Denis R. Clohisy, M.D. -- Recent Publications (Last Five Years), Department of Orthopaedic Surgery in the Medical School at the University of Minnesota

Clohisy DR and Ramnaraine ML: Evaluation of Mutant Mouse Production by Mice that are Heterogenous for the M-CSF/op Gene, Laboratory Animal Science 48:3, 300-302,1998.

Clohisy DR, Ramnaraine ML: Osteoclasts are Required for Tumors to Grow and Destroy Bone, J. Ortho. Res. 16(6):660-666, 1998.

Clohisy DR, section editor for Common Tumors, Craig's Textbook of Orthopaedic Surgery, Williams & Wilkins Pub, 965-1004, 1999.
Clohisy DR: Management of Skeletal Metastasis, chapter in Clinical Orthopaedics, edited by Edward V. Craig, Lipincott Williams & Wilkins Pub., 994-997, 1999.

Clohisy DR: Could apoptosis be responsible for localized imbalances in bone cell homeostasis? Invited editorial, J Lab Clin Med, Sep; 134(3): 190-1, 1999.

McGrath B, Scarborough MT and Clohisy DR: Malignant Bone Tumors, chapter in Craig's Clinical Orthopaedics, Lippincott Williams & Wilkins Pub., 988-993, 1999.

Schwei MJ, Honore P, Rogers SD, Salak-Johnson JL, Finke MP, Luger NM, Ramnaraine ML, Nichols ML, Clohisy DR, and Mantyh PW. Reorganization of the neurochemistry of the spinal cord in a murine model of bone cancer pain. J. Neurosci 19(24): 10886-97, 1999.

Clohisy DR, Le CT, Cheng EY, Dykes DC, Thompson RC Evaluation of Feasibility and Results of Measuring Health Status Changes in Patients Undergoing Surgical Treatment for Skeletal Metastases, J Orth Res, 18:1-9, 2000.

Clohisy DR, Ly T, Thompson R: Internal Fixation of Large Segment Allografts Using Plates Augmented with Cerclage Wires Yields Poor Results, Clin Orth Rel Res No 371, 198-205, 2000.

Clohisy DR, Perkins SL, Ramnaraine ML: Review of cellular mechanisms of tumor osteolysis. Clin Orth Rel Res, 373, 104-114, 2000.

Clohisy DR, Ramnaraine ML, Scully S, Qi M, Van G, Tan HL, Lacey DL: Osteoprotegerin inhibits tumor-induced osteoclastogenesis and bone tumor growth in osteopetrotic mice. Journal of Orthopaedic Research, 18: 967-976, 2000.

Clohisy DR: Growth and Metastasis of Musculoskeletal Tumors chapter in Orthopaedic Basic Science, 2nd Edition, edited by Buckwalter, Einhorn & Simon, published by AAOS, 427-442, 2000.

Clohisy, D.R.; Le, C.T.; Cheng, E.Y.; Dykes, D.C.; Thompson, R.C.: Evaluation of the Feasibility of and Results of Measuring Health Status Changes in Patients Undergoing Surgical Treatment for Skeletal Metastases.. J. Orth Res., 18:1-9, 2000.

Honore P, Sabino M, Schwei M, Rogers S, Mach D, O'Keefe P, Ramnaraine ML, Clohisy DR, Mantyh P: Osteoprotegerin blocks bone cancer-induced skeletal destruction, skeletal pain, and pain-related neurochemical reorganization of the spinal cord. Nature Medicine, 6(5): 521-527, 2000.

Honore P, Schwei J, Rogers SD, Salak-Johnson JL, Finke MP, Ramnaraine ML, Clohisy DR, Mantyh PW. Cellular and neurochemical remodeling of the spinal cord in bone cancer pain. Prog Brain Res, 129: 389-397, 2000.

Honore, P., Rogers, S.D., Schwei, M.J., Salak-Johnson, J.L., Luger, N.M., Sabino, M-A.C., Nichols, M.L., Clohisy, D.R. and Mantyh, P.W.: Murine models of inflammatory, neuropathic, and cancer pain each generates a unique set of neurochemical changes in the spinal cord and sensory neurons. Neuroscience, 98: 585-598, 2000.

Thompson RC, Garg A, Clohisy DR, Cheng EY: Fractures in Large Segment Allografts, Clin Orth Rel Res, No. 370, 227-235, 2000.
Thompson, R. C.: Invited Commentary. Principles & Practice in Geriatric Surgery. eds Rosenthal, Zenilman and Katlic, 847-849, Springer-Verlag New York, Inc., 2000.

Thompson, R.C.; Garg, A.; Clohisy, D.R.; Cheng, E.Y.: Fractures in Large Segment Allografts. Clin. Orthop.370:227-235, 2000.
Thompson, R.C.; Garg, A; Goswitz, J; Cheng, E.Y.; Clohisy, D.R.; Dusenbery, K.: Synovial Sarcoma: Large Size Predicts Poor Outcome. Clin. Orthop 373:18-24, 2000.

Wacnik PW, Wilcox GL, Clohisy DR, Ramnaraine ML, Eikmeier LJ, Beitze AJ: Cancer pain mechanisms and animal models of cancer pain. Proceedings of the 9th World Congress on Pain, Progress in Pain Research and Management, Vol. 16, IASP Press, Seattle, 2000.

Clohisy DR, Ramnaraine ML: Pamidronate decreases tumor-induced osteoclastogenesis through effects on myeloid precursor cells. Journal of Orthopaedic Research, 19, 554-558, 2001.

Luger NM, Honore P, Sabino MK, Schwei MJ, Rogers SD, Mach DB, Clohisy DR, Mantyh PW. Osteoprotegerin diminishes advanced bone cancer pain. Cancer Research, 61(10): 4038-47., 2001.

Clohisy DR, Pathophysiology of Metastatic Skeletal Disease, chapter in Orthopaedics, edited by Fitzgerald, Kaufer, Malkani, published by Mosby, 1078-1079, 2002.

Clohisy DR, Temple T: Musculoskeletal Tumors, chapter in Orthopaedic Knowledge Update 7, edited by Kenneth Koval, published by AAOS, Rosemont IL, 155-182, 2002.

Luger NM, Sabino MA, Schwei MJ, Mach DB, Pomonis JD, Keyser CP, Rathbun M, Clohisy DR, Honore P, Yaksh TL, Mantyh PW. Efficacy of systemic morphine suggests a fundamental difference in the mechanisms that generate bone cancer vs inflammatory pain. Pain 99(3) 397-406, 2002.

Mach DB, Robers SD, Sabino MAC, Luger NM, Schwei MJ, Pomonis JK, Clohisy DR, Adams DJ, O'Leary P, Mantyh PW. Sensory and sympathetic innervation of a normal mouse femur. Neuroscience, 113(1): 155 - 66, 2002.

Mantyh PW, Clohisy DR, Koltzenburg M, Hunt SP: Molecular mechanisms of cancer pain. Nature Reviews: Cancer, (2)201-209, March 2002.

Nagarajan R, Neglia J, Clohisy DR, Robison LL: Limb salvage and amputation in survivors of pediatric lower-extremity bone tumors: what are the long-term implications? J Clin Oncol, 20(22) 4493-4501, 2002.

Thompson RC, Cheng EY, Clohisy DR, Perentesis J, Manivel C, Le CT: Results of treatment for metastatic osteosarcoma in neoadjuvant chemotherapy and surgery. Clinical Orth, 397: 240-247, 2002.

Clohisy DR, Mantyh PW: Bone cancer pain. Cancer 97(3 Suppl), 866-873, 2003.

Clohisy DR: Cellular mechanisms of osteolysis. J Bone Joint Surg Am, 85-A Suppl 1: S4-6, 2003. 37. Mohla S, Weilbacher KN, Cher ML, Oyajobi BO, Poznak CV, and Clohisy DR Third North American symposium on skeletal complications of malignancy. Cancer 97: 719-725, 2003
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Clohisy DR: Tumor osteolysis and skeletal pain, chapter in Molecular Biology in Orthopaedics. Edited by Randy N. Rosier and Chrisopher Evans, published by AAOS, Rosemont IL, 121-132, 2003.

Clohisy DR:Metastatic bone disease: future directions. Clinical Orthopaedics and Related Research, Supplement: Metastases. Number 415, pp 1-5, 2003.

Goblirsch M, Mathews W, Lynch C, Alaei P, Gerbi BJ, Mantyh PW, Clohisy DR: Radiation treatment decreases bone cancer pain, osteolysis, and tumor size. Submitted 2003.

Nagarajan R, Clohisy DR, Neglia J, et al: Function and quality of life of survivors of pediatric lower extremity bone tumors: a report from the Childhood Cancer Survivor Study. Submitted 2003.

Nagarajan R, Neglia J, Clohisy DR, Yasui Y, Greenberg M, Hudson M, Zevon M, Robison L. Education, employment, insurance and marital status among 694 survivors of pediatric lower extremity bone tumors: a report from the Childhood Cancer Survivor Survey. Cancer 97(10), 2554-64, 2003

Ramnaraine ML, Pan W, Goblirsch M, Lynch C, Lewis V, Orchard P, Mantyh PW, Clohisy DR: Direct and bystander killing of sarcomas by novel cytosine deaminase fusion gene. Cancer Research, accepted for publication, June 2003

Skubitz KM, Cheng EY, Clohisy DR, Thompson RC, Skubitz AP: Differential gene expression in liposarcoma, lipoma, and adipose tissue. Submitted 2003.

Cheng, E.Y., Dusenbery, K.E., Le, C.T., Manivel, C.M., Clohisy, D.R., Skubitz, K.M, Thompson, R.C., Positive Margins After Attempted Wide Excision Of A Soft Tissue Sarcoma: Is Further Excision Necessary? In Progress.

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