Dan Kaufman, M.D./Ph.D., Stem Cell Institute at the University of Minnesota

kaufm020@umn.edu

Lab Website:  http://www.tc.umn.edu/~kaufm020/

Education

B.A., Stanford University
M.D., Ph.D. (Immunology), Mayo Medical School and Mayo Graduate School, Rochester, Minn.
Internal medicine residency and fellowship training in hematology, University of Wisconsin-Madison.

Research Interests

Dr. Kaufman is an assistant professor of Medicine in the Division of Hematology, Oncology.

His research interests focus on hematopoietic and endothelial cell development from human and non-human primate embryonic stem (ES) cells. This research uses ES cells to understand the earliest stages of hematopoiesis.

In vitro and in vivo models are used to elucidate both extracellular protein interactions and intracellular genetic regulation that impact these developmental pathways. ES cells offer a unique model to investigate basic developmental biology and may serve as a therapeutic cell source to replace or repair cells or tissues damaged by disease or other degenerative processes.

Selected Publications

• Tian X., P.S. Woll, J.K. Morris, J.L. Linehan, and Dan S. Kaufman. 2006. Hematopietic Engraftment of Human Embryonic Stem Cell-Derived Blood Cells is Regulated by Host Innate Immunity.   Stem Cells 24:1370-80.

• Cameron, CM, W-S. Hu, and DS. Kaufman. 2006. Improved Development of Human Embryonic Stem Cell-Derived Embryoid Bodies by Stirred Vessel Cultivation.   Biotechnology and Bioengineering. 94: 938-948.

• Hematti, Peiman, Petra Obrtlikova,, and Dan S. Kaufman. 2005. Nonhuman Primate Embryonic Stem Cells as a Pre-clinical Model for Hematopoietic and Vascular Repair.   Exp Hematol, 2005, 33: 980-986.

• Martin, Colin H. and Dan S. Kaufman. 2005. Synergistic use of adult and embryonic stem cells to study human hematopoiesis.  Curr Opin Biotechnol. 16: 510-515.

• Woll, Petter S., Colin H. Martin, Jeffrey S. Miller, and Dan S. Kaufman. 2005. Human embryonic stem cell-derived natural killer cells acquire functional receptors and cytolytic activity. J. Immunol. 175: 5095-5103.

• Schwartz, R. , J. Linehan, M. Painschab, W.-S. Hu, C. M. Verfaillie, and D. S. Kaufman.2005. Defined conditions for development of functional hepatic cells from human embryonic stem cells.   Stem Cells and Development,14: 643-55.

• Kaufman, Dan S., Rachel L. Lewis, Eric T. Hanson, Robert Auerbach, Johanna Plendl, and James A. Thomson. 2004. Functional Endothelial Cells Derived From Rhesus Monkey Embryonic Stem Cells.   Blood, 103:1325-1332.

• Tian, Xinghui., Julie Morris, Jon. Linehan, and Dan S. Kaufman. 2004. Cytokine requirements differ for stroma and embryoid body-mediated mediated hematopoiesis from human embryonic stem cells.   Exp Hematol, 2004, 32:1000-1009.

• Kaufman, Dan S., Eric T. Hanson, Rachel L. Lewis, Robert Auerbach, and James A. Thomson. 2001. Hematopoietic colony-forming cells derived from human embryonic stem cells. Proc. Natl. Acad. Sci. USA. 98:10716-10721.