US CASES

Rejection loss at 1 year was slightly lower but not significant, for US ED vs. BD in SPK (2.3 % vs. 3.1%) and PAK (6.6% vs. 9.0%).  However, the ED 1 year rejection loss rate in PTA was significantly higher, 14.6% vs. 5.4% (p=0.03). By multivariate analysis, only PAK BD vs. ED had a higher HR risk for rejection loss (Table 5).

Table 5.    Cox – regression for immunological pancreas graft failure (technically successful US DD primary pancreas transplants 1/1/2000 – 6/2004)

Variables

SPK

PAK

PTA
    p          RR*    p        RR*    p       RR* 
Large vs. Small Centers   0.17       1.43 0.51        - 0.15     3.08
BD vs. ED 0.71         - 0.007     2.53 0.30       -
Donor Risk vs. None 0.57         - 0.12       1.60 0.28       -
HLA A: 2 vs. 1&0 MM 0.005      2.08 0.11       1.61 0.86       -
HLA B: 2 vs. 1&0 MM 0.62         - 0.48        - 0.09      2.17
Receipient Age
15-29 yrs vs. 30-44 yrs
≥45 yrs vs. 30-44 yrs		 0.46
0.06       0.58		 0.48      
0.03       0.45		 0.32       -
0.04     0.33
Deplet. AB Therapy 0.32         - 0.13       0.57 0.91       -
Nondepl. AB Therapy 0.09      0.63 0.28         - 0.89       -
TAC&MMF vs. Other 0.75         - 0.02       0.46 0.38       -
SIR vs. None 0.16       0.51 0.17       0.36    -          -

Previous page / Next page / Index

©2002 Regents of the University of Minnesota. All rights reserved.

The University of Minnesota is an equal opportunity educator and employer.

Last modified on Tuesday Aug 29, 2006

This page is located at http://www.med.umn.edu//IPTR/annual_reports/2004_annual_report/12_imm_ther_ini_maint.html