Betsy A. Hirsch, Ph.D., Laboratory Medicine and Pathology, University of Minnesota

Associate Professor
612-273-4952
hirsc003@umn.edu

Educational Background

• Jackson College of Tufts University, Medford, MA (1976), B.A. (Psychology)
• University of Minnesota (1982), Ph.D. (Behavioral Genetics)
• University of Minnesota (1987), ABMG (Clinical Cytogenetics)

Professional Background

• Postdoctoral Associate, University of Minnesota, Genetics and Cell Biology, 1983 - 1986
• Assistant Professor/Assistant Director of Cytogenetics Laboratory, University of Minnesota Medical Center, Fairview, University of Minnesota, 1986 - 1993
• Associate Professor/Assistant Director of Cytogenetics Laboratory, University of Minnesota Medical Center, Fairview, University of Minnesota, 1993 - 1996
• Associate Professor/Director of Cytogenetics Laboratory at University of Minnesota Medical Center, University of Minnesota, 1996 - present

Publications

• Cervenka J. and Hirsch B., Cytogenetic differentiation of Fanconi Anemia, “idiopathic” aplastic anemia, and Fanconi Anemia heterozygotes. American Journal of Medical Genetics, 15(2):211-233, 1983
• Hirsch B., Sister chromatid exchanges are preferentially induced at expressed and nonexpressed common fragile sites. Human Genetics, 89:302-306, 1991
• Hirsch B., Sentz K.K., McGue M., Genetics and environmental influence on SCE. Environmental and Molecular Mutogenesis, 20(1):3-11, 1992
• Hirsch B. and Baldinger S., A periocentric inversion of chromosome 44 giving rise to dup(4p) and dup(4q) recombinants within a single kindred. American Journal of Medical Genetics, 45:5-8, 1993
• Schimmenti L.A., Berry S.A., Tuchman M., and Hirsch B., Infant with multiple congenital abnormalities and deletion (9)(q34.3). American Journal of Medical Genetics, 51:140-142, 1994
• Ross M.E., Allen K.M., Srivastava A.K., Featherstone T., Gleeson J.G., Hirsch B., Harding D.N., Andermann E., Abdullah R., Berg M., Czapansky-Beilman D., Flanders D.J., Guerrini R., Motte J., Mira A.P., Scheffer I., Berkovic S., Scaravilli F., King, R.A., Ledbetter D.H., Schesslingar D., Dobyns W.B., Walsh C.A., Linkage and physical mapping of X-linked lissencephaly: SOH (XLS): a gene causing neuronal migration defects in human brain. Human Molecular Genetics, 6(4):555-562, 1997
• Eugster E.A., Berryt S.A. and Hirsch B., Mosaicism for deletion 1p36.33 in patient with obesity and hyperphagia American Journal of Medical Genetics, 70:409-112, 1997
• Fink J.M., Hirsch B.A., Zheng C., Dietz G., Hatten M.E., and Ross, M.E., Astrotactin (ASTN) a gene for glial-guided neuronal migration maps to human chromosome 1q35.3 Genomics 10:302-205, 1997
• Fink J.M., Dobyns W.B., Guerrini R., and Hirsch B., Identification of a duplicaton of Xq28 associated with bilateral periventricular nodular heterotopia, American Journal of Human Genetics, 61:379-387, 1997
• Fox S.W., Lamperti E.D., Eksioglu Y.Z., Hong S.E., Feng Y., Graham D.A., Scheffer I.E., Dobyns W.B., Hirsch B.A., Radtke R.A., Barkovic S.F., Huttenlocher P.R., Welsh C.A., Mutations in filamin 1 prevent migration of cerebral cortical neurons in human periventricular heterotopia. Neuron, 21(6): 1313-1325, 1998
• Verfaille C.M., Bhatia R., Steinbuch M., Defor T., Hirsch B., Miller J.S., Weisdorf D., McGlave P.B., Comparative analysis of autografting in chronic myelogenous leukemia: effects of priming regimen and marrow or blood origin of stem cells. Blood, 92(3): 1820-1831, 1998.
• Raymond D.S., Parker E.D., Kettlewell J.R., Brown L.G., Page D.C., Kusz K., Jaruzelska J., Reinberg Y., Flejter W.L., Bardwell V.J., Hirsch B., Zarkower D., A region of human chromosomes 9p required for testis development contains two genes related to known sexual regulators. Human Molecular Genetics 8(6):989-996, 1999
• Brunstein C.G., Hirsch B.A., Miller J.S., McGlennen R.C., Verfaillie C.M., McGlave P.B., Weisdorf D.J. Non-leukemia autologous reconstitution after allogeneic bone marrow transplantation for Ph-positive chronic myelogenous leukemia: extended remission preceding eventual relapse. Bone Marrow Transplantation 26(11):1173-1177, 2000.
• Macmillan M.L., Auerbach A.D., Davies M., Defor T.E., Gillic A., Giller R., Harris R., Cairo M., Dusenbery K., Hirsch B., Ramsay N.K., Weisdorf D.J., Wagner J.E. "Haematopoietic cell transplantation in patients with Fanconi anaemia using alternate donors: results of a total body irradiation dose excalation trial. British Journal of Haematology. 109(1): 121-9, 2000.
• Bhatia R., Hirsch B., Miller J., Weisdorf D., McGlave P. Comparative analysis of autografting in CML: Effect of priming regimen in marrow or blood origin cells Blood (in Press).
• Gregory J.J., Jr., Wagner J.E., Verlander P.C., Levran O., Batish S.D., Eide C.R., Steffenhagen A., Hirsch B., and Auerbach A.D. "Somatic mosaicism in Fanconi anemia: Evidence of genotypic reversion in lymphohematopoietic stem cells",PNAS 98: 2532-2537,2001.
• Shah N., Oseth L., Tran, H. Hirsch B. , LeBien T.W. "Clonal variation in the B-lineage acute lymphoblastic leukemia response to multiple cytokines and bone marrow stromal cells." Cancer Research 61(13): 5268-5274, 2001.