(John) Jeffrey McCullough, M.D., Laboratory Medicine and Pathology, University of Minnesota

Professor
612-626-3272
mccul001@umn.edu

EDUCATION

• Northwestern University, Evanston, Illinois, B.A., 1959
• Ohio State University, Columbus, Ohio, M.D., 1963
• Vanderbilt University Hospital, Nashville, Tennessee, Intern, Department of Medicine, July 1963 - June 1964, Resident, July 1969 - June 1970
• University of Minnesota Hospitals, Resident, Department of Laboratory Medicine, 1967 - 1969; Chief Resident 1968 - 1969
• Executive Development Program, Kellogg Graduate School of Management, Northwestern University, Evanston, IL, August, 1982
• National Heart, Lung, and Blood Institute, Laboratory of Molecular Hematology: Sabbatical with Dr. French Andersen, 1985 - 1986

BOARD CERTIFICATION

Clinical Pathology, Blood Banking

PROFESSIONAL BACKGROUND

• Professor, Department of Laboratory Medicine and Pathology, University of Minnesota Medical School, 1978 to present
• American Red Cross Chair in Transfusion Medicine, 2003 to present
• Director, Biomedical Engineering Institute, 2000 to present
• Scientific Director, St. Paul Regional Red Cross Blood Service, 1992 to present
• Trustee, American Board of Pathology, 1997 to present
  Treasurer, 2003 - 2004
  President, 2006 to present

PROFESSIONAL AND ASSOCIATION MEMBERSHIPS

• Academy of Clinical Laboratory Physicians and Scientists
• American Association for the Advancement of Science
• American Association of Blood Banks
• American Society for Blood and Marrow Transplantation
• American Society for Investigative Pathology
• American Society of Hematology
• Biomedical Engineering Society
• College of American Pathologists
• International Society of Blood Transfusion
• International Society for Cell Therapy
• Minnesota Society of Pathologists

RECENT PUBLICATIONS

• Chrysler G, McKenna D, Schierman T, Kadidlo D, Askari S, Miller J, Clay M, McCullough J.  Cellular characteristics of cord blood and cord blood transplantation.  In:  Broxmeyer HE, ed.  Cord Blood:  Biology, Immunology, Banking, and Clinical Transplantation.  AABB Press, Bethesda, MD, 2004; 219-257.
• McCullough J, Dodd R, Gilcher R, Murphy S, Sayers M.  White particulate matter:  Report of the ad hoc industry review group.  Transfusion 2004; 44:1112-1118.
• McCullough J, Vesole DH, Benjamin RJ, Slichter SJ, Pineda A, Snyder E, Stadtmauer EA, Lopez-Plaza I, Coutre S, Strauss RG, Goodnough LT, Friday JL, Raife T, Cable R, Murphy S, Howard F, Davis K, Lin JS, Metzel P, Corash L, Koutsoukos A, Lin L, Buchholz DH, Conlan MG.  Therapeutic efficacy and safety of platelets treated with a photochemical process for pathogen inactivation: The SPRINT trial.  Blood 2004; 104:1534-1541.
• Laroche V, Eastlund DT, McCullough J.  Review: immunohematologic aspects of allogeneic hematopoietic progenitor cell transplantation.  Immunohematology 2004; 20:217-225.
• McCullough J.  Transfusion Medicine (2^nd ed).  Elsevier Churchill Livingstone; Philadelphia, PA, 2005; 584 pgs.
• Askari S, Miller J, Chrysler G, McCullough J.  Impact of donor- and collection-related variables on product quality in ex-utero cord blood banking.  Transfusion 2005; 45:189-194.
• Perez-Pujol S, Aras O, Lozano M, Cocking-Johnson D, Key NS, White JG, McCullough J, Escolar G.  Stored platelets contain residual amounts of tissue factor: evidence from studies on platelet concentrates stored for prolonged periods.  Transfusion 2005; 45:572-579.
• Slichter SJ, Davis K, Enright H, Braine H, Gernsheimer T, Kao KJ, Kickler T, Lee E, McFarland J, McCullough J, Rodey G, Schiffer CA, Woodson R.  Factors affecting post-transfusion platelet increments, platelet refractoriness, and platelet transfusion intervals in thrombocytopenic patients.  Blood 2005 105:4106-4114.
• McCullough J, McKenna D, Schierman T, Kadidlo D, Wagner J.  Issues in the quality of umbilical cord blood (UCB) stem cells for transplantation.  Transfusion 2005; 45:832-841.
• McKenna DH, Kadidlo DM, Miller JS, Orchard PJ, Wagner JE, McCullough J.  The Minnesota Molecular and Cellular Therapeutics Facility: a state-of-the-art biotherapeutics engineering laboratory.  Transfusion Medicine Reviews 2005; 19:217-228.
• Benjamin RJ, McCullough J, Mintz PD, Snyder E, Spotnitz WD, Rizzo RJ, Wages D, Lin JS, Wood L, Corash L, Conlan MG.  Therapeutic efficacy and safety of red blood cells treated with a chemical process (S-303) for pathogen inactivation: a Phase III clinical trial in cardiac surgery patients.  Transfusion 2005; 45:1730-1749.
• Snyder E, McCullough J, Slichter SJ, Strauss RG, Lopez-Plaza I, Lin SJ, Corash L, Conlan MG, and the SPRINT Study Group.  Clinical safety of platelets photochemically-treated with amotosalen HC1 and ultraviolet A light for pathogen inactivation:  the SPRINT trial.  Transfusion 2005; 45:1864-1875.
• Laroche V, McKenna D, Moroff G, Schierman T, Kadidlo D, McCullough J.  Cell loss and recovery in umbilical cord blood processing: a comparison of postthaw and postwash samples.  Transfusion 2005; 45:1909-1916.
• Murphy S, Snyder E, Cable R, Slichter SJ, Strauss RG, McCullough J, Lin JS, Corash L, Conlan MG.  Platelet dose consistency and its Effect on the number of platelet transfusions for support of thrombocytopenia: an analysis of the SPRINT trial of platelets photochemically treated with amotosalen HC1 and ultraviolet A light.  Transfusion 2006; 46:24-33.

ABSTRACTS OF PAPERS PRESENTED

More than 250 abstracts have been presented or co-authored for presentation at national or regional meetings.

MATERIAL IN PRESS

1. Mintz PD, Bass NM, Petz LD, Streiff M, McCullough J, Burks S, Valentine ME, Wage D, Van Doren S, Corash L.  Photochemically treated fresh frozen plasma for transfusion in patients with acquired coagulopathy.  Blood (in review, 3/04)
2. McCullough J.  Blood procurement and screening.  In:  Williams Hematology Textbook (7^th  Edition).  Lichtman MA, Beutler E, Kipps TJ, Seligsohn U, Kaushansky K, Prchal JT, eds.  McGraw-Hill, Inc., New York, 2004 (in press).
3. McCullough J.  Recent advances in transfusion medicine.  In: Rao G, Eastlund T, Jagannathan L, eds.  Handbook of Blood Banking and Transfusion Medicine. New Delhi: Jaypee Brothers Medical Publishing (in press, 3/05)
4. McKenna DH, Kadidlo DM, Miller JS, Orchard PJ, Wagner JE, McCullough J.  The Minnesota Molecular and Cellular Therapeutics Facility: a state-of-the-art biotherapeutics engineering laboratory.  Transfusion Medicine Reviews (in press 7/05)
5. McCullough J.  The role of physicians in blood centers.  Transfusion (in review, 5/05).
6. Pineda A, McCullough J, Benjamin RJ, Cable R, Strauss RG, Burgstaler E, Porter S, Lin L, Metzel P, Conlan MG.  Pathogen inactivation of platelets using a photochemical treatment with Amotosalen HC1 and ultraviolet light: process used in the SPRINT trial.  Transfusion (in press 8/05).
7. McCullough J, Kalish J, DeFor T, Nicklow R, Lennon S, Sheridan W, Weisdorf D.  Platelet utilization in a major metropolitan area.  Transfusion (submitted 2/06).