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Emily (Baechler) C. Gillespie, Ph.D.
Assistant Professor
Rheumatic and Autoimmune Diseases
Assistant Professor
Dr.
Emily Gillespie is an Assistant Professor of Medicine, and member of the
Autoimmunity Program of the Center for Immunology, and the Institute of Human
Genetics at the University of Minnesota. Dr. Gillespie¿s major scientific goal
is to use genomic and proteomic technologies to identify clinically useful
biomarkers for the diagnosis, monitoring, and management of autoimmune diseases.
Her research projects are primarily focused on systemic lupus erythematosus (SLE),
but she is also involved in studies of rheumatoid arthritis, Crohn¿s disease,
idiopathic thrombocytopenic purpura, and fatigue.
Research being conducted by Emily
Gillespie
Investigations by Emily
Gillespie are focused on the use of genomic and proteomic techniques to identify
pathways that are dysregulated in autoimmunity, with the hope that further study
of these pathways will lead to identification of the genes that confer
susceptibility to autoimmune disease. Many projects are based on the lupus
sample biorepository generated by the Autoimmune Biomarkers Collaborative
Network (ABCoN). This study included longitudinal collection of biological
samples and clinical data from 300 patients followed over approximately one
year. Samples were also collected from single visits of an additional 350 SLE
patients. One project based on this dataset seeks to identify peripheral blood
gene expression patterns that distinguish SLE patients from healthy control
individuals. Another goal is to identify gene expression and serum protein
profiles that predict disease activity or other clinical outcomes of SLE. A
third project aims to identify genetic variants that influence the patterns of
dysregulated gene and protein expression seen in lupus patients
Publications:
Pubmed
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Last modified on Wednesday Aug 30, 2006
This page is located at http://www.med.umn.edu//rheum/faculty/gillespie.html