Education
Faculty/Staff Positions
Administrative Appointments
Medical Licensure
Board Certification
Academic Awards
Membership in Societies
Grants
Bibliography
Publications: Book Chapters
Publications: Abstracts
Teaching
EDUCATION:
High School Attended and Date of Graduation:
Lutheran High School East, Detroit, Michigan 1966
Colleges and Universities Attended:
Oakland University, Oakland, B.A., Chemistry 1969
Oakland University, Oakland, M.S., Chemistry 1970
Johns Hopkins University Graduate School, Biophysics 1970-1971
Brandeis University Graduate School, Physical Chemistry 1972-1973
Wayne State University School of Medicine, M.D. 1977
University of Minnesota Graduate School, Physiology 1980-1983
Internship:
University of Minnesota, Department of Surgery 1977-1978
Residencies:
University of Minnesota, Department of Surgery 1978-1985
Chief Resident, University of Minnesota , Department of Surgery 1985-1986
Research Fellowships:
University of Minnesota, Department of Surgery, Research Fellow 1980-1984
Clinical Fellowships:
Critical Care, University of Minnesota, Department of Surgery 1986-1987
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FACULTY/STAFF POSITIONS:
Instructor, Department of Surgery, University of Minnesota 1988-1990
Assistant Professor, Department of Surgery, Univ. of Minnesota. 1991-1993
Associate Professor, Department of Surgery, Univ. of Minnesota. 1994-1999
Assistant Professor, Department of Food Science and Nutrition (Adjunct) 1992-1994
Graduate Faculty, Department of Food Science and Nutrition 1995-present
Graduate Faculty, Department of Surgery 1995-present
Staff Surgeon, Veterans Affairs Med. Ctr., Minneapolis, Minnesota 1987-present
Surgeon, Trauma Service, North Memorial Medical Center 1998-present
Professor, Department of Surgery, Univ. of Minnesota 1999-present
Vice Chairman, Department of Surgery, Univ. of Minnesota 1999-present
Director, Surgical Intensive Care Units, Veterans Affairs Med. Ctr., 1987-1997, Minneapolis, Minnesota
Chief, Surgical Service, Minneapolis Veterans Affairs Medical Center, 1999-present
Director, Speciality Patient Care Service Line, 1999-present
Minnesota, 1979
American Board of Surgery, 1988
American Board of Surgery, Critical Care Certification, 1988
American Board of Surgery Recertification, 1995
American Board of Surgery, Critical Care Recertification, 1996
National Science Foundation Undergraduate Research Fellowship, 1969
National Science Foundation Graduate Fellowship, 1970-1971
National Research Service Award "Lung Microvascular Injury in Sepsis", 1980-1983
Kellogg Nutrition Research Fellowship, 1988-1990
(Molecular Biology / Nutritional Biochemistry)
University of Minnesota, Department of Surgery
Owen Wangensteen Award for Academic Excellence in Teaching, 1991
American Association for the Advancement of Science
American College of Surgeons
ACS Veterans Administration Committee on Trauma
Councilor, Minnesota Chapter (1995-1998)
American Medical Association
American Society for Parenteral and Enteral Nutrition
American Thoracic Society
European Thoracic Society
Association for Academic Surgery
Association of Veterans Administration Surgeons
Central Surgical Society
New York Academy of Sciences
Phi Kappa Phi - University of Minnesota
Society for Experimental Biology and Medicine
Society for the Surgery of the Alimentary Tract
Society of Critical Care Medicine
Minneapolis Surgical Society
American College of Physician Executives
American Association of Immunologists
Surgical Infection Society
Scientific Studies Committee (1994-1997)
Societe Internationale Committee (1994-1997)
Societe Internationale de Chirurgie
Society of University Surgeons
University of Minnesota NIH Liver Core Center Grant. CYTOKINE MODULATION OF HEPATIC GENE EXPRESSION IN SEPSIS. 1989-1990
Role: Principle Investigator
Minnesota Medical Foundation. Regulation of Carnitine Palmitoyl Transferase in Sepsis, 1989 Role: Principle Investigator
Clintec International. BRANCHED-CHAIN AMINO ACID ENRICHED NUTRITIONAL SUPPORT AND HEPATIC ENCEPHALOPATHY. 1990-1991.
Role: Principal Investigator
Veterans Administration Merit Review Grant. REGULATION OF HEPATIC GENE EXPRESSION FOLLOWING PERITONEAL SEPSIS IN RAT. 1991-1994. Role: Principal Investigator
Sabita Roy, Ph.D. Co-Investigator
Veterans Administration Cooperative Study. CHOICE OF ANESTHESIA: GENERAL VS. EPIDURAL. Cooperative Study No. 345. 1991-1994, Role: Site Investigator
Minnesota Medical Foundation. REGULATION OF PROGRAMMED CELL DEATH IN THYMOCYTES FOLLOWING SEPSIS. 1994
Role: Principal Investigator
Sabita Roy, Ph.D. Co-Investigator
National Institutes of Health R29, EFFECTS OF MORPHINE ON THE IMMUNE CELLS
Sabita Roy, Ph.D., Principal Investigator, 1994-1999
Role: Consultant
Veterans Administration Merit Review Grant. REGULATION OF HEPATIC GENE EXPRESSION FOLLOWING PERITONEAL SEPSIS IN RAT. 1994-1997.
Role: Principal Investigator
Sabita Roy, Ph.D. Co-Investigator
Department of Defense / Veterans Affairs. REGULATION OF MACROPHAGE IL-12 EXPRESSION BY THE TRANSCRIPTION FACTOR C-FOS. 1998-2001 Role: Principal Investigator
Sabita Roy, Ph.D. Co-Investigator
National Institute of Health, RO1
ROLE OF m-OPIOID RECEPTOR IN IMMUNE FUNCTION,
1999-2003
Sabita Roy, Ph.D. Principal Investigator
Roderick A. Barke, M.D. Role: Co-Investigator
Evans & Sutherland, Ltd. Mathmatical Modeling of Medical Operations Management.
1999-2002
Roderick A. Barke, Principal Investigator
National Institute of Health, RO1
MU Opioid receptor and immune function
2003-2008
Sabita Roy, Ph.D. Principal Investigator
Roderick A. Barke, M.D. Co-Investigator
National Institute of Health, RO1
Stent induced artery wall hypoxia and intimal hyperplasia
2005-2008
Steven Santilli - Principal Investigator
Roderick A. Barke, M.D. Co-Investigator
1. Dunn DL, Barke RA, Condie RM, Humphrey EW, Simmons RL. The effect of stroma free hemoglobin on clearance of bacteria from the peritoneal cavity. Surgical Forum 1982;32:28-32.
2. Dunn DL, Barke RA, Condie RM, Humphrey EW, Simmons RL. Mechanisms of the adjuvant effect of hemoglobin in experimental peritonitis. VII. Hemoglobin does not inhibit clearance of Escherichia coli from the peritoneal cavity. Surgery 1983; 94(3):487-93.
3. Barke RA, Dunn DL, Dalmasso AP, Orser M, Simmons RL, Humphrey EW. The efficacy of ibuprofen treatment vs. ibuprofen pretreatment following Escherichia coli peritoneal contamination. Surgical Forum 1983; 34: 144-146.
4. Barke RA, Dunn DL, Dalmasso AP, Simmons RL, Humphrey EW. Comparative pulmonary effects of intraperitoneal inoculation of live vs. dead Escherichia coli. Arch. Surg. 1984; 119:173-179.
5. Dunn DL, Barke RA, Ahrenholz DH, Humphrey EW, Simmons RL. The adjuvant effect of peritoneal fluid in experimental peritonitis: Mechanisms and clinical implications. Ann. Surg. 1984, 199:37-43.
6. Dunn DL, Barke RA, Lee JT, Condie RM, Humphrey EW, Simmons RL. Use of bacterial mutants to study the adjuvant effect of hemoglobin in experimental E.coli peritonitis. Surgical Forum 1984; 25:132-134.
7. Abrams JM, Barke RA, Cerra FB. Quantitative evaluation of the clinical course in surgical ICU patients: The data conforms to catastrophe theory. J. Trauma 1984; 24(12): 1028-1037.
8. Dunn DL., Barke RA, Ewald DC, Simmons RL. Effects of Escherichia Coli and Bacteroides Fragilis on peritoneal host defenses. Infect. Immun. 1985; 48:287-291.
9. Dunn DL, Barke RA, Knight BN, Humphrey EW, Simmons RL: Role of the resident macrophage, peripheral neutrophils, and translymphatic absorption in bacterial clearance from the peritoneal cavity. Infect. Immun. 1985; 49:257-264.
10. Keller GA, Barke RA, Harty JT, Humphrey EW, Simmons RL: Do decreased hepatic glutathione levels in septic shock predispose to oxidative stress? An experimental approach. Arch. Surg. 1985; 120(8):941-5.
11. Dunn DL, Barke RA, Ewald DC, Simmons RL, Macrophages and translymphatic absorption represent the first line of host defense of the peritoneal cavity. Arch. Surg. 1987; 122:105-110.
12. Barke RA, Cerra FB. Multiple Systems Organ Failure. Topics Emerg. Med. 1988; 9(4):1-3.
13. Barke RA, Dunn DL, Dalmasso AP, O'Connor-Allen M, Simmons RL, Humphrey EW: The association of E.coli virulence and pulmonary microvascular damage. Arch. Surg. 1989; 124:449-452.
14. Barke RA: Invited editorial comment: Critical Care Outlook, QMP Clinical Series in Critical Care, 1989.
15. O'Connor-Allen M, Wilton PB, Barke RA, Gerding D, Forstrom L, Sheafer R, Vennes JA. Effects of biliary obstruction on hepatic clearance of bacteria. Arch. Surg. 1989; 124:973-977.
16. Compos CT, Nygaard S, Barke RA, Humphrey EW: Squamous cyst of the pancrease: Case Report and Literature Review. Minnesota Med. 1989; 46:36-40.
17. Barke RA, Dunn DL, Dalmasso AP, O'Connor-Allen M, Humphrey EW: Enterococcal sepsis and lung microvascular injury in sheep. Arch. Surg. 1990; 125(4)437-440.
18. Barke RA, Brady PS, Brady LJ: The modulation of hepatic gene expression by dopamine and dobutamine: The effect on fatty acid oxidation. Surgical Forum 1990; XLI:1-3.
19. Barke RA, Brady PS, Brady LJ: The Ca2+ second messenger system and IL-1a modulation of hepatic gene transcription and mitochondrial fat oxidation. Surgery 1991; 110(2):285-294.
20. Barke RA, Brady PS, Brady LJ. The effect of peritoneal sepsis on hepatic gene expression and mitochondrial fat oxidation. Surgical Forum 1991, XLII:62-65. D,P,I,A,W
21. Barke RA, Brady PS, Brady LJ. The Ca+2 Second Messenger System and TNFa Modulation of Hepatic Gene Transcription and Mitochondrial Fat Oxidation. European Surgical Research, 23(Supp. 1):20, 1991.
22. Barke RA, Brady PS, Roy S, Charboneau R, Brady LJ. The possible inhibitory role of the DNA binding protein c-Fos in the regulation of gene expression in sepsis. Surgery 1992, 112(2):412-8.
23. Barke RA, Brady PS, Brady LJ: The Regulation of Mitochondrial Fatty Acid Oxidation and Hepatic Gene Expression by Catecholamine. J. Surg. Res. 1993; 54(2):95-101.
24. Pasquale M, Druck P, McQuarrie D, Barke RA: The complications of arterial catheter monitoring: Brachial vs. Radial arterial catheters, Intensive Care Medicine 1993; 32:16-19.
25. Barke RA. Book Review: Atlas of Surgery of the Stomach, Duodenum, and Small Bowel by James C. Thompson, M.D., Gastrointestinal Endoscopy 1993, 39(1):116.
26. Barke RA. Book Review: Atlas of Laparoscopic Surgery, edited by Eddie Joe Reddick, M.D., Gastrointestinal Endoscopy 1994, 43(2):121
27. Barke RA, Roy S, Chapin R, Brady PS, Charboneau R, Brady LJ. Sepsis induced CNS release of IL-6 may induce the hepatic immediate-early gene program through a hypothalamic-hypophyseal mechanism. Surgery 1994; 116:141-9.
28. Barke RA, Roy S, Chapin R, Brady PS, Charboneau R, Brady LJ. Thymic programmed cell death (apoptosis) following peritoneal sepsis. The role of IL-2 gene transcription. Arch. Surg. 1994; 1256-1262
29. Chapin RB, Brady PS, Barke RA, Brady LJ. Hepatic CCAAT/Enhancer binding protein (C/EBPa and C/EBPb) expression changes with riboflavin deficiency, diet restriction and starvation in rats. J. Nutr. 124:2365-2375, 1994.
30. Roy S, Loh HH, Barke RA. Morphine-induced suppression of thymocyte proliferation is mediated by inhibition of IL-2 synthesis. Advances in Experimental Medicine & Biology. 373:41-8, 1995.
31. Chapin RB, Roy S, Charboneau R, Brady PS, Brady LJ, Barke RA. The regulation of the transcription factor C/EBPa following peritoneal sepsis. J. Surg. Res. 59:460-467, 1995.
32. Roy S, Cain K, Chapin R, Charboneau R, Barke RA. The possible role of a CNS dopaminergic mechanism in hepatic c-fos protein expression following peritoneal sepsis.
Arch. Surg. 130:1209-1216, 1995. D,A,W
33. Roy S, Loh HH, Barke RA. Morphine Induced Supression of Thymocyte Proliferation is Mediated by Inhibition of IL-2 synthesis. Adv.Exp.Med.Biol. (1995) 373:41-48.
34. Roy S, Loh HH, Barke RA. Morphine induced suppression of thymocyte proliferation is mediated by inhibition of IL-2 synthesis. The Brain Immune Axis and Substance Abuse, (B. Sharp, T. Eisenstein, J. Madden, H. Friedman, Eds.), Plenum Press, New York, 1995, pp. 41-48.
35. Barke RA. Book Review: Laparoscopic Digestive Surgery (Clinical Surgery International - 19), Edited by P. Testas, M.D., B Delaitre, Gastrointestinal Endoscopy 1996, 43(3):14
36. Roy S, Chapin R, Cain K., Charboneau R., Ramakrishnan, S., Barke RA. Morphine inhibits transcriptional regulation of IL-2 synthesis in thymocytes. Cell. Immunol. 1997, 179, 1-9.
37. Barke RA, Birklid S, Chapin R, Brady PS, Brady LJ. The effect of surgical treatment following cecal ligation and puncture in rat on hepatic gene expression. J. Surg. Res. 60:101-106, 1996.
38. Roy S, Sedqi M, Ramakrishnan S, Barke RA, Loh HH. Differential effects of opioids on the proliferation of a macrophage cell line, Bac 1.2F5. Cellular Immunology. 169(2):271-7, 1996 May 1.
39. Chendrasekhar A, Barke RA, Druck P. Recurrent amiodarone pulmonary toxicity. Southern Medical Journal. 89(1):85-6, 1996 Jan.
40. Carson L, Salzman, Roy S, Cain K, Olson T, Charboneau R, Barke RA. The hypopthalamic-hypophyseal genotypic response to ovarian carcinoma simulates the response to sepsis. Journal of Surgical Research. 75(2):97-102, 1998 Mar.
41. Roy S, Chapin RB, Cain KJ, Charboneau RG, Ramakrishnan S, Barke RA. Morphine inhibits transcriptional activation of IL-2 in mouse thymocytes. Cellular Immunology. 179(1):1-9, 1997 Jul 10.
42. Roy S, Cain KJ, Chapin RB, Charboneau RG, Barke RA. Morphine modulates NFkb activation in macrophages. Biochem. Biophys. Comm. 245:392-396, 1998.
43. Roy S, Chapin R, Cain K, Charboneau R, Barke RA Morphine accelerates the progression of sepsis. Adv.Exp.Med.Biol. (1998) 437: 21-31.
44. Roy S, Barke RA, Loh HH. MU-Opioid Receptor-Knockout Mice: Role of m-opiod receptor in Morphine Mediated Immune Functions. Mol. Brain Research (1998), 56; 281-283.
45. Roy S, Charboneau R., Barke R.A Morphine synergizes with LPS in an experimental sepsis model. J.Neuroimmunol. (1999) 95: 107-114.
46. Roy S, Charboneau R., Cain K., Melnyk DL, Deturris S., Barke R.A. Deficiency of the Transcription Factor c-Fos increase LPS induced macrophage IL-12 production. Surgery (1999) 126(2): 239-47.
47. Lazaron V. Barke RA. Gram-negative bacterial sepsis and the sepsis syndrome. [Review] [131 refs], Urologic Clinics of North America. 26(4):687-99, 1999 Nov.
48. Roy S, Charboneau R., Cain K., Melnyk DL, Barke R.A. IL-4 Regulates Macrophage IL-12 Protein Synthesis Through a c-fos Mediated Mechanism, Surgery In Press, 2000.
49. Roy S, Charboneau R., Barke R.A Morphine accelerates T-cell differentiation to Th2 phenotype following sepsis. Accepted Biochem. Biophys. Comm. 2000.
50. Sudha Balasubramanian, S. Ramakrishnan, Richard Charboneau, Jinghua Wang, Roderick Barke, Sabita Roy. Morphine Sulphate inhibits hypoxia induced vascular endothelial growth gractor expression in endothelial cells and cardiac myocytes. J. Mol. Cell. Cardiol. 33, 2179-2187, 2001.
51. Lazaron V. Barke RA. Gram-negative bacterial sepsis and the sepsis syndrome. Urologic Clinics of North America. 26(4):687-99, 1999 Nov.
52. Sabita Roy, Sudha Balasubramanian, S Sumandeep, Richard Charboneau, Jinghua Wang, Dean Melnyk, Greg J. Beilman, Rajan Vatassery, Roderick A. Barke. Morphine Directs T-cells Toward Th2 Differentiation, Surgery. 130(2):304-9, 2001 Aug.
53. Wang J. Charboneau R. Balasubramanian S. Barke RA. Loh HH. Roy S. Morphine modulates lymph node-derived T lymphocyte function: role of caspase-3, -8, and nitric oxide. Journal of Leukocyte Biology. 70(4):527-36, 2001.
54. Park Woo, Thompson JS, Lee KK, Veterans Affairs Cooperative Study #345 Study Group (Barke RA). Choice of Anesthesia: General versus Epidural. A V.A. Cooperative Study, Accepted, Annals of Surgery.
55. Jinhua Wang, Richard Charboneau, Roderick Barke, Horace Loh, Sabita Roy. Mu opioid receptor meiates chronic restraint stress induced lymphocyte apoptosis. J. Immunology 2002, 169:3630-3636.
56. Wang J., Charboneau R. Balasubramanian S., Barke RA, Loh HH. Roy S. The immunosuppressive effects of chronic morphine treatment are partially dependent on corticosterone and mediated by the mu-opioid receptor. Journal of Leukocyte Biology. 71(5):782-90, 2002 May.
57. Roy S., Balasubramanian S, Wang J, Chandrashekaran Y, Charboneau R, Barke RA. Morphine Inhibits VEGF Expression in Myocardial Ischemia. Surgery 2003; 134(2):336-44.
58. Wang J, Barke RA, Charboneau R, Loh HH, Roy S. Morphine negatively regulates interferon-gamma promoter activity in activiated murine T cells through two distinct cyclic AMP-dependent pathways. J Biol Chem. 2003 Sep 26;278(39):37622-31.
59. Roy S, Wang J, Gupta S, Charboneau R, Loh HH, Barke RA. Chronic morphine treatment differentiates T helper cells to Th2 effector cells to Th2 effector cells by modulating transcriptionfactors GATA 3 and T-bet. J Neuroimmunol. 2004 Feb; 147(1-2):78-81.
60. Wang JH, Barke RA, Charboneau R and Roy S. (2005) Morphine treatment impairs host innate immune response and increases susceptibility to S. Pneumoniae infection: Role of Galectin-3 and CXC chemokines. J. Immunol. 174; 426-434
61. Roy S., Wang JH, Charboneau RG, and Barke RA, (2005) Chronic Morphine treatment regulates IL-4 synthesis through adenylate cyclase Gai/o mechanism. J Immunol. (accepted)
62. Kelschenbach J, Barke RA, Roy S. Morphine withdrawal contributes to Th cell differentiation by biasing cells toward the Th2 lineage. J Immunol. 2005 Aug 15;175(4):2655-65.
Koodie L., Ramakrishnan S., Barke R.A. Roy S., (2006) Morphine modulates tumor angiogenesis through a HIF-1 alpha dependent pathway. Cancer Res. (manuscript in preparation)
1. Carson LF, Barke RA, Savage JE, Twiggs LB, Dunn DL: Infection and Pelvic Malignancies, In: Carson CC (ed.) Problems in Urology, Philadelphia, Lippincott, 1988.
2. Brady PS, Barke RA, Brady LJ: Regulation of the 68 kDa Hepatic Carnitine Palmitoyltransferase, In: Berdamer C and Hargreaves J (ed.) Nutrition and Gene Expression, CRC Reviews, New York, New York, CRC Press, 1991.
3. Barke RA: Fluids and Electrolytes, In: Abrams JH and Cerra FB (eds.) Essentials of Surgical Critical Care, Quality Medical Publishing, Inc.1992.
4. Pasquale M, Barke RA: Acute Abdomen, In: Abrams JH and Cerra FB (eds.) Essentials of Surgical Critical Care, Quality Medical Publishing, Inc. 1992.
5. Provost D, Barke RA: Nutritional support in the urologic patient. In: Topics in Clinical Urology: Complications of Interventional Techniques, Carson CC (Ed.), pp: 212-229, 1995.
6. Barke RA: Fluids and Electrolytes, In: Abrams JH and Cerra FB (2eds.) Essentials of Surgical Critical Care, Quality Medical Publishing, Inc. 2006 .
1. Barke RA, Dunn DL, Dalmasso AP, Orser M, Johnson JA, Simmons RL. The effects of live vs. dead E.coli peritoneal contamination on pulmonary function. Fed. Proc. 1983; 36:1922.
2. Barke RA, Dunn DL, Dalmasso AP, Simmons RL, Humphrey EW. Increased E.coli virulence results in increased lung microvascular injury following E.coli peritonitis. Fed. Proc. 1984; 43:885.
3. Dunn DL, Barke RA, Ahrenholz DH, Humphrey EW, Simmons RL. Adverse effects of peritoneal fluid on secondary bacterial peritonitis. Association for Academic Surgery, 17th Annual Meeting, Syracuse, New York, November 2-5, 1983.
4. Dunn DL, Barke RA, Nelson RD, Humphrey EW, Simmons RL. The effect of stroma-free hemoglobin and red cell stroma on clearance of bacteria from the peritoneal cavity. Surgical Infection Society, American College of Surgeons, November 1981.
5. Barke, RA, Dunn DL, Dalmasso AP, O'Connor-Allen M, Simmons RL, Humphrey EW. The association of E.coli virulence and pulmonary microvascular damage. Association of VA Surgeons, May 5, 1988.
6. Barke RA, Dunn DL, Dalmasso AP, O'Connor-Allen M, Humphrey EW. Enterococcal sepsis and lung microvascular injury in sheep. The Association of VA Surgeons, May 21, 1989.
7. Dunn DL, Barke RA, Simmons RL. Comparison of phagocytic rates and capacity of peritoneal macrophages and polymorphonuclear leukocytes. Surgical Infection Society, 9th Annual Meeting, April 13-14 Colorado, 1989.
8. Barke RA, Brady PS, Brady LJ. Regulation of Hepatic Fatty Acid Oxidation by Cytokines. FASEB 1990; 4(3): A654-2251.
9. Birklid SD, Brady PS, Brady LJ, Barke RA. Hepatic Gene Expression in a rat intra-abdominal sepsis model: Fatty acid oxidation. FASEB 1990; 4(3):A654-2250.
10. Barke RA, Brady PS, Brady LJ. The Ca+2 Second Messenger System and IL-1a Modulation of Hepatic Gene Transcription and Mitochondrial Fat Oxidation, Society of University Surgeons, February 7-9, Galveston, Texas, 1991.
11. Barke RA, Brady PS, Brady LJ. Modulation of hepatic mitochondrial fat oxidation and hepatic gene expression by tumor necrosis factor. Submitted to 2nd International Congress on the Immune Consequences of Trauma, Shock and Sepsis. Mechanism and Therapeutic Approaches. March 6-9, Munich, Germany, 1991.
12. Barke RA, Brady PS, Brady LJ. The Ca+2 Second Messenger System and IL-1a Modulation of Hepatic Gene Transcription and Mitochondrial Fat Oxidation, XXVIth Congress of the European Society for Surgical Research, 8th Tripartitie Meeting, Salzburg Austria, European Surgical Research, 23(Supp. 1):20, 1991
13. Barke RA, Brady PS, Roy S, Charboneau R, Brady LJ. The possible inhibitory role of the DNA binding protein c-Fos in the regulation hepatic gene expression in sepsis. Society of University Surgeons, February 11-12, Cincinnati, Ohio, 1992.
14. Barke RA, Birklid S, Bardy PS, Brady LJ. The effect of surgical treatment following cecal ligation and puncture in rat on hepatic gene expression. Surgical Infection Society, April 12-13, Los Angeles, Calif., 1992.
15. Barke RA, Brady PS, Brady LJ: The Regulation of Mitochondrial Fatty Acid Oxidation and Hepatic Gene Expression by Catecholamine. Association of VA Surgeons, April 30, 1992.
16. Barke RA, Birklid S, Brady PS, Brady LJ. The effect of surgical treatment following cecal ligation and puncture in rat on hepatic gene expression. Surgical Infection Society of Europe, June 8-10, Santiago de Compostela, Spain, 1992.
17. Barke RA, Roy S, Chapin R, Brady PS, Charboneau R, Brady LJ. Sepsis induced CNS release of IL-6 may induce the hepatic immediate-early gene program through a hypothalamic-hypophyseal mechanism. Society of University Surgeons, Jackson Mississippi, 1994.
18. Barke RA, Roy S, Chapin R, Brady PS, Roy S, Charboneau R, Brady LJ. Thymic programmed cell death (apoptosis) following peritoneal sepsis. The role of IL-2 gene transcription. Surgical Infection Society, Toronto, Canada, 1994.
19. Chapin RB, Roy S, Charboneau R, Brady PS, Brady LJ, Barke RA. The regulation of the transcription factor C/EBPa following peritoneal sepsis. Association of VA Surgeons, Reno, Nevada, 1994.
20. Roy S, Chapin R, Charboneau R, Loh HH, Barke RA. Morphine treatment inhibits IL-2 gene expression in Murine thymocytes at the transcriptional level. Substance Abuse and the Brain-Immune Axis, West Palm Beach, Florida, June 17, 1994.
21. Melnyk DL, Roy S, Cohen S, Barke RA. Effects of Intrathecal Morphine on Hepatic Gene Expression in a Rat Sepsis Model. American College of Anesthesiology. Atlanta, Georgia, October 14, 1994
22. Roy S, Cain K, Chapin R, Charboneau R, Barke RA. The possible role of a CNS dopaminergic mechanism in hepatic c-fos protein expression following peritoneal sepsis. Surgical Infection Society, Louisville, Kentucky, 1995.
23. Carson L, Salzman, Roy S, Cain K, Olson T, Charboneau R, Barke RA. The genotypic response to ovarian carcinoma simulates the response to sepsis. Society of Gynecologic Oncology, New Orleans, Louisiana, February 14, 1996.
24. Roy S, Cain K, Chapin R, Charboneau R, Barke RA. Lipopolysaccharide treatment of c-fos deficient mice results in a paradoxical increase in T-cell proliferation through a macrophage mediated mechanism. Experimental Biology '96, Washington DC.
25. Carson L, Salzman, Roy S, Cain K, Olson T, Charboneau R, Barke RA. Regulation of the transcription factors C/EBP, c-jun, c-fos with ovarian carcinoma simulates the response to sepsis. 1st European Symposium on Ovarian Cancer, June 15, 1996, Centre de congres "Espace Tete d'Or", Lyon, France
26. Roy, S., Sedqi, M, Ramakrishnan S., Loh, H.H. and Barke R.A (1995). Morphine inhibits the proliferation but not differentiation of a macrophage cell line. Brain Immune Axis.
27. Roy, S., Sedqi, M, Ramakrishnan S., Loh, H.H. and Barke R.A (1995). Differential effects of opioids on the proliferation of a macrophage cell line. Int. Narcotic Research Conference
28. Roy S, Cain K, Charboneau R, DeTurris S, Barke RA Deficiency of the Trancription factor c-fos increases LPS induced Macrophage IL-12 production. Society of University Surgeons 1999, New Orleans, LA
29. Roy S, Charboneau R., Cain K., Melnyk DL, Barke R.A. IL-4 Regulates Macrophage IL-12 Protein Synthesis Through a c-fos Mediated Mechanism, Society of University Surgeons 2000, Toronto, Canada.
30. Roy S, Charboneau R., Cain K., Melnyk DL, Barke R.A. Morphine regulates TNFa transcription through an NFkB mediated mechanism. Surgical Infection Society, 2000
31. Sabita Roy, Sudha Balasubramanian, S Sumandeep, Richard Charboneau, Jinghua Wang, Dean Melnyk, Greg J. Beilman, Rajan Vatassery, Roderick A. Barke. Morphine Directs T-cells Toward Th2 Differentiation, Society of University Surgeons, 2001.
32. Jinghua Wang, Richard Charboneau, Roderick Barke, Sabita Roy. mu-Opioid receptor is involved in restraint stress induced immunosuppression. PNIRS, 2002; 16(2):222.
33.Sabita Roy, Sudha Balasubramanian, S Sumandeep, Richard Charboneau, Jinghua Wang, Roderick A. Barke. Chronic morphine treatment regulates IL-4 synthesis through the transcription factor GATA-3, PNIRS, 2002; 16(2):212.
34. Sabita Roy, Richard Charboneau, Jinghua Wang, Roderick Barke. Morphine inhibits VEGF expression in myocardial ischemia. Society of University of Surgeons, Houston, Texas, 2003.
TEACHING:
Undergraduate
Department of Surgery
Surgery 5-500 (1986-1998)
Fluid and Electrolyte Management
Nutritional Support
Trauma
Surgery 5-502 (1988-present)
Surgical Intensive Care
Undergraduate
Medical Student Advisor
Graduate
Department of Surgery
UM Surgical Critical Care Conference
Metabolic / Immunologic Response to Injury
Department of Surgery
VAMC SICU Conference
Metabolic / Immunologic Response to Injury
Adult Respiratory Distress Syndrome
Nosocomial Pneumonia
Department of Obstetrics and Gynecology, Gynecologic Oncology Section
Issues in Critical Care
Surgical Education Committee
Graduate Students (Ph.D. students)
Chapin, Rebecca: The effect of peritoneal sepsis on transcriptional regulation: The role of C/EBP leucine zipper proteins. Department of Food Science and Nutrition.
Ph.D. Completed 1994 (Co-Advisor with Dr. Linda Brady, Ph.D.)
Stanley DeTurris. Regulation of transcription following sepsis. Department of Surgery
University of Minnesota