Professor of Medicine and Biomedical Engineering
Director, NIH Funded Laboratory of Cardiac Energetics and Laboratory of Cellular Therapy for Cardiac Failure, Division of Cardiology
Medical School: Shanghai Medical University, Shanghai, PRC
Ph.D.: Master of Science, School of Engineering, Tufts University, Medford, Massachusetts; Biomedical Engineering, Institute of Technology Graduate School, University of Minnesota, Minneapolis, Minnesota
Post-doctoral: Cardiology, University of Minnesota, Minneapolis, Minnesota
Research Interests: Myocardial energetics in heart with LV remodeling and congestive heart failure.
I received an Established Investigator Award from American Heart Association (AHA) and First Award from National Institutes of Health (NIH). Currently, I am principal investigator (PI) of three RO1 grants from NIH, and Co-PI of four RO1 grants. Over the years, our research lab has trained 30 trainees (PhD, Post-Doc, residents, and cardiology fellows) and I am currently advisor to four students earning their PhD in Biomedical Engineering.
Professional Organizations: American Physiological Society, American Heart Association, Society of Magnetic Resonance in Medicine, American Physiological Society. Reviewer on NIH SCCOR grant review panel, Special Review Committee (for PPG), and other study sections; Ad Hoc Scientific Journal Reviewer for Circulation, American Journal of Physiology and Diabetes.
Publications:
Park SJ, Zhang J, Ye Y, Ormaza S, Liang P, Bank AJ, Miller LW, Bache RJ. Myocardial creatine kinase expression after left ventricular assist device support. J Am Coll Card 2002;39:1773-1779.
Murakami Y, Wu X, Zhang J, Ochiai K, Bache R, Shimada T. Nicorandil improves myocardial high-energy phosphates in postinfarction porcine hearts. Clin Exp Pharm Phys 2002;29:639-645.
Gong G, Liu J, Liang P, Guo T, Hu Q, Ochiai K, Hou M, Ye Y, Wu X, Mansoor A, From AHL, Ugurbil K, Bache RJ, Zhang J. Oxidative capacity in failing hearts. Am J Physiol 2003 285(2):H541-8.
Zhang J, Ugurbil K, From AHL, Bache RJ. Myocardial Oxygenation and High Energy Phosphate Levels During KATP Channel Blockade. Am J Physiol Heart Circ Physiol 2003;285:H1420-H1427.
Gourine A, Hu Q, Sander P, Kuzmin A, Hanafy N, Davydova S, Zaretsky D, Zhang J. Interstitial purine metabolites in hearts with LV remodeling. Am J Physiol 2004;286:H677-H684.
Zhang J, Narula J. Molecular biology of myocardial recovery. Surg Clin N Am 2004;84:223-242.
Liu J, Hu Q, Wang ZL, Xu C, Gong G, Mansoor A, Hou M, Zeng L, Zhang JR, Jerosch-Herold M, Guo T, Bache RJ, Zhang J. Autologous stem cell therapy in myocardial infarcts. Am J Physiol;2004 287:H501-511.
Zhang J, Gong G, Ye Y, Guo T, Mansoor A, Hu Q, Ochiai K, Liu J, Wang X, Cheng Y, Iverson N, Lee J, From AHL, Ugurbil K, Bache, R. Nitric Oxide Regulation of Myocardial O2 Consumption and HEP Metabolism. Am J Physiol Heart Circ Physiol;2005;288:H310-H316.
Portman MA, Zhang J. Myocardial Energy Transport and Heart Failure. Current Cardiology Reviews, 2005;1(1):17-27.
Zhang G, Xiaohong W, Zongli W, Zhang J, Suggs L. A PEGylated Fibrin Patch for Mesenchymal Stem Cell. Tissue Engineering Tissue Eng. 2006 Jan;12(1):9-19.
Wang X, Hu Q, Mansoor A, Lee J, Wang Z, Xu C, Liu J, Lee T, Arthur From, Zhang J. Bioenergetic and Functional Consequences of Transplanting VEGF Overexpressing Mesenchymal Stem Cells into LVH Hearts. Am J Physiol Heart Circ Physiol. 2006 (in press)
Ochiai K, Hu Q, Lee J, Mansoor A, Liu J, Wang X, Gong G, Murakami Y, Ishibashi Y, Shimada T, Zhang J. Functional and Bioenergetic Consequences of AT1 Antagonist Olmesartan Medoxomil in Hearts with Postinfarction LV Remodeling. Journal of Cardiovascular Pharmacology 2006; 47 (5): 686-694
Hu Q, Wang X, Lee J, Mansoor A, Wang Z, From AH, Bache, RJ, Zhang J. Profound Bioenergetic Abnormalities in Peri-infarct Myocardial Regions. Am J Physiol Heart Circ Physiol (March 31, 2006). doi:10.1152/ajpheart.01387.2005
Lee J, Hu Q, Nakamura Y, Wang Z, Chen W, QL Yong, Zhang J. Open-chest 31P Magnetic Resonance Spectroscopy of Mouse Heart at 4.7 Tesla. JMRI 2006 (in press)
Wang X, Hu Q, Mansoor A, Lee J, Wang Z, Lee T, From AH, Zhang J. Bioenergetic and functional consequences of stem cell-based VEGF delivery in pressure-overloaded swine hearts. Am J Physiol Heart Circ Physiol. 2006 Apr;290(4):H1393-405
Wang X, Hu Q, Nakamura Y, Lee J, Zhang G, From AH, Zhang J. The Role of Sca-1+/CD31- Cardiac Progenitor Cell Population in Postinfarction LV Remodeling. Stem Cells. 2006 ;24:1779-1788
Zeng L, Rahrmann E, Hu Q, Zhang J, Verfaillie C. Multi-potent adult progenitor cells from swine bone marrow. Stem Cells 2006; published online Aug 24, 2006)
Zhang G, Nakamura Y, Wang X, Hu Q, Suggs L, Zhang J. Controlled Release of Stromal Cell Derived. Factor-1α in situ Increases Stem Cell Homing to the Infarcted Heart. Tissue Engineering (in press).