Research being conducted by Emily Gillespie
Investigations by Emily Gillespie are focused on the use of genomic and proteomic techniques to identify pathways that are dysregulated in autoimmunity, with the hope that further study of these pathways will lead to identification of the genes that confer susceptibility to autoimmune disease. Many projects are based on the lupus sample biorepository generated by the Autoimmune Biomarkers Collaborative Network (ABCoN). This study included longitudinal collection of biological samples and clinical data from 300 patients followed over approximately one year. Samples were also collected from single visits of an additional 350 SLE patients. One project based on this dataset seeks to identify peripheral blood gene expression patterns that distinguish SLE patients from healthy control individuals. Another goal is to identify gene expression and serum protein profiles that predict disease activity or other clinical outcomes of SLE. A third project aims to identify genetic variants that influence the patterns of dysregulated gene and protein expression seen in lupus patients.
Check out the Gillespie Lab Website!
