Perry Hackett, Ph.D., Institute of Human Genetics at the University of Minnesota

Professor
Developmental Biology and Genetics
Department of Genetics, Cell Biology and Development
University of Minnesota
1445 Gortner Avenue
St. Paul, MN 55108-1095
Phone: (612) 624-6736
Fax: (612) 625-5754
e-mail: perry@cbs.umn.edu website

Lab Photos

1. Sleeping Beauty-Mediated Gene Therapy

Website

http://biosci.cbs.umn.edu/labs/perry/

Recent Publications

• Wilber, A., J.L. Frandsen, A.M. Geurts, D.A. Largaespada, P.B. Hackett, and R.S. McIvor (2006). RNA as a source of transposase for Sleeping Beauty-mediated gene insertion and expression in somatic cells and tissues. Mol Ter. 13: 625-630.
• Geurts*, A.M., C.S. Hackett*, J.B. Bell, T.L. Bergemann, C.M. Carlson, L.S. Collier, D.A. Largaespada and P.B. Hackett (2006). Structure-based prediction of insertion-site preferences of transposons into chromatin. Nucl. Acids Res. 34: 2803-2811.
• Geurts, A.M., A.C. Wilber, C.M. Carlson, P.D. Lobitz, K.J. Clark, P.,B. Hackett, R.S. McIvor, D.A. Largaespads (2006). Conditional gene expression in the mouse using a Sleeping Beauty gene-trap transposon. BMC Biotech 6(1): 30.
• Balciunas, D., K.J. Wagensteen, A.C. Wilber, J.B. Bell, A.M. Geurts, S. Sivasubbu, X. Wang, P.B. Hackett, D.A. Largaespada, R.S. McIvor, and S.C. Ekker (2006). Harnessing an efficient large cargo-capacity transposon for vertebrate gene transfer applications. PLoS Genetics. 4: e169.
• Hackett, P.B. (2007). Integrating DNA vectors for gene therapy. Mol. Ther. 15: 10-12.
• Aronovich, E.L., J.B. Bell, L.R. Belur, R. Gunther, B. Koniar, D.C. Erickson, P.A. Schachern, R.S. McIvor, C.B. Whitley and P.B. Hackett (2007). Sleeping Beauty transposon-mediated gene therapy of murine mucopolysaccharidosis. J. Gene Med. 9: 403-415.
• Hackett, C.S., A.M. Geurts and P.B. Hackett (2007). Predicting DNA vector insertion sites: Implications for functional genomics and gene therapy. Genome Biol. 8 (Suppl 1): S12.
• Bell, J.B., K. Podetz-Pedersen, E.L. Aronovich, L. Belur, R.S. McIvor and P.B. Hackett (2007). Preferential delivery of the Sleeping Beauty transposon system to livers of mice by hydrodynamic injection. Nature Protocols 2 (12): 3153-3165.