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Home > Fellowship > Study Guides > Study Guide for Proteinases and Matrix Degradation
Study Guide for Proteinases and Matrix Degradation
 Chapter 4
November 24th, 2003
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Review the differences in catalytic site structure and localization of the proteases important to cartilage, bone and basement membrane degradation
- Consider the regulatory mechanisms: 1. conversion of proenzyme to active protease, 2. coordinated expression of enzyme and small molecular weight inhibitors important for control of proteolytic damage
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Describe how the proteolytic mechanisms of cartilage and bone damage differ in RA and OA
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