Assistant Professor, PediatricsDr. Sing Sing Way obtained his M.D. and Ph.D. degree in Microbiology & Immunology at the Albert Einstein College of Medicine, completed residency training in Pediatrics at the University of California-San Francisco, and additional training in Pediatric Infectious Diseases at the University of Washington. Dr. Way then joined faculty in the departments of Pediatrics and Microbiology at the University of Minnesota in 2007. Dr. Way's clinical interests include all aspects of medical care for infants and children with infection, including those with compromised immune systems. In the laboratory, Dr. Way's research group examines the immune response to infection with the goal of more rational design, specifically focusing on infections in developing countries and pathogens
for which no effective vaccine is currently available.
Honors
| 1993 | Merek Undergraduate Achievement Award |
| 1993 | Summa cum Laude, University of California at Berkeley |
| 1998 | Ph.D. Dissertation with Honors |
| 1999 | Alpha Omega Alpha, Albert Einstein College of Medicine |
| 2001 | Fellow, Pediatric Scientist Development Program |
| 2004 | Children's Hospital, Fellow's Research Day Award |
| 2004 | Pediatric Academic Societies Travel Award |
| 2005 | Child Health and Research Center Scholar, University of Washington. |
| 2006 | Infectious Disease Society of America, Wyeth Young Investigator Award |
| 2007 | Basil O'Connor Award, March of Dimes Foundation |
Selected Peer-Reviewed Publications
1. Way, S.S., Borczuk, A.C., Dominitz, R., Goldberg, M.B. (1998) An essential role for gamma interferon in innate resistance to Shigella flexneri infection. Infect Immun 66: 1342-1348.
2. Way, S.S., Goldberg, M.B. (1998) Clearance of Shigella flexneri infection occurs through a nitric oxide-independent mechanism. Infect Immun 66: 3012-3016.
3. Way, S.S., Sallustio, S., Magliozzo, R.S., Goldberg, M.B. (1999) Impact of either elevated or decreased levels of cytochrome bd expression of Shigella flexneri viruelnce. J Bacteriol 181: 1229-1237.
4. Way, S.S., Borczuk, A.C., Goldberg, M.B. (1999) Adaptive immune response to Shigella flexneri 2a cydC in Immunocompentent mice and mice lacking immunoglobulin A. Infect Immun 67: 2001-2004.
5. Way, S.S., Borczuk, A.C., Goldberg, M.B. (1999) Thymic independence of adaptive immunity to the intracellular pathogen Shigella flexneri serotype 2a. Infect Immun 67: 3970:3979.
6. Shetron-Rama L.M., Mueller K., Bravo J.M., Bouwer H.G., Way S.S., Freitag N.E. (2003) Isolation of Listeria monocytogenes mutants with high-level in vitro expression host cytosol-induced gene products. Mol Microbiol 48:1537-1551.
7. Way, S.S., Kollman, T.R., Hajjar, A.M., Wilson, C.B. (2003) Cutting Edge: Protective cell-mediated immunity to Listeria monocytogenes in the absence of Myeloid differentiation factor 88. J Immunol 171: 533-537.
8. Way, S.S., Thompson, L.J., Lopes, J.E., Hajjar, A.M., Kollman, T.R., Freitag, N.E., Wilson, C.B. (2004) Characterization of flagellin expression and its role in Listeria monocytogenes infection and immunity. Cell Microbiol 6: 235-242.
9. Kollmann TR, Way SS, Hajjar AM, Harowicz H, Wilson CB. (2004) Deficient MHC class I crosspresentation of soluble ovalbumin, but normal presentation of ovalbumin peptide by neonatal dentritic cells. Blood 103: 4240-4242.
10. Darveau, R.P., Pham, T.T., Lemley, L., Reife, R.A., Bainbridge, B.W., Coats, S.R., Way, S.S., Hajjar, A.M. (2004) Porphyromonas gingivalis lipopolysaccharide preparations contain multiple lipid A species and funtionally interact with multiple Toll-like receptors. Infect Immun 72: 5041-5051.
11. Way SS, Wilson CB. (2004) Cutting Edge: Immunity and IFN-g production during Listeria monocytogenes infection in the absence of T-bet. J Immunol 173: 5918-5922.
12. Way, SS, Wilson, CB (2005) The Mycobacterium tuberculosis ESAT-6 homologue in Listeria monocytogenes is dispensable for growth in vitro and in vivo. Infect Immun 73: 6151-6153.
13. Kollmann, T.R, Reikie B., Blimkie D, Way, S.S., Hajjar, A.M., Arispe, K., Wilson, C.B. (2007) Induction of Protective immunity to Listeria monocytogenes in neonates. J Immunol 178: 3695-3701.
14. Way, S.S., Kolumam, G.A., Havenar-Daughton, C., Murali-Krishna, K., (2007) IL-12 and type I-IFN synergize for IFN-g production by CD4 T cells, while neither are required for IFN-g production by CD8 T cells after Listeria monocytogenes infection. J Immunol 178: 4498-4505.
15. Orr, M.T., Orgun, N.N., Wilson, C.B., Way, S.S. (2007) Cutting Edge: Recombinant Listeria monocytogenes expressing a single immune-dominant peptide confers protective immunity to herpes simplex virus-1 infection. J Immunol 178: 4731-4735.
16. Way, S.S., Sidbury, R., Dooms, K., Shors, A., Qin, X., Crane H.M. (2007) Chromobacterium violaceum causing sepsis and focal ulceration in a healthy child. Infect Diseases Clinical Practice 15: 281-283.
17. Asplin, I.R, Carl, D.J., Way, S.S., Jones, A.L. (2007) Role of Toll-like receptor 2 in innate resistance to virulent group B Streptococcus. (submitted).
18. Orgun, N.N. and Way, S.S. (2007) A critical role for phospholipase C in protective immunity conferred by Listeriolysin O-deficient Listeria monocytogenes (submitted).