The faculty of the Endocrine Division of the University of Minnesota Pediatric Department are actively involved in many research projects. Currently funded projects include:
Antoinette Moran
Cystic Fibrosis Foundation
Microvascular Complications in Cystic Fibrosis Related Diabetes
PI: Antoinette Moran
4/01-3/04
The goal of this project is to define the prevalence of diabetes eye, kidney and nerve disease in patients with cystic fibrosis related diabetes, and to explore whether the presence of these complications is related to diabetes or CF factors.
NIH R01DK58356-01A1
Insulin Therapy to Improve BMI and Pulmonary Function in Cystic Fibrosis
PI: Antoinette Moran
7/01-5/06
The primary objective of this research is to determine whether treatment with either insulin or an oral diabetes agent that increases endogenous insulin secretion will improve body mass index and pulmonary function in cystic fibrosis patients who have diabetes without fasting hyperglycemia.
Aventis Pharmaceuticals
Insulin Glargine versus Standard Therapy in Cystic Fibrosis Related Diabetes
PI: Antoinette Moran
10/02-9/04
This research aims to determine whether basal insulin coverage with insulin glargine will improve hemoglobin A1c, weight and muscle mass in patients with CFRD with fasting hyperglycemia, compared to traditional regimens with less basal insulin.
NIH R01 HL52851
Influence of Insulin on BP Change in Adolescence
PI: Alan Sinaiko
Co-investigator: Antoinette Moran
6/95-5/2004
Continuation pending, 6/04-5/09
A cohort of approximately 350 young adults who have been studied since the age of about 13 are being followed longitudinally with insulin clamp studies and measurement of lipids, blood pressure and inflammatory factors in order to assess the development of the metabolic syndrome from its earliest origins in youth. Siblings and parents are also being studied.
NIH U01-DK61036
Type1 Diabetes - A Proposal for Prevention (TrialNet)
PI: David M. Brown
Co-investigator: Antoinette Moran
9/01 - 8/08
The aim of this multi-center study is to identify and test agents which may cure or prevent progression of type 1 diabetes.
Cystic Fibrosis Foundation
Improving the Detection and Management of Cystic Fibrosis Related Diabetes
PI: Bruce Marshall
Consultant: Antoinette Moran
7/02-6/07
This project seeks to improve the detection and management of CFRD, using the University of Minnesota system as a model. Dr. Moran is a consultant, helping the consortium of Mountain West CF Centers develop methods to improve their CFRD programs.
NIH DK56963
Tolerance to Islet Allografts in Type 2 Diabetes
PI: Bernhard Hering
Co-investigator: Antoinette Moran
9/1/03-8/31/05
This project seeks to improve the success of islet transplantation for type 1 diabetes. Dr. Moran is Director of the Metabolic Core and is responsible for establishing and implementing metabolic protocols to assess islet function after transplant.
TRAINING GRANTS
Juvenile Diabetes Research Foundation Research Fellowship in Diabetes: Training Grant
NMR Studies of Human Brain Glucose Metabolism
Sponsor: Antoinette Moran; Recipient: Amy Criego
8/1/02-7/31/05
NIDDK T32: Pre-Faculty Research Training in Pediatric Endocrinology
7/1/04-6/30/08
Awarded.
Anna Petryk, M.D.
NIH K08
Period: 1/03-1/06
PI: Anna Petryk
The Role of Twisted Gastrulation in Mouse Development.
Basil O'Connor Starter Scholar Research Award
Period: 02/01/02-01/31/04
PI: Anna Petryk
The Role of Twisted Gastrulation in Embryonic Development
Academic Health Center Seed Grant
Period: 7/01/03-6/30/04
PI: Rajaram Gopalakrishnan, D.D.S.
Co-Investigator: Anna Petryk
The Role of Twisted Gastrulation in Patterning and Development of the Mandible.
Minnesota Medical Foundation
Period: 5/01/03-4/30/04
PI: Michael Georgieff, M.D.
Co-Investigator: Anna Petryk
Development of a Genetic Model of Perinatal Iron Deficiency in the Hippocampus.
Viking Children's Fund Faculty Award, University of Minnesota
Period: 4/01/02-3/31/04
PI: Anna Petryk
The Role of Twisted Gastrulation in Skeletal Development and Postnatal Growth.
Genentech
Period: 11/01/02-4/01/04
PI: Anna Petryk
Bone Mineral Density in Children after Hematopoietic Stem Cell Transplant