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Emily Gillespie
Emily (Baechler) C. Gillespie, Ph.D.
Assistant Professor
Dr. Emily Gillespie is an Assistant
Professor of Medicine, and member of the Autoimmunity Program of the Center for
Immunology, and the Institute of Human Genetics at the University of Minnesota.
Dr. Gillespie's major scientific goal is to use genomic and proteomic
technologies to identify clinically useful biomarkers for the diagnosis,
monitoring, and management of autoimmune diseases. Her research projects are
primarily focused on systemic lupus erythematosus (SLE), but she is also
involved in studies of rheumatoid arthritis, Crohn?s disease, idiopathic
thrombocytopenic purpura, and fatigue.
Research being conducted by Emily Gillespie
Investigations by Emily Gillespie
are focused on the use of genomic and proteomic techniques to identify pathways
that are dysregulated in autoimmunity, with the hope that further study of these
pathways will lead to identification of the genes that confer susceptibility to
autoimmune disease. Many projects are based on the lupus sample biorepository
generated by the Autoimmune Biomarkers Collaborative Network (ABCoN). This
study included longitudinal collection of biological samples and clinical data
from 300 patients followed over approximately one year. Samples were also
collected from single visits of an additional 350 SLE patients. One project
based on this dataset seeks to identify peripheral blood gene expression
patterns that distinguish SLE patients from healthy control individuals.
Another goal is to identify gene expression and serum protein profiles that
predict disease activity or other clinical outcomes of SLE. A third project
aims to identify genetic variants that influence the patterns of dysregulated
gene and protein expression seen in lupus patients
Publications:
Pubmed
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