Jennifer Hall, Ph.D., Division of Cardiology in the Department of Medicine at the University of Minnesota

Associate Professor of Medicine
Director, Program in Translational Cardiovascular Genomics Division of Cardiology, Department of Medicine Lillehei Heart Institute, University of Minnesota Developmental Biology Center, University of Minnesota Microbiology, Immunology, and Cancer Biology PhD Program, MICaB Visiting Scientist, BROAD Institute of MIT and Harvard, Cambridge, MA

Specialties
Cardiovascular genomics, vascular biology

Ph.D.
University of California at Berkeley

PostDoc
Stanford and Brigham and Women’s Hospital, Harvard Medical School

Our interest is to identify the biological function of risk loci that are associated with cardiovascular disease and diabetes. Our laboratory incorporates genome wide association data, clinical studies, tissue specific gene expression from banked genotyped human specimens, and data from model organisms and cells. We are currently focused on identifying the biological function of a mutation in the gene TCF7L2 that increases risk for type 2 diabetes.

Please click here to view Dr. Hall's Laboratory.

Publications
Hall JL, Birks EJ, Rider J, Grindle S, Barton P, Mariash A, Charles N, Dyke DB, Pagoni F, Yacoub MH. Miller LW. Molecular signature of recovery following left ventricular assist device (LVAD) support (accepted for publication, Eur H J).

Basi D, Adhikari N, Mariash A, Li Q, Kao E, Mullegama S, Hall JL. Femoral artery neointimal hyperplasia is reduced after wire injury in Ref-1 (+/-) mice. Epub Am J Physiol Heart and Circ.

Cullen ME, Yuen AH, Felkin LE, Smolenski RT, Hall JL, Grindle S, Miller LW, Birks EJ, Yacoub MH, Barton PJ. Myocardial expression of the arginine:glycine amidinotransferase gene is elevated in heart failue and normalized after recovery: potential implications for local creatine synthesis. Circulation 4:114(I Suppl):I16-20, 2006.

Wang X, Li Q, Adhikari N, Hall JL. A role for muscle LIM protein (MLP) in vascular remodeling. J Mol Cell Cardiol. 40(4):503-9, 2006.

Adhikari N, Mariash A, McCue JD, Mullegama S, Helig C, Brosius F, Hall JL. A genetic approach to disssecting the role of glucose in vascular remodeling. Circulation 12(17);11-33:255, 2005.

Barton PJR, Felkin LE, Birks EJ, Cullen ME, Banner NR, Grindle S, Hall JL, Miller LW, Yacoub MH. Myocardial IGF-1 gene expression during recovery from heart failure following combined LVAD and clenbuterol therapy. Circulation 12 (suppl 9), I46-50, 2005.

Birks EJ, Hall JL, Barton PJR, Grindle S, Latif N, Hardy JP, Banner NR, Khaghani A, Miller LW, Yacoub MH. Gene profiling changes in cytoskeletal proteins during clinical recovery following left ventricular assist device (LVAD) support. Circulation 112(suppl 9), 2005.

Guan Z, A Mariash, X Wang, Q Li, Hall JL. Redox factor 1 is a critical mediator governing NF-kB and A20 regulation in the vascular endothelium. Arterioscler Thromb Vasc Biol. 25:96-101, 2005.

Kittleson MM, Ye SQ, Irizarry RA, Minhas KM, Edness G, Conte JV, Parmigiani G, Miller LW, Chen Y, Hall JL, Garcia JG, Hare JM. Identification of a gene expression profile that differentiates between ischemic and nonischemic cardiomyopathy. Circulation 110:3344-51, 2004.

Wang X, Adhikari N, Li Q, Hall JL. The LDL receptor related protein LRP6 regulates proliferation and survival through the Wnt cascade in vascular smooth muscle cells. AJP Heart 287(6):H2376-H2383, 2004.

Wang XH, Adhikari N, Li Q, Mariash A, Guan Z, Hall JL. The role of beta-transducin repeat containing protein in the regulation of NF-kB in vascular smooth muscle cells. Arterioscler Thromb Vasc Biol. 24:85-90, 2004.

Huebert RC, Li Q, Adhikari N, Charles NJ, Han X, Ezzat MK, Grindle S, Park S, Ormaza S, Fermin D, Miller LW, Hall JL. Identification and regulation of Sprouty1, a negative inhibitor of the ERK cascade, in the human heart. Physiological Genomics.18:284-289, 2004.

Huang, X, Pan W, Park S, Han X, Chen Y, Miller LW, Hall JL. Modeling the relationship between LVAD support time and gene expression changes in the human heart by penalized partial least squares. Bioinformatics, 20(6):888-94, 2004.

Hall JL, Grindle S, Han X, Fermin D, Park S, Chen Y, Bache RJ, Mariash A, Guan Z, Ormaza S, Thompson J, Graziano J, de Sam Lazaro S, Pan S, Simari RD, Miller LW. Genomic profiling of the human heart before and after mechanical support with a ventricular assist device reveals alterations in vascular signaling networks. Physiol Genomics 17:283-291, 2004.

Chen Y, Park S, Li Y, Missov E, Hou M, Han X, Hall JL, Miller LW, Bache RJ. Alterations of gene expression in the failing myocardium following left ventricular assist device support. Physiol Genomics 14:251-260, 2003.

Hall JL, Gibbon GH, Chatham JC. IGF-I promotes a shift in metabolic flux in vascular smooth muscle cells. Am J Physiol Endocrinol Metab 283:E465-71, 2002.

Wang XH, Xiao Y, Zhao Y, Hall JL. A role for the beta-catenin and T cell factor 4 (Tcf-4) signaling cascade in vascular remodeling. Circ Res 90:340-7, 2002.

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Last modified on Friday Jun 25, 2004

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