Education
License and Certification
Employment
Academic Appointments
Scholarly Honors and Activities
Orthopaedic Educational Activities
Medical School Activities
Scholarly Society Memberships and Offices
Professional Activities
Research Support
Publications
Editor or Sole Author/Book
Book Chapters
Invited Presentations, National
Scientific Presentations, National
Visiting Professorships
1976-79, Knox College
1979-83, Northwestern University Medical School, M.D. degree
1983-90, Surgical Residency, University of Minnesota, Minneapolis, Minnesota
1985-87, Post-doctoral Research Fellow
Washington University Medical Center, St. Louis, Missouri, Department of Pathology, PGY 3-4
1990-91, Musculoskeletal Oncology Fellow, Harvard Medical School, Department of Orthopaedic Surgery, Massachusetts General Hospital, PGY-8
State of Minnesota Medical License
American Board of Orthopaedic Surgeons board certified
1991 - present: University of Minnesota Medical Center, Minneapolis, MN
1991 - 1995: Assistant Professor, Dept of Orthopaedic Surgery, UMN
1995 - 1997: Director, Orthopaedic Surgery Residency Program, UMN
1996 - 2001: Associate Professor
1999 - present: Roby C. Thompson, Jr, MD Endowed Chair in Musculoskeletal Oncology
2001 - present: Professor
SCHOLARLY HONORS AND ACTIVITIES:
Kappa Delta Young Investigator's Award, 1997
NIH Clinical Investigator Award, 1993
NIH Clinical Sciences Special Emphasis Panel (ZRG4-GRM), 1998
NIH Special Emphasis Panel (ZAR1 JRL-NIAMS), 1998
NIH/NIAMS Scientific Review Group (OBM-2), 1999, 2000
NIH/NIAMS Long-Range Planning Meeting, 04/99
NIH/NIAMS Scientific Review Group (ORTH), 2000
Orthopaedic Research & Education Foundation Peer Review Committee, '98-'03
NIH/NIAMS Special Core Center Review Group, 2000
NCI Review Panel for study section NCI-C GRB, 02/01
NCI-C P, Basic and Preclinical Studies Scientific Review Group, 04/01
NCI Scientific Review Group, Subcommittee C, Basic and Preclinical Sciences, 04/01
NIH/NIAMS PO1 review, 07/02
NCI Microenvironment Study Section, 04/03
Fairview University Clinician Scholar Award, 2004
ORTHOPAEDIC EDUCATIONAL ACTIVITIES:
Faculty, University of Minnesota (UMN)
CME Bone and Soft Tissue Tumor Course, 1993, 1994, 1996
Resident Education Committee
UMN Dept. of Orthopaedic Surgery, 1993 - 2000
Director, Resident Transition Task Force
UMN Dept of Orthopaedic Surgery, 1994 - 1995
Director, Resident and Faculty Performance Evaluation Task Force
UMN Dept of Orthopaedic Surgery, 1995 - 1996
Director, Residency Program, UMN Dept. of Orthopaedic Surgery, 1995-1997
Research Committee, UMN Dept. of Orthopaedic Surgery, 1993-2000
Co-Chairman, University of Minnesota Discharge Planning Task Force, 1995
Department Head Search Committee for Orthopaedic Surgery, 96-97
Faculty Search Committee: Pediatric Hematology/Oncology, 97-98
Medical School Research Work Group, 97-98
Clinical Trials Scientific Review & Monitoring Committee, Cancer Center, 95-00
Executive Committee, UMN Cancer Center Tumor Bank, 95-present
Medical School Education Council Finance & Effort Committee, 98-99
Department Head Search Committee for Therapeutic Radiology, 98-99
Graduate Medical Education Hospital Affiliation Work Group, 98-99
Chairman, Graduate Medical Education Committee, UMN Medical School, 96-00
University of Minnesota Faculty Senate, 1998 - 2001 (elected)
Dean's Advisory Committee, 1998-2001 (elected)
Board of Directors, Stem Cell Institute, UMN, 2000 - present
Academic Health Center Faculty Consultative Committee, 2000-2003 (elected)
Executive Committee, UMPhysicians, Orthopaedic CSU, 2000-2003 (elected)
Search committee for dean of U of M School of Dentistry, 2003
Search committee for director of Cancer Center, 2004
Search committee for department head: Department of Surgery, 2005
Member, U of M Medical School Diversity Task Forcem 2005 - present
SCHOLARLY SOCIETY MEMBERSHIPS AND OFFICES:
National or International -
Interurban Orthopaedic Society
American Orthopaedic Association
Musculoskeletal Tumor Society
Childrens Cancer Group
Orthopaedic Research Society
American Academy of Orthopaedic Surgeons
American Board of Orthopaedic Surgeons
American Society of Bone and Mineral Research
American Society of Cell Biology
Regional or Local
Minnesota Orthopaedic Society
University of Minnesota Cancer Center
Cell Biology & Metastasis Group, University of Minnesota Medical School
Orthopedic societies and other CME activities -
Local Coordinator for Belgian Traveling Fellows, 1991
Co-Chairman, Minnesota Orthopaedic Society Meeting, 1994
Chairman, Second Minnesota Orthopaedic Alumni Reunion, 1996
Medica Quality Assurance Orthopaedic Subcommittee, 1994-1999
Board of Directors, Minnesota Orthopaedic Society, 1997 - present
Chairman, Third Minnesota Orthopaedic Alumni Reunion, 1999
Member, OREF Peer Review Committee, 1997 - present
Member, Program Committee, Orthopaedic Research Society, 2001 - present
Member, Program Committee, Third North American Symposium on Skeletal Complications of Malignancy, NCI, 2002
Member, Clinician/Scientist Program Committee, AAOS, 2002
Member, C. Howard Hatcher Pathology Fellowship Committee, AOA, 2003
Member, Orthopaedic Research Society Special Projects Committee, Feb 2003-2005
Chair, Cancer Topic Committee, Orthopaedic Research Society, 2006-2008
Vice Chair, AAOS Research Committee, 2005-2006
Chair, AAOS Research Committee 2006-present
Chair, Orthopaedic Research Society Special Projects Committee, 2006 - present
Member, Program Committee, Vth International Cancer-Induced Bone Disease Conference, 2005
Chair, C. Howard Hatcher Pathology Fellowship Committee (AOA), 2005-2006
Research Support < $100,000
1. National Aeronautics and Space Administration Research Associate, principal investigator, 1988. Topic - Osteoclast Precursor Differentiation
2. Orthopaedic Research and Education Foundation Research Award, principal investigator, 1986-87. Topic - Osteoclast Precursor Differentiation
3. Orthopaedic Research and Education Foundation Research Award, principal investigator, 1989. Topic - Osteoclast Precursor Differentiation
4. Minnesota Medical Foundation, 1992-1993 Topic - Tumor Osteolysis
5. Children's Cancer Research Fund, principal investigator, 1997. Topic - Macrophage Colony Stimulating Factor as Mediator of Sarcoma-Induced Bone Destruction
6. American Cancer Society Institutional Research Grant, principal investigator, 1995-1996. Topic - Osteoclast Formation and Tumor Osteolysis
7. AMGEN, Principal Investigator, Topic - Effect of Osteoprotegerin on Cancer-Induced Bone Destruction, 1998
8. University of Minnesota Cancer Center Brainstorm Award , Co-Principal Investigator with Catherine Verfaillie, Topic - A Model for Studying Human Osteoclast Formation at Sites of Human Myeloma Tumor, 1998
9. University of Minnesota Academic Health Center Seed Grant, Co-Principal Investigator with Catherine Verfaillie, Topic - A Model for Studying Human Osteoclast Formation at Sites of Breast Cancer Metastases to Bone
10. AMGEN, Principal Investigator, Topic - Effect of Osteoprotegerin on Cancer-Induced Bone Destruction, 1999 - 2000
11. Submitted June 2004: NIH R01, PI: Denis Clohisy. Topic: Bone cancer pain and novel therapies.
12. Minnesota Medical Foundation Special Grant. PI: Denis Clohisy. Blue (405nm) Diode Laser Upgrade for the FV500 Confocal Microscope.
Research Support ≥ $100,000
1. Orthopaedic Research and Education Foundation Research Award, principal investigator, 1993-95, Topic - Tumor Osteolysis
2. NIH Musculoskeletal/Orthopaedic Sciences Training Program, co-investigator, 1995-1997
3. NIH Clinical Investigator Award (KO8), National Institute of Arthritis and Musculoskeletal and Skin Diseases, principal investigator, 1993-1998. Topic - Osteoclasts and Tumor Osteolysis. (AR01909)
4. NIH First Award, National Institute of Arthritis and Musculoskeletal and Skin Diseases, principal investigator, 1997-2002. Topic - Osteoclast Formation and Tumor Osteolysis (AR43595)
5. NIH R01, National Institute of Neurologic Disorders and Stroke, 2000 - 2005. Co-investigator (8% effort). PI: Patrick Mantyh, PhD. Topic: Peripheral nociceptors in persistent pain (NS23970-15)
6. NIH R01, National Cancer Institute, 2001 - 2006. PI: Denis Clohisy. Topic: Bone cancer and skeletal pain
7. NIH R01, National Institute of Arthritis and Musculoskeletal and Skin Diseases, 2001-2006. PI: Denis Clohisy. Topic: Osteoclasts and bone cancer
8. NIH Shared equipment grant for Olympus FV500 confocal microscope system, PI: Denis Clohisy.
9. T32 Musculoskeletal Training Grant. PI: Denis Clohisy. Topic: training students and fellows for careers as basic scientists or clinical investigators studying the causes and treatments of musculoskeletal diseases.
1. Clohisy DR, and Gibson TP; Comparison of Pharmacokinetic Parameters of Intravenous Quinidine and Quinine in Dogs. J. Cardiovasc. Pharmacol. 4:107-110, 1982.
2. Clohisy DR, Quintanilla AP and Gibson TP; Effect of Quinidine on the Renal Clearance of Digoxin in the Presence of Low and High Serum Digoxin Concentrations. J. Pharmacol. Exp. Ther. 222: 49-51, 1982.
3. Clohisy DR, Bar-Shavit Z, Chappel J and Teitelbaum SL; 1,25-Dihy-droxy Vitamin D Modulate Bone Marrow Macrophage Precursor Proliferation and Differentiation. J. Biol. Chem. 262, 15922-15929, 1987.
4. Clohisy DR and Thompson RC; Fractures Associated with Neuropathic Arthropathy in Adults Who Have Juvenile Onset Diabetes. J. Bone and Joint Surg. 70A, 1192-1200, 1988.
5. Clohisy DR, Chappel J and Teitelbaum SL; Bone Marrow-Derived Mononuclear Phagocytes Autoregulate Mannose Receptor Expression. J. Biol. Chem. 264, 5370-5377, 1989.
6. Clohisy DR, Erdman J and Wilner GD; Thrombin Binds to Murine Bone Marrow-Derived Macrophages and Acts as a Co-Mitogen with CSF-1. J. Biol. Chem. 265, 7729-7732, 1990.
7. Clohisy DR, Vorlicky L, Oegema TR, Snover D and Thompson RC; Histochemical and Immunohistochemical Characterization of Cells Comprising Giant Cell Tumor of Bone. Clin. Ortho. and Rel. Res. 287, 259-265, 1993.
8. Thompson RC and Clohisy DR; Deformities Following Fracture in Diabetic Neuropathic Osteoarthropathy: Operative Results in Patients with Juvenile Onset Diabetes. J. Bone and Joint Surg. 75-A(12), 1765-1773, 1993.
9. Clohisy DR and Mankin HJ; Proximal Tibia Osteoarticular Allografts in the Management of Skeletal Defects after Tumor Resection. J. Bone and Joint Surg. 76-A(4), 549-554, 1994.
10. Clohisy DR, Ogilvie CM, and Ramnaraine ML: Tumor Osteolysis in Osteopetrotic Mice. J. Ortho. Res, 13-892-897, 1995.
11. Clohisy DR, Ogilvie CM, Carpenter RJ, and Ramnaraine ML: Localized, Tumor-Associated Osteolysis Involves Both Osteoclast Recruitment and Osteoclast Activation. J. Ortho. Res.14:2-6, 1996
.12. Clohisy DR, Palkert D, Ramnaraine ML, Pekurovsky I, and Oursler MJ: Human Breast Cancer induces Osteoclast Activation and Increases the Number of Osteoclasts at Sites of Tumor Osteolysis. J. Ortho. Res. 14:396-402, 1996.
13. Clohisy DR and Ramnaraine ML: Osteoclast Formation During Tumor Osteolysis Does Not Require Proliferating Osteoclast Precursor Cells. J. Ortho. Res. 15(2), 301-306, 1997.
14. Clohisy DR, Le CT and Umen AJ: Measuring Health Status in Patients with Skeletal Metastasis Treated by Surgery. Am. J. Clin. Oncol. (CCT) 20(4): 424-428, 1997.
15. Clohisy DR and Ramnaraine ML: Evaluation of Mutant Mouse Production by Mice that are Heterogenous for the M-CSF/op Gene, Laboratory Animal Science 48:3, 300-302,1998.
16. Clohisy DR, Ramnaraine ML: Osteoclasts are Required for Tumors to Grow and Destroy Bone, J. Ortho. Res. 16(6):660-666, 1998.
17. Schwei MJ, Honore P, Rogers SD, Salak-Johnson JL, Finke MP, Luger NM, Ramnaraine ML, Nichols ML, Clohisy DR, and Mantyh PW. Reorganization of the neurochemistry of the spinal cord in a murine model of bone cancer pain. J. Neurosci 19(24): 10886-97, 1999.
18. Clohisy DR: Could apoptosis be responsible for localized imbalances in bone cell homeostasis? Invited editorial, J Lab Clin Med, Sep; 134(3): 190-1, 1999.
19. Clohisy DR, Ly T, Thompson R: Internal Fixation of Large Segment Allografts Using Plates Augmented with Cerclage Wires Yields Poor Results, Clin Orth Rel Res No 371, 198-205, 2000.
20. Thompson RC, Garg A, Clohisy DR, Cheng EY: Fractures in Large Segment Allografts, Clin Orth Rel Res, No. 370, 227-235, 2000.
21. Thompson RC, Garg A, Clohisy DR, Cheng EY, Dusenbery K: Synovial Sarcoma - Size Predicts Outcome, Clinical Orthopaedics and Related Research, No. 373, 18-24, 2000.
22. Clohisy DR, Le CT, Cheng EY, Dykes DC, Thompson RC Evaluation of Feasibility and Results of Measuring Health Status Changes in Patients Undergoing Surgical Treatment for Skeletal Metastases, J Orth Res, 18:1-9, 2000.
23. Clohisy DR, Perkins SL, Ramnaraine ML: "Review of cellular mechanisms of tumor osteolysis". Clin Orth Rel Res, 373, 104-114, 2000.
24. Clohisy DR, Ramnaraine ML, Scully S, Qi M, Van G, Tan HL, Lacey DL: Osteoprotegerin inhibits tumor-induced osteoclastogenesis and bone tumor growth in osteopetrotic mice. Journal of Orthopaedic Research, 18: 967-976, 2000.
25. Honore P, Sabino M, Schwei M, Rogers S, Mach D, O'Keefe P, Ramnaraine ML, Clohisy DR, Mantyh P: Osteoprotegerin blocks bone cancer-induced skeletal destruction, skeletal pain, and pain-related neurochemical reorganization of the spinal cord. Nature Medicine, 6(5): 521-527, 2000.
26. Honore, P., Rogers, S.D., Schwei, M.J., Salak-Johnson, J.L., Luger, N.M., Sabino, M-A.C., Nichols, M.L., Clohisy, D.R. and Mantyh, P.W.: Murine models of inflammatory, neuropathic, and cancer pain each generates a unique set of neurochemical changes in the spinal cord and sensory neurons. Neuroscience, 98: 585-598, 2000.
27. Honore P, Schwei J, Rogers SD, Salak-Johnson JL, Finke MP, Ramnaraine ML, Clohisy DR, Mantyh PW. Cellular and neurochemical remodeling of the spinal cord in bone cancer pain. Prog Brain Res, 129: 389-397, 2000.
28. Luger NM, Honore P, Sabino MK, Schwei MJ, Rogers SD, Mach DB, Clohisy DR, Mantyh PW. Osteoprotegerin diminishes advanced bone cancer pain. Cancer Research, 61(10): 4038-47., 2001.
29. Clohisy DR, Ramnaraine ML: Pamidronate decreases tumor-induced osteoclastogenesis through effects on myeloid precursor cells. Journal of Orthopaedic Research, 19, 554-558, 2001.
30. Luger NM, Sabino MA, Schwei MJ, Mach DB, Pomonis JD, Keyser CP, Rathbun M, Clohisy DR, Honore P, Yaksh TL, Mantyh PW. Efficacy of systemic morphine suggests a fundamental difference in the mechanisms that generate bone cancer vs inflammatory pain. Pain 99(3) 397-406, 2002.
31. Mach DB, Robers SD, Sabino MAC, Luger NM, Schwei MJ, Pomonis JK, Clohisy DR, Adams DJ, O'Leary P, Mantyh PW. Sensory and sympathetic innervation of a normal mouse femur. Neuroscience, 113(1): 155 - 66, 2002.
32. Thompson RC, Cheng EY, Clohisy DR, Perentesis J, Manivel C, Le CT: Results of treatment for metastatic osteosarcoma in neoadjuvant chemotherapy and surgery. Clinical Orth, 397: 240-247, 2002.
33. Nagarajan R, Neglia J, Clohisy DR, Robison LL: Limb salvage and amputation in survivors of pediatric lower-extremity bone tumors: what are the long-term implications? J Clin Oncol, 20(22) 4493-4501, 2002.
34. Mantyh PW, Clohisy DR, Koltzenburg M, Hunt SP: Molecular mechanisms of cancer pain. Nature Reviews: Cancer, (2)201-209, March 2002.
35. Clohisy DR, Mantyh PW: Bone cancer pain. Cancer 97(3 Suppl), 866-873, 2003.
36. Clohisy DR: Cellular mechanisms of osteolysis. J Bone Joint Surg Am, 85-A Suppl 1: S4-6, 2003.
37. Mohla S, Weilbacher KN, Cher ML, Oyajobi BO, Poznak CV, and Clohisy DR Third North American symposium on skeletal complications of malignancy. Cancer 97: 719-725, 2003.
38. Nagarajan R, Neglia J, Clohisy DR, Yasui Y, Greenberg M, Hudson M, Zevon M, Robison L. Education, employment, insurance and marital status among 694 survivors of pediatric lower extremity bone tumors: a report from the Childhood Cancer Survivor Survey. Cancer 97(10), 2554-64, 2003.
39. Clohisy DR:Metastatic bone disease: future directions. Clinical Orthopaedics and Related Research, 415 Suppl, S95-9, 2003.
40. Ramnaraine ML, Pan W, Goblirsch M, Lynch C, Lewis V, Orchard P, Mantyh PW, Clohisy DR: Direct and bystander killing of sarcomas by novel cytosine deaminase fusion gene. Cancer Research, 63(20), 6847-54, 2003.
41. Goblirsch M, Mathews W, Lynch C, Alaei P, Gerbi BJ, Mantyh PW, Clohisy DR: Radiation treatment decreases bone cancer pain, osteolysis, and tumor size. Radiation Research, 161; 228-234, 2003.
42. Nagarajan R, Clohisy DR, Neglia J, et al: Function and quality of life of survivors of pediatric lower extremity bone tumors: a report from the Childhood Cancer Survivor Study. British Journal of Cancer (91), 1858-1865, 2004
43. Clohisy DR, and Mantyh PW: Bone cancer pain. Clin Orthop, 2003 (415 Suppl), S279-88.
44. Skubitz KM, Cheng EY, Clohisy DR, Thompson RC, Skubitz AP: Gene expression in giant cell tumors. J Lab Clin Med, 144(4): 193-200, 2004.
45. Goblirsch M, Lynch C, Mathews W, Manivel JC, Mantyh PW, Clohisy DR: Radiation treatment decreases bone cancer pain through direct effect on tumor cells. Radiation Research 164(4), 400-408, 2005.
46. Clohisy DR and Mantyh PW: "Bone cancer pain and the role of RANKL/OPG." J Musculoskelet Neuronal Interact 4(3): 293-300, 2004.
47. Pan WH, Mathews W, Donohue JM, Ramnaraine ML, Lynch C, Selski D, Walsh N, Cassady IA, Clohisy DR: Analysis of distinct tartrate-resistant acid phosphatase promoter regions in transgenic mice. J Biol Chem 280(6): 4888-93, 2005.
48. Nagarajan R, Clohisy DR, Weigel B: “New paradigms for therapy for osteosarcoma”. Current Oncology Reports, 7(6): 410-4, Nov 2005.
49. Ramnaraine M, Mantyh PW, Clohisy DR : "Osteoclasts direct bystander killing of breast cancer cells in vivo." Bone in press 2006.
50. Clohisy DR, Selski DJ: “A customized retroviral vector confers marker gene expression in osteoclast lineage cells” J of Cellular Biochemistry, 97:641-650, 2006.
51. Ramnaraine ML, Pan WH, Clohisy DR: “Osteoclasts direct bystander killing of cancer cells in vitro”. Bone 38: 4-12, 2006.
52. Zwolak P, Manivel C, Clohisy DR: “Forearm mass in an adolescent”. Clin Orth Rel Res, in press 2006.
53. Goblirsch M, Zwolak P, Ramnaraine M, Pan WH, Lynch C, Alaei P, Clohisy DR: “Novel CD fusion gene enhances radiation’s effect on breast cancer in bone by reducing tumor burden, osteolysis and skeletal fracture” Clin Can Research in press, 2006.
54. Nagarajan R, Ness KK, Ruccione K, Goldsby R, Leisenring W, Clohisy D, Neglia JP, Robison L: “Lower extremity amputation in bone cancer survivors: an analysis of quality of life, function and psychosocial status from the Childhood Cancer Survivor Study”. Submitted 2006.
1. Clohisy DR, section editor for "Common Tumors", Craig's Textbook of Orthopaedic Surgery, Williams & Wilkins Pub, 965-1004, 1999.
1. Arendt EA and Clohisy DR: Chapter 5, Stress Injuries of Bone, The Lower Extremity and Spine in Sports Medicine, Vol. 1, J.A. Nicholas and E.B. Hershman, 2nd edition, Mosby-Year Book Inc., pp. 65-80, 1995.
2. Clohisy DR: "Management of Skeletal Metastasis", chapter in Clinical Orthopaedics, edited by Edward V. Craig, Lipincott Williams & Wilkins Pub., 994-997, 1999.
3. McGrath B, Scarborough MT and Clohisy DR: "Malignant Bone Tumors", chapter in Craig's Clinical Orthopaedics, Lippincott Williams & Wilkins Pub., 988-993, 1999.
4. Wacnik PW, Wilcox GL, Clohisy DR, Ramnaraine ML, Eikmeier LJ, Beitze AJ: Cancer pain mechanisms and animal models of cancer pain. Proceedings of the 9th World Congress on Pain, Progress in Pain Research and Management, Vol. 16, IASP Press, Seattle, 2000.
5. Clohisy DR: "Growth and Metastasis of Musculoskeletal Tumors" chapter in Orthopaedic Basic Science, 2nd Edition, edited by Buckwalter, Einhorn & Simon, published by AAOS, 427-442, 2000.
6. Clohisy DR, "Pathophysiology of Metastatic Skeletal Disease", chapter in Orthopaedics, edited by Fitzgerald, Kaufer, Malkani, published by Mosby, 1078-1079, 2002.
7. Clohisy DR, Temple T: "Musculoskeletal Tumors", chapter in Orthopaedic Knowledge Update 7, edited by Kenneth Koval, published by AAOS, Rosemont IL, 155-182, 2002.
8. Clohisy DR: "Tumor osteolysis and skeletal pain", chapter in Molecular Biology in Orthopaedics. Edited by Randy N. Rosier and Chrisopher Evans, published by AAOS, Rosemont IL, 121-132, 2003.
9. Bella G, Clohisy DR: “Mechanisms in bone metastasis”, chapter in Orthopaedic Knowledge Update, Tumor 2. Published by AAOS, Rosemont IL, submitted 2006.
10. Bella G, Clohisy DR: “Musculoskeletal effects of neplasia”, chapter in Orthopaedic Knowledge Update, Tumor 2. Published by AAOS, Rosemont IL, submitted 2006.
INVITED PRESENTATIONS, National:
1. AAOS 1998, Musculoskeletal Tumor Society Specialty Day, February 1998. Topic: Biology and treatment of skeletal metastasis.
2. Salem Hospital (Salem, Oregon) Grand Rounds, April 1998. Topic: Skeletal Metastases.
3. 24th Annual San Antonio Breast Cancer Symposium. Topic: Cellular and molecular mechanism of bone cancer pain. San Antonio, TX, December 2001.
4. AAOS 2001 Molecular Biology Workshop. Topic: Tumor osteolysis and skeletal pain. Scottsdale, AZ, September 2001.
5. Third North American Symposium on Skeletal Complications of Malignancy. Sponsors: National Cancer Institute, The Paget Foundation, Penn State College of Medicine. Two lectures: Novel fusion gene eradicates bone cancers; Bone cancer pain. Bethesda, MD, April 2002.
6. Association of Bone & Joint Surgeons Workshop on Metastatic Bone Disease. Two lectures: Cellular and molecular mechanisms of bone cancer pain; Using an S. Cerevisae gene to kill bone cancer. Tampa, FL, November 2002.
7. Perspective of a physician scientist. AAOS Clinician Scientist Development Committee presentation. Charleston, South Carolina, June 2003.
8. Balancing Research and Clinical Time. American Orthopedic Association Meeting. Charleston, South Carolina, June 2003.
9. Abbott Laboratories, Abbott Park, Illinois. September 2003. Topic: bone cancer pain.
10. Bone Metastases and Hypercalcemia Advisory Board Meeting. Topic: Blocking Bone Cancer Pain. New York City, August 2004.
11. AAOS 2005. Development of Clinician Scientists.
12. Vth International Conference on Cancer-Induced Bone Disease. Davos, Switzerland, March 2005. Two presentations: “Osteoclasts direct bystander killing of breast cancer cells” and “Radiation treatment decreases bone cancer pain through direct effect on tumor cells”.
13. Skeletal Complications of Malignancy IV. Bethesda, Maryland, April 2005. Two invited presentations: “Mechanisms of bone cancer pain” and “Combining radiation therapy and cytosine deaminase suicide gene therapy to treat painful breast cancer tumors”.
14. Advances in treating metastatic bone cancer, Cambridge Massachusetts, October 2005. “Biology of bone pain”
15. American Society for Bone & Mineral Research, 28th Annual Meeting, Philadelphia Pennsylvania, September 2006. “Bone cancer pain: from model to mechanism to therapy”.
SCIENTIFIC PRESENTATIONS, National:
1. Clohisy, D. R., Bar-Shavit, Z., Kahn, A.J. and Tietelbaum, S.L.: 1,25-Dihydroxyvitamin D Inhibits Bone Marrow Macrophage Proliferation in a Differentiation-Dependent Manner. American Society for Bone and Mineral Research, San Francisco, 1986.
2. Clohisy, D. R. and Thompson, R.C.: The High Risk of Neuropathic Fractures in the Juvenile Onset Diabetic. AAOS Annual Meeting, New Orleans, LA, 1986.
3. . Clohisy, D.R., Chappel, J., Blair, H.C., Konsek, J. and Teitelbaum, S.L.: Vitamin D Enhances Osteoclast Precursor Differentiation. Orthopaedic Research Society, Atlanta, 1988.
4. Vitamin D as an Inducer of Cell Differentiation. Upjohn Company and Orthopaedic Research Society Invitational Symposium on Cellular Mechanisms of Bone Remodeling. Jacksonville, FL, 1988.
5. Erdmann, J., Clohisy, D.R., and Wilner, G.D.: Thrombin Binds to Bone Marrow - Derived Macrophages and Acts as a Co-Mitogen with CSF-1. American Society for Cell Biology, San Francisco, 1989.
6. Clohisy, D.R., Springfield, D.S. and Mankin, H.J.: Proximal Tibia Osteoarticular Allografts in the Management of Skeletal Defects after Tumor Resection. American Orthopaedic Association Meeting, Palm Beach, 1991.
7. Vorlicky, L., Oegema, T.R. Thompson, R.C., and Clohisy, D.R.: Histochemical and Immunohistochemical Characterization of Cells Comprising Giant Cell Tumor of Bone. Orthopaedic Research Society Meeting, San Francisco, CA, 1991.
8. Clohisy, D.R., Ogilvie, C., Ramnaraine, M.L., and Oursler, Localized, Tumor-Associated Osteolysis Involves Both Osteoclast Recruitment and Osteoclast Activation. Annual Meeting, American Society for Bone and Mineral Research, Kansas City, MO, 1994.
9. Clohisy, D.R., Ogilvie, C., Ramnaraine, M.L., and Oursler, M.J.: Localized, Tumor-Associated Osteolysis Involves Both Osteoclast Recruitment and Osteoclast Activation. Annual Meeting, Orthopaedic Research Society, Orlando, FL, 1995.
10. Clohisy, D.R., Palkert, D., Ramnaraine, M.L., Pekurovsky, I.: Human Breast Cancer Induces Osteoclast Activation and Increases the Number of Osteoclasts at Sites of Tumor Osteolysis. Orthopaedic Research Society, Atlanta, 1996.
11. Clohisy, D.R. and Ramnaraine, M.L.: Osteoclast Formation during Tumor Osteolysis Does Not Require Proliferating Osteoclast Precursor Cells, Orthopaedic Research Society, San Francisco, 1997.
12. Clohisy, DR, Schwei M, Honore P, Ramnaraine ML, Salak-Johnson J, Mantyh P: Unique reorganization of cellular and neurochemical features of the spinal cord in a murine model of bone cancer pain. 2nd Annual Symposium on Skeletal Complications of Malignancy, Montreal, Canada, 1999.
13. Clohisy DR, Ramnaraine ML, Scully S, Qi M, Van G, Tan HL, Lacey DL: Osteoprotegerin inhibits tumor-induced osteoclastogenesis and bone tumor growth in osteopetrotic mice. 2nd Annual Symposium on Skeletal Complications of Malignancy, Montreal, Canada, 1999.
19. Cellular and molecular mechanisms of bone cancer pain. Association of Bone and Joint Surgeons Workshop on Metastatic Bone Disease, Tampa, Florida, November 2002.
20. Clohisy DR, Orchard PJ, Lewis VA, Duenes T, et al: Novel fusion gene eradicates sarcoma. Orthopaedic Research Society 49th Annual Meeting, New Orleans, 2003.
21. Killing of bone and soft tissue tumors; Radiation treatment decreases bone cancer pain. Two presentations given at Musculoskeletal Tumor Society 2003 Annual Meeting. Northbrook IL, May 2003.
22. Progress in the treatment of childhood tumors. 2003 Spring Training Conference, The Orthopaedic Center, Minneapolis MN. June 2003.
23. Radiation treatment decreases bone cancer pain, osteolysis, and tumor size. American Society for Bone and Mineral Research 25th Annual Meeting, Minneapolis MN. September 2003.
24. A TRAP promoter element that responds early during RANK-Ligand introduction. American Society for Bone and Mineral Research 25th Annual Meeting, Minneapolis MN. September 2003.
1. Cellular Mechanisms of Tumor Osteolysis, Kappa Delta Young Investigator's Award presentation at Orthopaedic Research Society, San Francisco, 1997.
2. Case Western Reserve University visiting lecturer, January 1998. Topic: Biology and treatment of skeletal metastasis.
3. Distinguished Lecturer in Orthopaedics, Washington University, April 1998. Topic: Biology and treatment of skeletal metastasis.
4. University of Iowa: Annual Senior Residents' and Fellows' Day, May 2001. Review/discuss three resident/fellow papers, PGY-2 research proposals, and present two lectures.
5. Mayo Clinic Grand Rounds presentation: Molecular mechanisms of bone cancer pain. Rochester, MN. May 2003.
6. Columbia University, Department of Orthopedic Surgery. Grand rounds presentation, “ The path less traveled: A career in orthopedic research”. February 2006.
7. Mayo Clinic Grand Rounds presentation, Rochester MN, April 2006.