Ophthalmic Research
Dale S. Gregerson, Ph.D., Professor,
Department of Ophthalmology
Office Phone 612-626-0772
Lab Phone (612) 626-0773,
Fax (612) 626-0781
grege001@umn.edu
Dale S. Gregerson, Ph.D., is a Professor at the University of Minnesota in the Department of Ophthalmology. He is also a member of the Program in Microbiology, Immunology & Cancer Biology (MICaB). Dr. Gregerson did his post-doctoral studies at Yale University in the School of Medicine and was subsequently appointed to Assistant Professor in the Department of Ophthalmology and Visual Science in the School of Medicine at Yale University. Since 1983, he has been an Assistant Professor, Associate Professor and Professor at the University of Minnesota. Dr. Gregerson holds a B.A. in Biology from Luther College, Decorah, IA, and a Ph.D. in Microbiology from the University of British Columbia, Vancouver. He leads a team of scientists examining basic mechanisms of immunology, especially in ocular immunology and autoimmune disease. He has approximately 95 publications and one patent in his name. Dr. Gregerson has served on several NIH Study Sections and has been a technical consultant to venture capital fund managers and various biotechnology companies
Areas of Research Strength:
Immunology
Neuroscience
Cell interactions
Selected Publications:
Gregerson, D.S. and Kawashima, H. APC derived from donor splenocytes support retinal autoimmune disease in allogeneic recipients. J. Leukocyte Biol. 76:383-387, 2004.
Gregerson, D.S., Sam, T.N., and McPherson, S.W. The antigen presenting activity of fresh, adult parenchymal microglia and perivascular cells from retina. J. Immunol. 172:6587-6597, 2004.
McPherson, S.W., Yang, J., Chan, C.-C., Dou, C. and Gregerson, D.S. Resting CD8 T cells recognize beta-galactosidase expressed in the immune privileged retina, and mediate autoimmune disease when activated. Immunol. 110:386-396, 2003.
Gregerson, D.S. and Yang, J. CD45-positive cells of the retina and their responsiveness to in vivo and in vitro treatment with IFN-gamma or anti-CD40. Invest. Ophthalmol.Vis. Sci. 44:3083-3093, 2003.
Dinges, M.M., Gregerson, D.S., Tripp, T.J., McCormick, J.K. and Schlievert, P.M. Effects of total body irradiation and cyclosporin A on the lethality of toxic shock syndrome toxin-1 in rabbits. J. Infect. Dis.188:1142-1145, 2003.
Gregerson, D.S. and Dou, C. Spontaneous induction of immunoregulation by an endogenous retinal antigen. Invest. Ophthalmol. Vis. Sci. 43:2984-2991, 2002.
Gregerson, D.S. Peripheral expression of ocular antigens in regulation and therapy of ocular autoimmunity. Int. Rev. Immunol. 21:101-122, 2002.
Gregerson, D.S. and Xiao, J. Failure of memory (CD44 high) CD4 T cells to recognize their target antigen in retina. J. Neuroimmunol. 120:34-41, 2001.