Study Guide for Proteinases and Matrix Degradation, Division of Rheumatic and Autoimmune Diseases in the Department of Medicine at the University of Minnesota

Surgery Chapter 4
November 24th, 2003

  1. Review the differences in catalytic site structure and localization of the proteases important to cartilage, bone and basement membrane degradation
  2. Consider the regulatory mechanisms: 1. conversion of proenzyme to active protease, 2. coordinated expression of enzyme and small molecular weight inhibitors important for control of proteolytic damage
  3. Describe how the proteolytic mechanisms of cartilage and bone damage differ in RA and OA
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